Open access


Fri, May 25 – 10 Stories of The Day!

25 May,2018


1 – Report: Diet, Nutrition, Physical Activity and Cancer: a Global Perspective – World Cancer Research Fund (free)

Commentaries: A blueprint to beat cancer – World Cancer Research Fund (free) AND 10-year study shows obesity increases risk for 12 cancers – UPI (free)


2 – Metastatic Pancreatic Cancer: ASCO Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

Related Guideline: Pancreatic cancer in adults: diagnosis and management – National Institute for Health and Care Excellence (free)

Related Systematic Review: Chemotherapy and radiotherapy for advanced pancreatic cancer – Cochrane Library (free)


3 – Clinical Policy: Critical Issues in the Evaluation and Management of Adult Patients Presenting to the Emergency Department With Suspected Acute Venous Thromboembolic Disease – American College of Emergency Physicians (free)

Summary: ACEP Clinical Policy on Acute VTE 2018 – R.E.BE.L.em (free)

Related: Should We Anticoagulate Patients with Isolated Subsegmental Pulmonary Emboli? – NEJM Journal Watch (free)


4 – Review: The art of cardiovascular risk assessment – Clinical Cardiology (free)


5 – Review: Pitfalls on the replacement therapy for primary and central hypothyroidism in adults – European Journal of Endocrinology (free)


6 – Europe’s open-access drive escalates as university stand-offs spread – Nature News (free)


7 – Perspective: How Tech Can Turn Doctors Into Clerical Workers – The New York Times Magazine (10 articles per month are free)

“The threat that electronic health records and machine learning pose to physicians’ clinical judgment — and their well-being”.


8 – New Free Online Course: Introduction to Critical Care Medicine – University of Glasgow and FutureLearn (free) (via @classcentral)


9 – Severe and predominantly active atopic eczema in adulthood and long term risk of cardiovascular disease: population based cohort study – The BMJ (free)

Editorial: Atopic eczema and cardiovascular disease (free)

Commentaries: Severe eczema and increased risk of cardiovascular problems – The BMJ Opinion (free) AND Severe eczema linked to cardiovascular problems – OnMedica (free) AND People with severe eczema at higher risk of heart conditions – NHS Choices (free)


10 – Association Between Gestational Hypertension and Risk of Cardiovascular Disease Among 617 589 Norwegian Women – Journal of the American Heart Association (free for a limited period)

Editorial: Cardiovascular Sequels of Hypertension in Pregnancy (free for a limited period)

Related Studies: All Hypertensive Disorders of Pregnancy Increase the Risk of Future Cardiovascular Disease (free PDF and commentaries) AND Hypertensive Disorders in Pregnancy and the Risk of Subsequent Cardiovascular Disease (link to abstract and free commentaries)


Thu, May 24 – 10 Stories of The Day!

24 May,2018


1 – A Pragmatic Trial of E-Cigarettes, Incentives, and Drugs for Smoking Cessation – New England Journal of Medicine (free)

Commentaries: Money a better motivator to stop smoking than free e-cigs or quit aids – Reuters (free) AND E-cigarettes aren’t better at helping smokers quit than other strategies – Journalist’s Resource (free) AND For Smoking Cessation, Money Whispers Louder than Nicotine Replacement – MedPage Today (free registration required)

“Trial finds financial incentives most effective – but nothing very effective” (from MedPage Today)


2 – A Randomized Trial of a Family-Support Intervention in Intensive Care Units – New England Journal of Medicine (free)

Editorial: Nurse-Led Communication in the Intensive Care Unit (free)

Commentary: Team Approach to Support Families Improves ICU Patient-Centered Care and Lowers Costs – University of Pittsburg (free)


3 – Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Chemotherapy: ASCO Guideline for Geriatric Oncology – Journal of Clinical Oncology (free)


4 – Advocating for Life Support Training of Children, Parents, Caregivers, School Personnel, and the Public – Pediatrics (free)

Summary: Advocating for Life Support Training of Children, Parents, Caregivers, School Personnel, and the Public (free)

News Release: AAP policy says more people need access to life support training, AEDs (free)

Commentary: AAP: Children can be educated in assisting those in cardiac arrest – Healio (free registration required)


5 – Estimating the Association of the 2017 and 2014 Hypertension Guidelines With Cardiovascular Events and Deaths in US Adults: An Analysis of National Data – JAMA Cardiology (free for a limited period)

Author Interview: Association of the 2014 and 2017 Hypertension Guidelines With Cardiovascular Events and Deaths in US Adults (free)

Commentary: Under 2017 Guideline, More Than 105 Million Americans Have Hypertension – AJMC (free)

The researchers estimated risk reductions of CVD and all-cause mortality, as well as associated harms from therapy, assuming the entire US adult population achieved guideline-recommended systolic BP treatment goals.


