Open access

Fri, September 8 – 10 Stories of The Day!



1 – Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association (free)

See also: Advisory Highlights: Seven steps to keep your brain healthy from childhood to old age (free) AND News release: As brain problems increase, experts offer advice to keep yours healthy (free) AND Commentary: Optimal Cardiovascular Health and a Healthy Brain (free) AND Top Ten Things to Know: Defining Optimal Brain Health in Adults (free PDF)

Commentary: Heart and Stroke Groups Issue Advisory on Optimal Brain Health – Physician’s First Watch (free)


2 – Everybody active, every day: an evidence-based approach to physical activity – Public Health England (free report and other documents)

See also: 10 minutes brisk walking each day in mid-life for health benefits and towards achieving physical activity recommendations: evidence summary (free PDF)

Press release: 6 million adults do not do a monthly brisk 10-minute walk (free)

Commentaries: 10-minute walk a day app to tackle ‘inactivity epidemic’ – NHS Choices (free) AND 6 million middle-aged people take no exercise – The Guardian (free)


3 – Report: Size matters: The impact of upselling on weight gain – Royal Society for Public Health; Slimming World (free PDF)

See also: Press release (free)

Commentaries: Supersize us: upselling is fuelling the obesity epidemic, warns report – The Guardian (free) AND Going Large – Is Upselling Making You Gain Weight? – Medscape (free registration required)


4 – Extreme high high-density lipoprotein cholesterol is paradoxically associated with high mortality in men and women: two prospective cohort studies – European Heart Journal (free)

Commentaries: High levels of ‘good’ cholesterol linked to excessive mortality – University of Copenhagen, via ScienceDaily (free) AND Does ‘good cholesterol’ really deserve its name? – The Conversation (free) AND Can Your “Good” Cholesteral Be To High? – The New York Times (10 articles per month are free)


5 – Antipsychotic Use With and Without Comorbid Psychiatric Diagnosis Among Adults with Intellectual and Developmental Disabilities – The Canadian Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Antipsychotics common for adults with intellectual and developmental disabilities – Centre for Addiction and Mental Health (free) AND Antipsychotics Overused in Intellectually Disabled Adults – Medscape (free registration required)

“Antipsychotics are used inappropriately particularly in vulnerable groups: Poor children; Intellectually challenged; Autistic; Nursing homes. (RT @AllenFrancesMD see Tweet)


6 – Safety and Feasibility of Antiretroviral Preexposure Prophylaxis for Adolescent Men Who Have Sex With Men Aged 15 to 17 Years in the United States – JAMA Pediatrics (free)

Editorial: Human Immunodeficiency Virus Preexposure Prophylaxis for Adolescent Men (free)

Commentaries: Safety, Feasibility of PrEP for Adolescent Men Who Have Sex With Men – The JAMA Network (free) AND PrEP safe and effective for young men who have sex with men – OnMedica (free) AND HIV PrEP for adolescent men found to be safe, effective – UPI (free)


7 – Potential Implications of NORSTENT (Norwegian Coronary Stent Trial) in Contemporary Practice – Circulation (free)

Original article: Drug-Eluting or Bare-Metal Stents for Coronary Artery Disease – New England Journal of Medicine (free)

In this large trial, differences in outcomes between bare metal stents (BMS) and drug eluding stents (DES) were small. During 6 years of follow-up there was a 3.3% absolute risk reduction in any repeat revascularization with DES, without differences in cardiovascular mortality or death.


8 – Chronic Health Conditions and Key Health Indicators Among Lesbian, Gay, and Bisexual Older US Adults, 2013–2014 – American Journal of Public Health (link to abstract – $ for full-text)

Commentaries: Lesbian, Gay and Bisexual Older Adults Suffer More Chronic Health Conditions Than Heterosexuals, Study Finds – The University of Washington, via NewsWise (free) AND LGB Older Adults Suffer More Chronic Health Conditions Than Heterosexuals, Study Finds – Science Magazine (free)


9 – IBM pitched its Watson supercomputer as a revolution in cancer care. It’s nowhere close – STAT (free)


10 – Intravenous Versus Nonintravenous Benzodiazepines for the Cessation of Seizures: A Systematic Review and Meta-analysis of Randomized Controlled Trials – Academic Emergency Medicine (link to abstract – $ for full-text)

Source: Hospital Medicine Virtual Journal Club

 “Should you give your preferred benzo by the fastest means possible? Or establish an IV and administer via that route? The short answer provided by this study, is to give your benzo IM or IN. While seizures stopped sooner after IV administration, the additional time needed to establish an IV resulted in overall longer seizure time when administered via that method” (by Jeremy Fried in Research and Reviews in the Fastlane 182).


