Open access


Thu, March 8 – 10 Stories of The Day!

8 Mar,2018


1 – Association Between Estimated Cumulative Vaccine Antigen Exposure Through the First 23 Months of Life and Non–Vaccine-Targeted Infections From 24 Through 47 Months of Age – JAMA (link to abstract – $ for full-text)

Commentaries: Vaccines won’t overload your child’s immune system—or increase their risk of other infections – Science (free) AND Too Many Too Soon? No! – Science-Based Medicine (free) AND Study finds no immune overload for US kids’ vaccine schedule – CIDRAP (free)


2 – Frequency and level of evidence used in recommendations by the National Comprehensive Cancer Network guidelines beyond approvals of the US Food and Drug Administration: retrospective observational study – The BMJ (free)

Commentaries: Vinay Prasad on the NCCN’s cancer treatment guidelines: The US system needs an audit – The BMJ Opinion (free) AND US cancer network recommending expensive drugs based on weak evidence, study finds – The Guardian (free) AND New Study Questions Evidence for NCCN Recommendations – Medscape (free registration required)


3 – Digoxin and Mortality in Patients With Atrial Fibrillation – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Digoxin and Mortality in Patients With Atrial Fibrillation – American College of Cardiology, Latest in Cardiology (free) AND Digoxin Associated with Higher Mortality in Patients with Atrial Fibrillation – NEJM Physician’s First Watch (free)


4 – Effect of β‐Blockers Beyond 3 Years After Acute Myocardial Infarction – Journal of the American Heart Association (free for a limited period)

Related article: B-Blockers and Mortality After Acute Myocardial Infarction in Patients Without Heart Failure or Ventricular Dysfunction – Journal of The American College of Cardiology (free)


5 – Cancer screening recommendations: an international comparison of high income countries – Public Health Reviews (free) (via @hildabast see Tweet)


6 – Fluid therapy in neurointensive care patients: ESICM consensus and clinical practice recommendations – Intensive Care Medicine (free for a limited period) (via @luiscamacho02)


7 – Factor Xa inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in patients with atrial fibrillation – Cochrane Library (free)

Summary: Comparing two types of blood-thinning drugs, factor Xa inhibitors and vitamin K antagonists, to prevent blood clots in people with atrial fibrillation – Cochrane Library (free)

When available, Factor Xa inhibitors seem to be a better choice for treating these patients.


8 – The Science of Obesity Management: An Endocrine Society Scientific Statement – Endocrine Reviews (free)

Commentary: Research Finds Little Difference Among Diet Plans’ Long-Term Effectiveness – Endocrine Society, via NewWise (free)


9 – Cough Due to TB and Other Chronic Infections – CHEST Guideline and Expert Panel Report (free)

See also other recent CHEST guidelines on the management of cough in specific populations: Classification of Cough as a Symptom in Adults and Management Algorithms (free) AND Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold (free) AND Chronic Cough Due to Gastroesophageal Reflux in Adults (free) AND Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer (free) AND Cough in the athlete (free) AND Occupational and Environmental Contributions to Chronic Cough in Adults (free) AND Treatment of Unexplained Chronic Cough (free) AND Use of Management Pathways or Algorithms in Children With Chronic Cough (free) AND Management of Children With Chronic Wet Cough and Protracted Bacterial Bronchitis (free)


10 – Effect of Offering Same-Day ART vs Usual Health Facility Referral During Home-Based HIV Testing on Linkage to Care and Viral Suppression Among Adults With HIV in Lesotho: The CASCADE Randomized Clinical Trial – JAMA (free)

Editorial: The Global HIV Epidemic: What Will It Take to Get to the Finish Line? (free)

Commentary: HIV in sub-Sahara Africa: Testing and treatment start at home improves therapy – Swiss Tropical and Public Health Institute, via EurekAlert (free)

Related: Starting antiretroviral therapy immediately after HIV diagnosis reduces transmission of the virus – NIHR Signal (free)


Wed, March 7 – 10 Stories of The Day!

