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NEWS - TOP 10

Thu, March 22 – 10 Stories of The Day!

22 Mar,2018

 

1 – Low Back Pain – New Series from The Lancet Journals

– Homepage and Executive Summary (free)

– Article 1: What low back pain is and why we need to pay attention (free registration required)

– Article 2: Prevention and treatment of low back pain: evidence, challenges, and promising directions (free registration required)

– Invited Commentary: Low back pain: a major global challenge (free registration required)

– Viewpoint: Low back pain: a call for action (free registration required)

Commentaries: Low Back Pain Affects 540 Million People Worldwide, but Too Many Patients Receive the Wrong Care – University of Warwick, via NewsWise (free) AND Lower back pain being treated badly on a global scale, study says – The Guardian (free)

 

2 – Education Outcomes in a Duty-Hour Flexibility Trial in Internal Medicine – New England Journal of Medicine (free)

Commentaries: Limiting shifts for medical trainees affects satisfaction, but not educational outcomes – MedicalXpress (free) AND Controversial Duty-Hours Trial Finds Difference in Intern Education – MedPage Today (free registration required) AND Limiting hours of resident shifts improves satisfaction—but not educational outcomes – Clinical Inovation + Technology (free)

 

3 – Helicobacter pylori Therapy for the Prevention of Metachronous Gastric Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: H. pylori Treatment for Gastric Cancer Prevention (free)

Commentary: H pylori Eradication Benefits Patients With Early Gastric Cancer – Medscape (free registration required)

 

4 – Behaviors, movements, and transmission of droplet-mediated respiratory diseases during transcontinental airline flights – Proceedings of the National Academy of Sciences (free)

Commentaries: Localized Risk for Infection Transmission on Planes, Study Finds – Medscape (free registration required) AND Researchers Determine Routes of Respiratory Infectious Disease Transmission on Aircraft – Georgia Tech News Center (free) AND Why you should choose your plane seat wisely – Medical News Today (free)

“Direct disease transmission outside of the one-meter area of an infected passenger is unlikely” (from Georgia Tech)

 

5 – Selected Articles from the Annual Update in Intensive Care and Emergency Medicine 2018 – BMC (free) (via @CritCareReviews)

 

6 – For hypertension and diabetes, lower treatment targets not necessarily better – American Family Physician Community Blog (free)

Related: AAFP Decides to Not Endorse AHA/ACC Hypertension Guideline (free) AND ACC/AHA Hypertension Guideline: What Is New? What Do We Do? – American Family Physician (free) AND Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus: A Guidance Statement Update From the American College of Physicians (free)

 

7 – Causes of death among children aged 5–14 years in the WHO European Region: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet Child & Adolescent Health (free)

Invited commentary: Mortality in older children and adolescents: the forgotten ones (free)

Graphic 1: Top 25 causes of death in the WHO European Region, age 5–9 years, both sexes, 1990 and 2016 (free)

Graphic 2: Top 25 causes of death in the WHO European Region, age 10–14 years, both sexes, 1990 and 2016 (free)

 

8 – Time to Epinephrine Administration and Survival from Non-Shockable Out-of-Hospital Cardiac Arrest Among Children and Adults – Circulation (link to abstract – $ for full-text)

Commentary: Every Minute Counts with Epinephrine in Nonshockable Out-of-Hospital Cardiac Arrest – NEJM Journal Watch (free)

 

9 – Risk of maternal mortality in women with severe anaemia during pregnancy and post partum: a multilevel analysis – The Lancet Global Health (free)

Commentaries: Maternal anaemia and risk of mortality: a call for action – The Lancet Global Health (free) AND Risk of maternal death doubled in pregnant women with anemia – MedicalXpress (free)

 

10 – Socioeconomic disparities in first stroke incidence, quality of care, and survival: a nationwide registry-based cohort study of 44 million adults in England – The Lancet Public Health (free)

Invited commentary: Preventing stroke on the street where you live, work, and play (free)

Patients from the lowest socioeconomic groups had first stroke a median of 7 years earlier than those from the highest and a 26% higher adjusted risk of 1-year mortality.

 

Wed, March 21 – 10 Stories of The Day!