Thu, September 7 – 10 Stories of The Day!



1 – Guideline: Endometriosis: diagnosis and management – National Institute for Health and Care Excellence (NICE) (free)

News release: Suspect endometriosis in women with chronic pelvic pain, says NICE (free)


2 – Vision Screening in Children Aged 6 Months to 5 Years: US Preventive Services Task Force Recommendation Statement – JAMA (free)

USPSTF Recommendation Summary: Vision in Children Ages 6 Months to 5 Years: Screening (free)

Editorials: The 2017 US Preventive Services Task Force Report on Preschool Vision Screening – JAMA Ophthalmology (free) AND Vision Screening in Very Young Children—Making Sense of an Inexorable Diagnostic Process – JAMA Pediatrics (free)

Author interview: USPSTF Recommendation: Vision Screening in Children (free audio)


3 – Antidepressant use during pregnancy and psychiatric disorders in offspring: Danish nationwide register based cohort study – The BMJ (free)

Editorial: Prenatal exposure to antidepressants and increased risk of psychiatric disorders (free)

Commentary: Antidepressant Use During Pregnancy Linked to Psychiatric Disorders in Offspring – Physician’s First Watch (free)


4 – Treatment of idiopathic pulmonary fibrosis in Australia and New Zealand: A position statement from the Thoracic Society of Australia and New Zealand and the Lung Foundation Australia (free)


5 – European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis – endorsed by the European Academy of Neurology (free)


6 – Effectiveness of a Third Dose of MMR Vaccine for Mumps Outbreak Control – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Third Dose of MMR Vaccine to Reduce Risk of Mumps during Outbreaks? (free)

Commentary: Third dose of mumps vaccine could help stop outbreaks, researchers say – STAT (free)


7 – State of The Art Review: Perioperative tobacco use treatments: putting them into practice – The BMJ (free for 2 weeks)


8 – Review: The Diagnosis and Management of Bipolar I and II Disorders – Mayo Clinic Proceedings (free)


9 – Global Prevalence of Fetal Alcohol Spectrum Disorder Among Children and Youth: A Systematic Review and Meta-analysis – JAMA Pediatrics (link to abstract – $ for full-text)

Commentary: What Is the Global Prevalence of Fetal Alcohol Spectrum Disorder? – The JAMA Network (free)


10 – 2017 Focused Update of the 2016 ACC Expert Consensus Decision Pathway on the Role of Non-Statin Therapies for LDL-Cholesterol Lowering in the Management of Atherosclerotic Cardiovascular Disease Risk (free)

Commentary: Updated Decision Pathway For Non-Statin Therapies Published – American College of Cardiology, Latest in Cardiology (free)


Tue, September 5 – 10 Stories of The Day!



1 – Estimated economic impact of vaccinations in 73 low- and middle-income countries, 2001–2020 – Bulletin of the World Health Organization (free) (RT @Onisillos see Tweet)

Commentaries: Vaccines Save 20 Million Lives, $350 billion in Poor Countries since 2001 – Eshelman School of Pharmacy (free) AND Global vaccine program will save 20 million lives and $820 billion by 2020, research finds – International Business Times (free)


2 – Ranking 93 health interventions for low- and middle-income countries by cost-effectiveness – PLOS One (free) (RT @equitylist see Tweet)


3 – Effect of Palliative Care on Aggressiveness of End-of-Life Care Among Patients With Advanced Cancer – Journal of Oncology Practice (link to abstract – $ for full-text)