7 Mar,2018


1 – Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Opioids Don’t Beat Other Medications For Chronic Pain – NPR (free) AND More Data Opioids No Better for Chronic Back, Arthritis Pain – Medscape (free registration required) AND Opioids no better than NSAIDs for chronic back or arthritis pain – Reuters (free)

Related: Opioid Wisely – Choosing Wisely Canada (free) AND Guideline for opioid therapy and chronic noncancer pain – Canadian Medical Association Journal (free) 


2 – Effect of a Low-Intensity PSA-Based Screening Intervention on Prostate Cancer Mortality: The CAP Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: One-off PSA screening for prostate cancer does not save lives – eCancer News (free)

“Largest ever prostate cancer trial – CAP – published in the JAMA. No effect from low intensity PSA screening on prostate cancer mortality at 10 years”. (via @KariTikkinen see Tweet)


3 – Authors of premier medical textbook didn’t disclose $11 million in industry payments – STAT (free)

‘The most recognized book in all of medicine’ is also rife with hidden financial conflicts. Should Harrison’s authors be disclosing $11 million in payments from drug and device makers?” (via @caseymross see Tweet)


4 – One-Month Tuberculosis Prophylaxis as Effective as Nine-Month Regimen for People Living with HIV – National Institute of Allergy and Infectious Diseases (free) (via @iasociety see Tweet)

Related: New ways to fight HIV and tuberculosis emerge at AIDS conference – Science (free)


5 – Scandinavian SSAI clinical practice guideline on choice of inotropic agent for patients with acute circulatory failure – Anaesthesiologica Scandinavica (free)

Source: Critical Care Reviews Newsletter


6 – Why Apple, Amazon, and Google are making big health care moves – VOX (free)


7 – Opinion: Are Hospitals Becoming Obsolete? – The New York Times (10 articles per month are free)


8 – Big Swings in Daily Temperatures Linked to Spikes in MI Rates – TCTMD (free)


9 – Frailty and the management of patients with acute cardiovascular disease: A position paper from the Acute Cardiovascular Care Association – European Heart Journal: Acute Cardiovascular Care (free)


10 – Antithrombotic therapy and body mass: an expert position paper of the ESC Working Group on Thrombosis – European Heart Journal (free)


Tue, March 6 – 10 Stories of The Day!

6 Mar,2018


1 – Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus: A Guidance Statement Update From the American College of Physicians (free)

Commentary: Major Medical Associations Feud Over Diabetes Guidelines – NPR (free)

“Clinicians should aim to achieve an HbA1c level between 7% and 8% in most patients with type 2 diabetes”


2 – Treatment of infections caused by multidrug-resistant Gram-negative bacteria: report of the British Society for Antimicrobial Chemotherapy/Healthcare Infection Society/British Infection Association Joint Working Party – Journal of Antimicrobial Chemotherapy (free) (via @ABsteward)


3 – Highlights of the 2017 European AIDS Clinical Society (EACS) Guidelines for the treatment of adult HIV-positive persons version 9.0 (free)

See original EACS Guidelines in 7 languages (all free)


4 – Management of opioid use disorders: a national clinical practice guideline – Canadian Medical Association Journal (free) (via @DavidJuurlink see Tweet)


5 – Drug treatment effects on outcomes in heart failure with preserved ejection fraction: a systematic review and meta-analysis – Heart (free)

Editorial: Pharmacological strategies in heart failure with preserved ejection fraction: time for an individualised treatment strategy? (free)

Commentary: Heartbeat: Is there any effective therapy for heart failure with preserved ejection fraction? (free)

In this meta-analysis of RCT testing treatments for patients with heart failure with preserved ejection fraction, only beta-blockers demonstrated reductions in all-cause and cardiovascular mortality.


6 – Relation of Dietary Sodium (Salt) to Blood Pressure and Its Possible Modulation by Other Dietary Factors: The INTERMAP Study – Hypertension (link to abstract – $ for full-text)

Commentaries: Healthy diet may not offset high salt intake – Imperial College London (free) AND Dietary sodium’s impact may not be offset by other aspects of a diet – AHA / ASA Newsroom (free)


7 – Richard Lehman’s journal review, 5 March 2018 – The BMJ (free)

Richard Lehman reviews the latest research in the top medical journals.


