Open access


Wed, September 5 – 10 Stories of The Day!

5 Sep,2018


1 – cOAlition S: Making Open Access a Reality by 2020 – Science Europe (free)

See also: 10 principles of Plan S (free PDF) AND Press Release (free PDF)

Commentaries: Radical open-access plan could spell end to journal subscriptions – Nature News (free) AND ‘Plan S’ and ‘cOAlition S’ – Accelerating the transition to full and immediate Open Access to scientific publications – European Commission (free) AND Science without publication paywalls: cOAlition S for the realisation of full and immediate Open Access – PLOS Biology (free)

“…free access to all scientific publications from publicly funded research is a moral right of citizens.” (from European Comission)


2 – Centers for Disease Control and Prevention Guideline on the Diagnosis and Management of Mild Traumatic Brain Injury Among Children – JAMA Pediatrics (free)

Commentaries: CDC releases updated guideline on diagnosis and management of pediatric mTBI – Kennedy Krieger Institute, via EurekAlert (free) AND CDC Seeks to Standardize Mild TBI Management in Kids – MedPage Today (free registration required) AND New advice on kids’ concussions calls for better tracking – Associated Press (free) AND CDC issues first guidelines to treat youth concussions – CNN (free)


3 – Screening for Syphilis Infection in Pregnant Women: US Preventive Services Task Force Reaffirmation Recommendation Statement – JAMA (free)

Editorial: Congenital Syphilis—Still a Shadow on the Land (free)

“The USPSTF recommends early screening for syphilis infection in all pregnant women. (A recommendation)”


4 – Experts brace for more super-resistant gonorrhea – CIDRAP (free)


5 – Perspective: Good Documentation – JAMA (free for a limited period)

“In this narrative medicine essay, the author, who transitioned from paper and pen to computer-generated electronic health record keeping wonders whether the self-select menu items ultimately dehumanizes both the patient and the physician.” (via @JAMA_current see Tweet)


6 – Margaret McCartney: A summary of four and a half years of columns in one column – The BMJ (free) (via @oncology_bg)


7 – 2018 Korean Clinical Imaging Guideline for Hemoptysis – Korean Journal of Radiology (free)


8 – Policy Statement: Child Passenger Safety – American Academy of Pediatrics (free)

News Release: AAP Updates Recommendations on Car Seats for Children (free)

Commentary: Children Should Remain in Rear-Facing Car Seats as Long as Possible – Physician’s First Watch (free)


9 – Worldwide trends in insufficient physical activity from 2001 to 2016: a pooled analysis of 358 population-based surveys with 1·9 million participants – The Lancet Global Health (free)

Commentaries: Quarter of world’s population ‘not active enough to stay healthy’ – The Guardian (free) AND A quarter of adults are too inactive, putting health at risk – Reuters (free)


10 – Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Physician Burnout Poses Risks to Patient Safety – Psychiatric News Alert (free) AND Burnout in doctors doubles risk of patient safety incidents, study finds – Pulse (free)


Tue, September 4 – 10 Stories of The Day!

4 Sep,2018


1 – Guideline Summary: Medicines for Treatment Intensification in Type 2 Diabetes and Type of Insulin in Type 1 and Type 2 Diabetes in Low-Resource Settings: Synopsis of the World Health Organization Guidelines on Second- and Third-Line Medicines and Type of Insulin for the Control of Blood Glucose Levels in Nonpregnant Adults With Diabetes Mellitus – Annals of Internal Medicine (free)

Original Guideline: Guidelines on second-and third-line medicines and type of insulin for the control of blood glucose levels in non-pregnant adults with diabetes mellitus – World Health Organization (free PDF)


2 – Canadian Rheumatology Association Recommendations for the Assessment and Monitoring of Systemic Lupus Erythematosus – The Journal of Rheumatology (free PDF)

Related Guidelines: The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults (free) AND First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus: Latin American Group for the Study of Lupus (GLADEL, Grupo Latino Americano de Estudio del Lupus)–Pan-American League of Associations of Rheumatology (PANLAR) – Annals of Rheumatic Diseases (free)


3 – The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines – GUT (free)


4 – Perspective: Five of the scariest antibiotic-resistant bacteria in the past five years – The Conversation (free)


5 – Review: Hypertensive Disorders of Pregnancy and Future Maternal Cardiovascular Risk – Journal of the American Heart Association (free)