Commentaries: Palliative Care May Substantially Decrease Health-Care Utilization in Patients With Advanced Cancer – ASCO Post (free) AND End-of-Life Palliative Care Lowered Utilization for Patients With Cancer – AJMC (free) AND Palliative Care Cut Healthcare Use in Advanced Cancer – MedPage Today (free registration required)

Related guideline: Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update (free)


4 – Doctors want to give their cancer patients every chance. But are they pushing off hard talks too long? – STAT (free)


5 – Committee Opinion: Obesity in Adolescents – American College of Obstetricians and Gynecologists (free)

Commentary: ACOG Offers Tips for Managing Obesity in Adolescents – Physician’s First Watch (free)


6 – Can low doses of chemicals affect your health? A new report weighs the evidence – The Conversation (free)

Original report: Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals – The National Academies Press (free PDF)

Related Scientific Statement: EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals (free) AND Executive Summary (free)

Source: Global Health NOW Newsletter


7 – Richard Lehman’s journal review / 4 September 2017 (free)

Richard Lehman’s weekly review of medical journals.


8 – Zika virus: still no clear answers – The Globe and Mail (free) (RT @Onisillos  see Tweet)


9 – Self‐Care for the Prevention and Management of Cardiovascular Disease and Stroke: A Scientific Statement for Healthcare Professionals From the American Heart Association (free)


10 – Comparative Effectiveness and Safety of Cognitive Behavioral Therapy and Pharmacotherapy for Childhood Anxiety Disorders: A Systematic Review and Meta-analysis – JAMA Pediatrics (free)

Editorial: Medication and Cognitive Behavioral Therapy for Pediatric Anxiety Disorders: No Need for Anxiety in Treating Anxiety (free)

Commentary: SSRIs, Cognitive-Behavioral Therapy Effective for Childhood Anxiety – Physician’s First Watch (free) AND SSRIs, SNRIs Provide Modest Benefit to Kids with Mental Disorders – MedPage Today (free registration required)


Wed, September 6 – 10 Stories of The Day!



1 – Designing a High-Performing Health Care System for Patients with Complex Needs: Ten Recommendations for Policymakers – The Commonwealth fund (free)

Related: Redesigning Care for High-Cost, High-Risk Patients – Harvard Business Review (a few articles per month are free) AND Caring for High-Need, High-Cost Patients — An Urgent Priority – New England Journal of Medicine (free) AND Multimorbidity: clinical assessment and management – NICE Guideline (free) AND Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology (free) AND Focusing on High-Cost Patients — The Key to Addressing High Costs? – NEJM Catalyst (free) AND Richard Smith: The challenge of high need, high cost patients – The BMJ Blogs (free) AND Playbook: Better Care for People with Complex Needs – Institute for Healthcare Improvement (free)


2 – Reconciling the Effects of Screening on Prostate Cancer Mortality in the ERSPC and PLCO Trials – Annals of Internal Medicine (free)

Editorial: Prostate Cancer Screening: Time to Question How to Optimize the Ratio of Benefits and Harms (free)

Commentaries: A new study claims prostate cancer screenings significantly reduce deaths. Not everyone agrees – STAT (free) AND New Study Offers Support for Prostate Testing – The New York Times (10 articles per month are free)


3 – Scanning The Future, Radiologists See Their Jobs At Risk – NPR (free)

See more on the impact of artificial intelligence in healthcare in our June 14th issue (see #2), in our April 28th issue (see #1) and in our April 10th issue (see #8).


4 – Identifying incipient dementia individuals using machine learning and amyloid imaging – Neurobiology of Aging (free)

Commentaries: A.I., Big Data Project Predicts Dementia 2 Years Before Symptoms Onset, Researchers Show – Alzheimer’s News Today (free) AND Artificial intelligence predicts dementia before onset of symptoms – Science Daily (free)

See also related article and commentaries on Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons.


5 – Management of Atherosclerotic Carotid and Vertebral Artery Disease: 2017 Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS) (free)

Commentary with highlights from the document: European Society for Vascular Surgery Guidelines on the Management of Atherosclerotic Carotid and Vertebral Artery Disease (free)


6 – Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO) (free)

Related Guidelines: Management of febrile neutropaenia: ESMO Clinical Practice Guidelines (free) AND Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update (free)


7 – Headache and migraine: interventions for preventing or treating headache and migraine – Cochrane Library (free) (RT @CochraneUK see Tweet)

Migraine awareness week (3-9 September). Latest Cochrane Evidence on interventions for preventing or treating headache and migraine.