8 – Too Late To Operate? Surgery Near End Of Life Is Common, Costly – NPR (free)


9 – Summary for ED-relevant care: 2018 AHA/ASA Ischemic Stroke Updates – emDocs (free)

Original guideline: 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association (free PDF)


10 – Outcomes, experiences and palliative care in major stroke: a multicentre, mixed-method, longitudinal study – Canadian Medical Association Journal (free)

““Palliative care” had connotations of treatment withdrawal and imminent death… practicing the principles of palliative care is needed, but the term “palliative care” should be avoided or reframed”.

See related articles on this subject: Palliative care: renaming as supportive care and integration into comprehensive cancer care – CMAJ (free) AND Perceptions of palliative care among patients with advanced cancer and their caregivers (free)


Mon, March 5 – 10 Stories of The Day!

5 Mar,2018


1 – Guidelines for the diagnosis, prevention and management of cryptococcal disease in HIV-infected adults, adolescents and children – World Health Organization (free)

See also: Key Messages AND Policy Brief (free PDF)


2 – Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentaries: 5 Classifications of Diabetes Proposed – Physician’s First Watch (free) AND Should diabetes be divided into 5 categories to improve treatment? – Cardiovascular Business (free) AND Diabetes Consists of Five Types, Not Two, Say Researchers – Medscape (free registration required)


3 – New Guide to Infection Control in The Hospital – International Society for Infectious Diseases (free)

A free, online resource on the principles and interventions needed to reduce healthcare associated infections, with suggested control measures across different resource levels.


4 – Clinical Practice Guideline: Hoarseness (Dysphonia) – American Academy of Otolaryngology—Head and Neck Surgery (free)

See also: Executive Summary


5 – Opioid Wisely – Choosing Wisely Canada (free)

Related Guideline: Guideline for opioid therapy and chronic noncancer pain – Canadian Medical Association Journal (free) 

See complete lists from Choosing Wisely U.S. / Choosing Wisely UKChoosing Wisely Australia AND Choosing Wisely Canada

This campaign encourages thoughtful conversation between clinicians and patients to reduce harms associated with opioid prescribing, with recommendations relevant to different specialties.


6 – New campaign: Nursing Now campaign: empowering nurses to improve global health – World Health Organization (free)

Related: Global nursing movement launches – Devex (free) AND Nursing Now campaign: raising the status of nurses – The Lancet (free registration required)

See also: Nursing Now Website

Source: International Health Policies Newsletter


7 – Effectiveness of brief alcohol interventions in primary care populations – Cochrane Library (free)

In general practice or emergency care settings, brief alcohol interventions can reduce alcohol consumption and related harm.


8 – The Challenge of Doctor-Patient Relations in the Internet Age – The New York Times (10 articles per month are free)

Related: E-patients hold key to the future of healthcare – The BMJ Opinion (free)


9 – Editorial: Escalating Inhaled Glucocorticoids to Prevent Asthma Exacerbations (free)

Trial 1: Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations – The New England Journal of Medicine (free)

Trial 2: Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations – The New England Journal of Medicine (free)


10 – Nut Consumption and Survival in Patients With Stage III Colon Cancer: Results From CALGB 89803 (Alliance) – Journal of Clinical Oncology (link to abstract – $ for full-text)

Commentaries: Nut Consumption May Aid Colon Cancer Survival – Yale Cancer Center, via NewsWise (free) AND Nuts, Especially Tree Nuts, and Improved CRC Survival – Medscape (free registration required

A survival benefit was suggested by this observational trial.


Fri, March 2 – 10 Stories of The Day!

2 Mar,2018


1 – Hydrocortisone plus Fludrocortisone for Adults with Septic Shock – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Hydrocortisone-fludrocortisone cuts deaths in septic shock – The Hospitalist (free)

See related research and commentaries on adjunctive glucocorticoid therapy in patients with septic shock


2 – Policy Statement: Pediatric Medication Safety in the Emergency Department – American Academy of Pediatrics (free)

Commentaries: Recommendations Issued on Reducing Pediatric Medication Errors in the ED – NEJM Physician’s First Watch (free) AND Policy statement outlines ways to improve pediatric medication safety – 2 Minute Medicine (free)


3 – Mortality after coronary artery bypass grafting versus percutaneous coronary intervention with stenting for coronary artery disease: a pooled analysis of individual patient data – The Lancet (link to abstract – $ for full-text)

This meta-analysis of randomized trials showed CABG had a mortality benefit over PCI in patients with multivessel disease, particularly those with diabetes and higher coronary complexity. There was no mortality benefit in patients with left main disease.


