Open access


Fri, June 22 – 10 Stories of The Day!

22 Jun,2018


1 – Report: Sodium and Potassium Intake: Effects on Chronic Disease Outcomes and Risks – Agency for Healthcare Research and Quality (free)

See also: Evidence Summary (free PDF) AND Full Report (free PDF)


2 – NICE Guideline: Hearing loss in adults: assessment and management – National Institute for Health and Care Excellence (free)


3 – Conventional and biologic disease-modifying anti-rheumatic drugs for osteoarthritis: a meta-analysis of randomized controlled trials – Rheumatology (free)

Commentary: OA: DMARDs fail to relieve pain in meta-analysis – Univadis (free registration required)


4 – Presented at EULAR 2018: NSAIDs Account for Large Part of Osteoarthritis-CVD Link, Study Suggests – TCTMD (free)


5 – Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Sodium Thiosulfate for Cisplatin-Induced Hearing Loss (free)

Commentaries: New drug halves hearing loss in children following cancer treatment – Cancer Research UK, via ScienceDaily (free) AND Otoprotectant Guards Against Cisplatin-Induced Hearing Loss – Medscape (free registration required) AND Antioxidant Cuts Hearing Loss in Cisplatin-Treated Kids – MedPage Today (free registration required)


6 – Review: What’s new in severe pulmonary embolism? – Intensive Care Medicine (free for a limited period) (via @srrezaie)


7 – Perspective: This Mediterranean diet study was hugely impactful. The science just fell apart – VOX (free)

See Related Retraction and Republication: PREDIMED Study on Mediterranean Diet (free article and commentaries)


8 – Perspective: To Fight Burnout, Organize – New England Journal of Medicine (free)

The social determinants of health — and physicians’ sense of powerlessness in the face of them — seem crucially missing from the discussion of burnout”.


9 – Review: Acute myocardial infarction in young women: current perspectives – International Journal of Women’s Health (free)

Related Review: Young Women With Acute Myocardial Infarction: Current Perspectives – Circulation: Cardiovascular Quality and Outcomes (free)

Related Guideline: Acute Myocardial Infarction in Women: A Scientific Statement From the American Heart Association – Circulation (free)


10 – Review: Managing patients with chronic cough: challenges and solutions – Therapeutics and Clinical Risk Management (free)

See also recently published CHEST guidelines on the management of cough in specific populations: Classification of Cough as a Symptom in Adults and Management Algorithms (free) AND Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold (free) AND Cough Due to TB and Other Chronic Infections  (free) AND Chronic Cough Due to Gastroesophageal Reflux in Adults (free) AND Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer (free) AND Cough in the athlete (free) AND Occupational and Environmental Contributions to Chronic Cough in Adults (free) AND Treatment of Unexplained Chronic Cough (free) AND Use of Management Pathways or Algorithms in Children With Chronic Cough (free) AND Management of Children With Chronic Wet Cough and Protracted Bacterial Bronchitis (free)


Thu, June 21 – 10 Stories of The Day!

21 Jun,2018


1 – Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2017 update of the evidence-based guidelines from the world society of emergency surgery ASBO working group – World Journal of Emergency Surgery (free)


2 – NICE Guideline: Dementia: assessment, management and support for people living with dementia and their carers – National Institute for Health and Care Excellence (free)


3 – The association of lifetime alcohol use with mortality and cancer risk in older adults: A cohort study – PLOS Medicine (free)

Commentaries: Risks of cancer and mortality by average lifetime alcohol intake – PLOS, via ScienceDaily (free) AND Drinking Alcohol Can Raise Cancer Risk. How Much Is Too Much? – NPR (free) AND Light drinkers at a lower combined risk of earlier death or developing cancer – The Conversation (free) AND Expert reaction to the association between lifetime drinking and mortality and cancer risk – Science Media Centre (free)

Related Meta-analysis: Risk Thresholds for Alcohol Consumption (free study, editorial and commentaries)


4 – Association of Stress-Related Disorders With Subsequent Autoimmune Disease – JAMA (link to abstract – $ for full-text)

Commentaries: Association of Stress-Related Disorders With Subsequent Autoimmune Disease – University of Iceland (free) AND Stress disorders tied to increased risk of autoimmune diseases – Reuters (free) AND Does Psychological Stress Trigger Autoimmune Disorders? – MedPage Today (free registration required)


