Open access

Mon, October 23 – 10 Stories of The Day!



1 – Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis – The Lancet Global Health (free)

Invited commentary: Global causes of vision loss in 2015: are we on track to achieve the Vision 2020 target? (free)

Related study: Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis – The Lancet Global Health (free) AND Invited Commentary: Universal eye health: are we getting closer? (free)


2 – Upright versus lying down position in second stage of labour in nulliparous women with low dose epidural: BUMPES randomised controlled trial – The BMJ (free)

Commentaries: During Labor, Lie Down – The New York Times (10 articles per month are free) AND Normal birth more likely when lying down in late stages, post epidural – OnMedica (free)


3 – Summary with 10 key points to remember: Thrombophilia Testing and Venous Thrombosis – American College of Cardiology, Latest in Cardiology (free)

See also: Thrombophilia Testing and Venous Thrombosis – NEJM Resident 360 (free)

Original article: Thrombophilia Testing and Venous Thrombosis – New England Journal of Medicine (link to abstract – $ for full-text)


4 – Is gene editing ethical? – Medical News Today (free)

Related: Embryo Gene-Editing Experiment Reignites Ethical Debate – Scientific American (free) AND U.S. scientists edit genome of human embryo, but cast doubt on possibility of ‘designer babies’ – STAT (free)

Related Position Statement: Human Germline Genome Editing – American Society of Human Genetics (free) AND Commentary: 11 Organizations Urge Cautious but Proactive Approach to Gene Editing (free)


5 – Trial Evaluating Ambulatory Therapy of Travelers’ Diarrhea (TrEAT TD) Study: A Randomized Controlled Trial Comparing 3 Single-Dose Antibiotic Regimens With Loperamide – Clinical Infectious Diseases (link to abstract – $ for full-text)

Commentary: Azithromycin, levofloxacin, rifaximin all effective for travelers diarrhea – Healio (free registration required)


6 – Literature review: the economic costs of lung disease and the cost effectiveness of policy and service interventions – British Lung Foundation and British Thoracic Society (free PDF)

News release: New report identifies the most cost effective NHS activities and programmes to improve lung health – British Thoracic Society (free)

Source: Most cost effective treatments for lung disease identified – The BMJ News ($)

“The most cost effective treatments are: patient education and self management for asthma; stop smoking support for chronic obstructive pulmonary disease (COPD); vaccination programmes for pneumonia; and awareness campaigns for lung cancer” (from The BMJ).


7 – Walking in Relation to Mortality in a Large Prospective Cohort of Older U.S. Adults – American Journal of Preventive Medicine (free)

Commentaries: Regular Walking, Even if Minimal, Tied to Lower Death Risk – Medscape (free registration required) AND Study finds even regular walking can lower mortality risk – UPI (free)


8 – Weight Gain in Women at Midlife: A Concise Review of the Pathophysiology and Strategies for Management – Mayo Clinic Proceedings (free)

Commentary: Docs Call Attention to Women Piling on Pounds in Midlife – Medscape (free registration required)


9 – Carefully managed antibiotic use could halve antibiotic-resistant infections – NIHR Signal (free)

Original article: Effect of antibiotic stewardship on the incidence of infection and colonisation with antibiotic-resistant bacteria and Clostridium difficile infection: a systematic review and meta-analysis – The Lancet Infectious Diseases (link to abstract – $ for full-text)


10 – Placing wet gauze on babies’ tummies speeds up urine collection – NIHR Signal (free)

Original article: Faster clean catch urine collection (Quick-Wee method) from infants: randomised controlled trial – The BMJ (free)


Fri, October 20 – 10 Stories of The Day!



