Open access


Mon, November 27 – 10 Stories of The Day!

27 Nov,2017


1 – Management of tricuspid valve regurgitation: Position statement of the European Society of Cardiology Working Groups of Cardiovascular Surgery and Valvular Heart Disease – European Journal of Cardio-Thoracic Surgery (free) (via @rafavidalperez)


2 – A Test-and-Not-Treat Strategy for Onchocerciasis in Loa loa–Endemic Areas – New England Journal of Medicine (free)

Editorial: Mass Administration of Ivermectin in Areas Where Loa loa Is Endemic (free)

Quick Take Video Summary: Point-of-Care Loa loa Testing for Onchocerciasis Control (free)


3 – Low dose aspirin as adjuvant treatment for venous leg ulceration: pragmatic, randomised, double blind, placebo controlled trial (Aspirin4VLU) – The BMJ (free)

“Low dose aspirin does not increase time to healing of venous leg ulcers, percentage healed, estimated change in venous leg ulcer area, or change in health related quality of life”.


4 – AVATAR therapy for auditory verbal hallucinations in people with psychosis: a single-blind, randomised controlled trial – The Lancet Psychiatry (free)

Commentaries: Understanding AVATAR therapy: who, or what, is changing? – The Lancet Psychiatry (free) AND Avatars can help schizophrenia patients control threatening voices – Reuters (free) Avatar therapy ‘reduces power of schizophrenia voices’ – BBC (free)


5 – Cause-specific mortality for 249 causes in Brazil and states during 1990–2015: a systematic analysis for the global burden of disease study 2015 – Population Health Metrics (free) (via @PauloLotufo)


6 – Medical News & Perspectives: Loneliness Might Be a Killer, but What’s the Best Way to Protect Against It? – JAMA (free)

Commentary: How Do We Prevent Loneliness? – Made in America (free)


7 – Blood pressure self-monitoring works best when people are well-supported – NIHR Signal (free)

Original article: Self-monitoring of blood pressure in hypertension: a meta-analysis – PLOS Medicine (free)


8 – Prolonged Infusion Piperacillin-Tazobactam Decreases Mortality and Improves Outcomes in Severely Ill Patients: Results of a Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)

Source: ACP Journal Wise ($)

“Receipt of prolonged infusion of piperacillin-tazobactam was associated with reduced mortality and improved clinical cure rates across diverse cohorts of severely ill patients”.


9 – Seven-year tolerability profile of glucocorticoids use in early rheumatoid arthritis: data from the ESPOIR cohort – Annals of Rheumatic Diseases (free)

Commentaries: Long-Term Safety of Glucocorticoids in Patients with Early Rheumatoid Arthritis – Journal Watch (free) AND Long-term Low-dose Steroids OK in Early RA – MedPage Today (free registration required)

“Long-Term Safety of Glucocorticoids in Early Rheumatoid Arthritis. Stopping steroids completely is difficult in patients whose disease flares with tapering, but low-dose levels are relatively safe” (RT @JWatch see Tweet)


10 – Blood Pressure Status in Adult Survivors of Childhood Cancer: A Report from the St. Jude Lifetime Cohort Study – Cancer Epidemiology, Biomarkers & Prevention (link to abstract – $ for full-text)

Commentaries: Adult Survivors of Childhood Cancer Are More Likely to Develop High Blood Pressure – American Association for Cancer Research (free) AND Childhood cancer survivors 70% likely to develop hypertension as adults – Cardiovascular Business (free)

Related Guideline: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free)


Fri, November 24 – 10 Stories of The Day!