4 – Meta-analysis: Long-Term Outcomes of On- Versus Off-Pump Coronary Artery Bypass Grafting – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Long-Term Outcomes of On- vs. Off-Pump CABG – American College of Cardiology, Latest in Cardiology (free) AND Long-term survival benefit seen in on-pump vs off-pump CABG – Cardiovascular Business (free)

“Off pump CABG. probably best used in a limited set of patients…” (via @keaglemd see Tweet)


5 – Public Health: Tackling multiple unhealthy risk factors: Emerging lessons from practice – The King’s Fund (free PDF)

Commentary: Multiple unhealthy risk factors: why they matter and how practice is changing (free)

See also: Summary (free PDF) AND  Overview (free)


6 – TV viewing and incident venous thromboembolism: the Atherosclerotic Risk in Communities Study – Journal of Thrombosis and Thrombolysis (free)

Commentaries: Turn it off: Binge watching TV can cause venous thromboembolism—even if you’re fit – Cardiovascular Business (free) AND How too much TV could kill you – MedicalNewsToday (free)

Related article: Watching Television and Risk of Mortality From Pulmonary Embolism Among Japanese Men and Women – Circulation (free)


7 – Cancer diagnosis in patients with heart failure: epidemiology, clinical implications and gaps in knowledge – European Journal of Heart Failure (free)

Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)


8 – Robot-assisted laparoscopic surgery versus conventional laparoscopic surgery in randomized controlled trials: A systematic review and meta-analysis – PLOS One (free)

“Despite higher operative cost, robot-assisted laparoscopic surgery does not result in statistically better treatment outcomes, with the exception of lower estimated blood loss. Operative time and total complication rate are significantly more favorable with conventional laparoscopic surgery”.


9 – Comparative Effectiveness and Safety of Cognitive Enhancers for Treating Alzheimer’s Disease: Systematic Review and Network Meta-analysis – Journal of the American Geriatrics Society (free)

Source: Medscape (free registration required)

“Cognitive enhancers in general have minimal effects on cognition according to minimal clinically important difference and global ratings. The drugs appear safe, but this must be interpreted cautiously because trial participants may have less comorbidity and fewer adverse effects than those treated with these drugs in clinical practice”.


10 – A Time-Motion Study of Primary Care Physicians’ Work in the Electronic Health Record Era – Family Medicine (free)

Commentary: EHR Time Exceeds Patient Face Time in Family Practice Visits – Medscape (free registration required)

Related: Care-Centered Clinical Documentation in the Digital Environment: Solutions to Alleviate Burnout – National Academy of Medicine (free) AND Date Night with the EHR – NEJM Catalyst (free) AND Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free) AND Putting Patients First by Reducing Administrative Tasks in Health Care: A Position Paper of the American College of Physicians(free)


Thu, March 1 – 10 Stories of The Day!

1 Mar,2018


1 – Efficacy of self-monitored blood pressure, with or without telemonitoring, for titration of antihypertensive medication (TASMINH4): an unmasked randomised controlled trial – The Lancet (free)

Commentaries: Hypertension: time for doctors to switch the driver’s seat? (free) AND Should home-based blood pressure monitoring be commonplace in NHS? – University of Oxford News & Events (free)

“Self-monitoring, with or without telemonitoring, when used by general practitioners to titrate antihypertensive medication in individuals with poorly controlled blood pressure, leads to significantly lower blood pressure than titration guided by clinic readings”.


2 – Clinical course of untreated cervical intraepithelial neoplasia grade 2 under active surveillance: systematic review and meta-analysis – The BMJ (free)

Editorial: Treatment or surveillance for CIN2? (free)

Commentaries: Treatment or surveillance for CIN2: when less is more – The BMJ Opinion (free) AND Some irregular cervical lesions could be monitored rather that treated immediately – OnMedica (free) AND Regular monitoring rather than immediate treatment justified for some cervical lesions – EurekAlert (free)


3 – The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Hemorrhoids – Diseases of the Colon & Rectum (free)

Related guideline: ACG Clinical Guideline: Management of Benign Anorectal Disorders – The American Journal of Gastroenterology (free)


4 – Association of Varicose Veins With Incident Venous Thromboembolism and Peripheral Artery Disease – JAMA (link to abstract – $ for full-text)