6 – Perspective: Ten dubious beliefs in neurocritical care – PulmCrit (free)


7 – A state of the art review on optimal practices to prevent, recognize, and manage complications associated with intravascular devices in the critically ill – Critical Care Medicine (free for a limited period)

Source: Critical Care Reviews Newsletter


8 – Endovascular ultrasound renal denervation to treat hypertension (RADIANCE-HTN SOLO): a multicentre, international, single-blind, randomised, sham-controlled trial – The Lancet (link to abstract – $ for full-text)

Related Article: Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial (link to abstract – $ for full-text)

Commentaries: Two Sham-Controlled Renal Denervation Studies Offer Hope in Hypertension – TCTMD (free) AND Renal denervation linked to significant drops in blood pressure – Cardiovascular Business (free) AND Novel Renal Denervation Catheters Showing Modest BP Reductions – MedPage Today (free registration required)


9 – Incidence and cost of medication harm in older adults following hospital discharge: A multicentre prospective study in the UK – British Journal of Clinical Pharmacy (free PDF)

Commentaries: Medication-related harm is common in older adults after hospital discharge – OnMedica (free) AND Medication-related harm found to be common among older adults, but preventable  – News Medical (free)


10 – Using alternatives to the car and risk of all-cause, cardiovascular and cancer mortality – Heart (free)

Commentaries: Avoiding the car for travel could significantly lower risk of illness and death – BMJ, via EurekAlert (free) AND Ditching the car may reduce your risk of dying from heart disease and stroke by almost a third – The Conversation (free)


Tue, May 22 – 10 Stories of The Day!

22 May,2018


1 – Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection – New England Journal of Medicine (free)

Commentaries: Procalcitonin-Guided Care Doesn’t Reduce Antibiotics for Lower Respiratory Tract Infection – NEJM Journal Watch (free) AND Infection blood test of limited value in reducing antibiotic use – MedicalXpress (free)


2 – Joint statement from the American College of Surgeons Committee on Trauma (ACS COT) and the American College of Emergency Physicians (ACEP) regarding the clinical use of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) (free)

Commentary: EMCrit Guest Post – The good, the bad, and the ugly of the Joint Statement on REBOA by Zaffer Qasim (free)

Source: Critical Care Reviews Newsletter


3 – Committee Opinion: Postpartum Pain Management – American College of Obstetricians and Gynecologists (free)

News Release: ACOG Recommends Postpartum Pain Management Approach Tailored to Patients (free)

Commentaries: ACOG: Postpartum Pain Management Requires Individualized Approach – MedPage Today (free registration required) AND OB/GYN Group Releases Guidance on Managing Postpartum Pain – NEJM Physician’s First Watch (free)


4 – WHO supports Ebola vaccination of high risk populations in the Democratic Republic of the Congo – World Health Organization (free)

Commentaries: Experimental Ebola Vaccinations, Considered ‘Paradigm Shift,’ Begin In Congo – NPR (free) AND Ebola vaccine drive launches in DRC as cases rise to 49 – CIDRAP (free) AND Congo begins giving experimental Ebola vaccine to medics – Reuters (free)

See also: Frequently asked questions on Ebola virus disease vaccine – World Health Organization (free)

“Health workers operating in affected areas in the Democratic Republic of the Congo are being vaccinated today and community outreach has started to prepare for the ring vaccination” (via @WHO see Tweet)


5 – Health care is an essential human right – and so is a proper diagnosis – The Conversation (free)

Related Commentary: For First Time, W.H.O. Names Some Lab Tests ‘Essential’ – The New York Times (10 articles per month are free)

See Original WHO Report: List of Essential In Vitro Diagnostics First edition (2018) – World Health Organization (free report and news release)


6 – Review: Autism spectrum disorder: advances in diagnosis and evaluation – The BMJ (free for a limited period)


7 – Opinion: Don’t Put That in My Heart Until You’re Sure It Really Works – The New York Times (10 articles per month are free)

Commentary: Cardiologist wants more rigorous testing before devices, techniques are adopted – Cardiovascular Business (free)

See also: Commentaries (PRO and Con) on the CABANA Trial (all free)


8 – Richard Lehman’s weekly journal review, 21 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.


9 – Review: Identifying and managing depression in patients with coronary artery disease – Journal of the American Academy of Pas (free)

Commentaries: Depression in Patients With CAD – American College of Cardiology (free) AND Early Depression Diagnosis is Deadly Serious for Patients with Coronary Artery Disease – Florida State University, via NewsWise (free)


10 – Association of Burden of Atrial Fibrillation With Risk of Ischemic Stroke in Adults With Paroxysmal Atrial Fibrillation: The KP-RHYTHM Study – JAMA Cardiology (free)

Commentaries: Atrial Fibrillation Burden and Stroke Risk – American College of Cardiology (free) AND Greater burden of atrial fibrillation linked to higher stroke risk – Kaiser Permanente, via EurekAlert (free)


Wed, May 23 – 10 Stories of The Day!