5 – Pancreatic Cancer Following Incident Diabetes in African Americans and Latinos: The Multiethnic Cohort – Journal of the National Cancer Institute (link to abstract – $ for full-text)

Commentaries: Diabetes may be an early manifestation of pancreatic cancer – eCancer News (free) AND Recent-onset diabetes linked to pancreatic cancer for some minorities – UPI (free) AND Diabetes after 50 could be early sign of pancreatic cancer, study says – CNN (free)


6 – Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Commentary: Ebola outbreak in Congo ‘largely contained’, says WHO – Reuters (free)


7 – The venous ulcer continues to be a clinical challenge: an update – Burns & Trauma (free)

Related Cochrane Review: Dressings and topical agents for treating venous leg ulcers (free) AND Summary (free)


8 – Long-term Patient-Reported Outcomes in Postmastectomy Breast Reconstruction – JAMA Surgery (free for a limited period)

Invited Commentary: Autologous vs Prosthetic Breast Reconstruction: Where Do We Stand? (free for a limited period)

Author Interview: Long-term Patient-Reported Outcomes in Postmastectomy Breast Reconstruction (free audio)

Commentaries: Breast reconstruction more satisfying than implants after cancer, survey says – UPI (free) AND Flap vs Implant for Breast Reconstruction: How to Choose – MedPage Today (free registration required) AND Study explores satisfaction, quality of life after breast reconstruction – Brigham and Women’s Hospital, via MedicalXpress (free)


9 – Idiopathic intracranial hypertension: consensus guidelines on management – Journal of Neurology, Neurosurgery & Psychiatry (free) 


10 – Association of Antidepressant Use With Drug-Related Extrapyramidal Symptoms: A Pharmacoepidemiological Study – Journal of Clinical Psychopharmacology (link to abstract – $ for full-text)

Commentaries: Incidence of Extrapyramidal Symptoms Higher With Certain Antidepressants – MPR (free) AND Antidepressants tied to Parkinson’s-like symptoms – Univadis (free registration required)

“Observational study: Incidence of EPSs with antidepressants. RRs: duloxetine, 5.68; mirtazapine, 3.78; citalopram, 3.47; escitalopram, 3.23; paroxetine, 3.07; sertraline, 2.57; venlafaxine, 2.37; bupropion, 2.31; and fluoxetine, 2.03 (all significant)” (via @psychopharmacol see Tweet)


Wed, June 20 – 10 Stories of The Day!

20 Jun,2018


1 – Clinical Review Podcast (28 min): A Goal Too Far: Rethinking HbA1c Targets for Diabetes Treatment – JAMA Internal Medicine (free)

Related: For Patients with Type 2 Diabetes, What’s the Best Target Hemoglobin A1C? (Free Commentary, ADA Position Statement and ACP Guideline)


2 – Expert consensus document on the management of hyperkalaemia in patients with cardiovascular disease treated with renin angiotensin aldosterone system inhibitors: coordinated by the Working Group on Cardiovascular Pharmacotherapy of the European Society of Cardiology – European Heart Journal Cardiovascular Pharmacology (free)


3 – Comparison of prostatic artery embolisation (PAE) versus transurethral resection of the prostate (TURP) for benign prostatic hyperplasia: randomised, open label, non-inferiority trial – The BMJ (free)

Commentary: Prostatic artery embolisation: time to improve collaboration – The BMJ Opinion (free)


4 – Prevalence and outcomes of incidental imaging findings: umbrella review – The BMJ (free)

Related: Giles Maskell: Incidental anarchy – The BMJ Opinion (free)

“Incidentalomas. If you order imaging studies, you know they are a problem. This meta-analysis quantifies incidentaloma prevalence for specific types of imaging. For MRI of the brain, the prevalence was 22% (95%CI 14 to 31) (via @RasoiniR and @eloder, see Tweet)


5 – The Impact of the National HPV Vaccination Program in England Using the Bivalent HPV Vaccine: Surveillance of Type-Specific HPV in Young Females, 2010–2016 – The Journal of Infectious Diseases (free)

Commentaries: HPV vaccine leads to steep drop in cancer-causing infections in England – CNN (free) AND HPV vaccine has almost wiped out infections in young women, figures show – The Telegraph (free)

Related Cochrane Review: Prophylactic Vaccination Against HPV to Prevent Cervical Cancer (link to review and commentaries)