8 – Comprehensive assessment may reduce risk of delirium after hip fracture – NIHR Signal (free)

Original article: Comprehensive Geriatric Assessment for Prevention of Delirium After Hip Fracture: A Systematic Review of Randomized Controlled Trials – Journal of The American Geriatrics society (link to abstract – $ for full-text)

“Comprehensive geriatric assessment reduced the risk of delirium by 20% in patients having hip fracture surgery” (RT @NIHR_DC see Tweet)


9 – Physical Activity Frequency and the Risk of Stroke: A Nationwide Cohort Study in Korea – Journal of The American Heart Association (free)

“Even 1 to 2 times a week of moderate to vigorousintensity physical activity might be beneficial to prevent a firstever stroke in the general population… from a public health perspective, we need to encourage inactive people to start exercising with moreachievable goals”.


10 – Association between sedentary time and mortality across levels of frailty – Canadian Medical Association Journal (free)

Commentary: Prolonged sitting and frailty a deadly combination – Medical News Today (free) AND Inactivity Toll Worst for Frailest Elders – Medscape (free registration required)


Mon, September 4 – 10 Stories of The Day!



1 – Reducing the Global Burden of Cardiovascular Disease, Part 1: The Epidemiology and Risk Factors – Circulation Research (free)


2 – Reducing the Global Burden of Cardiovascular Disease, Part 2: Prevention and Treatment of Cardiovascular Disease – Circulation Research (free)


3 – Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure (free)

Source: Hospital Medicine Virtual Journal Club


4 – Review: Mechanical Ventilation: State of the Art – Mayo Clinic Proceedings (free)


5 – Guideline: Psoriasis: assessment and management – National Institute for Health and Care Excellence (NICE) (free)


6 – FDA News Release: FDA approval brings first gene therapy to the United States (free)

Commentaries: A $475,000 cancer drug: Wall Street sees ‘bargain’; patients see ‘completely broken’ system – HealthNewsReview (free) FDA Approves First CAR-T Cell Therapy for Pediatric Acute Lymphoblastic Leukemia – National Institutes of Health (free) AND FDA Approves First Gene-Altering Leukemia Treatment, Costing $475.000 – New York Times (10 articles per month are free) AND The FDA Approves a Landmark Cancer Drug – The Atlantic (free)

“…is a cancer therapy that represents several things at once: a game-changing way to treat cancer through genetic engineering, a novel paradigm for the biotech business, and the latest turn in the debate over just how astronomically expensive a life-saving therapy can be”. (from The Atlantic)


7 – ACC/AATS/AHA/ASE/ASNC/HRS/SCAI/SCCT/SCMR/STS 2017 Appropriate Use Criteria for Multimodality Imaging in Valvular Heart Disease (free)

Commentary with highlights from the document: Appropriate Use Criteria Published for Valvular Heart Disease Imaging Tests – American College of Cardiology, Latest in Cardiology (free)


8 – Accelerometer-assessed sedentary work, leisure time and cardio-metabolic biomarkers during one year: Effectiveness of a cluster randomized controlled trial in parents with a sedentary occupation and young children – PLOS One (free)

Commentaries: Sitting for 20 minutes less a day won’t make you ‘more muscly’ – NHS Choices (free) AND Just 21 minutes less sitting improves health – Medical News Today (free)


9 – New Nutrition Study Changes Nothing – The Atlantic (free) (RT @drjohnm see Tweet)

See original article and commentaries in our August 30 issue (see #1 and #2)

“Why the science of healthy eating appears confusing – but isn’t”


10 – Molluscum contagiosum is best left to clear by itself – NIHR Signal (free)

Original article: Interventions for cutaneous molluscum contagiosum – Cochrane Library (link to abstract – $ for full-text)

“Clinicians should advise people with a healthy immune system to leave molluscum contagiosum to clear by itself” (RT @NIHR_DC  see Tweet)


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