6 – Review: Ischemia and No Obstructive Coronary Artery Disease (INOCA): What Is the Risk – Journal of the American Heart Association? (free)


7 – Ann Robinson’s research reviews, 3 September 2018 – The BMJ Opinion (free)


8 – Primary antifungal prophylaxis for cryptococcal disease in HIV‐positive people – Cochrane Library (free for a limited period)

Summary: Preventing cryptococcal disease in HIV-positive people – Cochrane Library (free)

Antifungal prophylaxis reduced the risk of developing and dying from cryptococcal disease. Therefore, where CrAG screening is not available, antifungal prophylaxis may be used in patients with low CD4 counts at diagnosis and who are at risk of developing cryptococcal disease.”


9 – Performance of Electronic Prediction Rules for Prevalent Delirium at Hospital Admission – JAMA Network Open (free)

Commentary: New prediction rule may help detect delirium at hospital admission – ACP Hospitalist (free)


10 – Strategy of endovascular versus open repair for patients with clinical diagnosis of ruptured abdominal aortic aneurysm: the IMPROVE RCT – Health Technology Assessment (free)

Commentary: Endovascular aortic repair (EVAR) surgery more beneficial for ruptured abdominal aortic aneurysms than open repair – NIHR Signal (free)


Mon, September 3 – 10 Stories of The Day!

3 Sep,2018


1 – Consensus document of the Italian Association of Medical Oncology and the Italian Society of Palliative Care on early palliative care – Tumori Journal (free PDF)

Related Video: Early Palliative Care: a video for health and care professionals – University of Edinburgh (free)

Related Systematic Review: Early palliative care for adults with advanced cancer – Cochrane Library (free) AND Summary: Early palliative care for adults with advanced cancer – Cochrane Library (free)

Related guideline: Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update (free)


2 – Podcast: #111: Hotcakes – Complementary Medicine in Cancer, Dosing Aspirin by Body Weight, Marijuana & Respiratory Symptoms, Penicillin Allergies and More! – The Curbsiders (free audio and summary)


3 – Review: Cardiorenal Syndrome Revisited – Circulation (free) (via @Abraham_RMI)


4 – “So, Blood Cultures… or No?” – Use of Blood Cultures in the ED – emDocs (free)

Related Review: How to Optimize the Use of Blood Cultures for the Diagnosis of Bloodstream Infections? A State-of-the Art – Frontiers in Microbiology (free)


5 – Government proposes energy drinks ban for children – BBC (free)

Related: England Proposes Ban on Selling Energy Drinks to Children – The New York Times (10 articles per month are free)


6 – Abraar Karan: Changing the way we communicate about patients – The BMJ Opinion (free) (via @NUNESDOC)

“Father of 2, retired car salesman and keen on football NOT the colon cancer in Bed 4 – social history brings humanity back to the bedside” (via @hospicedoctor see Tweet)


7 – American Epilepsy Society: Five Things Physicians and Patients Should Question – Choosing Wisely (free)

Commentary: Choosing Wisely: 5 Practices to Question When Treating Epilepsy – NEJM Physician’s First Watch (free)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada


8 – Antidepressants for treating depression in dementia – Cochrane Library (free for a limited period)

Summary: Antidepressants for treating depression in dementia – Cochrane Library (free)

“On the only measure of efficacy for which we had high-quality evidence (depression rating scale scores), antidepressants showed little or no effect.”


9 – The impact of exposure to air pollution on cognitive performance – Proceedings of the National Academies of Sciences (link to abstract – $ for full-text)

Commentaries: Air pollution could be making us less intelligent – Science Magazine (free) AND Air Pollution Exposure Harms Cognitive Performance, Study Finds – NPR (free) AND Air pollution may harm cognitive intelligence, study says – BBC (free) AND Pollution May Dim Thinking Skills, Study in China Suggests – New York Times (10 articles per month are (free) AND Air pollution is making you less intelligent, according to a new study – World Economic Forum (free)


10 – Kawasaki disease: guidelines of the Italian Society of Pediatrics, part I – definition, epidemiology, etiopathogenesis, clinical expression and management of the acute phase – Italian Journal of Pediatrics (free)

Part II: Treatment of resistant forms and cardiovascular complications, follow-up, lifestyle and prevention of cardiovascular risks (free)

Related guideline: Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association (free)

Related reviews: Dissecting Kawasaki disease: a state-of-the-art review – European Journal of Pediatrics (free) AND Diagnosis and Management of Kawasaki Disease – American Family Physician (free) AND Controversies in diagnosis and management of Kawasaki disease – World Journal of Clinical Pediatrics (free)


Thu, August 30 – 10 Stories of The Day!