6 – Commentary: IOTA – Liberal vs Conservative Oxygen Therapy in the Critically Ill – The Bottom Line (free)

Original Meta-Analysis: Liberal vs Conservative Oxygen Therapy in Acutely ill Adults (link to abstract and commentary)

“Hyperoxia is BAD –> Aim for lowest safest inspired O2 in critically ill pts & titrate FiO2 down if SpO2 >95%” (via @srrezaie see Tweet)


7 – Sex-specific relevance of diabetes to occlusive vascular and other mortality: a collaborative meta-analysis of individual data from 980 793 adults from 68 prospective studies – The Lancet Diabetes & Endocrinology (free)

Commentaries: Diabetes and cardiovascular mortality: the impact of sex – The Lancet Diabetes & Endocrinology (free) AND Diabetes triples women’s risk of death from ischemic heart disease – Cardiovascular Business (free)


8 – Influence of Lifestyle on Incident Cardiovascular Disease and Mortality in Patients With Diabetes Mellitus – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Healthy Lifestyle Lowers CVD Risk in Diabetes Patients – American College of Cardiology (free) AND Healthy lifestyle changes after diabetes diagnosis lower CVD risk – Cardiovascular Business (free) AND Reduction in CVD Events, Even Mortality, in Patients With Diabetes Who Adopt a Healthier Lifestyle – TCTMD (free)


9 – Prognostic Implications of Single-Sample Confirmatory Testing for Undiagnosed Diabetes: A Prospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Diagnosing Diabetes From a Single Blood Sample – Johns Hopkins Bloomberg School of Public Health, via NewsWise (free) AND One Blood Test Might Be Enough to Diagnosis (free) AND Diabetes Dx Predicted Accurately with Single Blood Sample – MedPage Today (free registration required) AND Diabetes Diagnoses Confirmable from Single-Sample Measurements – NEJM Physician’s First Watch (free)

“The standard practice of repeat blood tests may not always be necessary, a new study suggests” (from Johns Hopkins Bloomberg School of Public Health)


10 – Marital status and risk of cardiovascular diseases: a systematic review and meta-analysis – Heart (free)

Commentaries: Marriage tied to lower risk of fatal heart attacks and strokes – Reuters (free) AND Expert reaction to study looking at marital status and risk of heart disease, stroke and death – Science Media Centre (free)


Tue, June 19 – 10 Stories of The Day!

19 Jun,2018


1 – Just Released! ICD-11: Classifying disease to map the way we live and die – World Health Organization (free)

See also: ICD-11 is Here! – World Health Organization (free)

Browse: ICD-11 for Mortality and Morbidity Statistics (ICD-11 MMS), 2018 version – World Health Organization (free)


2 – Gaming addiction as a mental disorder: it’s premature to pathologise players – The Conversation (free)

Related: Gaming addiction classified as mental health disorder by WHO – Reuters (free) AND WHO classifies ‘gaming disorder’ as mental health condition – CNN (free)


3 – European Heart Rhythm Association (EHRA) consensus document on management of arrhythmias and cardiac electronic devices in the critically ill and post-surgery patient – EP Europace (free)


4 – State of The Art Review: Secondary peritonitis: principles of diagnosis and intervention – The BMJ (free)


5 – Editorial: Helping patients choose wisely – The BMJ (free)

Related: The Choosing Wisely initiative was launched 6 years ago, and now has over 550 recommendations from 18 countries (free)

See complete lists from: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia / Choosing Wisely Canada

“One of the main barriers to tackling the problem of overuse is that doctors are concerned patients will find it difficult to accept fewer interventions. However, informed patients often opt for less intervention, not more.” (via @bmj_latest see Tweet)


6 – Guideline: Diagnosis and Management of Gastroesophageal Reflux in Preterm Infants – Pediatrics (free)

Commentaries: AAP Issues Guidance on Reflux in Preterm Infants – Medscape (free registration required) AND Pediatrics Group Offers Tips for Managing GERD in Preterm Infants – NEJM Physician’s First Watch (free)


7 – Effect of Tamsulosin on Passage of Symptomatic Ureteral Stones: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

Editorial: Medical Expulsive Therapy for Ureteral Stones—Stone Age Medicine (free for a limited period)

Commentaries: Recent Clinical Trial Finds Tamsulosin Not Effective in Kidney Stone Passage – George Washington University, via NewsWise (free) AND For Passing Smaller Ureteral Stones, Tamsulosin May Be No Better Than Placebo – NEJM Physician’s First Watch (free)


8 – Richard Lehman’s journal review, 18 June 2018 – The BMJ (free)

Richard Lehman reviews the latest research in the top medical journals.