21 Mar,2018

 

1 – Screening for Skin Cancer: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Related Recommendation Statement: Behavioral Counseling to Prevent Skin Cancer: US Preventive Services Task Force (free)

JAMA Editorials:  Sun Protection and Skin Self-examination and the US Preventive Services Task Force Recommendation on Behavioral Counseling for Skin Cancer Prevention (free) AND Should Pediatricians Be More Proactive in Counseling Children About Skin Cancer Risk? Implications of the USPSTF Recommendation Statement (free) AND The Potential of Behavioral Counseling to Prevent Skin Cancer (free) AND USPSTF Recommendations for Behavioral Counseling for Skin Cancer Prevention: Throwing Shade on UV Radiation (free) AND The Value of Behavioral Counseling for Skin Cancer Prevention: Actions We Can Take Now and Guidance for the Future (free)

Author Interviews: Screening for Skin Cancer (free audio) AND USPSTF Recommendation: Behavioral Counseling to Prevent Skin Cancer (free)

Commentaries: Doctors endorse counseling of some kids, young adults to prevent skin cancer – Reuters (free) AND Evidence insufficient to make recommendation regarding visual skin examination by a clinician – The JAMA Network, via EurekAlert (free)

 

2 – Gender differences in the associations between age trends of social media interaction and well-being among 10-15 year olds in the UK – BMC Public Health (free)

Commentaries: Mental health risks to girls who spend more than an hour a day on social media – new study  – The Conversation (free) AND How much is too much? Does increasing use of social media having a damaging effect on young girls? – BMC Series Blog (free) AND Social Media May Be More Harmful To Girls Than Boys, Study Finds – Forbes (free)

See also a recent Pediatrics supplement: Children, Adolescents and Screens: What We Know and What We Need To Learn (free articles) and related texts on Social Media and Mental Health (free articles and commentaries)

 

3 – Are we prepared for the looming epidemic threat? – The Guardian (free) (via @Onisillos)

Related: The World Is Not Ready for the Next Pandemic – TIME cover story AND The World Is Completely Unprepared for a Global Pandemic – Harvard Business Review (free) AND Seven reasons we’re at more risk than ever of a global pandemic – CNN (free) AND Video: Pandemics – a worrying global public health threat (free)

 

4 – Cardiology World Erupts Into Controversy Over Change In Major Clinical Trial – Cardiobrief (free)

Related Article: Moving the Goalposts Into Unblinded Territory – Circulation: Cardiovascular Quality and Outcomes (free)

 

5 – Blood pressure-lowering treatment strategies based on cardiovascular risk versus blood pressure: A meta-analysis of individual participant data – PLOS Medicine (free)

Related study with similar conclusions: Impact of Cardiovascular Risk on the Relative Benefit and Harm of Intensive Treatment of Hypertension – Journal of the American College of Cardiology (link to abstract – $ for full-text)

“An intelligent approach towards blood pressure management: by the individual’s risk instead of just their measurements” (via @EricTopol see Tweet)

 

6 – Burden of cardiovascular risk factors and cardiovascular disease in childhood cancer survivors: data from the German CVSS-study – European Heart Journal (free)

Commentaries: Survivors of childhood cancer are at great risk of heart problems in adulthood – eCancerNews (free) AND Higher heart risk for survivors of childhood cancer – OnMedica (free)

Related study: The cumulative burden of surviving childhood cancer: an initial report from the St Jude Lifetime Cohort Study (SJLIFE) – The Lancet (link to abstract – $ for full-text)

Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)

 

7 – Extensive impact of non-antibiotic drugs on human gut bacteria – Nature (link to abstract – $ for full-text)

Commentaries: The overlooked side effect of many drugs – Nature Microbiology Community (free) AND Study: Non-antibiotic drugs affect gut bacteria, could promote resistance – CIDRAP (free)

 

8 – Pulse oximetry for diagnosis of critical congenital heart defects – Cochrane Library (free)

Original article: Pulse oximetry screening for critical congenital heart defects – Cochrane Library (free)

Related study: Association of US State Implementation of Newborn Screening Policies for Critical Congenital Heart Disease With Early Infant Cardiac Deaths – JAMA (link to abstract – $ for full-text)

Related guidelines: Pulse oximetry screening for critical congenital heart defects: a European consensus statement – The Lancet Child & Adolescent Health (free) AND Canadian Cardiovascular Society/Canadian Pediatric Cardiology Association Position Statement on Pulse OximetryScreening in Newborns to Enhance Detection of Critical Congenital Heart Disease (free) AND Role of Pulse Oximetry in Examining Newborns for Congenital Heart Disease: A Scientific Statement from the AHA and AAP (free)

 

9 – European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on arrhythmias and cognitive function: what is the best practice? (free)

Commentary: New Expert Statement on Arrhythmias and Cognitive Function – Medscape (free registration required)

 

10 – Association of Inhaled Corticosteroids and Long-Acting β-Agonists as Controller and Quick Relief Therapy With Exacerbations and Symptom Control in Persistent Asthma: A Systematic Review and Meta-analysis – JAMA (free for a limited period)

Related Meta-Analysis: Association of Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists With Asthma Control in Patients With Uncontrolled, Persistent Asthma: A Systematic Review and Meta-analysis – JAMA (free for a limited period)

Commentary: Reviews Reveal Benefits of LAMAs, LABAs, and SMART in Asthma – Medscape (free registration required)

 

Tue, March 20 – 10 Stories of The Day!