1 – Levels & Trends in Child Mortality – UNICEF (free PDF)

News release: Levels and Trends in Child Mortality (free)

Commentaries: 7,000 newborns die every day, despite steady decrease in under-five mortality, new report says – The World Bank (free) AND New child mortality estimates show that 15,000 children died every day in 2016 – The World Bank (free) AND Unconscionable': 7,000 babies die daily despite record low for child mortality – The Guardian (free)


2 – Report: The Lancet Commission on pollution and health (Report, Executive Summary, Video, Audio and Comments – free registration required)

Commentaries: Report: Pollution Kills 3 Times More than AIDS, TB And Malaria Combined – NPR (free) AND Pollution linked to one in six deaths – BBC (free)


3 – 2017 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea (free)

Commentary: New diarrhea guidelines stress implications of molecular tests – CIDRAP (free)


4 – Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology (free)


5 – Elevated blood pressure and risk of mitral regurgitation: A longitudinal cohort study of 5.5 million United Kingdom adults – PLOS Medicine (free)

Commentaries: High Blood Pressure Is a Risk Factor For Mitral Regurgitation – Medical Research (free) AND High Blood Pressure May Raise Mitral Regurgitation Risk – TCTMD (free) AND Inevitable or preventable? High blood pressure linked to mitral regurgitation – Cardiovascular Business (free)


6 – High-flow oxygen via nasal cannulae in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis – Systematic Reviews (free)

“In patients with acute hypoxemic respiratory failure HFNC was not associated with a difference in mortality compared to Noninvasive ventilation or standard oxygen”


7 – Imaging Studies Offer New Insights Into Inflammation In CV Disease – Cardiobrief (free)

Original article: Colchicine Therapy and Plaque Stabilization in Patients With Acute Coronary Syndrome – Journal of The American College of Cardiology (link to abstract – $ for full-text)

“Preliminary evidence that colchicine may reduce coronary plaque”.


8 – Evidence-based guidelines for supportive care of patients with Ebola virus disease – The Lancet (free)

Commentaries: New Ebola guidelines address immediate supportive care – CIDRAP (free)


9 – Update: Interim Guidance for the Diagnosis, Evaluation, and Management of Infants with Possible Congenital Zika Virus Infection – MMWR / CDC (free)

Commentaries: CDC Offers New Guidance on Diagnosing and Managing Zika in Infants – Physician’s First Watch (free)


10 – A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets – Cell Host Microbe (free)

Commentaries: H7N9 study finds virus poised to become more lethal, resistant to treatment – CIDRAP (free) AND H7N9 influenza is both lethal and transmissible in animal model for flu – University of Wisconsin–Madison (free) AND Will the World’s Most Worrying Flu Virus Go Pandemic? – The Atlantic (free)


Thu, October 19 – 10 Stories of The Day!



1 – 2017 ACC Expert Consensus Decision Pathway on the Management of Mitral Regurgitation – Journal of The American College of Cardiology (free)

Commentaries: Expert Consensus Decision Pathway for Management of Mitral Regurgitation – American College of Cardiology, Latest in Cardiology (free) AND ACC Recommends ‘Structured Approach’ to Mitral Regurgitation – MedPage Today (free registration required)


2 – Update to Practice Standards for Electrocardiographic Monitoring in Hospital Settings: A Scientific Statement From the American Heart Association – Circulation (free PDF)

Commentaries: 12 key points to remember: Standards for Inpatient Electrocardiographic Monitoring – American College of Cardiology, Latest in Cardiology (free) AND AHA updates practice standards for electrocardiographic monitoring – ACP Hospitalist (free)


3 – Dark chocolate is now a health food. Here’s how that happened – VOX (free)

Related: Chocolate health: advice by Thomas Lüscher and peer review by Jonas Malmstedt – For Better Science (by @schneiderleonid)

“Big Chocolate’s investment in health science was a marketing masterstroke…” Interesting tale by @juliaoftoronto (RT @hildabast see Tweet)


4 – Long-term antibiotics likely to reduce risk of recurrent cellulitis – NIHR Signal (free)

Original article: Interventions for the prevention of recurrent erysipelas and cellulitis – Cochrane Library (link to abstract – $ for full-text)


5 – Comparing the Outcomes of Adults With Enterobacteriaceae Bacteremia Receiving Short-Course Versus Prolonged-Course Antibiotic Therapy in a Multicenter, Propensity Score–Matched Cohort – Clinical Infectious Diseases (link to abstract – $ for full-text)

