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1 – Tracking Universal Health Coverage: 2017 Global Monitoring Report – Joint Report from the World Bank and the World Health Organization (free PDF)

Press Release: World Bank and WHO: Half the world lacks access to essential health services, 100 million still pushed into extreme poverty because of health expenses (free)

Infographic: Tracking Universal Health Coverage: 2017 Global Monitoring Report (free)

Commentaries: Healthcare costs are pushing millions into extreme poverty. This outrage must end – World Economic Forum (free) AND Almost 100 million people a year ‘forced to choose between food and healthcare’ – The Guardian (free)

 

2 – Is treatment with corticosteroids beneficial and safe for people with pneumonia? – The Cochrane Library (free)

Related: Corticosteroids for Pneumonia: Ready for Primetime? – emDocs (free)

“Corticosteroid therapy reduced mortality and morbidity in adults with severe CAP; the number needed to treat for an additional beneficial outcome was 18 patients (95% CI 12 to 49) to prevent one death. Corticosteroid therapy reduced morbidity, but not mortality, for adults and children with non-severe CAP”

 

3 – Estimates of global seasonal influenza-associated respiratory mortality: a modelling study – The Lancet (link to abstract – $ for full-text)

Commentaries: Respiratory diseases linked to seasonal flu claim thousands of lives every year – UN health agency (free) AND Up to 650 000 people die of respiratory diseases linked to seasonal flu each year – World Health Organization (free) AND CDC says more people die of influenza worldwide than some experts have estimated – PBS NewsHour (free)

 

4 – Effect of High-Intensity Treadmill Exercise on Motor Symptoms in Patients With De Novo Parkinson Disease: A Phase 2 Randomized Clinical Trial – JAMA Neurology (link to abstract – $ for full-text)

Commentaries: Exercise May Aid Parkinson’s Disease, but Make It Intense – The New York Times (10 articles per month are free) AND High-Intensity Exercise May Cut Parkinson’s Motor Symptoms – Medscape (free registration required) AND Vigorous Exercise May Hold Benefit in Early Parkinson’s – MedPage Today (free registration required) High-intensity exercise delays Parkinson’s progression – Northwestern University, via ScienceDaily (free)

 

5 – Associations between fast food and physical activity environments and adiposity in mid-life: cross-sectional, observational evidence from UK Biobank – The Lancet Public Health (free)

Commentaries: The built environment and obesity in UK Biobank: right project, wrong data? – The Lancet Public Health (free) AND Living near exercise facilities linked to lower BMI and smaller waists – OnMedica (free) Living near physical activity facilities linked to smaller waistline, lower BMI and lower body fat percentage – London School of Hygiene & Tropical Medicine (free)

 

6 – Association between microcephaly, Zika virus infection, and other risk factors in Brazil: final report of a case-control study – The Lancet Infectious Diseases (link to abstract – $ for full-text) (via @Onisillos)

Commentaries: Zika virus, not vaccine or insecticide, linked to birth defects in Brazil – STAT (free) AND Study bolsters Zika-microcephaly link, rules out others – CIDRAP (free)

 

7 – Healthcare-acquired infections: prevention strategies – Internal Medicine Journal (free)

Source: Hospital Medicine Virtual Journal Club

 

8 – Association Between Methylphenidate and Amphetamine Use in Pregnancy and Risk of Congenital Malformations: A Cohort Study From the International Pregnancy Safety Study Consortium – JAMA Psychiatry (free)

Editorial: Shedding Light on the Risks of Methylphenidate and Amphetamine in Pregnancy (free)

Commentary: ADHD med use during pregnancy and risk of birth defects – Brigham and Women’s Hospital, via ScienceDaily (free) AND Class of ADHD medication linked to increased risk of congenital heart defects – Cardiovascular Business (free)

“Researchers find small increase in the risk of heart defects following first-trimester exposure to methylphenidate but not to amphetamines” (from ScienceDaily)

 

9 – The Surprising Effects of Loneliness on Health – The New York Times (10 articles per month are free)

 

10 – Individualized Glycemic Control for U.S. Adults With Type 2 Diabetes: A Cost-Effectiveness Analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Individualized Glycemic Control Could Safely Cut Costs in Type 2 Diabetes – Physician’s First Watch (free) AND Individualized HbA1c Targets for Diabetes Drop Cost, Improve QoL – Medscape (free registration required) AND Personalized Blood Sugar Goals Can Save Diabetes Patients Thousands – University of Chicago Medical Center, via NewsWise (free)

 


 

1 – The BMJ Christmas Issue – “The soul of the Christmas issue is originality. We don’t want to publish anything that resembles anything we’ve published before” (see details).