20 Mar,2018

 

1 – 2018 ESC Guidelines for the diagnosis and management of syncope – European Heart Journal (free for a limited period)

News release: European Society of Cardiology guidelines on syncope launched today at EHRA 2018 (free)

Related guideline: 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines, and the Heart Rhythm Society (free)

 

2 – The 2018 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation – European Heart Journal (free for a limited period)

News release: New EHRA Practical Guide on non-vitamin K antagonist oral anticoagulants launched (free)

 

3 – MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis – New England Journal of Medicine (free)

Commentaries: Prostate MRI reveals more treatable cancers, reduces overdiagnosis than standard biopsy – European Urology Association, via EurekAlert (free) AND MRI Before Biopsy Better Than TRUS in Prostate Cancer – Medscape (free registration required)

 

4 – Direct-Acting Antiviral Prophylaxis in Kidney Transplantation From Hepatitis C Virus–Infected Donors to Noninfected Recipients: An Open-Label Nonrandomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: HCV Prophylaxis Could Expand Kidney Availability – Renal & Urology News (free) AND HCV-infected kidney donors could save lives – 2 Minute Medicine (free) AND One year posttransplant, recipients of hepatitis C kidneys disease-free – Johns Hopkins Medicine, ScienceDaily (free)

 

5 – Physical activity, sedentary behaviour and colorectal cancer risk in the UK Biobank – British Journal of Cancer (link to abstract – $ for full-text)

Commentaries: Binge watching TV could increase bowel cancer risk in men – Imperial College London (free) AND Expert reaction to study on physical activity, sedentary behaviour and bowel cancer risk – Science Media Centre (free)

 

6 – Efficacy of Vaginal Estradiol or Vaginal Moisturizer vs Placebo for Treating Postmenopausal Vulvovaginal Symptoms: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

Invited commentary: Rethinking the Approach to Managing Postmenopausal Vulvovaginal Symptoms (free for a limited period)

Author interview: Efficacy of Vaginal Estradiol or Moisturizer vs Placebo for Postmenopausal Vulvovaginal Symptoms (free)

Commentary: Vaginal Estradiol Offers Little Help for Postmenopausal Symptoms – Moisturizer no better than placebo gel, either – MedPage Today (free registration required)

 

7 – MMWR Report: Fatal Yellow Fever in Travelers to Brazil, 2018 – Centers for Disease Control and Prevention (CDC) (free)

Commentaries: Thinking of Going to Brazil? You Will Need a Yellow Fever Vaccination – The New York Times (free) AND Brazil’s yellow fever outbreak, explained – VOX (free)

 

8 – Richard Lehman’s journal review, 19 March 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Are shorter courses of systemic steroids as effective as conventional longer courses in the treatment of patients with flare-ups of COPD? – Cochrane Library (free)

“Information from a new large study has increased our confidence that five days of oral corticosteroids is likely to be sufficient for treatment of adults with acute exacerbations of COPD”.

 

10 – Suicide After Deliberate Self-Harm in Adolescents and Young Adults – Pediatrics (free)

Commentary: Young People Who Self-Harm Face Striking Increase in Suicide Risk – Physician’s First Watch (free)

Teens who self-harm are nearly 50 times more likely to commit suicide in the next year compared with their non-self-harming peers” (via @Physns1stWatch see Tweet)

 

Mon, March 19 – 10 Stories of The Day!

19 Mar,2018

 

1 – The impact of confounding on the associations of different adiposity measures with the incidence of cardiovascular disease: a cohort study of 296 535 adults of white European descent – European Heart Journal (free)

Commentaries: New study casts further doubt on the idea that you can be ‘fat and fit’ – NHS Choices (free) AND A ‘Sweet Spot’ for Heart Health – The New York Times (10 articles per month are free) AND A ‘sweet spot’ BMI to reduce heart disease risk? What you need to know – HealthNewsReview (free)

 

2 – Clinical Guideline Synopsis: Evaluation and Treatment of Male Hypogonadism – JAMA (free)

Original Guideline: Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline – The Journal of Clinical Endocrinology & Metabolism (free PDF)

Commentary: New Testosterone Treatment Guidelines ‘Useful but Not Gospel’ – Medscape (free registration required)

 

3 – Free Online Course (small fee if applying for certificate). Starts March 26, 2018. The Sustainable Development Goals – A global, transdisciplinary vision for the future – University of Copenhagen and Coursera

 

4 – New Series from The Lancet Journals: Pathology and laboratory medicine in low-income and middle-income countries (free registration required for all articles and commentaries)

 

5 – Preventing physician suicide – ACP Hospitalist (free)