Commentaries: Patients with varicose veins at greater risk for thrombosis, other vascular diseases – Cardiovascular Business (free) AND Varicose Veins Linked to Greater Risk for VTE, PAD – NEJM Physician’s First Watch (free) AND Varicose Veins May Increase Likelihood of Blood Clots – Physician’s Weekly (free)


5 – Sex Differences in the Association Between Measures of General and Central Adiposity and the Risk of Myocardial Infarction: Results From the UK Biobank – Journal of the American Heart Association (free for a limited period)

Commentaries: Wait and hip measurement better indicator of heart attack risk than obesity – OnMedica (free) AND Larger waist, hips may raise women’s heart attack risk – MedicalNewsToday (free)


6 – Impact of frailty on outcomes after discharge in older surgical patients: a prospective cohort study – Canadian Medical Association Journal (free)

Commentary: Frailty associated with readmission risk and postdischarge mortality in older surgical patients – ACP Hospitalist (free)

Related Systematic Review: Identifying older adults at risk of harm following elective surgery: a systematic review and meta-analysis – BMC Medicine (free) AND Commentary: Age itself is not a risk factor for complications after surgery among older patients – OnMedica (free)


7 – Korean Guidelines for the Pharmacological Treatment of Social Anxiety Disorder: Initial Treatment Strategies – Psychiatric Investigation (free)

Related guideline: Social anxiety disorder: recognition, assessment and treatment – NICE (free) AND Summary: Recognition, assessment and treatment of social anxiety disorder: summary of NICE guidance – The BMJ (free)


8 – Patterns and Predictors of Short-Term Peripherally Inserted Central Catheter Use: A Multicenter Prospective Cohort Study – Journal of Hospital Medicine (free PDF)

Commentary: Short-term use of IV devices is common — and risky — study shows – University of Michigan, via ScienceDaily (free)

“Intravenous devices known as PICCs should be reserved for long-term use, but a new study shows 1 in 4 are used for 5 days or less” (from ScienceDaily)


9 – Real-World Effectiveness of Pharmacologic Treatments for the Prevention of Rehospitalization in a Finnish Nationwide Cohort of Patients With Bipolar Disorder – JAMA Psychiatry (link to abstract – $ for full-text)

Editorial: Enthusiasm and Skepticism About Using National Registers to Analyze Psychotropic Drug Outcomes (free for a limited period)

Commentaries: Lithium treatment for bipolar disorder linked to lowest risk of rehospitalization – Karolinska Institutet, via EurekAlert (free) AND Lithium Top Choice for Preventing Bipolar Rehospitalization – MedPage Today (free registration required)

Related study: Effectiveness of maintenance therapy of lithium vs other mood stabilizers in monotherapy and in combinations: a systematic review of evidence from observational studies – Bipolar Disorders (free)

These observational studies suggest Lithium may be a better choice for treating these patients, but long-term randomized controlled trials are needed to clarify this issue (see editorial).


10 – Beta-blocker Therapy and Clinical Outcomes in Patients with Moderate COPD and Heightened Cardiovascular Risk: An Observational Sub-study of SUMMIT – Annals of the American Thoracic Society (link to abstract – $ for full-text)

Commentary: Beta-blockers may not change COPD lung function – Univadis (free registration required)

Related review and meta-analysis: Beta-blockers in patients with chronic obstructive disease and coexistent cardiac illnesses – COPD Research and Practice (free) AND Beta-blocker use and COPD mortality: a systematic review and meta-analysis – BMC Pulmonary Medicine (free)

Related observational studies: β-Blockers in COPD: A Cohort Study From the TONADO Research Program – CHEST (free) AND Effect of β blockers in treatment of chronic obstructive pulmonary disease: a retrospective cohort study – The BMJ (free)


Wed, February 28 – 10 Stories of The Day!