30 Aug,2018


1 – ESC Council on hypertension position document on the management of hypertensive emergencies – European Heart Journal – Cardiovascular Pharmacotherapy (free) (@Abraham_RMI)

“Patients that lack acute hypertension-mediated end organ damage to the heart, retina, brain, kidneys, or large arteries do not have a hypertensive emergency and can be treated with oral BP-lowering agents and usually discharged after a brief period of observation.”


2 – ERS/EACTS statement on the management of malignant pleural effusions – European Respiratory Journal (free)


3 – Guideline for the management of hip and knee osteoarthritis – Royal Australian College of General Practitioners (free PDF)

News Release: Updated osteoarthritis guideline designed to reduce unnecessary imaging and surgery (free)

Commentary: Australia hopes to reduce unnecessary imaging, surgery with updated osteoarthritis guidelines – Health Imaging (free)

“The Guideline for the management of knee and hip osteoarthritis,” offer up exercise and weight loss as a first line defense, and warn against costly treatments using glucosamine, opioids and arthroscopic surgery, said David Hunter, co-chair of the RACGP group responsible for the update.” (from Health Imaging)


4 – Opinion: Is one drink per day really unsafe? That new alcohol study, explained – VOX (free)

Related Commentary: Study Causes Splash, but Here’s Why You Should Stay Calm on Alcohol’s Risks – The New York Times (10 articles per month are free)

Original Article: Alcohol Use and Burden for 195 Countries and Territories (free study and commentaries)


5 – Earwax, Of All Things, Poses Unrecognized Risk In Long-Term Care – Kaiser Health News (free)

“Of all the indignities that come with aging, excessive earwax may be the most insidious… when it goes unrecognized, it can pose serious problems, especially for the 2.2 million people who live in U.S. nursing homes and assisted living centers.”


6 – #ESCCongress – Early Versus Standard Care Invasive Examination and Treatment of Patients with Non-ST-Segment Elevation Acute Coronary Syndrome: The VERDICT (Very EaRly vs Deferred Invasive evaluation using Computerized Tomography) – Randomized Controlled Trial – Circulation (free PDF)

Editorial: Timing of Intervention in Non ST Elevation Acute Coronary Syndromes: And the VERDICT is? (free PDF)

Commentaries: VERDICT: Very Early Invasive Coronary Angiography vs. Standard Care in NSTE-ACS Patients- American College of Cardiology (free) AND ESC: Early Invasive Strategy in NSTEMI Does Not Improve Outcomes – MedPage Today (free registration required) AND VERDICT: Very Early Invasive Angiography No Help Overall for NSTE ACS – TCTMD (free)


7 – #ESCCongress – Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data – The Lancet (free)

Commentaries: Imaging of coronary inflammation for cardiovascular risk prediction – The Lancet (free) AND New Imaging Biomarker of Coronary Inflammation Shows Prognostic Value Exceeding All Current Noninvasive Measures – Cleveland Clinic (free) AND Imaging biomarker can predict coronary inflammation – UPI (free)


8 – #ESCCongress – Radial versus femoral access and bivalirudin versus unfractionated heparin in invasively managed patients with acute coronary syndrome (MATRIX): final 1-year results of a multicentre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

Commentaries: MATRIX: 1-Year Results Confirm Superiority of Transradial PCI – TCTMD (free) AND Radial vs. Femoral Access for Angiography with or Without Bivalirudin in Patients with Acute Coronary Syndrome – NEJM Journal Watch (free for a limited period) AND ESC: Radial Access Tied to Better 1-Year Outcomes in ACS – MedPage Today (free registration required)


9 – #ESCCongress – Psychological Distress and Risk of Myocardial Infarction and Stroke in the 45 and Up Study: A Prospective Cohort Study – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Distress boosts heart attack and stroke risk – Medical News Today (free) AND High Mental Distress Tied to Heart Troubles – MedPage Today (free registration required)


10 – #ESCCongress – Deep forehead wrinkles may signal a higher risk for cardiovascular mortality – ESC Press Releases (free)

Commentaries: Forehead wrinkles – an early sign of cardiovascular disease? – Medical News Today (free) AND Excessive forehead wrinkles may be early sign of atherosclerosis – Cardiovascular Business (free)


Fri, August 31 – 10 Stories of The Day!