23 May,2018


1 – Low-dose corticosteroids for adult patients with septic shock: a systematic review with meta-analysis and trial sequential analysis – Critical Care Medicine (free for a limited period)

Source: Critical Care Reviews Newsletter

“In adults with septic shock treated with low dose corticosteroids, short- and longer-term mortality are unaffected, adverse events increase, but duration of shock, mechanical ventilation and ICU stay are reduced”.


2 – Aldosterone Antagonist Therapy and Mortality in Patients With ST-Segment Elevation Myocardial Infarction Without Heart Failure: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)

Invited Commentary: Mineralocorticoid Receptor Antagonists in ST-Segment Elevation Myocardial Infarction – JAMA Internal Medicine (free for a limited period)

Aldosterone antagonists are beneficial for patients with STEMI and reduced ejection fraction. This meta-analysis suggests that patients with STEMI and LVEF greater than 40% or without heart failure also have improved outcomes with aldosterone antagonists.


3 – Effect of More vs Less Frequent Follow-up Testing on Overall and Colorectal Cancer–Specific Mortality in Patients With Stage II or III Colorectal Cancer: The COLOFOL Randomized Clinical Trial – JAMA (free for a limited period)

Related Trial: Association Between Intensity of Posttreatment Surveillance Testing and Detection of Recurrence in Patients With Colorectal Cancer (free for a limited period)

Commentaries: Surveillance intensity not associated with earlier detection of recurrence or improved survival in colorectal cancer – MedicalXpress (free) AND CRC: No Increase in Survival with Stepped-Up Surveillance – MedPage Today (free registration required) AND CRC recurrence surveillance studies: No benefit to high-intensity strategy – Oncology Practice (free)


4 – Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma – New England Journal of Medicine (free)

Related Article: Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma – New England Journal of Medicine (free)

Editorial: New Biologics for Asthma (free)

Commentary: Dupilumab Improves Severe Asthma – NEJM Physician’s First Watch (free)


5 – Five-Year Outcomes with PCI Guided by Fractional Flow Reserve – New England Journal of Medicine (free)

Commentary: FFR in PCI for Stable CAD: Lasting Benefit Shown by FAME 2, SCAAR Data – TCTMD (free)


6 – Pro/Con Debate: CTA as the Initial Test in Stable Angina – American College of Cardiology

Pro: Coronary CTA Should Be the Initial Test in Most Patients with Stable Chest Pain (free)

Con: Coronary CTA Should Be the Initial Test in Most Patients with Stable Chest Pain (free)


7 – How PrEP, the pill to prevent HIV, may be fueling a rise in other STDs – Vox (free)

Original Meta-Analysis: Effects of Pre-exposure Prophylaxis for the Prevention of Human Immunodeficiency Virus Infection on Sexual Risk Behavior in Men Who Have Sex With Men: A Systematic Review and Meta-analysis – Clinical Infectious Diseases (link to abstract – $ for full-text)

See also: Guidelines on HIV Pre-exposure Prophylaxis (all free)


8 – Associations of egg consumption with cardiovascular disease in a cohort study of 0.5 million Chinese adults – Heart (free)

Commentaries: BMJ’s scrambled message on eggs and heart disease: a recipe for rotten news coverage – Health News Review (free) AND Expert reaction to eggs and CVD – Science Media Centre (free) AND No, Eating Eggs Will NOT Protect You From Cardiovascular Death – The Methods Man (free)


9 – Rapid Recommendations: Atraumatic (pencil-point) versus conventional needles for lumbar puncture: a clinical practice guideline – The BMJ (free)

“We issue a strong recommendation for use of atraumatic needles in all patients (adults and children) undergoing lumbar puncture because they decrease complications and are no less likely to work than conventional needles”


10 – New BMJ Series: Universal Health Coverage

The BMJ in partnership with The Harvard Global Health Institute are launching a collection of articles that will explore how to achieve effective Universal Health Coverage (UHC)”

Analysis: Rethinking assumptions about delivery of healthcare: implications for universal health coverage (free)

Opinion: Non-communicable diseases must be part of Universal Health Coverage (free)

Opinion: Ensuring effective investments in Universal Health Coverage at the national level (free)

Opinion: Paying and investing in community health workers accelerates universal health coverage (free)


Mon, May 21 – 10 Stories of The Day!