24 Nov,2017


1 – Living systematic review series published in Journal of Clinical Epidemiology (free articles)

– News Release – Cochrane Community (free)

– Living systematic review: 1. Introduction—the why, what, when, and how (free)

– Living systematic reviews: 2. Combining human and machine effort (free)

– Living systematic reviews: 3. Statistical methods for updating meta-analyses (free)

– Living systematic reviews: 4. Living guideline recommendations (free)

See also Cochrane Community Page on Living Systematic Reviews with updates and resources

“Living Systematic Reviews are future of all Reviews” (RT @PaulGlasziou see Tweet)


2 – Thyroid Function and the Risk of Atherosclerotic Cardiovascular Morbidity and Mortality: The Rotterdam Study – Circulation Research (free PDF)

Commentaries: Higher thyroid hormone levels associated with artery disease and death – AHA/ASA Newsroom (free) AND High Thyroid-Hormone Levels Linked to Increased CVD Mortality – Medscape (free registration required)


3 – 2017 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations Summary – Resuscitation (free)

Commentary: Updated International Guidelines for Ventilation During CPR – Journal Watch (free)


4 – Inappropriate Management of Asymptomatic Patients With Positive Urine Cultures: A Systematic Review and Meta-analysis – Open Forum Infectious Diseases (free)

“OFID: Despite guidelines, continued overtreatment of patients with positive urine cultures but no symptoms” (RT @IDSAInfo see Tweet)


5 – Predictors of pneumonia in lower respiratory tract infections: 3C prospective cough complication cohort study – European Respiratory Journal (free)

Commentaries: Four clinical signs can improve GP pneumonia diagnosis, finds study – Pulse (free) AND Four simple tests could help GPs spot pneumonia and reduce unnecessary antibiotics – European Lung Fundation, via EurekAlert (free)


6 – Systematic Review and Meta-analysis Comparing the Efficacy of Nonsteroidal Anti-inflammatory Drugs, Opioids, and Paracetamol in the Treatment of Acute Renal Colic – European Urology (free) (via @KariTikkinen and @EUplatinum)

In kidney stone–related acute pain episodes in patients with adequate renal function, treatment with nonsteroidal anti-inflammatory drugs offers effective and most sustained pain relief, with fewer side effects, when compared with opioids or paracetamol”.


7 – Multidrug resistant (or antimicrobial-resistant) pathogens – alternatives to new antibiotics? – Swiss Medical Weekly (free)


8 – Point-of-use fortification of foods with micronutrient powders containing iron in children of preschool and school-age – Cochrane Library (link to summary – $ for full-text)

Powdered vitamins and minerals added to foods at the point-of-use reduces anaemia and iron deficiency in preschool- and school-age children”.


9 – High-flow nasal cannula oxygen therapy is superior to conventional oxygen therapy but not to noninvasive mechanical ventilation on intubation rate: a systematic review and meta-analysis – Critical Care (free)


10 – Comprehensive assessment when older people are in hospital improves their chances of getting home and living independently – NIHR Signal (free)

Original article: Comprehensive geriatric assessment for older adults admitted to hospital – Cochrane Library (free summary – $ for full-text) AND News Release: Comprehensive geriatric assessment for older adults admitted to hospital (free)

“Comprehensive assessment when older people are in hospital improves their chances of getting home and living independently” (RT @NIHR_DC see Tweet)


Thu, November 23 – 10 Stories of The Day!

23 Nov,2017


1 – Children, Adolescents and Screens: What We Know and What We Need To Learn – Pediatrics Supplement (free articles)

– Table of contents

– Introduction

– Digital Screen Media and Cognitive Development

– Media Multitasking and Cognitive, Psychological, Neural, and Learning Differences

– Benefits and Costs of Social Media in Adolescence

– Digital Life and Youth Well-being, Social Connectedness, Empathy, and Narcissism

– Digital Media, Anxiety, and Depression in Children

– Internet Gaming Disorder in Children and Adolescents

– Virtual Reality in Pediatric Psychology

– Digital Media and Sleep in Childhood and Adolescence

– Screen Media Exposure and Obesity in Children and Adolescents

– Digital Media and Risks for Adolescent Substance Abuse and Problematic Gambling