31 Aug,2018


1 – Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study – The BMJ (free)

Commentaries: Vitamin D: a pseudo-vitamin for a pseudo-disease – The Conversation (free) AND Fracture risk not linked to low vitamin D or calcium levels – OnMedica (free)

Related: Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It (free commentaries and NICE Guideline)


2 – Bacterial Factors That Predict Relapse after Tuberculosis Therapy – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Bacterial Factors That Predict Relapse after Antituberculosis Therapy – NEJM Resident 360 (free) AND MICs of Isoniazid, Rifampin May Predict Tuberculosis Relapse – Drugs.com (free) AND Variation in bacterial drug susceptibility tied to TB relapse risk – CHEST Physician (free)


3 – Revisiting the timetable of tuberculosis – The BMJ (free)

Related: Soumya Swaminathan: TB programmes should focus on people with highest risk of progression to disease – The BMJ Opinion (free)


4 – Clinical Decisions: Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome – New England Journal of Medicine (free)


5 – 2018 STD Prevention Conference – Centers for Disease Control and Prevention (free)

Press Release: New CDC analysis shows steep and sustained increases in STDs in recent years (free)

Commentaries: 5 reasons why 3 STDs are roaring back in America – VOX (free) AND Rates of three STDs in US reach record high, CDC says – CNN (free) AND Record High Number Of STD Infections In U.S., As Prevention Funding Declines – NPR (free) AND STD cases in U.S. hit record highs as officials warn about resistant gonorrhea – STAT (free) AND US sees record STD cases, rising gonorrhea resistance – CIDRAP (free)


6 – Clinical Implications and Challenges of Artificial Intelligence and Deep Learning – JAMA (free for a limited period)

Related Viewpoints: Deep Learning—A Technology With the Potential to Transform Health Care – JAMA (free for a limited period) AND Deep Learning—A Technology With the Potential to Transform Health Care – JAMA (free for a limited period)


7 – Publication: Immigration as a Social Determinant of Health: Proceedings of a Workshop – National Academies of Sciences, Engineering, and Medicine (free PDF)

“Immigration as a social determinant of health – NEW publication explores complex interactions between immigration and health disparities + grappling with the complexities of immigration” (via @julianmfisher see Tweet)


8 – Optimal Blood Pressure Target in Diabetic and Nondiabetic Hypertensive Patients – Circulation Research (free)

See counterpoint suggesting lower BP targets: Sprinting Toward the Optimal Blood Pressure Target for Hypertensive Patients – Circulation Research (free)

“We have reviewed the randomized trial evidence in favor of a target blood pressure (BP) around 130/80 mm Hg in hypertensive patients with and without diabetes mellitus”


9 – Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis – The BMJ (free)

Editorial: Environmental metals and cardiovascular disease (free)

Commentary: Experts warn of cardiovascular risk from heavy metal pollution – University of Cambridge (free)

“Since metals are associated with cardiovascular disease even at relatively low levels of exposure, population wide strategies to minimize exposure can further contribute to overall cardiovascular prevention efforts” (from @bmj_latest see Tweet)


10 – Functional Status and Survival After Breast Cancer Surgery in Nursing Home Residents – JAMA Surgery (free for a limited period)

Commentaries: Surgical Decision Making in Elderly, Impaired Nursing Home Patients – JAMA Surgery (free for a limited period) AND For Nursing Home Patients, Breast Cancer Surgery May Do More Harm Than Good – Kaiser Health News (free)


Wed, August 29 – 10 Stories of The Day!