21 May,2018


1 – Outbreaks Associated with Treated Recreational Water — United States, 2000–2014 – MMWR, CDC (free)

Commentaries: Hotel pools a factor in water-related illness outbreaks – CIDRAP (free) AND Crypto, Pseudomonas and Legionella responsible for most outbreaks in swimming venues – Outbreak News Today (free) AND Sparkling Pool Water May Hold Disease-Causing Parasites – The New York Times (10 articles per month are free) AND CDC: How To Avoid Getting Sick From A Hotel Swimming Pool – Forbes (free)


2 – May Measurement Month 2017: an analysis of blood pressure screening results worldwide – The Lancet Global Health (free)

Commentary: One in Three Have Hypertension – AJP (free)

What do we learn from checking blood pressure in >1.2 million people of 80 countries who have not had their BP measured in a year? 34% HTN, 46% not controlled, Saturday spikes and a lot more” (via @EricTopol see Tweet)


3 – Perspective: Trying to Put a Value on the Doctor-Patient Relationship – The New York Times Magazine (10 articles per month are free)

“In its push for profits, the U.S. health care system has made it difficult for patients to get personal attention from doctors. But what if hands-on medicine actually saves money — and lives?”


4 – E-cigarettes: A win or loss for public health? – Knowable Magazine (free)

Related Perspective: The Promise of Vaping and the Rise of Juul – The New Yorker (free)

See also: related guidelines, reports and commentaries on e-cigarettes (all free)

“Arguments over whether e-cigarettes are harmful or helpful seem gridlocked as emerging research underscores both the toxicity of vaping and its possible benefits”. (via @ghn_news see Tweet)


5 – Dose Increase Versus Unchanged Continuation of Antidepressants After Initial Antidepressant Treatment Failure in Patients With Major Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized, Double-Blind Trials – The Journal of Clinical Psychiatry (link to abstract – $ for full-text)

Commentary: Depression: boosting SSRIs doesn’t work – Univadis (free registration required)

“Meta-analysis: there is evidence from RCTs against increasing the dose of SSRIs (with the possible exception of citalopram) in adult patients with major depression and antidepressant treatment failure” (via @psychopharmacol see Tweet)


6 – Statement on the 1st meeting of the IHR Emergency Committee regarding the Ebola outbreak in 2018 – World Health Organization (free)

Commentaries: WHO: Ebola in DRC not global emergency; ring vaccination starts in 2 days – CIDRAP (free) AND Ebola outbreak is concerning, but falls short of global emergency, WHO panel says – STAT (free)


7 – Effect of Use of a Bougie vs Endotracheal Tube and Stylet on First-Attempt Intubation Success Among Patients With Difficult Airways Undergoing Emergency Intubation: A Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: JC: Don’t blame it on the Bougie – St Emlyn’s (free) AND EM Nerd-The Peculiar Case of the Parallel Pathways – EmNerd (free) AND The humble bougie markedly boosts first-pass intubation success – Univadis (free registration required)


8 – Risk of suicide following an alcohol-related emergency hospital admission: An electronic cohort study of 2.8 million people – PLOS One (free)

Commentaries: Emergency hospital admissions for alcohol a red flag for suicide risk – new study – Public Health Wales (free) AND Alcohol-Related Emergency Admissions: A Marker for Suicide Risk – NEJM Journal Watch (free for a limited period)


9 – Report: World Health Statistics 2018: Monitoring health for the SDGs – World Health Organization (free)

Commentary: World Health Statistics: Over Half Of World’s Population Lack Essential Healthcare – WHO – Vigil 360 (free)


10 – Seafood Long-Chain n-3 Polyunsaturated Fatty Acids and Cardiovascular Disease: A Science Advisory From the American Heart Association – Circulation (free PDF)

News Release: Keep saying yes to fish twice a week for heart health (free)

AHA News: Eating fish twice a week reduces heart, stroke risk (free)

Commentary: Omega-3 Fatty Acids and Coronary Heart Disease: A Very Fishy Story (free)

Top Ten Things to Know: Seafood Long-Chain n-3 Polyunsaturated Fatty Acids and Cardiovascular Disease (free PDF)


Fri, May 18 – 10 Stories of The Day!

18 May,2018


1 – Inhaled Combined Budesonide–Formoterol as Needed in Mild Asthma – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Inhaled Combined Therapy as Needed in Mild Asthma (free)

Related Trial: As-Needed Budesonide–Formoterol versus Maintenance Budesonide in Mild Asthma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: International Study Suggests Alternative Treatment for Mild Asthma – McMaster University, via NewsWise (free) AND On Demand as Effective as Maintenance Therapy for Mild Asthma – Medscape (free registration required)


2 – Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial – The BMJ (free)

Commentaries: Exercise Doesn’t Slow Cognitive Decline in Patients with Dementia – NEJM Physician’s First Watch (free) AND Rigorous exercise does not halt dementia decline, study concludes – The Guardian (free) AND Expert reaction to effects of exercise on dementia in old people – Science Media Centre (free) AND Exercise ‘doesn’t slow’ progression of dementia – NHS Choices (free)