 

Original Article 1: Does Peppa Pig encourage inappropriate use of primary care resources? (free) AND Commentary: Peppa Pig might inspire unrealistic expectations of GPs – OnMedica (free)

Original Article 2 The science behind “man flu” (free) AND Commentary: Of mice and “man flu” – HealthNewsReview (free)

See also: The top six BMJ Christmas papers – Medical News Today (free) AND The BMJ Holiday Issue: Rain Doesn’t Mean More Joint Pain; Wine Glasses Getting Bigger – Physician’s First Watch (free)

 

2 – The Less-Is-More Crusade — Are We Overmedicalizing or Oversimplifying? – New England Journal of Medicine (free)

 

3 – Noninvasive Cardiac Radiation for Ablation of Ventricular Tachycardia – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: A ‘Game Changer’ for Patients With Irregular Heart Rhythm – The New York Times (10 articles per month are free)

“The use of stereotactic radiotherapy in five patients with refractory ventricular tachycardia (VT) showed a 99.9% reduction in VT burden”. (via @NEJM see Tweet with infographic)

 

4 – The American Society of Colon and Rectal Surgeons Clinical Practice Guideline for the Prevention of Venous Thromboembolic Disease in Colorectal Surgery – Diseases of The Colon & Rectum (free)

 

5 – AAFP Decides to Not Endorse AHA/ACC Hypertension Guideline – American Academy of Family Physicians (free) (via @kennylinafp see Tweet)

Commentary: New Hypertension Guideline: A Case of Guideline Creep? – Medscape (free registration required)

 

6 – Artificial Intelligence Promising for CA, Retinopathy Diagnoses – Physician’s Weekly (free)

Original Article 1: Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer – JAMA (link to abstract – $ for full-text) AND Commentary: Findings Show Potential Use of Artificial Intelligence in Detecting Spread of Breast Cancer – The JAMA Network (free)

Original Article 2: Development and Validation of a Deep Learning System for Diabetic Retinopathy and Related Eye Diseases Using Retinal Images From Multiethnic Populations With Diabetes – JAMA (link to abstract – $ for full-text) AND Commentary: Artificial Intelligence Detects Diabetic Retinopathy and Related Eye Diseases among Patients with Diabetes – The JAMA Network (free)

 

7 – People Don’t Take Their Pills. Only One Thing Seems to Help. – The New York Times (10 articles per month are free)

“High-tech approaches and “reminder” packaging don’t work well. Reducing prices does”.

 

8 – Supplement: The Economics of Hypertension and Cardiovascular Disease – American Journal of Preventive Medicine (free editorials, reviews and research articles)

Source: EvidenceAlerts

 

9 – Phone Addiction Is Real — And So Are Its Mental Health Risks – Forbes (free)

Related commentaries: We Need to Talk About Kids and Smartphones – TIME (free) AND Have Smartphones Destroyed a Generation? – The Atlantic (free) How Smartphones Hijack Our Minds – The Wall Street Journal (a few articles per month are free)

 

10 – Atraumatic versus conventional lumbar puncture needles: a systematic review and meta-analysis – The Lancet (link to abstract – $ for full-text)

Commentaries: Atraumatic needles associated with fewer side effects for lumbar puncture – ACP Hospitalist Weekly (free) AND Atraumatic Lumbar Puncture Needles Show Major Benefit in Meta-Analysis – Physician’s First Watch (free)

 


 

1 – The Altmetric TOP 100 Articles. What academic research caught the public imagination in 2017? (free)

 

2 – Universal Health Coverage Day, 12 December 2017 – World Health Organization (free resources)

Fact Sheet: Universal Health Coverage (UHC) – World Health Organization (free)

Related: Opinion: 5 ways to make progress towards universal health coverage – Devex (free)

 

3 – Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Women: US Preventive Services Task Force Recommendation Statement – JAMA (free)

JAMA Editorials: Menopausal Hormone Therapy for Primary Prevention of Chronic Disease (free) AND Evidence for Postmenopausal Hormone Therapy to Prevent Chronic Conditions: Success, Failure, and Lessons Learned (free) AND Menopausal Hormone Therapy for the Primary Prevention of Chronic Conditions: Unfulfilled Expectations (free)

Audio Interview: USPSTF Recommendation Statement: Hormone Therapy After Menopause (free)

Summary: Hormone Therapy Not Recommended for Prevention of Chronic Conditions in Postmenopausal Women – The JAMA Network (free)

“The U.S. Preventive Services Task Force (USPSTF) recommends against the use of combined estrogen and progestin in postmenopausal women, or estrogen alone in postmenopausal women who have had a hysterectomy, to prevent chronic conditions such as heart disease, dementia and stroke”.

 

4 – CAR T-Cell Therapies Drive Outcomes in Lymphoma, Myeloma: Treatments Hold Promise for People with Hard-to-Treat Blood Cancers – 2017 American Society of Hematology Annual Meeting (free)

Related commentary: CAR T-Cell Therapy Makes Further Inroads in Lymphoma and Myeloma – ASCO Post (free)

Related Study: Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas – New England Journal of Medicine (free), Editorial: A Milestone for CAR T Cells (free) AND Visual Abstract (free)

 

5 – Topical Tranexamic Acid Compared With Anterior Nasal Packing for Treatment of Epistaxis in Patients Taking Antiplatelet Drugs: Randomized Controlled Trial – Academic Emergency Medicine (link to abstract – $ for full-text)

Commentary: Topical TXA in Epistaxis – R.E.B.E.L.em (free)

 

6 – Get Ready For A Tsunami Of ECGs – Cardiobrief (free)

Related: Thoughts on the Apple Watch and Mobile ECG, by Dr John Mandrola (free) AND Overdiagnosis Only a Matter of Time With ECG Watches – Medscape (free registration required)