29 Aug,2018


1 – Report: Crossing the Global Quality Chasm: Improving Health Care Worldwide – National Academies Of Sciences, Engineering, and Medicine (free PDF)

News Release: Up to 8 Million Deaths Occur in Low- and Middle-Income Countries Yearly Due to Poor-Quality Health Care, Says New Report; Major Quality Chasm Must Be Fixed in Order to Reap Benefits of Universal Health Coverage (free)

Videos: The Scope of the Problem (free) AND Health Systems of the Future (free)

See also: Report Highlights (free PDF) AND Recommendations (free PDF)


2 – #ESCCongress – Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis – New England Journal of Medicine (free for a limited period)

Commentaries: Partial Oral Treatment of Endocarditis – POET – American College of Cardiology (free) AND New treatment can halve hospital stays for some patients with heart infection – ESC Press Releases (free)


3 – #ESCCongress – High-sensitivity troponin in the evaluation of patients with suspected acute coronary syndrome: a stepped-wedge, cluster-randomised controlled trial – The Lancet (free)

Commentaries: Diagnosing myocardial infarction: a highly sensitive issue – The Lancet (free) AND Hs-TnI in Suspected ACS: High-STEACS Trial – American College of Cardiology (free)

Introduction of a high-sensitivity cardiac troponin I assay reclassified 1 in 6 patients with previously undetected myocardial necrosis, but did not lead to improved clinical outcomes in this large randomised trial” (via @chapdoc1 see Tweet)

Very important study. What’s weird is that the “better” (more sensitive) troponin assays get, the less helpful the test becomes at the bedside. Look for a coming tsunami of iatrogenesis from overzealous evaluation of troponin bumps.” (via @drjohnm see Tweet)


4 – #ESCCongress – One-Year Outcomes after PCI Strategies in Cardiogenic Shock – New England Journal of Medicine (free for a limited period)

Commentaries: Less Is Still More in Patients with Acute Myocardial Infarction and Cardiogenic Shock – NEJM Journal Watch (free for a limited period) AND 1-year outcomes still support culprit-only PCI for cardiogenic shock – Cardiovascular Business (free) AND CULPRIT-SHOCK: 1-Year Results Continue to Support Culprit-Only PCI for Shock Patients – TCTMD (free)


5 – #ESCCongress – Efficacy of telemedical interventional management in patients with heart failure (TIM-HF2): a randomised, controlled, parallel-group, unmasked trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Telemedicine in Heart Failure Patients (TIM-HF2) – American College of Cardiology (free) AND ESC: Telemonitoring of HF Cuts Admissions, Mortality MedPage Today (free registration required)


6 – Global Mortality From Firearms, 1990-2016 – JAMA (free for a limited period)

Video Summary: Global Firearm Mortality, 1990-2016 – JAMA (free)

Infographic: Firearm deaths around the world 1990–2016 – Institute for Health Metrics and Evaluation (free) (via @kleachkemon)

Commentaries: Six countries in the Americas account for half of all firearm deaths – Institute for Health Metrics and Evaluation (free) AND Gun-related homicides, suicides kill more people than war, study says – CNN (free)


7 – Zackary Berger’s journal reviews, 28 August 2018 – The BMJ Opinion (free)


8 – Guide to Statistics and Methods: Case-Control Studies: Using “Real-world” Evidence to Assess Association – JAMA (free for a limited period)


9 – Guiding Principles for the Care of People With or at Risk for Diabetes – National Institute of Diabetes and Digestive and Kidney Diseases (free PDF)

Commentaries: NIDDK Updates ‘Guiding Principles’ for Diabetes, Prediabetes – Medscape (free registration required) AND NDEP revises principles for managing diabetes, prediabetes – Cardiovascular Business (free)

Related Book: Diabetes in America, 3rd Edition – National Institutes of Health (free reference book, just released)


10 – Evaluating the replicability of social science experiments in Nature and Science between 2010 and 2015 – Nature Human Behavior (free for a limited period)

Commentaries: More social science studies just failed to replicate. Here’s why this is good – VOX (free) AND High-profile journals put to reproducibility test – Nature News (free) AND ‘Replication crisis’ spurs reforms in how science studies are done – ScienceNews (free) AND The Science Behind Social Science Gets Shaken Up—Again – WIRED (Free) AND In Psychology And Other Social Sciences, Many Studies Fail The Reproducibility Test – NPR (free)

We replicated 21 social science experiments in Science or Nature. We succeeded with 13. Replication effect sizes were half of originals.” (via @BrianNosek see Tweet)


Tue, August 28 – 10 Stories of The Day!