3 – WHO concerned as one Ebola case confirmed in urban area of Democratic Republic of the Congo – World Health Organization (free)

Commentaries: As Ebola hits major DRC city, WHO convenes emergency panel – CIDRAP (free) AND WHO to weigh declaration of international emergency over Ebola outbreak – STAT (free) AND Congo and WHO race to prevent runaway Ebola outbreak – Reuters (free) AND Fears of Larger Contagion as Ebola Spreads to Major Congo City  The New York Times (10 articles per month are free)


4 – Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank – The Lancet Psychiatry (link to abstract – for full-text)

Commentaries: Disrupted sleep-wake cycle linked to mental health problems – new study – The Conversation (free) AND Study: Body clock disruption linked to mood disorders – UPI (free) AND Body clock disruptions linked to mood disorders – NHS Choices (free) AND Maintaining a daily rhythm is important for mental health, study suggests – CNN (free)


5 – Psychological therapies for treatment-resistant depression in adults – Cochrane Library (free)

Summary: Are psychological therapies effective in treating depression that did not get better with previous treatment? – Cochrane Library (free)


6 – Chemotherapy-Induced Peripheral Neuropathy in Long-term Survivors of Childhood Cancer: Clinical, Neurophysiological, Functional, and Patient-Reported Outcomes – JAMA Neurology (free for a limited period)

Commentaries: Peripheral Neuropathy Common in Childhood Cancer Survivors – MPR (free) AND Chemo-Induced Neuropathy Common after Childhood Cancer – MedPage Today (free registration required)


7 – Opinion: The ten pitfalls of lactate clearance in sepsis – Intensive Care Medicine (free)

Source: Critical Care Reviews Newsletter


8 – Executive summary of the Clinical Guidelines of Pharmacotherapy for Neuropathic Pain: second edition by the Japanese Society of Pain Clinicians – Journal of Anesthesia (free)


9 – Adverse effects of statin therapy: perception vs. the evidence – focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract – European Heart Journal (free)

Commentary: EAS Consensus Document Examines Safety of Statins Beyond Muscle Symptoms – TCTMD (free)


10 – Summary: The Practice of Cardio-Oncology in Spain: Position Statement From Scientific Societies Involved in Cancer and Heart Disease – American College of Cardiology (free)

Original Guideline: Cardio-Onco-Hematology in Clinical Practice. Position Paper and Recommendations – Revista Espanola de Cardiologia (free)

Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)


Thu, May 17 – 10 Stories of The Day!

17 May,2018


#ESOC2018 – Highlights from the 4th European Stroke Organization Conference


1 – #ESOC2018 – Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial – The Lancet (free)

Editorial: Haemostatic treatment for intracerebral haemorrhage (free)

Commentaries: Study: Drug to treat bleeding may reduce stroke deaths – UPI (free) AND Drug to treat bleeding may benefit some stroke patients, study finds – University of Nottingham, via EurekAlert (free)


2 – #ESOC2018 – Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA – New England Journal of Medicine (free)

Editorial: Antiplatelet Therapy after Ischemic Stroke or TIA (free)

Commentary: Dual Antiplatelet Therapy or Aspirin Alone After TIA or Minor Stroke? – NEJM Physician’s First Watch (free)


3 – #ESOC2018 – MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset – New England Journal of Medicine (free)

Editorial: MRI-Guided Intravenous Alteplase for Stroke — Still Stuck in Time (free)

Commentary: New treatment option for ‘wake-up’ stroke patients – University of Glasgow, via MedicalXpress (free)


4 – #ESOC2018 – Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source – New England Journal of Medicine (free)

Commentaries: NAVIGATE ESUS: Rivaroxaban Fails to Prevent More Recurrent Cryptogenic Strokes Than Aspirin – TCTMD (free) AND Rivaroxaban Not Superior to Aspirin for Patients with Embolic Stroke of Unknown Source – NEJM Physician’s First Watch (free)


5 – #ESOC2018 – Five-Year Risk of Stroke after TIA or Minor Ischemic Stroke – New England Journal of Medicine (free)

Commentaries: Elevated Stroke Risk Continues for 5 Years After TIA – NEJM Physician’s First Watch (free) AND Five Years after TIA or Minor Stroke, Second-Event Risk Persists – MedPage Today (free)


6 – Manual: Managing epidemics: Key facts about major deadly diseases – World Health Organization (free)

“Managing epidemics. This @WHO manual provides concise, up-to-date knowledge on 15 infectious diseases that have the potential to become international threats, and tips on how to respond to each of them”. (via @Onisillos and @claireekt see Tweet)


7 – Report: Saving lives, spending less: a strategic response to noncommunicable diseases – World Health Organization (free PDF)