 

7 – State of The Art Review: Recent advances in pre-exposure prophylaxis for HIV – The BMJ (free fo 2 weeks)

Related Guidelines: WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection – World Health Organization (free) AND Summary: WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection (free PDF)

Related Commentary: Why PrEP takers should still use condoms with HIV+ partners – The Conversation (free)

 

8 – All-cause mortality and major cardiovascular outcomes comparing percutaneous coronary angioplasty versus coronary artery bypass grafting in the treatment of unprotected left main stenosis: a meta-analysis of short-term and long-term randomised trials – OpenHeart (free)

“PCI is associated with a reduction in the risk of major cardiovascular outcomes at short-term follow-up in patients with LMCA stenosis; but at long term, MACCE rate is increased for PCI”

 

9 – Pediatric Injuries Related to Window Blinds, Shades, and Cords – Pediatrics (free)

Commentaries: Researchers: Window Blind Cords as Dangerous to Young Children as Bodies of Water – Physician’s First Watch (free) AND Kids continue to die in window-blind accidents, despite safety warnings – Reuters (free)

 

10 – Severe COPD and the transition to a palliative approach – Breathe (free)

See more on palliative care in chronic respiratory disorders in our Decembe 6th issue (see #10)

 



Efficacy and safety of stress ulcer prophylaxis in critically ill patients: a network meta-analysis of randomized trials – Intensive Care Medicine (free)

“PPIs are the most effective agents in preventing CIB, but they may increase the risk of pneumonia”.

 


Does Cancer Screening Save More Lives Overall? Not Necessarily – WBUR (free) (via @HealthNewsRevu see Tweet)

Related systematic review: Does screening for disease save lives in asymptomatic adults? Systematic review of meta-analyses and randomized trials – International Journal of Epidemiology (free)

“We are not suggesting that cancer screening is useless. Our critique aims to show that screening tests are like any other medical intervention: there are benefits and harms.  And it’s why we support informed decision-making”.

 


 

1 – The other big drug problem: Older people taking too many pills – The Washington Post (free)

Related Articles and Commentaries: Current and future perspectives on the management of polypharmacy – BMC Family Medicine (free) 11 Drugs You Should Seriously Consider Deprescribing – Medscape Slideshow (free registration required) AND Too Many Meds? America’s Love Affair With Prescription Medication – Consumer Reports (free) AND Common ED Medication Errors: Polypharmacy – emDocs (free)

Related Website and Guidelines: Canadian Deprescribing Network (CaDeN) (free) AND CaDeN Deprescribing Guidelines and Algorithms (free) AND Deprescribing guidelines for the elderly – Ontario Pharmacy Evidence Network (free)

 

2 – Treated Incidence of Psychotic Disorders in the Multinational EU-GEI Study – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Environment May Play Major Role in Psychosis – PsychCentral (free) AND Psychosis incidence highly variable internationally – University College London, via EurekAlert (free)

 

3 – Mortality Associated with Metformin Versus Sulfonylurea Initiation: A Cohort Study of Veterans with Diabetes and Chronic Kidney Disease – Journal of General Internal Medicine (link to abstract – $ for full-text)

Commentaries: Metformin appears better than sulfonylureas as first-line therapy for patients with CKD – ACP Diabetes (free) AND Metformin May Up Survival in Older Men With Moderate CKD – Medscape (free registration required)

 

4 – Diet quality is associated with disability and symptom severity in multiple sclerosis – Neurology (link to abstract – $ for full-text)

Commentaries: Healthy diet may be linked to less disability, fewer symptoms for people with MS – News Medical (free) AND High-quality Diet, Healthy Lifestyle May Reduce MS Disability – Medscape (free registration required) AND Healthy Diet Tied to Less MS Disability – MedPage Today (free registration required)

 

5 – Review: Lung Manifestations in the Rheumatic Diseases – Chest (free)

Source: Critical Care Reviews Newsletter

 

6 – Review: Diagnosis and treatment of hyperkalemia – Cleveland Clinic Journal of Medicine (free)

Source: Critical Care Reviews Newsletter

 

7 – Viewpoint: Disclosures in Nutrition Research: Why It Is Different – JAMA (free)

“Medical researchers must disclose financial conflicts of interest. An article in @JAMA_current says nutrition researchers should also be obliged to disclose their food-related religious beliefs, comments to the public and personal diet”. (via @davidludwigmd see Tweet)

 

Expert consensus document: Advances in the physiological assessment and diagnosis of GERD – Nature Reviews Gastroenterology & Hepatology (free)

Commentary: Expert Consensus on the Assessment and Diagnosis of GERD – PracticeUpdate (free registration required)

 

9 – Intrauterine insemination with ovarian stimulation versus expectant management for unexplained infertility (TUI): a pragmatic, open-label, randomised, controlled, two-centre trial – The Lancet (link to abstract – $ for full-text)

Commentary: Fertility study shows cheaper treatment is effective – MedicalXpress (free)

 

10 – Caesarean section is better for extremely premature breech babies but not necessarily for their mothers – NIHR Signal (free)