– Small Screen Use and Driving Safety

– Parenting and Digital Media

– Children’s Privacy in the Big Data Era: Research Opportunities

– Developing Digital and Media Literacies in Children and Adolescents

– Digital Media, Participatory Politics, and Positive Youth Development

– Digital Inequality and Developmental Trajectories of Low-income, Immigrant, and Minority Children

– Global Perspectives on Children’s Digital Opportunities: An Emerging Research and Policy Agenda

– Screen Violence and Youth Behavior

– Defining Cyberbullying

The Effect of Advertising on Children and Adolescents

– Social Group Stories in the Media and Child Development

– Sexual Media and Childhood Well-being and Health


2 – Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double‐Blind Randomized Controlled Trial – Journal of The American Heart Association (free)

“Initial combination therapy can be recommended for patients with BP >150/95 mm Hg”


3 – Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes – The BMJ (free)

Editorial: Coffee gets a clean bill of health (free)

Commentaries: Moderate coffee drinking ‘more likely to benefit health than to harm it’ say experts – The BMJ, via EurekAlert (free) AND Coffee: No Harm, No Foul If Only 4 Cups Daily – MedPage Today (free registration required)


4 – Oxygen therapy for acute myocardial infarction: A systematic review and meta-analysis – International Journal of Nursing Studies (link to abstract – $ for full-text)

Source: Supplemental Oxygen Is Associated with Excess Risk for Recurrent Myocardial Infarction – Journal Watch ($)

See related article – “Oxygen Therapy in Suspected Acute Myocardial Infarction” – and commentaries in our August 29th issue (see #1)

“Supplemental Oxygen Associated w/ Excess Risk for Recurrent Myocardial Infarction. It’s time to stop the free flow of oxygen when not absolutely needed” (RT @JWatch see Tweet)


5 – An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence – Hormone Research in Paediactrics (free)


6 – Richard Smith: How might artificial intelligence improve healthcare? – The BMJ Opinion (free)


7 – Counting the costs: U.S. hospitals feeling the pain of physician burnout – Reuters (free)


8 – Sugar industry sponsorship of germ-free rodent studies linking sucrose to hyperlipidemia and cancer: An historical analysis of internal documents – PLOS Biology (free)

Commentaries: What The Industry Knew About Sugar’s Health Effects, But Didn’t Tell Us – NPR (free) AND Sugar Industry Long Downplayed Potential Harms – The New York Times (10 articles per month are free) AND Big Sugar Buried These Concerning Health Studies 50 Years Ago – ScienceAlerts (free) AND Sugar Industry Suppressed Evidence of Health Risks of Sucrose – UC San Francisco (free)


9 – As Malaria Resists Treatment, Experts Warn of Global Crisis – The New York Times (10 articles per month are free)


10 – Effects of Sodium Reduction and the DASH Diet in Relation to Baseline Blood Pressure – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: DASH Diet, Sodium, and Baseline Blood Pressure – Latest in Cardiology, American College of Cardiology (free) AND Big BP Reductions When DASH Diet Combined With Low Sodium Intake – TCTMD (free)


Wed, November 22 – 10 Stories of The Day!

22 Nov,2017


1 – Arthroscopic subacromial decompression for subacromial shoulder pain (CSAW): a multicentre, pragmatic, parallel group, placebo-controlled, three-group, randomised surgical trial – The Lancet (free)

Editorial: No benefit of arthroscopy in subacromial shoulder pain (free)

Commentaries: Common shoulder surgery may offer little pain relief – OnMedica (free) AND Is a common shoulder surgery useless? – MedicalXpress (free) AND Popular Surgery To Ease Chronic Shoulder Pain Called Into Question – NPR (free)


2 – Hepatitis B Vaccination, Screening, and Linkage to Care: Best Practice Advice From the American College of Physicians and the Centers for Disease Control and Prevention – Annals of Internal Medicine (free)

Commentaries: ACP, CDC issue best practice advice on HBV – ACP Internist (free) AND CDC, ACP Offer Joint Guidance on Hepatitis B Vaccination and Screening – Physician’s First Watch (free)