News Release: Investing in noncommunicable disease control generates major financial and health gains – World Health Organization (free)

“For every US$1 invested in each policy area, the following returns have been documented:

US$12.82 from promoting healthy diets

US$9.13 from reducing the harmful use of alcohol

US$7.43 from lower tobacco use

US$3.29 from providing drug therapy for cardiovascular disease

US$2.80 from increasing physical activity

US$2.74 from managing cancer”


8 – ASCO 2018: Shortening Adjuvant Trastuzumab to 6 Months in Patients With HER2-Positive Early Breast Cancer Is Effective and Reduces Cardiac Toxicities – The ASCO Post (free)

Commentaries: Test of Herceptin Finds Briefer Treatment Can Work, With Fewer Side Effects – NPR (free) AND Shorter drug treatment OK for many breast cancer patients – Associated Press (free) AND For Women With Early Breast Cancer, Herceptin Treatment Can Be Much Shorter – The New York Times (10 articles per month are free)

““For women with early-stage breast cancer who needed the drug Herceptin, 6 months of treatment were as good as 12, a major study found. Less risk of side effects, less cost, less time “being a patient.”” (via @NYTHealth see Tweet)


9 – Global Burden of Multiple Myeloma: A Systematic Analysis for the Global Burden of Disease Study 2016 – JAMA Oncology (free)

“Global incident cases of multiple myeloma more than doubled from 1990-2016 w/incident cases increasing by 126%. The largest increase was in middle-SDI countries, particularly E. Asia with a 262% increase in incidence cases”. (via @IHME_UW see Tweet)


10 – Ibuprofen versus pivmecillinam for uncomplicated urinary tract infection in women—A double-blind, randomized non-inferiority trial – PLOS Medicine (free)

Commentary: Ibuprofen alone not an option for simple UTIs, study finds – CIDRAP (free) AND Randomized trial finds ibuprofen not a safe alternative to antibiotics for UTIs – PLOS, via ScienceDaily (free)

Related Research: Symptomatic treatment of uncomplicated lower urinary tract infections in the ambulatory setting: randomised, double blind trial- The BMJ (free)


Wed, May 16 – 10 Stories of The Day!

16 May,2018


1 – News Release: First-ever WHO list of essential diagnostic tests to improve diagnosis and treatment outcomes (free) (via @Onisillos)

Executive summary: List of Essential In Vitro Diagnostics, First edition (2018) – World Health Organization (free PDF)


2 – Report: The Characteristics of Pandemic Pathogens: Improving Pandemic Preparedness by Identifying the Attributes of Microorganisms Most Likely to Cause a Global Catastrophic Biological Event – Johns Hopkins Bloomberg School of Public Health (free PDF)

News release: Study by center for health security identifies characteristics of microorganisms most likely to cause a global pandemic (free)

Commentaries: Is this the face of Disease X? The deadly pathogens which could cause the next global pandemic – The Telegraph (free) AND The Next Deadly Pandemic Could Be Unlike Any Threats We Know, Say Experts – Science Alert (free) AND The Next Pandemic: Forget Zika Or Ebola, Airborne Viruses Like The Flu And The Common Cold Are The Real Threat – Inquisitr (free) AND Report: Next Pandemic Will Likely Be Respiratory-Based Virus – MedPage Today (free registration required)

Related: Are we prepared for the looming epidemic threat? (free commentaries and video)


3 – Position Paper: Pathways and mechanisms linking dietary components to cardiometabolic disease: thinking beyond calories – Obesity Reviews (free)

Commentary: Some calories more harmful than others – University of California, via EurekAlert (free)


4 – Review: Diagnostic workup, etiologies and management of acute right ventricle failure – Intensive Care Medicine (free for a limited period)

Source: Critical Care Reviews Newsletter


5 – Improving Prediction of Dementia in Primary Care – Annals of Family Medicine (free)

Commentaries: Screening Tool Improves Dementia Prediction – Medscape (free registration required) AND Visual Test Could Help Predict Dementia Risk in Elders – NEJM Physician’s First Watch (free)


6 – Use of Flutemetamol F 18–Labeled Positron Emission Tomography and Other Biomarkers to Assess Risk of Clinical Progression in Patients With Amnestic Mild Cognitive Impairment – JAMA Neurology (free)

Commentaries: Biomarkers, PET imaging may predict cognitive decline en route to Alzheimer’s – Health Imaging (free) AND Amyloid PET Scan Can Predict Progression to Alzheimer’s in Patients With Mild Cognitive Impairment – MedicalResearch.com (free)

Related Studies: Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons (link to abstract and free commentaries) AND Identifying incipient dementia individuals using machine learning and amyloid imaging (free full-text and commentaries) AND High performance plasma amyloid-β biomarkers for Alzheimer’s disease (link to abstract and free commentaries)