“Delivering extremely preterm breech babies (23 to 27 weeks) by caesarean reduced the risk of infant death or brain bleeds by around 40%, compared with vaginal delivery”. (RT @NIHR_DC see Tweet)

 


 

1 – ADA 2018 Standards of Medical Care in Diabetes – Diabetes Care (Free Supplement)

News Release: American Diabetes Association Releases 2018 Standards of Medical Care in Diabetes, with Notable New Recommendations for People with Cardiovascular Disease and Diabetes (free)

Summary of Revisions: Standards of Medical Care in Diabetes—2018 (free)

Commentaries: ADA 2018 Standards Address Diabetes Drugs With CV Benefit – Medscape (free registration required)

 

2 – Standards of Medical Care in Diabetes—2018 Abridged for Primary Care Providers – Diabetes Care (free PDF)

Commentary: ADA 2018 Abridged Standards of Medical Care in Diabetes: Update for Primary Care – Medscape (free registration required

 

3 – Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Pharmacomechanical Thrombolysis for Deep-Vein Thrombosis – NEJM Resident 360 (free) AND Pharmacomechanical Thrombolysis for DVT – American College of Cardiology, Latest in Cardiology (free)

Pharmacomechanical thrombolysis did not result in lower risk of post-thrombotic syndrome and was associated with higher risk of major bleeding.

 

4 – Efficacy and safety of stress ulcer prophylaxis in critically ill patients: a network meta-analysis of randomized trials – Intensive Care Medicine (free)

PPIs are the most effective agents in preventing CIB, but they may increase the risk of pneumonia”.

 

5 – Seven-Year Weight Trajectories and Health Outcomes in the Longitudinal Assessment of Bariatric Surgery (LABS) Study – JAMA Surgery (free)

Commentaries: We’re barely using the best tool we have to fight obesity – VOX (free) AND Gastric bypass patients sustain long-term weight loss, comorbidity reduction – Cardiovascular Business (free) AND Weight Loss After Bariatric Procedures Mostly Sustained Over Time – Medical Research (free)

 

6 – Bedtime Use of Technology and Associated Sleep Problems in Children – Global Pediatric Health (free)

Commentary: Screen time before bed linked with less sleep, higher BMIs in kids – Penn State, via ScienceDaily (free)

 

7 – Opinion: Does Cancer Screening Save More Lives Overall? Not Necessarily – WBUR (free) (via @HealthNewsRevu see Tweet)

Related systematic review: Does screening for disease save lives in asymptomatic adults? Systematic review of meta-analyses and randomized trials – International Journal of Epidemiology (free)

“We are not suggesting that cancer screening is useless. Our critique aims to show that screening tests are like any other medical intervention: there are benefits and harms.  And it’s why we support informed decision-making”.

 

8 – Themed Review: Comprehensive Care: Older People Living With Frailty in Hospitals  – NIHR Dissemination Centre (free download)

 

9 – Non-invasive cardiovascular imaging for evaluating subclinical target organ damage in hypertensive patients: A consensus paper from the European Association of Cardiovascular Imaging (EACVI), the European Society of Cardiology Council on Hypertension, and the European Society of Hypertension (ESH) – European Heart Journal Cardiovascular Imaging (free)

 

10 – The best and worst analogies for CRISPR, ranked – STAT (free)

Related: Simple guide to CRISPR, one of the biggest science stories of the decade – VOX (free)

 


Caesarean section is better for extremely premature breech babies but not necessarily for their mothers – NIHR Signal (free)

“Delivering extremely preterm breech babies (23 to 27 weeks) by caesarean reduced the risk of infant death or brain bleeds by around 40%, compared with vaginal delivery”. (RT @NIHR_DC see Tweet)

 


First Dementia Global Monitoring System Launched: Global Dementia Observatory (free resources)

News release: Dementia: number of people affected to triple in next 30 years – World Health Organization (free)

 


 

1 – First Dementia Global Monitoring System Launched: Global Dementia Observatory (free resources)

News release: Dementia: number of people affected to triple in next 30 years – World Health Organization (free)

 

2 – The global burden of tuberculosis: results from the Global Burden of Disease Study 2015 – The Lancet Infectious Diseases (free)

Invited Commentary: Tuberculosis eradication: renewed commitment and global investment required (free)

 

3 – Practical Recommendations of the Obesity Management Task Force of the European Association for the Study of Obesity for the Post-Bariatric Surgery Medical Management (free)

 

4 – Systematic review of dietary trans-fat reduction interventions – Bulletin of The World Health Organization (free)

Related: Banning trans fats in New York prevented thousands of heart attacks, study finds – STAT News (free) AND The Worst Fat in the Food Supply – The New York Times (10 articles per month are free)

 

5 – Perioperative Myocardial Injury After Noncardiac Surgery: Incidence, Mortality, and Characterization – Circulation (free PDF)

Commentaries: Myocardial Injury After Noncardiac Surgery Linked With Higher 1-Year Mortality – TCTMD (free) AND Perioperative Myocardial Injury After Noncardiac Surgery – American College of Cardiology, Latest in Cardiology (free)

 

6 – Analysis: Transvaginal mesh failure: lessons for regulation of implantable devices – The BMJ (free)