Commentary: Short course of antibiotics worked as well as long for Enterobacteriaceae bacteremia – ACP Hospitalist (free)


6 – Report: Opportunities for Organ Donor Intervention Research: Saving Lives by Improving the Quality and Quantity of Organs for Transplantation (2017) – National Academies Press (free PDF)

Related Viewpoint: Organ Donor Research: Overcoming Challenges, Increasing Opportunities – JAMA (free)


7 – Short and Long Term Complications of In Utero Exposure to Lamotrigine – British Journal of Clinical Pharmacology (free PDF)

News release: Study Finds Epilepsy Drug to Be Safe During Pregnancy – Wiley (free)

Source: Study finds lamotrigine to be safe during pregnancy – The BMJ Research News ($)


8 – Richard Lehman’s journal review, 17 October 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.


9 – Association of Patient Frailty With Increased Morbidity After Common Ambulatory General Surgery Operations – JAMA Surgery (link to abstract – $ for full-text)

Commentaries: Frailty Associated With Increased Risk of Complications Following Common, Outpatient Operations – The JAMA Network (free) AND Frailty tied to higher risk of complications with common surgeries – Reuters (free) AND Frailty linked to higher rate of perioperative morbidity – OnMedica (free)


10 – 25-Year Physical Activity Trajectories and Development of Subclinical Coronary Artery Disease as Measured by Coronary Artery Calcium – Mayo Clinic Proceedings (free)

Commentaries: Excessive Exercise May Harm The Heart, Study Suggests – Forbes (free) AND Physically active white men at high risk for plaque buildup in arteries – ScienceDaily (free)


Wed, October 18 – 10 Stories of The Day!



1 – Guideline: 2017 Appropriate Use Criteria for the Treatment of Patients With Severe Aortic Stenosis (free)

Commentaries: 2017 AUC for Management of Severe Aortic Stenosis – American College of Cardiology, Latest in Cardiology (free) AND First Appropriate Use Criteria Issued for Severe Aortic Stenosis – Medpage Today (free registration required)


2 – Association of Blood Transfusion From Female Donors With and Without a History of Pregnancy With Mortality Among Male and Female Transfusion Recipients – JAMA (link to abstract – $ for full-text)

Commentaries: Blood Boundaries: Should Transfusions Be Matched by Sex? – Scientific American (free) AND Are transfusions harmful to men if the blood comes from women who have been pregnant? – STAT (free) AND Receipt of Blood Transfusion From Previously Pregnant Donor Associated with Increased Risk of Death Among Male Recipients – The JAMA Network (free)


3 – Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients—A Systematic Review and Meta-Analysis – Antibiotics (free)

Antibiotic-associated diarrhea ocurred in 8.0% of the probiotic group compared to 17.7% in the control group. The number needed to treat (NNT) to prevent one case of diarrhea was 11 (95% CI 6 to 13).


4 – Approach to recurrent fever in childhood – Canadian medical Association Journal (free)


5 – Comparative safety of direct oral anticoagulants and warfarin in venous thromboembolism: multicentre, population based, observational study – The BMJ (free)

Commentary: New Anticoagulants Not Linked To Excess Bleeding Rates – Cardiobrief (free)


6 – How Low to Go With Glucose, Cholesterol, and Blood Pressure in Primary Prevention of CVD – Journal of The American College of Cardiology (free)

Summary with 12 key points to remember: Glucose, Cholesterol, BP Targets for CVD Risk Factors – American College of Cardiology, Latest in Cardiology (free)


7 – Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentaries: Omega-6 fats may help prevent type 2 diabetes – George Institute for Global Health (free) AND Eating More Nuts Could Protect Against Type 2 Diabetes – Medscape (free registration required) AND Omega-6 could lower type 2 diabetes risk by 35 percent – Medical News Today (free)