7 – Last Month in Oncology with Dr. Bishal Gyawali: April 2018 – eCancer News (free)


8 – Effect of Intravesical Instillation of Gemcitabine vs Saline Immediately Following Resection of Suspected Low-Grade Non–Muscle-Invasive Bladder Cancer on Tumor Recurrence: SWOG S0337 Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Intravesical Gemcitabine Therapy Cuts Bladder Cancer Recurrence – MPR (free) AND Simple post-surgery step reduces bladder cancer recurrence – SWOG, via EurekAlert (free)


9 – Drug-eluting stents versus bare-metal stents in saphenous vein grafts: a double-blind, randomised trial – The Lancet (link to abstract – $ for full-text)

Commentary: Outcomes similar with DES vs. BMS in saphenous vein graft lesions – Healio (free registration required)


10 – Association of Colonoscopy Adenoma Findings With Long-term Colorectal Cancer Incidence – JAMA (free for a limited period)

Related Reviews: Optimizing post‐polypectomy surveillance: A practical guide for the endoscopist – Digestive Endoscopy (free) AND Optimal Colonoscopy Surveillance Interval after Polypectomy – Clinical Endoscopy (free)

Related Guidelines: Guidelines for Colonoscopy Surveillance After Screening and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer (free) AND Korean Guidelines for Postpolypectomy Colonoscopy Surveillance – Digestive Endoscopy (free) AND Colorectal cancer surveillance after index colonoscopy: Guidance from the Canadian Association of Gastroenterology (free) AND Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline (free)

Advanced adenomas are associated with subsequent increased risk for colorectal cancer, but nonadvanced adenomas don’t seem to be associated with increased risk.


Tue, May 15 – 10 Stories of The Day!

15 May,2018


1 – News Release: WHO plan to eliminate industrially-produced trans-fatty acids from global food supply – World Health Organization (free)

See also: REPLACE Action package: Trans Fat Free by 2023 – World Health Organization (free resources)

Commentaries: Editorial Board Opinion: The World Doesn’t Need Trans Fats – The New York Times (10 articles per month are free) AND WHO calls for trans fats to be eliminated within five years – Reuters (free) AND Industrial trans fats must be removed from food supply, WHO says – The Guardian (free) AND The new global plan to eliminate the most harmful fat in food, explained – VOX (free)


2 – Experimental vaccine to be used against Ebola outbreak in the DRC – STAT (free)

Related: WHO to send vaccines to fight new Ebola outbreak – NBC News (free) AND The New Ebola Outbreak Could Take ‘Three, Maybe Four’ Months to Control – The Atlantic (free)

See also: WHO News: Ebola Outbreak Declared in Democratic Republic of the Congo (free news release and commentaries)


3 – Complete Revascularization During Primary Percutaneous Coronary Intervention Reduces Death and Myocardial Infarction in Patients With Multivessel Disease: Meta-Analysis and Meta-Regression of Randomized Trials – JACC: Cardiovascular Interventions (link to abstract – $ for full-text)

Commentary: Complete Revascularization During PCI for Multivessel STEMI – American College of Cardiology (free)

Related: Meta-Analysis of Culprit-Only vs Multivessel PCI in Patients with STEMI and Multivessel Coronary Disease (link to abstract, commentaries and Cochrane Review on the subject)


4 – The Burnout Crisis in American Medicine – The Atlantic (free)

Related: Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free) AND Counting the costs: U.S. hospitals feeling the pain of physician burnout – Reuters (free) AND Panic, chronic anxiety and burnout: doctors at breaking point – The Guardian (free) AND To Care Is Human — Collectively Confronting the Clinician-Burnout Crisis – New England Journal of Medicine (free) AND Beyond Burnout — Redesigning Care to Restore Meaning and Sanity for Physicians – New England Journal of Medicine (free)


5 – Richard Lehman’s journal review, 14 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.


6 – Perspective: Deployment of Preventive Interventions — Time for a Paradigm Shift – New England Journal of Medicine (free)


7 – Headline vs. study: Sometimes fishy, sometimes pulling a rabbit out of a hat – Health News Review (free)


8 – Guideline: Deprescribing benzodiazepine receptor agonists – Canadian Family Physician (free) (via @Deprescribing)

Related: CaDeN Deprescribing Guidelines and Algorithms (free) AND 11 Drugs You Should Seriously Consider Deprescribing – Medscape Slideshow (free registration required) AND Current and future perspectives on the management of polypharmacy – BMC Family Practice (free)


9 – NAP6 Report: Anaesthesia, Surgery and Life-Threatening Allergic Reactions: Report and findings of the Royal College of Anaesthetists’ 6th National Audit Project (free PDF)

News Release: RCoA undertakes largest ever study of anaphylaxis in anaesthesia and surgery (free)