Related commentaries: Women harmed because vaginal mesh regulation ‘not fit for purpose’ – The Guardian (free) AND Vaginal mesh operations for prolapse should be banned, watchdog to say – The Guardian (free)

 

7 – Case-control and Cohort studies: A brief overview – Students 4 Best Evidence (free)

 

8 – Blood Pressure Trajectories in the 20 Years Before Death – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Blood pressure declines 14 to 18 years before death – University of Connecticut, via ScienceDaily (free) AND Long, Slow Decline in BP Often Precedes Seniors’ Death – MedPage Today (free registration required)

 

9 – Understanding common misconceptions about p-values – The 20% Statistician (free)

Related review: Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations – European Journal of Epidemiology (free)

Source: Nature Briefing Newsletter

 

10 – Low FODMAP diet may improve irritable bowel symptoms more than other diets – NIHR Signal (free)

Original article: Low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet improves symptoms in adults suffering from irritable bowel syndrome (IBS) compared to standard IBS diet: A meta-analysis of clinical studies – PLOS One (free)

 

 


Book: Child and Adolescent Health and Development – Disease Control Priorities, 3rd Edition (free)

Press Release: DCP3 Publishes Latest Volume: Child and Adolescent Health and Development (free)

Key Messages From the Series: Disease Control Priorities 3rd edition – The Lancet (7 reviews – free registration required)

Other books in the series: Essential Surgery / Reproductive, Maternal, Newborn, and Child Health / Cancer / Mental, Neurological, and Substance Use Disorders / Injury Prevention and Environmental Health / Major Infectious Diseases /Cardiovascular, respiratory, and related disorders / Disease Control Priorities (all free)

“Third edition of Disease Control Priorities launches today. A vast resource evaluating policy choices affecting the access, uptake & quality of interventions & delivery platforms to improve health in LMICs”. (RT @MRCTEG_LSHTM see Tweet)

 


A Failure to Heal – The New York Times Magazine (10 articles per month are free) (RT @camialderighi see Tweet)

 


 

1 – Book: Child and Adolescent Health and Development – Disease Control Priorities, 3rd Edition (free)

Press Release: DCP3 Publishes Latest Volume: Child and Adolescent Health and Development (free)

Key Messages from the Series: Disease Control Priorities 3rd edition – The Lancet (7 reviews – free registration required)

Other books in the series: Essential Surgery / Reproductive, Maternal, Newborn, and Child Health / Cancer / Mental, Neurological, and Substance Use Disorders / Injury Prevention and Environmental Health / Major Infectious DiseasesCardiovascular, respiratory, and related disorders / Disease Control Priorities (all free)

“Third edition of Disease Control Priorities launches today. A vast resource evaluating policy choices affecting the access, uptake & quality of interventions & delivery platforms to improve health in LMICs”. (RT @MRCTEG_LSHTM see Tweet)

 

2 – Contemporary Hormonal Contraception and the Risk of Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Even Low-Dose Contraceptives Slightly Increase Breast Cancer Risk – NPR (free) AND Study confirms higher breast cancer risk with hormone-based contraception – Reuters (free) AND Small risk of breast cancer seen with hormone contraceptives – Associated Press (free) All forms of hormonal contraception carry breast cancer risk, study finds – the Guardian (free) AND Birth Control Pills Still Linked to Breast Cancer, Study Finds – The New York Times (10 articles per month are free)

 

3 – Effectiveness of and overdiagnosis from mammography screening in the Netherlands: population based study – The BMJ (free)

Editorial: Breast cancer screening (free)

Commentaries: Breast cancer screening has ‘little impact’ on cancer deaths – OnMedica AND It’s Time to End Mammograms, Some Experts Say – TIME (free)

See more on the arguments for and against screening for breast cancer with mammography in our November 7th issue (see #4)

 

4 – Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Gene Therapy for Factor IX Deficiency (free)

Commentary: One-dose gene therapy produces clotting factor, safely stops bleeding in hemophilia B patients – MedicalXpress (free)

 

5 – Recovery after critical illness: putting the puzzle together—a consensus of 29 – Critical Care (free)

 

6 – Moral Choices for Today’s Physician – JAMA (free)

 

7 – Two nerve drugs are not suitable for treating long-term low back pain – NIHR Signal (free)

Original Article: Benefits and safety of gabapentinoids in chronic low back pain: A systematic review and meta-analysis of randomized controlled trials – PLOS One (free)

“Evidence supports NICE guidance not to use two nerve drugs (gabapentin and pregabalin) to treat long-term lower back pain”. (RT @NIHR_DC see Tweet)

 

8 – Oral Sex and Condom Use in a U.S. National Sample of Adolescents and Young Adults – Journal of Adolescent Health (link to abstract – $ for full-text)

Commentary: Kids aren’t protecting themselves against STDs during oral sex – Reuters (free)

 

9 – Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study – The Lancet (free)

Commentaries: Walking to a pathway for cardiovascular effects of air pollution – The Lancet (free) AND Traffic fumes in city streets ‘largely wipe out exercise benefits for over-60s’ – The Guardian (free)

 

10 – Impact of London’s road traffic air and noise pollution on birth weight: retrospective population based cohort study – The BMJ (free)

Editorial: Traffic pollution is linked to poor pregnancy outcomes (free)