28 Aug,2018


1 – Effectiveness of interventions for managing multiple high-burden chronic diseases in older adults: a systematic review and meta-analysis – Canadian Medical Association Journal (free)

Commentaries: Care coordination improves health of older patients with multiple chronic diseases – CMAJ, via EurekAlert (free) AND Seniors healthier when medical care is coordinated – Reuters (free)

Related: Ten Recommendations: Designing a High-Performing Health Care System for Patients with Complex Needs (free Guidance and related perspectives) AND Multimorbidity: A Priority for Global Health Research (free research and commentaries)


2 – A Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure With Preserved Ejection Fraction – Circulation (free) (via @CircAHA see Tweet with Infographic)

Editorial: H2FPEF Score: At Last, a Properly Validated Diagnostic Algorithm for Heart Failure With Preserved Ejection Fraction (free)


3 – Clinical Guideline Synopsis: Diagnosis and Treatment of Clostridium difficile Infection – JAMA (free for a limited period) (via @ABsteward and @Abraham_RMI)

Original Guideline: Clinical Practice Guidelines for Clostridium difficileInfection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) – Clinical Infectious Diseases (free)


4 – Review: Acute Clinical Care for Transgender Patients – JAMA Internal Medicine (free for a limited period) (via @CarlosdelRio7)


5 – Antithrombotic Therapy for Atrial Fibrillation: CHEST Guideline and Expert Panel Report (free PDF)

News Release: The American College of Chest Physicians updates their antithrombotic therapy guidelines for patients with atrial fibrillation (free)


6 – Clinical Report: Marijuana Use During Pregnancy and Breastfeeding: Implications for Neonatal and Childhood Outcomes – Pediatrics (free)

News Release: Counsel against marijuana use in pregnancy, breastfeeding – American Academy of Pediatrics (free)

Related Article: Marijuana Use by Breastfeeding Mothers and Cannabinoid Concentrations in Breast Milk – Pediatrics (free)

Commentaries: A Modern Conundrum for the Pediatrician: The Safety of Breast Milk and the Cannabis-Using Mother – Pediatrics (free) AND Marijuana study finds THC in breast milk up to 6 days after mom’s use – CNN (free) AND Pediatricians Put It Bluntly: Motherhood And Marijuana Don’t Mix – Kaiser Health News (free) AND Clinical report provides guidance on marijuana use in pregnancy and lactation – 2 Minute Medicine (free)


7 – #ESCCongress – Effects of n−3 Fatty Acid Supplements in Diabetes Mellitus – New England Journal of Medicine (free for a limited period)

Commentaries: Fish oils do not prevent heart attack or strokes in people with diabetes – ESC News Releases (free) AND Omega-3 Fatty Acids Fail to Reduce CVD Events in Diabetic Patients: ASCEND – TCTMD (free)

Related Cochrane Review: Omega-3 fatty Acids for the Prevention of Cardiovascular Disease (link to abstract and commentaries)

Related Meta-Analysis: Omega-3 Fatty Acid Supplements Don’t Reduce Cardiovascular Risk (free study and commentary)


8 – #ESCCongress – Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients – New England Journal of Medicine (free for a limited period)

Editorial: Lorcaserin — Elixir or Liability? (free for a limited period)

Commentaries: CAMELLIA-TIMI 61: Weight Loss Drug Lorcaserin Did Not Increase CV Events – American College of Cardiology (free) AND Weight-Loss Drug Lorcaserin Clears Cardiovascular Safety Hurdle: CAMELLIA-TIMI 61 – TCTMD (free) AND Weight loss drug lorcaserin found safe in large study – Reuters (free)


9 – #ESCCongress – Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness – New England Journal of Medicine (free for a limited period)

Commentaries: VTE risk unchanged by rivaroxaban after discharge – The Hospitalist (free) AND MARINER: Rivaroxaban vs. Placebo Post-Discharge in Patients at High Risk For VTE – American College of Cardiology (free) AND MARINER: No Reduction in Death, VTE With Rivaroxaban After Discharge in Medically Ill Patients – Medscape (free registration required)


10 – #ESCCongress – Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy – New England Journal of Medicine (free for a limited period)

Editorial: Stabilizing Transthyretin to Treat ATTR Cardiomyopathy (free for a limited period)

Commentaries: Tafamidis, a Transthyretin Stabilizer, Offers Hope for Rare Cardiomyopathy – TCTMD (free) AND ATTR-ACT: Tafamidis Findings Offer Hope For Patients With ATTR-CM – American College of Cardiology (free) AND Drug reduces deaths and hospitalizations from underdiagnosed form of heart failure – Columbia University Irving Medical Center, via EurekAlert (free)


Mon, August 27 – 10 Stories of The Day!