3 – Management of Tiny Unruptured Intracranial Aneurysms: A Comparative Effectiveness Analysis – JAMA Neurology (free)

Editorial: Leaving Tiny, Unruptured Intracranial Aneurysms Untreated: Why Is It So Hard? (free)


4 – Association of Hormonal Contraception With Suicide Attempts and Suicides – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Hormonal Contraception May Increase Risk of Suicide, Study Suggests – Psychiatric News Alert (free) AND Oral Contraceptives Linked to Suicide – Medscape (free registration required)


5 – 2017 SEOM clinical guideline for treatment of cancer pain – Clinical and Translational Oncology (free)


6 – Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States – CA: A Cancer Journal for Clincians (free)

Commentaries: Cancer: 42 percent of cases down to risk factors you can change – Medical News Today (free) AND Preventable Cancer Estimate Reaches 40% – MedPage Today (free registration required)


7 – New Choosing Wisely Canada list: Six Things Pharmacists and Patients Should Question (RT @CPhAAPhC see Tweet)

See more on the Choosing Wisely initiative in our April 5 issue (see #6)


8 – Deprescribing antihyperglycemic agents in older persons: Evidence-based clinical practice guideline – Canadian Family Physician (free)

Related algorithm: Antihyperglycemic deprescribing algorithm (free PDF)

See also other Deprescribing Guidelines and Algorithms (free resources)


9 – Detecting hip fractures with radiologist-level performance using deep neural networks – Cornell University Library (free)

Related: CheXNet: Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learning – Stanford ML Group (free)


10 – Conjoint Associations of Gestational Diabetes and Hypertension With Diabetes, Hypertension, and Cardiovascular Disease in Parents: A Retrospective Cohort Study – American Journal of Epidemiology (free)

Invited Commentary: Gestational Hypertension and Diabetes—A Major Public Health Concern (free)

Commentaries: Pregnancy-related conditions taken together leave moms — and dads — at risk – McGill University Health Centre, via EurekAlert (free) AND Gestational Diabetes and Hypertension = Huge Risk for Later Disease – Medscape (free registration required)


Tue, November 21 – 10 Stories of The Day!

21 Nov,2017


1 – Development and validation of QDiabetes-2018 risk prediction algorithm to estimate future risk of type 2 diabetes: cohort study – The BMJ (free) (RT @JuliaHCox see Tweet)

See QDiabetes 2018 risk calculator (free)


2 – Clinical Guidelines Synopsis: Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults – JAMA (free)

Editorial: The New 2017 ACC/AHA Guidelines “Up the Pressure” on Diagnosis and Treatment of Hypertension (free)

Related Viewpoint: The 2017 Clinical Practice Guideline for High Blood Pressure (free)

See original AHA/ACC Hypertension Guidelines and related resources in our November 13th issue (see #1)


3 – Policy Statement: Stigma Experienced by Children and Adolescents With Obesity – American Academy of Pediatrics (free)

News release: The AAP and the Obesity Society Address the Social and Emotional Impact of Weight Stigma on Children and Teens (free)

Commentaries: Help obese kids avoid weight stigma, doctors advise – Reuters (free) AND How Not to Talk to a Child Who Is Overweight – The New York Times (10 articles per month are free)


4 – Association between maternal sleep practices and late stillbirth – findings from a stillbirth case-control study – British Journal of Obstetrics and Gynaecology (free)

Commentary: Stillbirth risk doubled in women sleeping on their back – OnMedica (free) AND Women advised to sleep on side to help prevent stillbirth – BBC (free)


5 – Direct medical costs of motorcycle crashes in Ontario – Canadian Medical Association Journal (free)

Commentaries: Motorcycle crashes cause 5 times as many deaths as car accidents, 6 times the health costs – CMAJ, via EurekAlert (free) AND Motorcycle crashes are alarmingly common — and incredibly costly – STAT (free)


6 – Elimination of schistosomiasis: the tools required – Infectious Diseases of Poverty (free)


7 – Current and new challenges in occupational lung diseases – European Respiratory Review (free)


8 – Richard Lehman’s journal review, 20 November 2017 – The BMJ (free)

Richard Lehman reviews the latest research in the top medical journals.