9 – Hip arthroscopy versus best conservative care for the treatment of femoroacetabular impingement syndrome (UK FASHIoN): a multicentre randomised controlled trial – The Lancet (free)

Commentaries: Hip arthroscopy: an evidence-based approach – The Lancet (free) AND New surgery for groin pain found to be more effective than physiotherapy – University of Warwick (free)


10 – European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children

Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I – Journal of the European Academy of Dermatology and Venereology (free)

Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II – Journal of the European Academy of Dermatology and Venereology (free)

Commentary: New European guidelines issued for atopic dermatitis – Univadis (free registration required)


Mon, June 18 – 10 Stories of The Day!

18 Jun,2018


1 – British Thoracic Society Guideline for the initial outpatient management of pulmonary embolism (PE) – Thorax (free)


2 – Benefits and harms of screening men for abdominal aortic aneurysm in Sweden: a registry-based cohort study – The Lancet (free to abstract – $ for full-text)

Commentaries: Screening Programs for Abdominal Aortic Aneurysm Need a Rethink, Swedish Study Contends – TCTMD (free) AND Screening for aortic aneurysms in older men questioned – University of Gothemburg, via EurekAlert (free) AND Screening for Abdominal Aortic Aneurysm Questioned – NEJM Physician’s First Watch (free) AND Routine Aortic Aneurysm Screening Questioned – MedPage Today (free registration required)


3 – Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Does Infusion Rate Affect Neurologic Outcomes in Pediatric DKA? (free)

Commentaries: PEM Practice Changing Paper: Clinical Trial of Fluid Infusion Rates for Pediatric DKA – Aliem (free) AND The Rate of Resuscitation in Pediatric DKA – Emergency Medicine Literature of Note (free) AND Infusion Type Doesn’t Affect Brain Outcomes in Pediatric DKA – Medscape (free)


4 – Expert Analysis: ACS Management in a Patient in Need of Noncardiac Surgery – American College of Cardiology (free)


5 – Coronary Computed Tomography Angiography Versus Stress Echocardiography in Acute Chest Pain: A Randomized Controlled Trial – JACC: Cardiovascular Imaging (link to abstract – $ for full-text)

Commentary: The Patient Presenting With Chest Pain: Stress Echo Gives Coronary CTA a Run for Its Money – TCTMD (free)


6 – Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs – American Academy of Neurology and the American Epilepsy Society

Part I: Treatment of new-onset epilepsy (free PDF)

Part II: Treatment-resistant epilepsy (free PDF)

Commentary: New Epilepsy Guidelines Shed Light on Explosion of New Drugs – MedPage Today (free registration required)


7 – Palliative Care in the Global Setting: ASCO Resource-Stratified Practice Guideline – Journal of Global Oncology (free)

Commentary: ASCO Guideline Addresses Palliative Care in the Global Setting – ASCO Daily News (free)


8 – Age-attuned Hospice care: An opportunity to better end of life care for older people – StCristopher’s (free PDF) (via @hospicedoctor see tweet)

“Despite the evidence that more people will die of frailty and multiple long-term conditions than of cancer, our services for those moving towards the end of their life remain focussed on the needs of the latter group”


9 – Caring for the caregiver: A guide for physicians – American Medical Association (free PDF)

Commentary: AMA Releases New Physician Guide on Caring for the Caregiver – The ASCO Post (free)


10 – Association of Perioperative Red Blood Cell Transfusions With Venous Thromboembolism in a North American Registry – JAMA Surgery (free for a limited period)

Commentary: Peri-Op RBC Transfusions Linked to Postoperative VTE – MPR (free) AND Risk for Clot Increases After Surgery With Transfusion – Medscape (free registration required) AND Post-Op VTE Risk Up After Intra-Op Blood Transfusion – MedPage Today (free registration required) AND VTE Risk Higher in Surgical Patients Who Get Transfusions – TCTMD (free)


Fri, June 15 – 10 Stories of The Day!