Commentary: Air pollution from London traffic is affecting the health of unborn babies – Imperial College London (free) AND Traffic pollution linked to low birth weight of unborn babies, study reveals – Medical News (free)

 


 

1 – Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Intensive weight loss can ‘reverse’ type 2 diabetes – OnMedica (free) AND Weight Management May Reverse T2D – MedPage Today (free registration required) AND Radical diet can reverse type 2 diabetes, new study shows – The Guardian (free)

 

2 – Modern contraceptive use, unmet need, and demand satisfied among women of reproductive age who are married or in a union in the focus countries of the Family Planning 2020 initiative: a systematic analysis using the Family Planning Estimation Tool – The Lancet (free)

Related Report: FP2020 – The Way Ahead (free)

Commentaries: Contraceptive use gaining momentum in world’s poorest countries – Reuters (free) AND FP2020 reports progress on family planning, but faces an uphill battle – Devex (free)

 

3 – Validation and diagnostic accuracy of predictive curves for age-associated longitudinal cognitive decline in older adults – Canadian Medical Association Journal (free)

Commentaries: New easy-to-use tool can help determine Alzheimer’s risk, similar to pediatric growth curves – CMAJ, via EurekAlert (free) AND Cognitive Decline Charts Could Help Flag Whether Patient Has Dementia – Physician’s First Watch (free)

 

4 – Readmissions After Revascularization Procedures for Peripheral Arterial Disease: A Nationwide Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Burden of Readmission High in PAD Patients Following Revascularization – TCTMD (free) AND 1 in 6 Patients Undergoing Peripheral Arterial Revascularization Readmitted Within 30 Days – Physician’s First Watch (free) AND 1 in 6 Readmitted After Peripheral Revascularization – MedPage Today (free registration required)

 

5 – It’s Gonna Get a Lot Easier to Break Science Journal Paywalls – Wired (Free) (via @EricTopol)

 

6 – Cherry-picking by trialists and meta-analysts can drive conclusions about intervention efficacy – Journal of Clinical Epidemiology (free)

 

7 – A Failure to Heal – The New York Times Magazine (10 articles per month are free) (RT @camialderighi see Tweet)

 

8 – Association of Clinician Denial of Patient Requests With Patient Satisfaction – JAMA Internal Medicine (free)

Commentaries: Clinician denial of certain patient requests linked with decreased satisfaction – 2 Minute Medicine (free) AND Denial of some patient requests, but not others, associated with decreased patient satisfaction, study finds – ACP Internist (free) AND Patient satisfaction surveys are worthless – Physician’s Weekly (free)

 

9 – Association of US State Implementation of Newborn Screening Policies for Critical Congenital Heart Disease With Early Infant Cardiac Deaths – JAMA (free)

Commentaries: Newborn Screening Policies For CHD Associated With Lower Infant Deaths – American College of Cardiology, Latest in Cardiology (free) AND Infant CCHD deaths cut by 33% after mandatory pulse oximetry testing – Cardiovascular Business (free) AND Screening for Critical Congenital Heart Disease at Birth Saves Lives – CDC (free)

Related guideline: Canadian Cardiovascular Society/Canadian Pediatric Cardiology Association Position Statement on Pulse Oximetry Screening in Newborns to Enhance Detection of Critical Congenital Heart Disease (free)

 

10 – Advance care planning for patients with chronic respiratory diseases: a systematic review of preferences and practices – Thorax (link to abstract – $ for full-text)

Commentary: Doctors rarely discuss end-of-life care for chronic lung conditions – Reuters (free)

Related guideline: An Official American Thoracic Society Clinical Policy Statement: Palliative Care for Patients with Respiratory Diseases and Critical Illnesses (free)

 


Our Review Criteria – HealthNewsReview (free)

“Such a great list! Ten Criteria for Reviewing a News Article on Health. Cost, harms, quality of evidence, disease-mongering, conflict of interest, etc.” (RT @CaulfieldTim see Tweet)

 


Richard Lehman’s journal review, 4 December 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


 

1 – Association of Overlapping Surgery With Increased Risk for Complications Following Hip Surgery: A Population-Based, Matched Cohort Study – JAMA Internal Medicine (free)

Editorial: Overlapping Surgery – Perspectives From the Other Side of the Table (free)

Commentaries: Study: Overlapping surgeries boost complication risks – Becker’s Hospital Review (free) AND Does Overlapping Surgery Increase Complication Risk After Hip Surgery? – The JAMA Network (free)

 

2 – Cheese consumption and risk of cardiovascular disease: a meta-analysis of prospective studies – European Journal of Nutrition (link to abstract – $ for full-text)

Commentary: Eating 40g of cheese a day may reduce heart attack and stroke risk – NHS Choices (free)

Related meta-analysis: Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality: dose–response meta-analysis of prospective cohort studies – European Journal of Epidemiology (free)

 

3 – WHO reviewing data on Sanofi dengue vaccine, urges limited use – Reuters (free)

Related: Brazil recommends restrictions on Sanofi dengue vaccine – Reuters (free) AND Sanofi restricts dengue vaccine but downplays antibody enhancement – CIDRAP (free) AND New dengue vaccine could worsen disease in some people – STAT (free)