Infographic: Anaesthesia, Surgery and Life-Threatening Allergic Reactions (free PDF)

“The study found teicoplanin is 17-fold more likely to cause anaphylaxis than penicillin and similar drugs. As 90 per cent of patients who report penicillin allergy are in fact not allergic, better identification of true allergy would reduce risk”. (from News Release)


10 – Guideline: Screening for impaired vision in community-dwelling adults aged 65 years and older in primary care settings – Canadian Task Force on Preventive Health Care (free)

See also: Summary of recommendations for clinicians and policy-makers (free)

Commentaries: Screening for impaired vision in older adults: New Canadian guideline – Canadian Medical Association Journal, via EurekAlert (free) AND Canadian Guideline Recommends Against Vision Screening of Older Adults in Primary Care Settings – NEJM Physician’s First Watch (free)


Mon, May 14 – 10 Stories of The Day!

14 May,2018


1 – Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery – New England Journal of Medicine (free)

Editorial: Finding the Right Balance (free)

Commentaries: Restrictive fluids tied to kidney injury after major abdominal surgery – MDedge (free) AND Restricting Fluids During Abdominal Surgery Shows No Benefit, Possible Renal Risk – Medscape (free registration required)


2 – Investigational Testing for Zika Virus among U.S. Blood Donors – New England Journal of Medicine (free)

Quick Take Video Summary: Testing Blood Donations for Zika Virus (free)

Sounding Board: Revisiting Blood Safety Practices Given Emerging Data about Zika Virus (free)

Commentaries: Study: Zika blood donation screening costly, finds few cases – CIDRAP (free) AND Testing for Zika virus in blood donors finds few infections — at a cost of about $5.3 million each – STAT (free)


3 – Corticosteroids Reduce Risk of Death Within 28 Days for Patients With Severe Alcoholic Hepatitis, Compared With Pentoxifylline or Placebo—a Meta-analysis of Individual Data – Gastroenterology (link to abstract – $ for full-text)

Commentary: Severe alcoholic hepatitis: corticosteroids alone are best for short-term survival – Univadis (free registration required)


4 – Advice for Patients: Are blood pressure measurement mistakes making you chronically ill? – American Heart Association News (free text and infographic)

Commentary: BP measurement: you’re probably doing it wrong – Univadis (free registration required)


5 – Oral Antibiotic Exposure and Kidney Stone Disease – Journal of the American Society of Nephrology (link to abstract – $ for full-text)

Commentaries: Study suggests oral antibiotics may increase kidney stone risk – CIDRAP (free) AND Antibiotics May Raise the Risk for Kidney Stones – The New York Times (free) AND Oral Antibiotics May Raise Risk of Kidney Stones – Children’s Hospital of Philadelphia, via NewsWise (free)


6 – Viewpoint: Management Reasoning: Beyond the Diagnosis – JAMA (free for a limited Period)


7 – Association of Efficacy of Resistance Exercise Training With Depressive Symptoms: Meta-analysis and Meta-regression Analysis of Randomized Clinical Trials – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Resistance Exercise Might Improve Depression Symptoms – NEJM Physician’s First Watch (free) AND Resistance exercise may reduce depressive symptoms in adults – MedicalXpress (free) AND Resistance Exercise Training May Alleviate Some Depressive Symptoms – MedicalResearch.com (free)


8 – Global statistics on alcohol, tobacco and illicit drug use: 2017 status report – Addiction (free PDF)

Commentaries: Alcohol and tobacco are by far the biggest threat to human welfare of all addictive drugs – Society for the Study of Addiction, via ScienceDaily (free) AND Which drugs pose the biggest threat to public health? – Medical News Today (free)


9 – Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents – assessment of adverse events in non-randomised studies – Cochrane Library (link to abstract – $ for full-text)

Summary: Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents – assessment of harmful effects – Cochrane Library (free)

“Our findings suggest that methylphenidate may be associated with a number of serious adverse events as well as a large number of non-serious adverse events in children and adolescents, which often lead to withdrawal of methylphenidate”.


10 – Cost-effectiveness of Electroconvulsive Therapy vs Pharmacotherapy/Psychotherapy for Treatment-Resistant Depression in the United States – JAMA Psychiatry (free for a limited period)

Author interview: Cost-effectiveness of Electroconvulsive Therapy for Treatment-Resistant Depression in the United States (free)

Commentaries: Study about ‘shock therapy’ for depression suggests more patients should try it sooner – Michigan Medicine – University of Michigan, via EurekAlert (free) AND Third-Line Electroconvulsive Therapy May Be Best for Patients With Treatment-Resistant Depression – Psychiatric News Alert (free) AND ECT Found Cost Effective Early in Depression Treatment – MedPage Today (free registration required)


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