15 Jun,2018


1 – Report: Noninvasive Nonpharmacological Treatment for Chronic Pain: A Systematic Review – Agency for Healthcare Research and Quality (free)

See also: Evidence Summary (free PDF) and Full Report (free PDF)


2 – The WHO essential diagnostic list: a tool for the future – BMJ Global Health Blog (free)

Related: The desperate global need for medical diagnostics – The Conversation (free) AND Health care is an essential human right – and so is a proper diagnosis – The Conversation (free)

See Original WHO Report: List of Essential In Vitro Diagnostics First edition (2018) – World Health Organization (free report and news release)


3 – Oral Fluconazole in Pregnancy and Risk of Stillbirth and Neonatal Death – JAMA (link to abstract – $ for full-text)

Commentaries: No link found between oral antifungal drug and stillbirth – Karolinska Institutet, via ScienceDaily (free) AND Antifungal Use During Pregnancy and Risk of Stillbirth: What’s the Link? – MPR (free) AND Study Finds No Link Between Fluconazole During Pregnancy and Stillbirth or Neonatal Death – MedicalResearch.com (free) AND Oral Fluconazole for Thrush in Pregnancy Doesn’t Up Stillbirth – Medscape (free registration required)


4 – Controversy: Is there still a place for the Swan-Ganz catheter?

YES (free for a limited period) / NO (free for a limited period) WE ARE NOT SURE (free for a limited period)


5 – Draft Recommendation Statement: Unhealthy Alcohol Use in Adolescents and Adults: Screening and Behavioral Counseling Interventions – U.S. Preventive Services Task Force (free)

Commentary: USPSTF Again Recommends Screening for Unhealthy Alcohol Use in Adults – NEJM Physician’s First Watch (free)


6 – Flynn effect and its reversal are both environmentally caused – Proceedings of the National Academy of Sciences (link to abstract – $ for full-text)

Commentaries: Researchers find IQ scores dropping since the 1970s – MedicalXpress (free) AND IQ Scores Are Falling in “Worrying” Reversal of 20th Century Intelligence Boom – Science Alert (free) AND IQ Scores Are Falling Due to Environmental Factors, Study Finds – TIME (free)


7 – Diagnosis and management of primary aldosteronism: the Endocrine Society guideline 2016 revisited – European Journal of Endocrinology (free)

Related Guideline: The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline – The Journal of Clinical Endocrinology & Metabolism (free)


8 – Review: Optimal duration of dual antiplatelet therapy for coronary artery disease – Netherlands Heart Journal (free)

Related Guidelines: 2018 Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology Focused Update of the Guidelines for the Use of Antiplatelet Therapy (free) AND 2017 European Society of Cardiology focused update on dual antiplatelet therapy in coronary artery disease (free) AND 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease (free)


9 – Invasive Procedures Associated With the Development of Infective Endocarditis – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Infective endocarditis risk increased after many types of medical procedures – ACP Hospitalist (free) AND Many Invasive Procedures, Including Cardiovascular, Up Risk of Infective Endocarditis – TCTMD (free) AND Invasive procedures—including cardiovascular—boost risk of endocarditis – Cardiovascular Business (free) AND Endocarditis: Any Invasive Procedure Is a Risk – MedPage Today (free registration required)


10 – Effect of Increased Inpatient Attending Physician Supervision on Medical Errors, Patient Safety, and Resident Education: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Effect of increased inpatient attending physician supervision on medical errors, patient safety, and resident education: a randomized clinical trial – PSNet (free) AND Increased attending supervision on rounds didn’t significantly reduce medical errors – ACP Hospitalist (free) AND Additional physician resident supervision doesn’t improve patient safety – Modern Healthcare (free) AND Closer Resident Supervision Does Not Reduce Medical Errors – Medscape (free registration required) AND Is More Supervision of Medical Residents Always Better for Patient Care? – MedicalResearch.com (free)


Thu, June 14 – 10 Stories of The Day!