28 Feb,2018


1 – Balanced Crystalloids versus Saline in Critically Ill Adults – New England Journal of Medicine (free)

Related article: Balanced Crystalloids versus Saline in Noncritically Ill Adults – New England Journal of Medicine (free)

Commentary: Balanced Crystalloids May Be Better Than Saline for Critically Ill Patients – NEJM Physician’s First Watch (free)

Balanced crystalloids may be superior to saline in critically ill patients — but not in patients hospitalized outside an ICU” (from Physician’s First Watch)


2 – Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests – Circulation (free PDF for a limited period)

Commentary: Bystander defibrillator use tied to better cardiac arrest outcomes – Reuters (free)

Related articles: The Effects of Public Access Defibrillation on Survival After Out-of-Hospital Cardiac Arrest: A Systematic Review of Observational Studies – Circulation (link to abstract – $ for full-text) AND Bystander Efforts and 1-Year Outcomes in Out-of-Hospital Cardiac Arrest – New England Journal of Medicine (Link to abstract – $ for full-text)


3 – Medical Education: Hidden Curricula, Ethics, and Professionalism: Optimizing Clinical Learning Environments in Becoming and Being a Physician: A Position Paper of the American College of Physicians – Annals of Internal Medicine (free)

News Release: ACP calls on medicine to optimize learning environments by aligning positive ’hidden’ curriculum with formal curriculum of medical education (free)


4 – 2018 consensus of the Taiwan Society of Cardiology and the Diabetes Association of Republic of China (Taiwan) on the pharmacological management of patients with type 2 diabetes and cardiovascular diseases – Journal of the Chinese Medical Association (free)

Related guideline: Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes, 2018 – American Diabetes Association (free)


5 – Management of anaemia and iron deficiency in patients with cancer: ESMO Clinical Practice Guidelines – Annals of Oncology (free)


6 – Nutritional labelling for healthier food or non-alcoholic drink purchasing and consumption – Cochrane Library (free)

News release: New Cochrane Review evidence suggests that nutritional labelling on menus in restaurants and cafes may reduce our calorie intake (free)

Video: Nutritional labelling for healthier food or non alcoholic purchasing and consumption (free)

Commentary: Expert reaction to Cochrane review on nutrition labelling and calorie intake – Science Media Centre (free)

For a typical lunch with an intake of 600 calories, such as a slice of pizza and a soft drink, labelling may reduce the energy content of food purchased by about 8% (48 calories)”


7 – Association Between Bariatric Surgery and Rates of Continuation, Discontinuation, or Initiation of Antidiabetes Treatment 6 Years Later – JAMA Surgery (link to abstract – $ for full-text)

Commentaries: Bariatric Surgery Associated With Reduced Need For Diabetes Medications at Six Years – MedicalResearch (free) AND Roughly Half of Obese Patients Who Have Bariatric Surgery Are Off Type 2 Diabetes Meds at 6 Years – TCTMD (free)

See related studies on the long-term effects of Bariatric Surgery in our January 17th issue (see #1, #2 and #3)


8 – Pediatric Palliative Care for Children with Progressive Non-Malignant Diseases – Children (free)


9 – Plastic Additive BPA Not Much Of A Threat, Government Study Finds – NPR (free)

See original FDA statement on National Toxicology Program draft report on Bisphenol A (free) AND Endocrine Society Experts Express Concern with FDA Statement on BPA Safety – Endocrine Society, via NewsWise (free)


10 – Cardiac Arrest in the Operating Room: Resuscitation and Management for the Anesthesiologist Part 1 – Anesthesia & Analgesia (free)

See also: Cardiac Arrest in the Operating Room: Part 2—Special Situations in the Perioperative Period (free)

Source: Critical Care Reviews Newsletter


Tue, February 27 – 10 Stories of The Day!

27 Feb,2018


1 – 2018 Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology Focused Update of the Guidelines for the Use of Antiplatelet Therapy (free)

Related guidelines: 2017 European Society of Cardiology focused update on dual antiplatelet therapy in coronary artery disease (free) AND 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease (free)


2 – Guidelines for Adolescent Depression in Primary Care – American Academy of Pediatrics

Part I. Practice Preparation, Identification, Assessment, and Initial Management (free)

 Part II. Treatment and Ongoing Management (free)

Commentary: Pediatricians Call For Universal Depression Screening For Teens – NPR (free)


3 – Guidelines for Burn Care Under Austere Conditions: Surgical and Nonsurgical Wound Management – Journal of Burn Care & Research (free)

See also: Guideline for Burn Care Under Austere Conditions: Special Care Topics (free)