9 – Practical Considerations for the Diagnosis and Management of Asthma in Older Adults – Mayo Clinic Proceedings (free)


10 – Pharmacologic management of chronic neuropathic pain: Review of the Canadian Pain Society consensus statement – Canadian Family Physician (free)

Related article: Guideline for opioid therapy and chronic noncancer pain – Canadian Medical Association Journal (free)


Mon, November 20 – 10 Stories of The Day!

20 Nov,2017


1 – News release: New global commitment to end tuberculosis – World Health Organization (free)

Commentary: Global health ministers commit to end TB – CIDRAP (free)

Related report: Global tuberculosis report 2017 – World Health Organization (free) AND News Release: WHO report signals urgent need for greater political commitment to end tuberculosis (free)


2 – Infection prevention and control measures and tools for the prevention of entry of carbapenem-resistant Enterobacteriaceae into healthcare settings: guidance from the European Centre for Disease Prevention and Control – Antimicrobial Resistance & Infection Control (free)

Related document: Guidelines for the prevention and control of carbapenem-resistant Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosain health care facilities – World Health Organization (free)


3 – The association between paternal and adolescent depressive symptoms: evidence from two population-based cohorts – The Lancet (free)

Editorial: The effect of paternal depression on depressive symptoms in adolescent offspring (free)

Commentaries: Dads’ Depression Tied to Increased Depression Risk in Teenage Children – Physician’s First Watch (free) AND Teenage depression linked to father’s depression – University College London, via ScienceDaily (free)


4 – The High Costs of Unnecessary Care – JAMA (free)


5 – “Maybe I Will Just Send a Quick Text…” – An Examination of Drivers’ Distractions, Causes, and Potential Interventions – Frontiers in Psycology (free)

Commentaries: Young Men, Frequent Drivers Most Likely To Get Distracted While Driving – NPR (free) AND Risk of distracted driving predicted by age, gender, personality and driving frequency – MedicalXpress (free)


6 – Dog ownership and the risk of cardiovascular disease and death – a nationwide cohort study – Scientific Reports (free)

Commentaries: Dog ownership linked to lower mortality – Uppsala University, via ScienceDaily (free) AND Owning A Dog May Help Your Heart, Study Shows – Forbes (free)


7 – Bird Flu Is Spreading in Asia, Experts (Quietly) Warn – The New York Times (10 articles per month are free)


8 – Taking Care of the Physician – The New York Times (10 articles per month are free)


9 – Pearls and pitfalls in comprehensive critical care echocardiography – Critical Care (free)


10 – Validation of the Ottawa Subarachnoid Hemorrhage Rule in patients with acute headache – Canadian Medical Association Journal (free)

Commentaries: Thunderclap Headache: Ottawa Rule To Exclude Subarachnoid Bleeding – Medical Research (free) AND New tool identifies headache patients at risk of aneurysms in emergency department – CMAJ, via EurekAlert (free)


Fri, November 17 – 10 Stories of The Day!

17 Nov,2017


1 – Exploring Attributes of High-Value Primary Care – Annals of Family Medicine (free)

Commentaries: Lower cost, higher quality primary care practices are distinguished by six attributes – American Academy of Family Physicians, via ScienceDaily (free) AND Identifying ‘high-value’ practices in primary care; a Stanford study pinpoints key attributes – Stanford Medicine (free)


2 – Critical Lessons From High-Value Oncology Practices – JAMA Oncology (free)

Editorial: Strategies to Achieve High-Value Oncology Care: A Beginning (free)

Audio interview: Critical Lessons From High-Value Oncology Practices (free)