14 Jun,2018


1 – Effect of Negative Pressure Wound Therapy vs Standard Wound Management on 12-Month Disability Among Adults With Severe Open Fracture of the Lower Limb: The WOLLF Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: High-tech treatment of open leg wounds no better than using regular dressings – University of Warwick (free) AND Negative-Pressure Therapy No Better for Open Fractures – Medscape (free registration required)

“Negative pressure wound therapy did not improve 12-month disability for patients with severe open fracture of the lower limb compared with standard wound dressing”


2 – Retraction and Republication: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts – New England Journal of Medicine (free)

Correspondence: Retraction and Republication: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet. N Engl J Med 2013;368:1279-90 (free)

Commentaries: That Huge Mediterranean Diet Study Was Flawed. But Was It Wrong? – New York Times (free) AND Errors Trigger Retraction Of Study On Mediterranean Diet’s Heart Benefits – NPR (free) AND Expert reaction to retraction and republication of study looking at Mediterranean diet and heart disease – Science Media Centre (free)


3 – Dietary and nutritional approaches for prevention and management of type 2 diabetes – The BMJ (free)


4 – Perspective: The Search for Cancer Treatment Beyond Mutant-Hunting – The New York Times (10 articles per month are free)


5 – Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy – New England Journal of Medicine (free)

Perspective: Trolleyology and the Dengue Vaccine Dilemma – New England Journal of Medicine (free)

Commentaries: Study confirms higher risk of dengue in kids who got Sanofi vaccine – Reuters (free) AND Sanofi’s new dengue challenge: find a diagnostic that will make its vaccine safe to use – STAT (free)


6 – Ebola Situation Report: Ebola Virus Disease in Democratic Republic of Congo – World Health Organization (free)

Related: More suspected DRC Ebola cases amid enhanced surveillance – CIDRAP (free) AND ‘We are still at war’ with Ebola: WHO chief – Reuters (free) AND Speedy Ebola tests help contain Africa’s latest outbreak – Nature News (free)


7 – Thrombocytopenia in the ICU: disseminated intravascular coagulation and thrombotic microangiopathies—what intensivists need to know – Critical Care (free)


8 – Guideline: Cancer of the upper aerodigestive tract: assessment and management in people aged 16 and over – National Institute for Health and Care Excellence (NICE) (free)


9 – Integrative Therapies During and After Breast Cancer Treatment: ASCO Endorsement of the SIO Clinical Practice Guideline – Journal of Clinical Oncology (free)

Commentary: Mozart, meditation and a yoga mat: Oncologists welcome integrative therapies for breast cancer – eCancer News (free)


10 – Association between systolic blood pressure and dementia in the Whitehall II cohort study: role of age, duration, and threshold used to define hypertension – European Heart Journal (free)

Commentaries: Dementia risk increased in 50-year-olds with blood pressure below hypertension threshold – European Society of Cardiology, via EurekAlert (free) AND Blood pressure below treatable threshold linked to heightened dementia risk – OnMedica (free) AND Studies: Higher blood pressure increases risk for dementia – UPI (free) AND High Blood Pressure at Age 50 Tied to Dementia Risk – The New York Times (10 articles per month are free) AND Dementia risk to 50-year-olds with raised blood pressure – study – The Guardian (free)


Wed, June 13 – 10 Stories of The Day!

13 Jun,2018


1 – Screening for Cardiovascular Disease Risk With Electrocardiography: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: The Screening ECG and Cardiac Risks (free) AND Screening for Cardiovascular Disease Risk With Electrocardiography (free)

JAMA Patient Page: Screening for Cardiovascular Disease Risk With ECG (free)

Author Interview: USPSTF Recommendation: Screening for Cardiovascular Disease Risk With Electrocardiography (free audio)

Commentaries: Doctors Told Not To Order Electrocardiograms For Low-Risk Patients – NPR (free) AND USPSTF Finds Insufficient Evidence For Preventative ECG Screening in Asymptomatic, Low-Risk Adults – American College of Cardiology (free) AND Do Not Screen Asymptomatic Adults For CVD With ECGs, Says USPSTF – TCTMD (free)

The USPSTF recommends against screening with resting or exercise electrocardiography (ECG) to prevent cardiovascular disease (CVD) events in asymptomatic adults at low risk of CVD events”.