 

4 – 2017 Update in perioperative medicine: 6 questions answered – Cleveland Clinic Journal of Medicine (free)

 

5 – Pulmonary embolus in the ED – Which patients require systemic thrombolytics? – emDocs (free)

 

6 – An Unconscious Patient with a DNR Tattoo – New England Journal of Medicine (free)

Commentary: His tattoo said “do not resuscitate.” Doctors wanted another opinion – The New York Times (free)

 

7 – Headline vs. study: The unbearable heaviness of false hope – HealthNews Review (free)

 

8 – Our Review Criteria – HealthNewsReview (free)

“Such a great list! Ten Criteria for Reviewing a News Article on Health. Cost, harms, quality of evidence, disease-mongering, conflict of interest, etc.” (RT @CaulfieldTim see Tweet)

 

9 – Richard Lehman’s journal review, 4 December 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

10 – Cognitive trajectories from infancy to early adulthood following birth before 26 weeks of gestation: a prospective, population-based cohort study – Archives of Disease in Childhood (free)

Commentary: Does Cognition in Children Born Extremely Preterm Catch Up by Early Adulthood? – Journal Watch (free)

 


 

1 – SIGN Guidelines on Pharmacological management of glycaemic control in people with type 2 diabetes & Management of diabetes – Scottish Intercollegiate Guidelines Network (free guidelines and resources) (via @kamleshkhunti)

 

2 – HIV Prevention Efforts and Incidence of HIV in Uganda – New England Journal of Medicine (free)

Commentaries: Combination HIV prevention reduces new infections by 42 percent in Ugandan district – National Institutes of Health (free) AND Combination HIV Prevention Reduces Infections – MD Magazine (free)

 

3 – 2017 ACC Expert Consensus Decision Pathway on Management of Bleeding in Patients on Oral Anticoagulants – Journal of The American College of Cardiology (free)

Commentary and Summary: Consensus for Management of Bleeding on Oral Anticoagulants – American College of Cardiology, Latest in Cardiology (free)

 

4 – Clinical Guidelines Synopsis: Diagnostic Testing for Obstructive Sleep Apnea in Adults – JAMA (free)

 

5 – Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials – The BMJ (free)

Commentaries: Evidence Insufficient to Recommend Prenatal Vitamin D Supplementation, Researchers Say – Physician’s First Watch (free) AND Jury Still Out on Vitamin D Supplements in Pregnancy – MedPage Today (free registration required)

 

6 – Risk of death associated with new benzodiazepine use among persons with Alzheimer disease: A matched cohort study – International Journal of Geriatric Psychiatry (link to abstract – $ for full-text) (RT @Deprescribing see Tweet)

Commentaries: Benzodiazepines linked to increased risk of death among Alzheimer’s disease patients – News Medical (free) AND Benzodiazepines Tied to a 41% Increased Mortality Risk in AD – Medscape (free registration required)

 

7 – Rational decision making in medicine: Implications for overuse and underuse – Journal of Evaluation in Clinical Practice (free) (via @AllenFrancesMD)

 

8 – Cardiovascular and type 2 diabetes morbidity and all-cause mortality among diverse chronic inflammatory disorders – Heart (free)

 

9 – Disparities in the Quality of Cardiovascular Care Between HIV‐Infected Versus HIV‐Uninfected Adults in the United States: A Cross‐Sectional Study – Journal of The American Heart Association (free)

Commentaries: HIV-positive adults are under-treated for cardiovascular problems compared to those without HIV – UCLA Research Alert (free) AND HIV patients less likely to be prescribed aspirin, statins despite increased cardiovascular risk – Cardiovascular Research (free)

Related: Cardiovascular risk and dyslipidemia among persons living with HIV: a review – BMC Infectious Diseases (free)

 

10 – European Thyroid Association Guidelines for Ultrasound Malignancy Risk Stratification of Thyroid Nodules in Adults: The EU-TIRADS – European Tyroid Journal (free)

Related guideline: ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White Paper of the ACR TI-RADS Committee – Journal of the American College of Radiology (free PDF)

 


 

1 – World AIDS Day, 1 December 2017 – World Health Organization (free)

 

2 – Book: Cardiovascular, respiratory, and related disorders – Disease Control Priorities, 3rd Edition (free)

Press Release: Disease Control Priorities, 3rd Edition Launches Volume on Cardiovascular, Respiratory, and Related Disorders (free)

Summary: Cardiovascular, respiratory, and related disorders: key messages from Disease Control Priorities, 3rd edition – The Lancet (free registration required)

Previous volumes: 1 – Essential Surgery / 2 – Reproductive, Maternal, Newborn, and Child Health / 3 – Cancer / 4 – Mental, Neurological, and Substance Use Disorders / 5 – Injury Prevention and Environmental Health / 6 – Major Infectious Diseases (all free)

 

3 – Guideline: Protecting, promoting and supporting breastfeeding in facilities providing maternity and newborn services – World Health Organization (free)

 

4 – Guideline: Outbreak Response and Incident Management: SHEA Guidance and Resources for Healthcare Epidemiologists in United States Acute-Care Hospitals – Infection Control and Hospital Epidemiology (free)