Related: What I’ve learned from my tally of 757 doctor suicides – The Washington Post (free) AND Why are doctors killing themselves? – MJA InSight (free) AND Why are doctors plagued by depression and suicide? A crisis comes into focus – STAT (free) AND Protecting interns and other physicians from depression and suicide – STAT (free)

 

6 – The DiPEP (Diagnosis of PE in Pregnancy) biomarker study: An observational cohort study augmented with additional cases to determine the diagnostic utility of biomarkers for suspected venous thromboembolism during pregnancy and puerperium – British Journal of Haematology (free)

Commentary: Imaging is the only way to diagnose blood clots in pregnancy – NIHR Signal (free)

No blood test can accurately tell if a pregnant or recently pregnant woman has a blood clot. All pregnant women with a suspected clot should continue to have imaging investigations” (via @NIHR_DC  see Tweet)

 

7 – Tracheotomy in the intensive care unit: guidelines from a French expert panel – Annals of Intensive Care (free)

 

8 – Older Abuse: Sometimes It’s Self-Inflicted – The New York Times (10 articles per month are free)

The house is filthy. The elderly resident is struggling. But who has the right to intervene?” (via @NYTHealth see Tweet)

 

9 – Diastolic Blood Pressure and Adverse Outcomes in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) Trial – Journal of the American Heart Association (free for a limited period)

“DBP values ≥90 and <60 mm Hg are associated with a significant risk of adverse outcomes in patients with heart failure with preserved ejection fraction who are treated for hypertension”.

 

10 – Oral vitamin B12 compared with intramuscular vitamin B12 for vitamin B12 deficiency – Cochrane Library (free)

Commentary: Oral vs. Intramuscular Vitamin B12: Efficacy, Safety Compared – MPR (free)

 

Fri, March 16 – 10 Stories of The Day!

16 Mar,2018

 

1 – Mapping child growth failure in Africa between 2000 and 2015 – Nature (free)

Invited commentary, by Kofi Annan: Data can help to end malnutrition across Africa (free)

Other commentaries: Africa ‘very, very far away’ from meeting global target to end child malnutrition – The Guardian (free) Local Burden of Disease – Child Growth Failure – IHME (free) AND Zooming in on advances and opportunities – IHME (free)

 

2 – Guideline: Attention deficit hyperactivity disorder: diagnosis and management – National Institute for Health and Care Excellence (NICE) (free)

 

3 – State of The Art Review: Pulmonary arterial hypertension: pathogenesis and clinical management – The BMJ (free for a limited period)

Related Guidelines: Pharmacologic Therapy for Pulmonary Arterial Hypertension in Adults – CHEST Guideline and Expert Panel Report (free) AND 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension (free)

 

4 – Very interesting resource: A Visual introduction to the basic concepts of probability theory – Seeing Theory (free) (via @CochraneUK see Tweet)

 

5 – Midlife cardiovascular fitness and dementia: A 44-year longitudinal population study in women – Neurology (free)

Commentaries: High Cardiovascular Fitness in Midlife Tied to Lower Dementia Risk Later – NEJM Physician’s First Watch (free) AND Physically fit women nearly 90 percent less likely to develop dementia – American Academy of Neurology, via ScienceDaily (free)

 

6 – Like It Or Not, Personal Health Technology Is Getting Smarter – NPR (free)

“Nice article about wearables related issues, such as medicalization of the healthy, privacy loss, low adherence, uncertain reliability of measurements and uncertain health benefits”. (via @RasoiniR see Tweet)

 

7 – Wearable technology to screen for atrial fibrillation: does it raise more questions than it answers? – HealthNewsReview (free)

Related: Get Ready For A Tsunami Of ECGs – Cardiobrief (free) AND: Thoughts on the Apple Watch and Mobile ECG, by Dr John Mandrola (free) AND Overdiagnosis Only a Matter of Time With ECG Watches – Medscape (free registration required)

 

8 – Panic, chronic anxiety and burnout: doctors at breaking point – The Guardian (free)

 

9 – Statement: American Diabetes Association® Deeply Concerned About New Guidance from American College of Physicians Regarding Blood Glucose Targets for People with Type 2 Diabetes (free)

See original guideline and commentary: ACP Guideline: Hemoglobin A1c Targets for Glycemic Control in Type 2 Diabetes

 

10 – Calcium and vitamin D supplementation and increased risk of serrated polyps: results from a randomised clinical trial – Gut (link to abstract – $ for full-text)

Commentaries: Calcium and vitamin D supplements may raise risk of polyps – MedicalNewsToday (free) AND Calcium Supplements Up Risk for Precancerous Serrated Polyps – Medscape (free registration required)

See related meta-analysis of RCT showing calcium and vitamin D don’t prevent bone fractures

 

Thu, March 15 – 10 Stories of The Day!