2 – Prevalence of Prescription Medications With Depression as a Potential Adverse Effect Among Adults in the United States – JAMA (link to abstract – $ for full-text)

Commentaries: One-Third of US Adults May Unknowingly Use Medications That Can Cause Depression – University of Illinois at Chicago, via EurekAlert (free) AND Many U.S. adults take medicines that can cause depression – Reuters (free) AND Rx With Depression as Potential Adverse Effect Widely Used – Medscape (free registration required)


3 – Clinical Update: Antithrombotic Therapy for Peripheral Artery Disease in 2018 – JAMA (free for a limited period)


4 – Position Paper on Overdiagnosis and Action to be Taken – WONCA (free PDF) (via @RasoiniR)

Related: Overdiagnosis across medical disciplines: a scoping review – BMJ Open (free) Overdiagnosis: what it is and what it isn’t – BMJ Evidence Based Medicine (free) AND Too much medical care: bad for you, bad for health care systems – STAT News (free)


5 – The American Cancer Society public health statement on eliminating combustible tobacco use in the United States – CA: A Cancer Journal for Clinicians (free)


6 – A sleep prescription for medicine – The Lancet (free registration required)

“Junior doctors working a 34 h shift will make 460% more diagnostic mistakes than when well rested. Matthew Walker asks how can we change the culture of sleep within medicine?” (via @TheLancet see Tweet)


7 – Shaking hands is disgusting – here’s what else you can do – The Conversation (free)

Related: Handshake-free zones to prevent infections? (link to abstract and commentaries)


8 – Antiepileptic drugs in critically ill patients – Critical Care (free)


9 – Work stress and risk of death in men and women with and without cardiometabolic disease: a multicohort study – The Lancet Diabetes & Endocrinology (free)

Commentaries: Stress at work in patients with cardiometabolic disease – The Lancet Diabetes & Endocrinology (free) AND Job strain linked to heightened risk of early death in men with heart disease/diabetes – OnMedica (free) AND Work stress raises risk of premature death in vulnerable men – study – The Guardian (free) AND Job Strain as Bad as Smoking in Men With Diabetes, Heart Disease – Medscape (free registration required)


10 – Association of Viral Suppression With Lower AIDS-Defining and Non–AIDS-Defining Cancer Incidence in HIV-Infected Veterans: A Prospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Long-term viral suppression may help decrease cancer rates in patients with HIV – ACP Internist (free) AND Long Term HIV Viral Suppression Reduces But Does Not Eliminate Elevated Cancer Risk – MedicalResearch.com (free) AND Viral Suppression of HIV Tied to Less Cancer Risk – NEJM Physician’s First Watch (free)


Tue, June 12 – 10 Stories of The Day!

12 Jun,2018


1 – Burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in the era of conjugate vaccines: global, regional, and national estimates for 2000–15 – The Lancet Global Health (free)

Commentaries: Pneumococcal and Haemophilus influenzae type b disease: moving numbers in the right direction – The Lancet Global Health (free) AND 1.35 million children’s lives saved by HiB and pneumococcal vaccines since 2000 – Johns Hopkins University Bloomberg School of Public Health, via MedicalXpress (free) AND Dramatic reduction in two killer childhood diseases, study finds – The Telegraph (free)


2 – A Placebo-Controlled Trial of Bezafibrate in Primary Biliary Cholangitis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: A Trial of Bezafibrate in Primary Biliary Cholangitis – NEJM Resident 360 (free) AND Bezafibrate Normalizes Liver Enzymes in PBC – MedPage Today (free registration required)

“In a randomized trial of patients with primary biliary cholangitis, bezafibrate and ursodeoxycholic acid resulted in a higher rate of complete biochemical response than ursodeoxycholic acid alone” (via @NEJM see Tweet with visual abstract)


3 – Viewpoint: Type 2 Myocardial Infarction—Diagnosis, Prognosis, and Treatment – JAMA (free for a limited period)

Related Review: Type 2 myocardial infarction due to supply–demand mismatch – Trends in Cardiovascular Medicine (free)


4 – Viewpoint: Progress in Prevention and Treatment of Acute Kidney Injury: Moving Beyond Kidney Attack – JAMA (free for a limited period)


5 – Erectile Dysfunction as an Independent Predictor of Future Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis – Circulation (free PDF)

AHA News Release: Erectile dysfunction means increased risk for heart disease, regardless of other risk factors (free)

Commentaries: Men With Erectile Dysfunction Are Twice As Likely to Have Heart Disease, Study Says – TIME (free) AND Erectile Dysfunction Linked To Higher Chances Of Heart Problems In Men – Medical Daily (free)


6 – pH‐neutralizing esophageal irrigations as a novel mitigation strategy for button battery injury – The Laryngoscope (free)

Commentaries: Ingesting honey after swallowing button battery reduces injury and improves outcomes – Children’s Hospital of Philadelphia, via ScienceDaily (free) AND Honey + Sucralfate May Reduce Injury After Accidental Button Battery Ingestion – MPR (free)


7 – Richard Lehman’s journal review, 11 June 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.