Commentary: High-Value Cancer Care Keeps Costs Down? Yes, It’s Possible! – Medscape (free registration required) AND High-value oncology practices include “support for the patient journey” – Stanford Medicine (free)


3 – Changing Health Care Compensation by Rewarding Value-Based Outcomes – NEJM Catalyst (free)


4 – Speed of processing training results in lower risk of dementia – Alzheimer’s & Dementia: Translational Research & Clinical Interventions (free)

Commentaries: Can brain training reduce dementia risk? Despite new research, the jury is still out – The Guardian (free) AND Nonpharma Intervention Cuts Dementia Risk by a Third – Medscape (free registration required) AND Dementia breakthrough? Brain-training game ‘significantly reduces risk’ – Medical News Today (free)

“There are good reasons to be cautious about a new study claiming computer-based training can reduce the risk of dementia. But what does work?” (from The Guardian).


5 – Timing of Angiography and Outcomes in High-Risk Patients With Non–ST-Segment–Elevation Myocardial Infarction Managed Invasively – Circulation (free)

“High risk NSTEMI undergoing cath within 12 hours had lower risk of death and MI at 180 days” (RT @CircAHA see Tweet)


6 – Why we should care that many editors of top medical journals get healthcare industry payments – Health News Reviews (free)

Original article: Payments by US pharmaceutical and medical device manufacturers to US medical journal editors: retrospective observational study – The BMJ (free)


7 – Review: Undernutrition and severe acute malnutrition in children – The BMJ (free)

Infographic: Screening and referring children under 5 years old with acute undernutrition (free PDF)


8 – Review: Diabetic foot – The BMJ (free)

Infographic: A visual overview of the primary care assessment and monitoring of a diabetic foot (free PDF)


9 – Review of Strategies to Reduce Central Line-Associated Bloodstream Infection (CLABSI) and Catheter-Associated Urinary Tract Infection (CAUTI) in Adult ICUs – Journal of Hospital Medicine (free) (via @brhospitalist)


10 – Simple steps help prevent ICU delirium – ACP Hospitalist (free)


Thu, November 16 – 10 Stories of The Day!

16 Nov,2017


1 – Periodic preventive health visits: a more appropriate approach to delivering preventive services – Canadian Task Force on Preventive Health Care (free)

Summary: Periodic preventive health visits: A more appropriate approach to delivering preventive services (free)

News release: Annual checkups do not result in better health outcomes, national task force reaffirms (free)


2 – Sudden Cardiac Arrest during Participation in Competitive Sports – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Sudden Cardiac Arrest Rare During Competitive Sports – Physician’s First Watch (free) AND Cardiac arrest study in young athletes raises heart screening questions – Reuters (free) AND Cardiac Arrest Rare in Young Athletes But Tough to Predict – Health (free) AND Screening programs unlikely to prevent sudden cardiac arrest in competitive athletes – St. Michael’s Hospital, via EurekAlert (free)


3 – Guidelines for the prevention and control of carbapenem-resistant Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosain health care facilities – World Health Organization (free)

Commentary: WHO offers guidance on carbapenem-resistant bacteria – CIDRAP (free)


4 – CheXNet: Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learning – Stanford ML Group (free)

We develop an algorithm that can detect pneumonia from chest X-rays at a level exceeding practicing radiologists


5 – The Patients vs. Paperwork Problem for Doctors – The New York Times (10 articles per month are free)

Related guideline: Putting Patients First by Reducing Administrative Tasks in Health Care: A Position Paper of the American College of Physicians (free)


6 – World Chronic Obstructive Pulmonary Disease Day, 15 November 2017: A round up of Cochrane evidence – Evidently Cochrane (free)


7 – Comparative clinical effectiveness and cost effectiveness of endovascular strategy vopen repair for ruptured abdominal aortic aneurysm: three year results of the IMPROVE randomised trial – The BMJ (free)

Editorial: Endovascular or open repair for ruptured abdominal aortic aneurysm? (free)