15 Mar,2018

 

1 – Pregnancy Outcomes after ZIKV Infection in French Territories in the Americas – New England Journal of Medicine (free)

Editorial: Recognizing the Global Impact of Zika Virus Infection during Pregnancy (free)

Quick Take Video Summary: Pregnancy Outcomes after Zika (free)

Commentaries: Study: 7% risk of birth defects in Zika pregnancies – CIDRAP (free) AND Birth defect rate pegged at 7 percent for babies born to Zika-infected women – Reuters (free)

 

2 – Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa – New England Journal of Medicine (free)

Commentary: Combo Tx Offers New Hope for Cryptococcal Meningitis – MedPage Today (free registration required)

 

3 – Management of Multi-Casualty Incidents in Mountain Rescue: Evidence-Based Guidelines of the International Commission for Mountain Emergency Medicine (ICAR MEDCOM) (free)

Source: Critical Care Reviews Newsletter

 

4 – Grader Variability and the Importance of Reference Standards for Evaluating Machine Learning Models for Diabetic Retinopathy – Ophthalmology (link to abstract – $ for full-text)

Commentary: Google’s AI program: Building better algorithms for detecting eye disease – ScienceDaily (free)

 

5 – Editorial: AI diagnostics need attention – Nature (free) (via @RasoiniR see Tweet)

 

6 – #ACC18 – More Deaths, Strokes Seen with Perioperative Beta Blocker One Year After Surgery – American College of Cardiology (free)

Related systematic review (just published): Perioperative beta-blockers for preventing surgery-related mortality and morbidity – Cochrane Library (free)

 

7 – #ACC18 – Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout – New England Journal of Medicine (free)

Commentaries: Gout Drug Febuxostat Linked to More CV Deaths Without Uptick in CV Events: CARES Trial – TCTMD (free) AND CARES: Increased Risk of Death With Febuxostat in Patients With Gout and CV Disease – American College of Cardiology (free)

 

8 – Colonoscopy and Colorectal Cancer Mortality in the Veterans Affairs Health Care System: A Case–Control Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Colonoscopy significantly reduces mortality from colorectal cancer in Veterans Affairs study – 2 Minute Medicine (free) AND Colonoscopy Significantly Reduces CRC Deaths – Medscape (free registration required)

 

9 – N-Terminal Pro–B-Type Natriuretic Peptide in the Emergency Department – Journal of the Americana College of Cardiology (link to abstract – $ for full-text)

Commentary: NT-proBNP cutpoints validated for diagnosing and ruling out heart failure in the ED – ACP Hospitalist (free)

Related review: BNP in the emergency department: The evidence – First10EM (free)

“In acutely dyspneic patients seen in the ED setting, age-stratified NT-proBNP cutpoints may aid in the diagnosis of acute HF. An NT-proBNP <300 pg/ml strongly excludes the presence of acute HF”.

 

10 – Sustained Physical Activity, Not Weight Loss, Associated With Improved Survival in Coronary Heart Disease – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: For CHD Patients, Physical Activity More Meaningful Than Weight Changes Over Time – TCTMD (free)

 

Wed, March 14 – 10 Stories of The Day!

14 Mar,2018

 

1 – Endovascular treatment for acute ischaemic stroke in routine clinical practice: prospective, observational cohort study (MR CLEAN Registry) – The BMJ (free)

Related guideline: 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association / American Stroke Association (free PDF) AND Summary for ED-relevant care: 2018 AHA/ASA Ischemic Stroke Updates – emDocs (free)

“In routine clinical practice, endovascular treatment for patients with acute ischemic stroke is at least as effective and safe as in the setting of a randomized controlled trial”.

 

2 – Editorial: Dialysis Modality Survival Comparison: Time to End the Debate, It’s a Tie – American Journal of Kidney Diseases (free)

Related commentary: PD or HD: Which Road Do We Take? – AJKD Blog (free)

Original article: Comparison of Patient Survival Between Hemodialysis and Peritoneal Dialysis Among Patients Eligible for Both Modalities – American Journal of Kidney Diseases (link to abstract – $ for full-text)

Source: Hemodialysis vs. Peritoneal Dialysis for End-Stage Renal Disease – NEJM Journal Watch ($)

 

3 – Low-level lead exposure and mortality in US adults: a population-based cohort study – The Lancet Public Health (free)

Commentaries: Lead and the heart: an ancient metal’s contribution to modern disease – The Lancet Public Health (free) AND Lead exposure may be linked to 412,000 premature US deaths yearly, study says – The Guardian (free) AND Lead and CDV deaths in US adults – Science Media Centre (free) AND Expert reaction to lead and CVD deaths in the US – Science Media Centre (free)

 

4 – Health Care Spending in the United States and Other High-Income Countries – JAMA (free article, editorials, author interview and video summary)