27 Aug,2018


#ESCCongress – Highlights from the 2018 Meeting of the European Society of Cardiology



1 – #ESCCongress – 2018 ESC/ESH Guidelines for the management of arterial hypertension – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)


2 – #ESCCongress – 2018 ESC/EACTS Guidelines on myocardial revascularization – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)


3 – #ESCCongress – Fourth universal definition of myocardial infarction (2018) – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)


4 – #ESCCongress – 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)


5 – #ESCCongress – Recommendations for participation in competitive sports of athletes with arterial hypertension: a position statement from the sports cardiology section of the European Association of Preventive Cardiology (EAPC) – European Heart Journal (free)


6 – #ESCCongress – Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery – New England Journal of Medicine (free for a limited period)

In moderate-to-high-risk patients undergoing cardiac surgery, six-month outcomes show that a restrictive red-cell transfusion strategy is noninferior to a liberal strategy” (via @NEJM see Tweet with Visual Abstract)


7 – #ESCCongress – CLARIFY: No Survival Benefit With Beta-Blockers Beyond 1 Year Post-MI in Stable CAD – TCTMD (free)

Related Study: B-Blockers and Mortality After Acute Myocardial Infarction in Patients Without Heart Failure or Ventricular Dysfunction (free study and commentary)

“The problem, said Sorbets, is that there have never been large randomized trials to test the prognostic effects of beta-blockers in this patient group and instead, recommendations have been drawn from meta-analyses using data extracted from the acute MI setting or from observational studies.”


8 – #ESCCongress – Coronary CT Angiography and 5-Year Risk of Myocardial Infarction – New England Journal of Medicine (free for a limited period)

Commentary: Five Reasons I Don’t Believe an Imaging Test Improves Outcomes – by Dr. John Mandrola, in Medscape (free registration required)

See also an interesting Tweetorial by @AnilMakam, also suggesting caution before adopting this study results in clinical practice.


9 – #ESCCongress – Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus – New England Journal of Medicine (free for a limited period)

Commentaries: Bleeds and benefit with aspirin balanced in patients with diabetes and no effect on cancer – ESC Press Releases (free) AND  ASCEND: Aspirin Doesn’t Look Good for Primary CV Prevention in Diabetic Patients – TCTMD (free)


10 – #ESCCongress – Use of aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Aspirin Fails to Prevent CV Events in People at ‘Moderate’ Risk of Disease: ARRIVE – TCTMD (free) AND ARRIVE: New Findings Contribute to Growing Body of Evidence Surrounding Aspirin Use – American College of Cardiology (free) AND Daily Aspirin Fails to Lower CV Risk in Long-term, Primary Prevention ARRIVE Trial – Medscape (free registration required) AND Jury still out on aspirin a day to prevent heart attack and stroke – ESC Press Releases (free)


Fri, August 24 – 10 Stories of The Day!

24 Aug,2018


1 – Alcohol use and burden for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet (free)

Commentaries: No level of alcohol consumption improves health – The Lancet (free) AND No amount of alcohol is good for your overall health, global study says – CNN (free) AND New scientific study: no safe level of alcohol – Institute for Health Metrics and Evaluation (free)

“Alcohol was responsible for nearly 3 million deaths in 2016, the study says. It was the leading risk factor for disease and premature death in men and women between the ages of 15 and 49 worldwide in 2016, accounting for nearly one in 10 deaths.” (from @cnni see Tweet)


2 – Antibiotics should not be issued as first line of treatment for a cough, says NICE and PHE – NICE News and Features (free)

Commentaries: Promote honey rather than antibiotics for coughs, doctors told – The Guardian (free) AND Use honey first for a cough, new guidelines say – BBC (free)

Related: Honey for acute cough in children – Cochrane Library (free systematic review and commentary)


3 – How scientists are learning to predict your future with your genes – VOX (free) (via @EricTopol)

There’s not one light switch but hundreds, each with the ability to slightly increase or decrease the chances of developing the illness.”


4 – Perspective: Adolescents’ Use of “Pod Mod” E-Cigarettes — Urgent Concerns – New England Journal of Medicine (free)


5 – A Late-Life Surprise: Taking Care Of Frail, Aging Parents – Kaiser Health News (free)


6 – Viewpoint: The Challenge of Reforming Nutritional Epidemiologic Research – JAMA (free)

“…the emerging picture of nutritional epidemiology is difficult to reconcile with good scientific principles. The field needs radical reform.”