Source: Critical Care Reviews Newsletter


4 – “Is there a doctor on board?”: Practical recommendations for managing in-flight medical emergencies – Canadian Medical Association Journal (free)

News release: Responding to inflight medical emergencies can be stressful for doctors – CMAJ News (free)

Related video: Managing medical emergencies at 36,000 ft: A guide to Air Canada’s in-flight emergency medical kit (free)


5 – Impact of treatment delay on mortality in ST-segment elevation myocardial infarction (STEMI) patients presenting with and without haemodynamic instability: results from the German prospective, multicentre FITT-STEMI trial – European Heart Journal (free)

Commentaries: 3% rise in deaths for every 10 min delay in restoring blood flow after heart attack – OnMedica (free) AND Treatment Delay and Mortality in STEMI With Shock – American College of Cardiology, Latest in Cardiology (free)


6 – Interventions for paracetamol (acetaminophen) overdose – Cochrane Library (free)

Original article: Interventions for paracetamol (acetaminophen) overdose – Cochrane Library (link to abstract – $ for full-text)


7 – Richard Lehman’s journal review, 26 February 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.


8 – FDA Safety Alert: Clarithromycin (Biaxin): Drug Safety Communication – Potential Increased Risk of Heart Problems or Death in Patients With Heart Disease (free)

Commentaries: FDA: Antibiotic Linked to Increased Risk of Death in Heart Disease Patients – MPR (free) AND FDA: Clarithromycin Risks Persist in Patients With CAD – TCTMD (free) FDA Alert: Clarithromycin Risky in Patients With Heart Disease – Medscape (free registration required)


9 – Idiopathic pulmonary fibrosis: pathogenesis and management – Respiratory Research (free)

Related guidelines: An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline: Treatment of Idiopathic Pulmonary Fibrosis (free) AND German Guideline for Idiopathic Pulmonary Fibrosis – Update on Pharmacological Therapies 2017 – Pneumologie (free) AND Diagnosis and management of idiopathic pulmonary fibrosis: French practical guidelines – European Respiratory Review (free) AND Idiopathic pulmonary fibrosis in adults: diagnosis and management – NICE (free)


10 – Effect of the Pulmonary Embolism Rule-Out Criteria on Subsequent Thromboembolic Events Among Low-Risk Emergency Department Patients: The PROPER Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Pulmonary Embolism Rule-out Criteria non-inferior to usual care for patients at low-risk for pulmonary embolism – 2 Minute Medicine (free) AND EM Nerd-The Case of the Diagnostic Absurdity (free) AND Using PERC & Sending Home Pulmonary Emboli For Fun and Profit – Emergency Literature of Note (free)


Mon, February 26 – 10 Stories of The Day!

26 Feb,2018


1 – Latent TB Infection: Updated and consolidated guidelines for programmatic management – World Health Organization (free)

News release: WHO issues new recommendations calling for accelerated uptake of testing and treatment for TB prevention (free)


2 – ACG Clinical Guideline: Alcoholic Liver Disease – The American Journal of Gastroenterology (free)

Commentary and summary: New Guideline for Management of Alcoholic Liver Disease – NEJM Journal Watch (free for a limited period)


3 – Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning – Nature Biomedical Engineering (link to abstract – $ for full-text) (via @EricTopol see Very interesting Tweet)

Commentaries: Assessing Cardiovascular Risk Factors with Computer Vision – Google Research Blog (free) AND Google’s new AI algorithm predicts heart disease by looking at your eyes – TheVerge (free) AND Combination of AI, eye images could predict cardiovascular disease – Cardiovascular Business (free) AND It’s All in the Eyes: Google AI Calculates Cardiovascular Risk From Retinal Images – Medium (free)


4 – Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

Related guidelines: Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO) (free) AND Management of febrile neutropaenia: ESMO Clinical Practice Guidelines (free) AND Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update (free)


5 – Opinion: Doctors, Revolt! – The New York Times (free)

“Healing is replaced with treating, caring is supplanted by managing, and the art of listening is taken over by technological procedures. Bernard Lown” (via @lucadf see Tweet)


6 – The global crackdown on parents who refuse vaccines for their kids has begun – VOX (free)

“Countries like Italy and Australia are tired of measles outbreaks — so they’re moving to fine anti-vaccine parents”.