Commentaries: Why Is U.S. Health Care So Expensive? Some of the Reasons You’ve Heard Turn Out to Be Myths – The New York Times (10 articles per month are free) AND Huge cost of US healthcare driven by drug prices and salaries – The Guardian (free) AND Healthcare: It’s The Prices, Stupid. Isn’t It? – Forbes (free) AND Physician Salaries, Drug Prices Drive High US Health Costs – Medscape (free registration required)

 

5 – Digital Rectal Examination for Prostate Cancer Screening in Primary Care: A Systematic Review and Meta-Analysis – Annals of Family Medicine (free)

Commentaries: New analysis recommends against using digital rectal exam in primary care – American Academy of Family Physicians, vie EurekAlert (free) AND Little Evidence Supports Use of Digital Rectal Exam – Medscape (free registration required) AND Digital Rectal Exams for Routine Prostate Screening Discouraged – NEJM Physician’s First Watch (free)

 

6 – Korean Clinical Practice Guidelines for Aneurysmal Subarachnoid Hemorrhage – Journal of Korean Neurosurgical Society (free)

 

7 – Did a pricey cholesterol-lowering drug really reduce deaths, as headlines claim? – Health News Review (free)

See original article and commentaries in our March 12th issue (see #2)

 

8 – Effects of stress on the development and progression of cardiovascular disease – Nature Reviews Cardiology (free PDF for a limited period) (via @Abraham_RMI)

  

9 – Chronic kidney disease and arrhythmias: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference – European Heart Journal (free)

 

10 – The 2017 ESC Guidelines on PADs: what’s new? – European Heart Journal (free) AND The ‘Ten Commandments’ of 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases – European Heart Journal (free)

Original Guideline: 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS) (free)

 

Mon, March 12 – 10 Stories of The Day!

12 Mar,2018

 

#ACC18 – Highlights from the American College of Cardiology’s 67th Annual Scientific Session

 

1 – Acute Myocardial Infarction Mortality During Dates of National Interventional Cardiology Meetings – Journal of the American Heart Association (free)

Commentaries: Survival benefit seen for some patients when cardiologists are away at academic conferences – Harvard Medical School, via ScienceDaily (free) AND TCT paradox: Patients more likely to survive MI during interventional cardiology conference – Cardiovascular Business (free)

Related study: Mortality and Treatment Patterns Among Patients Hospitalized With Acute Cardiovascular Conditions During Dates of National Cardiology Meetings – JAMA Internal Medicine (free)

“The study’s release date is particularly timely considering another major conference—the American College of Cardiology’s Scientific Session—kicks off this weekend”. (from Cardiovascular Business)

 

2 – #ACC18 – The ODYSSEY Trial Ends Well— But Will It Be Enough? – Cardiobrief (free) AND Ten Quick Thoughts on ODYSSEY – John Mandrola, via Medscape (free registration required)

“An absolute risk reduction of 1.6% in the primary endpoint translates to a number needed to treat of 64. Using the current price of $14,500 per year, Kaul calculated that preventing one event over the trial period of almost 3 years would cost about $2.6 million” (via John Mandrola). This study was presented at #ACC18 and has not been published yet. Among the many commentaries, these two were selected for a balanced point of view.

 

3 – #ACC18 – Carvedilol for Prevention of Chemotherapy Related Cardiotoxicity – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Beta Blocker Shows Mixed Results in Protecting Against Chemo-Induced Heart Damage – American College of Cardiology (free) AND Carvedilol Effect in Preventing Chemotherapy Induced CardiotoxicitY – CECCY – American College of Cardiology (free)

Related study from #ACC18: Heart Drugs Prevented Cardiotoxicity in Breast Cancer Treated With Anthracycline and Trastuzumab – American College of Cardiology (free)

“According to the CECCY trial, carvedilol had no effect on left ventricular function in breast cancer patients treated w/ doxorubicin, but did result in a reduction in troponin I levels & diastolic dysfunction”. (via @ACCinTouch see Tweet)

 

4 – #ACC18 – Effect of Loading Dose of Atorvastatin Prior to Planned Percutaneous Coronary Intervention on Major Adverse Cardiovascular Events in Acute Coronary Syndrome: The SECURE-PCI Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Lipid Lowering in Acute Coronary Syndrome: Is Treatment Early Enough? (free for a limited period)

Commentaries: Statins Evaluation in Coronary Procedures and Revascularization – SECURE-PCI – American College of Cardiology (free) AND No Benefits Likely with Very Early Statins in ACS Patients – MedPage Today (free registration required) AND SECURE-PCI Comes Up Short for Statin Preloading in ACS Patients – TCTMD (free)

 

5 – #ACC18 – Hospital Readmission After Perioperative Acute Myocardial Infarction Associated With Noncardiac Surgery – Circulation (free PDF for a limited period)