Commentary: Keyhole surgery more effective than open surgery for ruptured aneurysm – MedicalXpress (free)


8 – Health Effects and Public Health Concerns of Energy Drink Consumption in the United States: A Mini-Review – Frontiers in Public Health (free)

Commentaries: Serious health risks associated with energy drinks – ScienceDaily (free)

“To curb this growing public health issue, policy makers should regulate sales and marketing towards children and adolescents and set upper limits on caffeine” (from ScienceDaily)


9 – Effects of Bariatric Surgery in Obese Patients With Hypertension: The GATEWAY Randomized Trial (Gastric Bypass to Treat Obese Patients With Steady Hypertension) – Circulation (free)

Commentary: Bariatric Surgery Can Lead to HTN ‘Remission’ in Obese: GATEWAY – Medscape (free registration required) AND Gastric Bypass to Treat Obese Patients With Steady Hypertension – GATEWAY – American College of Cardiology, Latest in Cardiology (free)


10 – Effects of weight loss interventions for adults who are obese on mortality, cardiovascular disease, and cancer: systematic review and meta-analysis – The BMJ (free)


Wed, November 15 – 10 Stories of The Day!

15 Nov,2017


1 – Association of Blood Pressure Lowering With Mortality and Cardiovascular Disease Across Blood Pressure Levels: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Treating modestly high blood pressure may not boost survival odds – Reuters (free) AND No cardiovascular disease reduction with intensive blood pressure lowering treatment – Umea University, via EurekAlert (free)

See also new AHA/ACC Hypertension Guidelines and related resources in our November 13th issue (see #1)

“”Primary preventive BP lowering is associated with reduced risk for death and CVD if baseline SBP is 140 mm Hg or higher.” published same day as @ACCinTouch guideline w/SBP goals <130 mm Hg. Cognitive dissonance?” (RT @kennylinafp see Tweet)


2 – Noninvasive Cardiac Testing vs Clinical Evaluation Alone in Acute Chest Pain: A Secondary Analysis of the ROMICAT-II Randomized Clinical Trial – JAMA Internal Medicine (free)

Editorial: Acute Chest Pain in the Emergency Department (free)

Commentaries: Does Clinical Evaluation Plus Noninvasive Cardiac Testing Improve Outcomes in Emergency Department Patients with Chest Pain? – The JAMA Network (free) AND Noninvasive Cardiac Testing No Better Than Clinical Eval for Low-Risk Acute Chest Pain – Physician’s First Watch (free)

“Non-invasive testing of chest pain patients in the ED – longer stay; more testing, radiation and cost; no benefit”. (RT @JAMA_current see Tweet)


3 – World Antibiotic Awareness Week, 13-19 November 2017: A round up of Cochrane evidence – Evidently Cochrane (free)


4 – Guidelines on the management of abnormal liver blood tests – Gut (free)


5 – Increases in Depressive Symptoms, Suicide-Related Outcomes, and Suicide Rates Among U.S. Adolescents After 2010 and Links to Increased New Media Screen Time – Clinical Psychological Science (free)

Commentaries: Increased Hours Online Correlate With An Uptick In Teen Depression, Suicidal Thoughts – NPR (free) AND Smartphones a likely culprit in the recent decline in teen mental health – STAT (free)


6 – Tinder and Grindr don’t want to talk about their role in rising STDs – VOX (free)


7 – Review: The Diagnosis of Chronic Coronary Heart Disease – Deutsches Ärzteblatt international (free)


8 – Aspirin in Patients With Previous Percutaneous Coronary Intervention Undergoing Noncardiac Surgery – Annals of Internal Medicine (free)

Commentaries: Perioperative aspirin may improve short-term outcomes after noncardiac surgery in patients with prior PCI – ACP Internist (free) AND Aspirin can prevent heart attacks after noncardiac surgery in patients with prior PCI – University of Alberta Faculty of Medicine & Dentistry, via ScienceDaily (free) AND Aspirin Protective Against Early Death/MI in Prior PCI Patients Undergoing Noncardiac Surgery – TCTMD (free)