8 – The oncologic burden of hepatitis C virus infection: A clinical perspective – CA: A Cancer Journal for Clinicians (free)


9 – Recommendations for Prevention and Control of Influenza in Children, 2017 – 2018 – American Academy of Pediatrics (free)

Commentary: 2017-2018 recommendations for pediatric influenza vaccination – Clinical Advisor (free) AND Fall Weather Headed Your Way? Time For Flu Shots – NPR (free)


10 – Individual support of nurses using electronic medicine monitors can improve HIV treatment – NIHR Signal (free)

Original article: Effectiveness and cost-effectiveness of a nurse-delivered intervention to improve adherence to treatment for HIV: a pragmatic, multicentre, open-label, randomised clinical trial – The Lancet Infectious Diseases (free)


Tue, October 17 – 10 Stories of The Day!



1 – Association of History of Gestational Diabetes With Long-term Cardiovascular Disease Risk in a Large Prospective Cohort of US Women – JAMA Internal Medicine (free)

Commentaries: CVD Risk for Women Rises After Gestational Diabetes – TCTMD (free) AND Does Gestational Diabetes Per Se Up Long-Term Cardiovascular Risk? – Medscape (free registration required) AND Gestational Diabetes Raises Heart Attack, Stroke Risk, NIH Study Finds – AJMC (free)


2 – Association of Antidepressant Medications With Incident Type 2 Diabetes Among Medicaid-Insured Youths – JAMA Pediatrics (link to abstract – $ for full-text)

Commentaries: Antidepressant Use in Youth Tied to Increased Diabetes Risk – Physician’s First Watch (free)

Related article: The risk of new-onset diabetes in antidepressant users – A systematic review and meta-analysis – PLOS One (free) AND Commentary: Type 2 Diabetes and Antidepressant Drug Use: Is There a Causal Link? – Endocrinology Advisor (free)


3 – State of The Art Review: Why and how to step down chronic asthma drugs – The BMJ (free)


4 – Clinical Use of a Home Sleep Apnea Test: An American Academy of Sleep Medicine Position Statement (free)

News release: AASM releases position statement on home sleep apnea testing (free)

Commentaries: AASM: Position Statement on Home Sleep Apnea Testing – MPR (free) AND Sleep Medicine Academy Releases Statements on Home Apnea Testing – Physician’s First Watch (free)


5 – Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) – Circulation (link to abstract – $ for full-text)

Commentaries: A-fib strikes men a decade earlier than women – Medical News Today (free) And AHA: Men develop AFib a decade before women do; BMI linked to increased risk – Cardiovascular Business (free)


6 – Modelled Cost-Effectiveness of a Package Size Cap and a Kilojoule Reduction Intervention to Reduce Energy Intake from Sugar-Sweetened Beverages in Australia – Nutrients (free)

Commentaries: Cutting sugar in soft drinks would save 155,000 lives and $8 billion: experts – The Age (free) AND Study spells out huge health benefits by cutting back sugar in sugary drinks – University of New South Wales, Sidney (free)


7 – We may soon have our first $1 million drug. Who will pay for it? And how? – STAT (free)


8 – Long-term Outcomes of Multiple Arterial Coronary Artery Bypass Grafting: A Population-Based Study of Patients in British Columbia, Canada – JAMA Cardiology (free)

Commentaries: Study: Triple-Vessel CABG Strategy Matters in the Long Run – MedPage Today (free registration required)

In patients with multivessel disease who are undergoing coronary artery bypass grafting, multiple arterial grafting (MAG) is associated with reduced mortality, repeated revascularization, myocardial infarction, and heart failure when compared with left internal thoracic artery (LITA) supplemented by saphenous vein grafts (LITA+SVG).


9 – 2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery (free)


10 – Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus – Nature Communications (free)

Commentaries: Proton pump inhibitors linked to liver disease, researchers find – The Pharmaceutical Journal (free) AND Liver disease risk may be heightened by gastric acid drugs – Medical News Today (free) AND Common acid reflux medications promote chronic liver disease – EurekAlert (free)


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