Commentaries: Hospital Readmissions After Perioperative AMI – American College of Cardiology, Latest in Cardiology (free) AND Perioperative MIs Bring Too Many Patients Back to the Hospital After Noncardiac Surgery – TCTMD (free)

 

6 – #ACC18 – Big Swings in Daily Temperatures Linked to Spikes in MI Rates – TCTMD (free) AND Heart Attacks Often Follow Extreme Temperature Changes – Cardiosmart (free) AND Outdoor Temperature Swings Tied to STEMI Uptick – Medscape (free registration required) AND Dramatic swings in temperature linked to significantly more heart attacks – News Medical (free)

 

7 – #ACC18 – Inflammatory Bowel Disease Increases Likelihood of a Heart Attack – American College of Cardiology (free) AND Inflammatory bowel disease may raise heart attack risk – Medical News Today (free) AND Those with IBD twice as likely to have heart attack – Cardiovascular Business (free) AND Inflammatory Bowel Disease Makes Heart Attack Twice as Likely – Cardiosmart (free)

 

8 – #ACC18 – Getting flu shot halves death risk for heart failure patients – Cardiovascular Business (free) AND Flu Vaccine Reduces Mortality, Hospitalization in HF Patients: Meta-analysis – TCTMD (free) AND Flu Shot Cuts Risk for Death by Half in Heart Failure – Medscape (free registration required) AND Getting Flu Vaccine Cuts Risk of Death by Half in People with Heart Failure – American College of Cardiology (free)

This meta-analysis of observational studies suggests a possible benefit.

 

9 – #ACC18 – Aspirin Lowers Risk of Death for Patients with Diabetes, Heart Failure – American College of Cardiology (free) AND Aspirin Linked to Lower Mortality in Diabetes With Heart Failure – Medscape (free registration required) AND ACC 2018: Aspirin Lowers Risk of Death in Patients With Diabetes and Heart Failure – PracticeUpdate (free registration required)

 

10 – #ACC18 – MANAGE: Reduced Mortality and Cardiovascular Events in MINS Patients Receiving Dabigatran – American College of Cardiology (free) AND MANAGE Suggests Dabigatran Could Be Useful for Treating Myocardial Injury After Noncardiac Surgery – TCTMD (free)

“One expert called the trial results “provocative” but said its methods were “muddy,” making the findings difficult to interpret” (from TCTMD)

 

Tue, March 13 – 10 Stories of The Day!

13 Mar,2018

 

1 – Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline – The Journal of Clinical Endocrinology & Metabolism (free)

Key Points: Evaluation and Treatment of Hirsutism in Premenopausal Women – JAMA Clinical Guidelines Synopsis (free for a limited period)

 

2 – #ACC18 – Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops – New England Journal of Medicine (free for a limited period)

Commentaries: Barbershop-Based Intervention Leads to Blood Pressure Reductions in African-American Men – American College of Cardiology (free) AND Mixing Haircuts and Hypertension Rx a ‘Home Run’ for Blood Pressure Control – TCTMD (free)

Among black male barbershop patrons with uncontrolled hypertension, health promotion by barbers resulted in larger blood-pressure reduction when coupled with medication management in barbershops by specialty-trained pharmacists”.

 

3 – #ACC18 – 6-month versus 12-month or longer dual antiplatelet therapy after percutaneous coronary intervention in patients with acute coronary syndrome (SMART-DATE): a randomised, open-label, non-inferiority trial – The Lancet (link to abstract – $ for full-text)

Commentaries: SMART-DATE: Myocardial Infarction Risk Higher with Six-Month Versus Twelve-Month DAPT – American College of Cardiology (free) AND Too Soon for 6-Month DAPT, Say SMART-DATE Investigators, Despite Positive Trial – TCTMD (free)

Related Guidelines: 2018 Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology Focused Update of the Guidelines for the Use of Antiplatelet Therapy (free) AND 2017 European Society of Cardiology focused update on dual antiplatelet therapy in coronary artery disease (free) AND 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease (free)

 

4 – #ACC18 – Low-Dose ‘Triple Pill’ Lowers Blood Pressure More Than Usual Care – American College of Cardiology (free) AND Low-Dose, Three-Drug Polypill TRIUMPHs for Blood Pressure – TCTMD (free)

 

5 – Viewpoint: Big Data and Machine Learning in Health Care – JAMA (free for a limited period)

 

6 – Aromatherapy Versus Oral Ondansetron for Antiemetic Therapy Among Adult Emergency Department Patients: A Randomized Controlled Trial – Annals of Emergency Medicine (link to abstract – $ for full-text)

Commentaries: Practice Changing: Inhaled Isopropyl Alcohol Superior to Oral Ondansetron as an Antiemetic – NEJM Journal Watch (free) AND Wake Up And Smell the Isopropyl – Emergency Medicine Literature of Note (free)

 

7 – Do Antidepressants Work? – The New York Times (10 articles per month are free)

“The most comprehensive study on them has recently been published, showing mostly modest effects”.

