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This Mediterranean diet study was hugely impactful. The science just fell apart – VOX (free)

See Related Retraction and Republication: PREDIMED Study on Mediterranean Diet (free article and commentaries)


To Fight Burnout, Organize – New England Journal of Medicine (free)

“The social determinants of health — and physicians’ sense of powerlessness in the face of them — seem crucially missing from the discussion of burnout”.


Association of Antidepressant Use With Drug-Related Extrapyramidal Symptoms: A Pharmacoepidemiological Study – Journal of Clinical Psychopharmacology (link to abstract – $ for full-text)

Commentaries: Incidence of Extrapyramidal Symptoms Higher With Certain Antidepressants – MPR (free) AND Antidepressants tied to Parkinson’s-like symptoms – Univadis (free registration required)

“Observational study: Incidence of EPSs with antidepressants. RRs: duloxetine, 5.68; mirtazapine, 3.78; citalopram, 3.47; escitalopram, 3.23; paroxetine, 3.07; sertraline, 2.57; venlafaxine, 2.37; bupropion, 2.31; and fluoxetine, 2.03 (all significant)” (via @psychopharmacol see Tweet)


Cardiovascular disease risk factors in chronic kidney disease: A systematic review and meta-analysis – PLOS One (free)

“In addition to established traditional general population cardiovascular risk factors, left ventricular hypertrophy, serum albumin, phosphate, urate and hemoglobin were all found to be statistically significant in their association with future cardiovascular events”.


Prevalence and outcomes of incidental imaging findings: umbrella review – The BMJ (free)

Related: Giles Maskell: Incidental anarchy – The BMJ Opinion (free)

“Incidentalomas. If you order imaging studies, you know they are a problem. This meta-analysis quantifies incidentaloma prevalence for specific types of imaging. For MRI of the brain, the prevalence was 22% (95%CI 14 to 31) (via @RasoiniR and @eloder, see Tweet)


IOTA – Liberal vs Conservative Oxygen Therapy in the Critically Ill – The Bottom Line (free)

Original Meta-Analysis: Liberal vs Conservative Oxygen Therapy in Acutely ill Adults (link to abstract and commentary)

“Hyperoxia is BAD –> Aim for lowest safest inspired O2 in critically ill pts & titrate FiO2 down if SpO2 >95%” (via @srrezaie see Tweet)


Prognostic Implications of Single-Sample Confirmatory Testing for Undiagnosed Diabetes: A Prospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Diagnosing Diabetes From a Single Blood Sample – Johns Hopkins Bloomberg School of Public Health, via NewsWise (free) AND One Blood Test Might Be Enough to Diagnosis – HealthDay (free) AND Diabetes Dx Predicted Accurately with Single Blood Sample – MedPage Today (free registration required)

“The standard practice of repeat blood tests may not always be necessary, a new study suggests” (from Johns Hopkins Bloomberg School of Public Health)


Helping patients choose wisely – The BMJ (free)

Related: The Choosing Wisely initiative was launched 5 years ago, and now has over 490 recommendations from 18 countries (free)

See complete lists from: Choosing Wisely U.S., Choosing Wisely UKChoosing Wisely Australia AND Choosing Wisely Canada

“One of the main barriers to tackling the problem of overuse is that doctors are concerned patients will find it difficult to accept fewer interventions. However, informed patients often opt for less intervention, not more.” (via @bmj_latest see Tweet)


Richard Lehman’s journal review, 18 June 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.


Clinical Presentation and Outcome in a Contemporary Cohort of Patients with Acute Myocarditis: The Multicenter Lombardy Registry – Circulation (link to abstract – $ for full-text)

Commentary: Outcome of Acute Myocarditis Patients – American College of Cardiology (free)

“Retrospective study of 443 patients w/ acute myocarditis from 19 Italian hospitals reports relatively benign overall outcomes” (via @ACCinTouch see Tweet)


E-cigarettes, Juuls and Heat-Not-Burn Devices: The Science and Regulation of Vaping – Hopkins Bloomberg Public Health Magazine (free)

E-cigarettes can help some people quit smoking but may entice others to start. So how should they be regulated?


Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs – American Academy of Neurology and the American Epilepsy Society

Part I: Treatment of new-onset epilepsy (free PDF)

Part II: Treatment-resistant epilepsy (free PDF)

Commentary: New Epilepsy Guidelines Shed Light on Explosion of New Drugs – MedPage Today (free registration required)


Age-attuned Hospice care: An opportunity to better end of life care for older people – StCristopher’s (free PDF) (via @hospicedoctor see tweet)

“Despite the evidence that more people will die of frailty and multiple long-term conditions than of cancer, our services for those moving towards the end of their life remain focussed on the needs of the latter group”


Controversy: Is there still a place for the Swan-Ganz catheter? – Intensive Care Medicine

YES (free for a limited period) / NO (free for a limited period) WE ARE NOT SURE (free for a limited period)


Effect of Negative Pressure Wound Therapy vs Standard Wound Management on 12-Month Disability Among Adults With Severe Open Fracture of the Lower Limb: The WOLLF Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: High-tech treatment of open leg wounds no better than using regular dressings – University of Warwick (free) AND Negative-Pressure Therapy No Better for Open Fractures – Medscape (free registration required)

“Negative pressure wound therapy did not improve 12-month disability for patients with severe open fracture of the lower limb compared with standard wound dressing”


A sleep prescription for medicine – The Lancet (free registration required)

“Junior doctors working a 34 h shift will make 460% more diagnostic mistakes than when well rested. Matthew Walker asks how can we change the culture of sleep within medicine?” (via @TheLancet see Tweet)


A Placebo-Controlled Trial of Bezafibrate in Primary Biliary Cholangitis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: A Trial of Bezafibrate in Primary Biliary Cholangitis – NEJM Resident 360 (free) AND Bezafibrate Normalizes Liver Enzymes in PBC – MedPage Today (free registration required)

“In a randomized trial of patients with primary biliary cholangitis, bezafibrate and ursodeoxycholic acid resulted in a higher rate of complete biochemical response than ursodeoxycholic acid alone” (via @NEJM see Tweet with visual abstract)


Richard Lehman’s journal review, 11 June 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.


The flu vaccine is being oversold – it’s not that effective – The Conversation (free)

See Related Cochrane Systematic Reviews: Vaccines for Preventing Influenza and Its Complications (free)

“The infection rate in adults drops from 2% per year to 1%. You could say that’s halved, but it effectively only drops by 1%. So this means that out of every 100 healthy adults vaccinated, 99 get no benefit against laboratory confirmed influenza”.


Association of Hypertensive Disorders of Pregnancy With Risk of Neurodevelopmental Disorders in Offspring: A Systematic Review and Meta-analysis – JAMA Psychiatry (free for a limited period)

Commentary: Hypertension in Pregnancy Tied to Autism, ADHD – MedPage Today (free registration required)

“Researchers call for greater pediatric surveillance of infants in hypertensive moms” (from MedPage Today)


Supplement: Advanced Aortic Imaging and Intervention – Cardiovascular Diagnosis and Therapy (free articles)

Series of review articles on the topic.


Mental Health ATLAS 2017 – World Health Organization (free PDF)

News Release: Mental health: massive scale-up of resources needed if global targets are to be met (free)

See also: WHO Campaign on Mental Health (free resources)

“Every US$ 1 invested in scaling up treatment for common mental illnesses such as depression and anxiety leads to a return of US$ 4 in better health and ability to work” (via @WHO see Tweet)


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