9 – Perinatal mortality associated with induction of labour versus expectant management in nulliparous women aged 35 years or over: An English national cohort study – PLOS Medicine (free)

Commentaries: Labor induction at 40 weeks associated with lower risk of perinatal mortality – PLOS, via ScienceDaily (free) AND Induction at Term Cuts Rates of Infant Death in Older First-Time Moms – MedPage Today (free registration required) Inducing Older Moms at 40 Weeks May Lower Stillbirth Risk – Medscape (free registration required)


10 – Effect of an Intervention to Promote Breastfeeding on Asthma, Lung Function, and Atopic Eczema at Age 16 Years: Follow-up of the PROBIT Randomized Trial – JAMA Pediatrics (free)

Commentary: Prolonged breastfeeding linked to halving of later eczema risk – OnMedica (free)


Tue, November 14 – 10 Stories of The Day!

14 Nov,2017


1 – 2017 ACC/AHA Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults (free PDF)

See also: High Blood Pressure Guidelines Hub / Executive Summary / ACC/AHA Slide Set / ACC Key Points to Remember (free resources)


2 – Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine – New England Journal of Medicine (free)

Commentaries: Neither Sodium Bicarbonate nor Oral Acetylcysteine Prevents Contrast-Induced Kidney Injury – Physician’s First Watch (free) AND PRESERVE: No Benefit from Sodium Bicarbonate, Acetylcysteine After Angiography – Medscape (free registration required)


3 – Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery – New England Journal of Medicine (free)

Commentaries: TRICS III: Restrictive Red-Cell Transfusion Noninferior to Liberal Use in Cardiac Surgery – TCTMD (free) AHA: Restrictive Blood Transfusion OK for Select Patients – MedPage Today (free registration required)

Related article: Transfusion Requirements After Cardiac Surgery: The TRACS Randomized Controlled Trial – JAMA (free)


4 – Sexual Activity as a Trigger for Sudden Cardiac Arrest – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Sex poses little risk of triggering sudden cardiac arrest – Cedars-Sinai Heart Institute, via EurekAlert (free) AND Instances of cardiac arrest after sex are low, but so are the survival rates – Cardiovascular Business (free)


5 – Comparison of Hospital Resource Use and Outcomes Among Hospitalists, Primary Care Physicians, and Other Generalists – JAMA Internal Medicine (free)

Editorial: The Costs and Benefits of Hospital Care by Primary Physicians: Continuity Counts (free)

Audio interview: Hospital Resource Use and Outcomes Among Generalist Physicians (free)

Commentaries: Study: For Inpatients, Primary Care Docs Outperform Hospitalists – MedPage Today (free registration required) AND Mortality Lower When Inpatients See Their Own PCP in Hospital – Medscape (free registration required)


6 – Review: Eosinophilic esophagitis: update on management and controversies – The BMJ (free for 2 weeks)


7 – Risks for blood clot in a vein may rise with increased TV viewing – Presented at American Heart Association’s (AHA) Scientific Sessions 2017 (free)

Commentary: More TV viewing linked to higher risk of blood clots in veins – Medical News Today (free)


8 – Nut Consumption and Risk of Cardiovascular Disease – Journal of The American College of Cardiology (free)

Commentary: Eating Regular Variety of Nuts Associated With Lower Risk of Heart Disease – American College of Cardiology (free) AND Variety of nuts tied to lower risk of heart disease – Reuters (free)


9 – Richard Lehman’s journal review, 13 November 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.


10 – 20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: ‘Unrelenting’: 20-Year Recurrence Risks in Breast Cancer – Medscape (free registration required) AND Breast cancer recurrence risk lingers years after treatment ends – MedicalXpress (free) AND Risk of breast cancer’s return continues long after treatment ends – Medical News Today (free)


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