See related meta-analysis and commentaries in our February 23rd issue (see #3)

 

8 – Richard Lehman’s journal reviews, 12 March 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Plasma 25-hydroxyvitamin D concentration and subsequent risk of total and site specific cancers in Japanese population: large case-cohort study within Japan Public Health Center-based Prospective Study cohort – The BMJ (free)

“Wake me up when there is a positive randomized trial of vitamin D pills for anything” (from Richard Lehman’s review, see above).

 

10 – Risk of stroke in patients with dengue fever: a population-based cohort study – Canadian Medical Association Journal (free)

Commentary: Dengue fever linked to increased risk of stroke – CMAJ, via ScienceDaily (free)

 

Fri, March 9 – 10 Stories of The Day!

9 Mar,2018

 

1 – The Tobacco Atlas, Sixth Edition (free PDF)

News Release: Big tobacco is targeting the world’s most vulnerable to increase profits – American Cancer Society (free)

See companion website: TobaccoAtlas.org

Related: Explore the GBD tool to compare tobacco risks globally – IHME (free interactive tool)

 

2 – European Society of Cardiology, acute cardiovascular care association, SCAD study group: a position paper on spontaneous coronary artery dissection – European Journal of Cardiology (free)

Commentary with key points to remember: European Position Paper on Spontaneous Coronary Artery Dissection – American College of Cardiology, Latest in Cardiology (free)

Related position statement: Spontaneous Coronary Artery Dissection: Current State of the Science: A Scientific Statement From the American Heart Association – Circulation (free)

 

3 – Fluoroquinolone use and risk of aortic aneurysm and dissection: nationwide cohort study – The BMJ (free)

Related: Aortic Dissection and Aortic Aneurysms Associated with Fluoroquinolones: A Systematic Review and Meta-Analysis – American Journal of Medicine (free) AND Fluoroquinolones and collagen associated severe adverse events: a longitudinal cohort study – BMJ Open (free) AND Risk of Aortic Dissection and Aortic Aneurysm in Patients Taking Oral Fluoroquinolone – JAMA Internal Medicine (free)

 

4 – Graduate students need more mental health support, new study highlights – Science (free) AND Mental Health Crisis for Grad Students – Inside Higher Ed (free) AND Depression, anxiety high in graduate students, survey shows – University of Texas Health Science Center, via ScienceDaily (free)

 

5 – Case report: Self-Management of an Inferior ST-Segment Elevation Myocardial Infarction – New England Journal of Medicine (free)

 

6 – Maintenance proton pump inhibition therapy and risk of oesophageal cancer – Cancer Epidemiology (link to abstract – $ for full-text)

Commentary: Long-term PPI Use and Increased Esophageal CA Risk – Medscape (free registration required)

Related studies suggesting a link with gastric cancer: Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study – Gut (link to abstract – $ for full-text) AND Maintenance therapy with proton pump inhibitors and risk of gastric cancer: a nationwide population-based cohort study in Sweden – BMJ Open (free)

This observational study suggests a possible link.

 

7 – Metformin use in PCOS pregnancies increases the risk of offspring overweight at 4 years of age; follow-up of two RCTs – The Journal of Clinical Endocrinology & Metabolism (link to abstract – $ for full-text)

Commentaries: Diabetes drug use during pregnancy linked to child’s weight – The Endocrine Society, via ScienceDaily (free) AND Diabetes drug use during pregnancy affects child’s weight – OnMedica (free) AND Metformin in Pregnancy May Increase Childhood Obesity Risk – Medscape (free registration required)

 

8 – EVOLVE: The Australian Rheumatology Association’s ‘top five’ list of investigations and interventions doctors and patients should question – Internal Medicine Journal (free) (via @RSiemieniuk)

See other lists of low-value practices in Choosing Wisely U.S. / Choosing Wisely UKChoosing Wisely Australia AND Choosing Wisely Canada

Another interesting list of commonly used low-value practices that should be questioned.

 

9 – Inflammatory Bowel Disease Increases Likelihood of a Heart Attack – American College of Cardiology (free) AND Inflammatory bowel disease may raise heart attack risk – Medical News Today (free) AND Those with IBD twice as likely to have heart attack – Cardiovascular Business (free)

 

10 – Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis – PLOS Medicine (free)

Commentary: Probiotics and fish oil in pregnancy may reduce allergies in children – NHS Choices (free) AND Diet During Pregnancy May Cut Offspring Allergy Risk – MedPage Today (free registration required) AND Probiotics and Fish Oil During Pregnancy May Curb Allergies in Kids – The New York Times (10 articles per month are free)

 

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