7 – Review: Difficult tracheal intubation in critically ill – Journal of Intensive Care (free)


8 – Glucocorticoids for croup in children – Cochrane Library (free for a limited period)

Summary: Glucocorticoids for croup in children – Cochrane Library (free)

Commentary: Glucocorticoid Therapy Examined in Pediatric Patients With Croup – MPR (free)


9 – Risk of Esophageal Adenocarcinoma After Antireflux Surgery in Patients With Gastroesophageal Reflux Disease in the Nordic Countries – JAMA Oncology (free for a limited period)


10 – Association of Cardiovascular Health Level in Older Age With Cognitive Decline and Incident Dementia – JAMA (link to abstract – $ for full-text)

Commentaries: Study confirms that keeping the heart healthy also reduces dementia risk – NHS Choices (free) AND The Healthier Your Heart, the Healthier Your Brain May Be – The New York Times (10 articles per month are free) AND Cardiovascular Risk Factors Also Linked to Dementia – MedicalResearch.com (free) AND Reducing CV Risk May Improve Brain Health at Any Stage in Life, Studies Hint – TCTMD (free)


Wed, August 22 – 10 Stories of The Day!

22 Aug,2018


1 – Screening for Cervical Cancer: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Related articles: Screening for Cervical Cancer With High-Risk Human Papillomavirus Testing: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA (free) AND Screening for Cervical Cancer in Primary Care: A Decision Analysis for the US Preventive Services Task Force – JAMA (free)

Editorials: Screening for Cervical Cancer: New Tools and New Opportunities (free for a limited period) AND Cervical Cancer Screening—Moving From the Value of Evidence to the Evidence of Value (free for a limited period)

Author Interview: USPSTF Recommendation: Screening for Cervical Cancer (free)

Final Update Summary: Cervical Cancer: Screening – US Preventive Service Task Force (free)

Commentaries: Cervical cancer screening without Pap test OK for some women – Reuters (free) AND For Cervical Cancer Screening, Women Over 30 Can Now Choose The HPV Test Only – NPR (free) AND Annual Pap Test a ‘Thing of the Past?’ – Florida Atlantic University (free)


2 – Joint Consensus Document: Management of antithrombotic therapy in AF patients presenting with ACS and/or undergoing PCI – European Heart Journal (free)


3 – CSI position statement on management of heart failure in India – Indian Heart Journal (free)


4 – 2017 WSES guidelines on colon and rectal cancer emergencies: obstruction and perforation – World Journal of Emergency Surgery (free)


5 – The Japanese Clinical Practice Guideline for acute kidney injury 2016 – Journal of Intensive Care (free)


6 – Our first year together – World Health Organization (free)

“Delighted to share my first annual letter as WHO Director-General. It outlines our major achievements over the past year and what I believe are the keys to achieving #HealthForAll. I’m proud of everything we’ve achieved – but we’re just getting started!” (via @DrTedros see Tweet)


7 – How smartphones are becoming a weapon in the global fight against tuberculosis – STAT (free)


8 – Long-Term Association of Low-Density Lipoprotein Cholesterol With Cardiovascular Mortality in Individuals at Low 10-Year Risk of Atherosclerotic Cardiovascular Disease – Circulation (free)

Commentaries: ‘Bad’ cholesterol can be deadly in otherwise healthy people – AHA News (free) AND LDL >160 Tied to Increased Mortality in Low-Risk Patients – Physician’s First Watch (free) AND Study: Elevated LDL, non-HDL increase CVD mortality risk in young, healthy individuals – Cardiovascular Business (free) AND Moderate ‘bad cholesterol’ levels tied to early death for healthy people – Reuters (free)


9 – Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials – Critical Care (free)

Commentary: Procalcitonin guidance linked to improved sepsis survival – Univadis (free registration required)


10 – Pregabalin and the Risk for Opioid-Related Death: A Nested Case–Control Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Pregabalin may increase the risk of death when coprescribed with opioids – 2 Minute Medicine (free) AND Pregabalin Linked To Increased Risk for Opioid-Related Deaths – MedicalResearch.com (free) AND Anticonvulsant With Opioids Tied To Higher Mortality – MedPage Today (free registration required)


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