Commentary: New document guides hospitals in responding to infectious disease outbreaks – Society for Healthcare Epidemiology of America (free)

 

5 – Marriage and risk of dementia: systematic review and meta-analysis of observational studies – Journal of Neurology Neurosurgery and Psychiatry (free)

Commentaries: Single people have a higher risk of dementia – OnMedica (free) AND Marriage linked to lower dementia risk – Reuters (free)

 

6 – Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment – The Lancet Diabetes & Endocrinology (free)

Editorial: Diabetes and adiposity: a heavy load for cancer (free)

Commentaries: Diabetes and obesity together responsible for nearly 800,000 cancers worldwide – Imperial College London (free) AND ‘Alarming’ rise in cancer rates driven by diabetes, obesity – Medical News Today (free) AND Nearly 6% of cancers worldwide are attributable to diabetes and obesity – eCancer News (free)

 

7 – Conventional Polysomnography Is Not Necessary for the Management of Most Patients with Suspected Obstructive Sleep Apnea. Noninferiority, Randomized Controlled Trial – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)

Commentary: Conventional Polysomnography vs. Home Testing for Obstructive Sleep Apnea – Journal Watch (free) AND Home Sleep Testing OK for Evaluating Suspected Sleep Apnea – MedPage Today (free registration required)

Related: Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline (free)

 

8 – Unnecessary Tests and Treatment Explain Why Health Care Costs So Much – Scientific American (free)

 

9 – Big data often yields small returns. Here’s how to fix that – STAT (free)

 

10 – Diagnostic Accuracy of Pediatric Teledermatology Using Parent-Submitted Photographs: A Randomized Clinical Trial – JAMA Dermatology (link to abstract – $ for full-text)

Commentaries: Parent-Supplied Photos Allow Pediatric Dermatology Diagnoses without an Office Visit in Most Instances – Children’s Hospital of Philadelphia (free) AND Smartphone pics may be sharp enough for dermatology diagnosis – Reuters (free)

 


European Society of Cardiology: Cardiovascular Disease Statistics 2017 – European Journal of Cardiology (free)

“The European Atlas of Cardiology brings together data from 56 countries to demonstrate the prevalence and cost of cardiovascular disease, and the need to utilise resources more effectively” (RT @OUPMedicine see Tweet)

 


 

1 – Guideline: Asthma: diagnosis, monitoring and chronic asthma management – National Institute for Health and Care Excellence (free)

News release: New ways to diagnose and manage asthma can improve care, says NICE (free)

Commentaries: NICE changes guidelines on asthma – PharmaTimes (free) AND NICE releases the latest asthma management standards – News Medical (free)

 

2 – The potential impact of food taxes and subsidies on cardiovascular disease and diabetes burden and disparities in the United States – BMC Medicine (free) (via @ArsenaultBenoit)

Related Guideline: Fiscal policies for diet and the prevention of noncommunicable diseases – World Health Organization (free)

Related articles: Reducing US cardiovascular disease burden and disparities through national and targeted dietary policies: A modelling study – PLOS Medicine (free) AND Taxes and Subsidies for Improving Diet and Population Health in Australia: A Cost-Effectiveness Modelling Study – PLOS Medicine (free) AND Policy lessons from health taxes: a systematic review of empirical studies – BMC Public Health (free)

 

3 – Association Between Wait Time and 30-Day Mortality in Adults Undergoing Hip Fracture Surgery – JAMA (link to abstract – $ for full-text)

Commentaries: Delaying Surgery for Hip Fracture for More Than One Day Associated with Small Increased Risk of Death – The JAMA Network (free) AND Delaying Hip Fracture Surgery for 1 Day Tied to Higher Mortality Risk – Physician’s First Watch (free) AND Emergency Hip Surgery Best Done Within 24 Hours – Medscape (free registration required)

 

4 – Gene Therapy Shows Promise For A Growing List Of Diseases – NPR (free)

 

5 – A three-talk model for shared decision making: multistage consultation process – The BMJ (free)

 

6 – Treatment eligibility and retention in clinical HIV care: A regression discontinuity study in South Africa – PLOS Medicine (free)

Commentary: Immediate ART treatment improves retention rates – Boston University School of Medicine (free)

 

7 – Platelet Transfusion for Patients With Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

 

8 – European Society of Cardiology: Cardiovascular Disease Statistics 2017 – European Journal of Cardiology (free)

“The European Atlas of Cardiology brings together data from 56 countries to demonstrate the prevalence and cost of cardiovascular disease, and the need to utilise resources more effectively” (RT @OUPMedicine see Tweet)

 

9 – Computerised decision support can improve antibiotic prescribing in hospitals – NIHR Signal (free)

Original Article: The effectiveness of computerised decision support on antibiotic use in hospitals: A systematic review – PLOS One (free)

 

10 – Palliative Care Eligibility, Symptom Burden, and Quality-of-Life Ratings in Nursing Home Residents – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Nursing home residents eligible for palliative care often don’t get it – Reuters (free) AND Most nursing home residents eligible for palliative care but lack access – MedicalXpress (free)

 


World Malaria Report 2017 – World Health Organization (free)

News release: Global response to malaria at crossroads (free)

“After unprecedented global success in malaria control, progress has stalled”

 


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