7 – Scientists Aim to Pull Peer Review Out Of The 17th Century – NPR (free)

Related: The Future of Peer Review – Scientific American (free) AND Peer review is a black box. Let’s open it up – STAT News (free) AND Exposing peer review – Research Information (free) AND Researchers debate whether journals should publish signed peer reviews – Science (free) AND The peer-review system for academic papers is badly in need of repair – The Conversation (free)


8 – Antifibrinolytic drugs for treating primary postpartum haemorrhage – Cochrane Library (free)

Related: Updated WHO Recommendation on Tranexamic Acid for the Treatment of Postpartum Haemorrhage (free PDF) AND Early use of tranexamic acid reduces bleeding more effectively – NIHR Signal (free) AND Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients – The Lancet (free)


9 – Spironolactone Versus Clonidine as a Fourth-Drug Therapy for Resistant Hypertension: The ReHOT Randomized Study (Resistant Hypertension Optimal Treatment) – Hypertension (free)

Commentary: Spironolactone bests clonidine as fourth drug for resistant hypertension – Univadis (free registration required)


10 – Infant Hospitalizations and Mortality After Maternal Vaccination – Pediatrics (free)

Commentaries: Maternal vaccination during pregnancy not associated with infant hospitalization, mortality – 2 Minute Medicine (free) AND Getting Recommended Vaccines During Pregnancy Doesn’t Lead to Harm in Infants – Physician’s First Watch (free)


Fri, February 23 – 10 Stories of The Day!

23 Feb,2018


1 – Spontaneous Coronary Artery Dissection: Current State of the Science: A Scientific Statement From the American Heart Association – Circulation (free PDF)

See also: Commentary: Spontaneous Coronary Artery Dissection: Making strides, long journey ahead! (free) AND Top Ten Things to Know (free PDF)


2 – Diagnosis and Treatment of Neurocysticercosis: 2017 Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH) – Clinical Infectious Diseases (free)


3 – Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis – The Lancet (free)

Commentaries: More data, more answers: picking the optimal antidepressant – The Lancet (free) AND All antidepressants are more efficacious than placebo – OnMedica (free) AND Expert reaction to largest review of antidepressants – Science Media Centre (free) AND Antidepressants can help adults with major depression – The Mental Elf (free)


4 – Human Neonatal Rotavirus Vaccine (RV3-BB) to Target Rotavirus from Birth – New England Journal of Medicine (free)

Commentaries: New rotavirus vaccine to curb child deaths in developing countries – New Zealand Doctor (free) AND Researchers successfully develop a rotavirus vaccine which could benefit millions of children – MedicalXpress (free)


5 – Potential workload in applying clinical practice guidelines for patients with chronic conditions and multimorbidity: a systematic analysis – BMJ Open (free) (via @acpatient and @MaryDixonWoods)


6 – The Origin of Spousal Resemblance for Alcohol Use Disorder – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: For Better or Worse: Risk of Alcohol Use Disorder Rises When Spouse is Diagnosed – Psychiatric News Alert (free) AND Spouses have strong influence on risk for alcohol abuse – Reuters (free)


7 – Cleaning at Home and at Work in Relation to Lung Function Decline and Airway Obstruction – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)

Commentaries: Women Who Clean at Home or Work Face Increased Lung Function Decline – American Thoracic Society, via NewsWise (free) AND Cleaning Chemicals ‘Likely Cause Substantial Damage To Women’s Lungs’, Study Finds – Huffpost (free) AND Cleaning at home or work linked to faster lung function decline in women – Univadis (free registration required)


8 – Perspective: Our Other Prescription Drug Problem – New England Journal of Medicine (free)

Related opinion: Benzodiazepines: our other prescription drug epidemic – STAT (free)


9 – Perspective: The Psychology of Clinical Decision Making — Implications for Medication Use – New England Journal of Medicine (free)


10 – Robot-assisted radical prostatectomy vs laparoscopic and open retropubic radical prostatectomy: functional outcomes 18 months after diagnosis from a national cohort study in England – British Journal of Cancer (free)

Commentary: After-effects not necessarily reduced with robotic prostate surgery – Reuters (free)

Related Cochrane Review with similar results: Laparoscopic and robotic-assisted versus open radical prostatectomy for the treatment of localised prostate cancer – Cochrane Library (free)


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