8 – Hydroxychloroquine: An old drug with new relevance – Cleveland Clinic Journal of Medicine (free)

Source: Hospital Medicine Virtual Journal Club


9 – New European Hypertension Guidelines Not in Harmony With US Guidance – TCTMD (free)


10 – A serious new hurdle for CRISPR: Edited cells might cause cancer, find two studies – STAT (free)

Related: Genome-editing tool could increase cancer risk – eCancer News (free) AND Gene editing tool may raise cancer risk in cells, scientists warn – Reuters (free) AND Expert reaction to using CRISPR/Cas9 and potential cancer risk in cells – Science Media Centre (free)


Mon, June 11 – 10 Stories of The Day!

11 Jun,2018


1 – The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for Anal Squamous Cell Cancers (Revised 2018) – Diseases of the Colon & Rectum (free)


2 – Association of Long-Term Risk of Respiratory, Allergic, and Infectious Diseases With Removal of Adenoids and Tonsils in Childhood – JAMA Otolaryngology-Head & Neck Surgery (free for a limited period)

Commentaries: Tonsillectomy in childhood raises risk of respiratory diseases – OnMedica (free) AND Tonsillectomy, Adenoidectomy in Childhood Tied to Long-Term Health Risks – Physician’s First Watch (free) AND Tonsillectomy Risks May Outweigh Benefits – The New York Times (10 articles per month are free)


3 – Opinion: The flu vaccine is being oversold – it’s not that effective – The Conversation (free)

See Related Cochrane Systematic Reviews: Vaccines for Preventing Influenza and Its Complications (free)

The infection rate in adults drops from 2% per year to 1%. You could say that’s halved, but it effectively only drops by 1%. So this means that out of every 100 healthy adults vaccinated, 99 get no benefit against laboratory confirmed influenza”.


4 – Outpatient Antibiotic Prescribing for Acute Respiratory Infections During Influenza Seasons – JAMA Network Open (free)

Commentaries: CDC study: Antibiotics still widely overused for respiratory infections – CIDRAP (free) AND Antibiotics Still Widely Prescribed for Viral ARIs – MedPage Today (free)


5 – High-Sensitivity Troponins and Outcomes After Myocardial Infarction – Journal of the American College of Cardiology (free for a limited period)

Commentary: High-Sensitivity Troponins and Outcomes After MI – American College of Cardiology (free) AND Advent of High-Sensitivity Troponin Tests in Sweden Leads to Only Small Uptick in MI Diagnoses – TCTMD (free)

The introduction of high-sensitive troponins was associated with an increased incidence of MI, although with no impact on survival.


6 – Is Posthospital Syndrome a Result of Hospitalization-Induced Allostatic Overload? – Journal of Hospital Medicine (free)

Source: Hospital Medicine Virtual Journal Club


7 – At one-month mark in Ebola outbreak, the focus shifts to remote areas – World Health Organization (free)

Related: WHO says Ebola situation in DRC shows promise – CIDRAP (free) AND WHO chief says Ebola outbreak in Congo is stabilizing – Reuters (free) AND An Encouraging Prediction About The Ebola Outbreak – NPR (free)


8 – Arrhythmia-Induced Cardiomyopathy – Deutsches Ärzteblatt international (free)


9 – Trends in State Suicide Rates — United States, 1999–2016 and Circumstances Contributing to Suicide — 27 States, 2015 – Centers for Disease Control and Prevention (free)

Commentaries: CDC: U.S. Suicide Rates Have Climbed Dramatically – NPR (free) AND CDC: Suicide rates rose 30% across nation since 1999 – UPI (free) AND More Americans Are Dying From Suicide – The Atlantic (free)


10 – Incidence of Diabetes After Cancer Development: A Korean National Cohort Study – JAMA Oncology (free for a limited period)

Commentaries: Diabetes risk increased by 9 cancers – eCancer News (free) AND Cancer Increases Risk of Developing Type 2 Diabetes, Study Finds – AJMC (free) AND Nine Cancers Linked to Diabetes Risk – Medscape (free registration required)


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