Open access

Mon, November 13 – 10 Stories of The Day!



1 – World Antibiotic Awareness Week, 13-19 November 2017 – World Health Organization (free resources)


2 – Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct – New England Journal of Medicine (free)

Editorial: A New DAWN for Imaging-Based Selection in the Treatment of Acute Stroke (free)

Commentaries: Landmark study may impact standard stroke treatment guidelines – MedicalXpress (free) AND Thrombectomy Works While Infarct Core is Small – MedPage Today (free registration required)

“DAWN data: Consider a “tissue window” rather than a “time window”” (from MedPage Today)


3 – Mechanical or Biologic Prostheses for Aortic-Valve and Mitral-Valve Replacement – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Mechanical heart valve often the safest choice – Stanford Medicine (free) AND Mechanical or Biologic Prostheses for Aortic-Valve and Mitral-Valve Replacement? – NEJM 360 Resident (free) AND Mechanical or Tissue Valve for AVR and MVR – American College of Cardiology, Latest in Cardiology (free) AND Mechanical Valves Show Mortality Benefit Over Biologic Valves – Medscape (free registration required) AND Heart valve replacement success may depend on age, valve type – Reuters (free)


4 – NICE Guideline: Bipolar disorder: assessment and management (free)


5 – Choice of implant combinations in total hip replacement: systematic review and network meta-analysis – The BMJ (free)

Commentary: What is the most effective type of hip implant combination for patients undergoing a hip replacement? – University of Bristol (free)

“…there is no evidence that any of the newer hip implant combinations, such as ceramic or uncemented, are better than the widely used small head metal-on-plastic cemented hip combination, which has been commonly used since the 1960s”.


6 – White Smoke From the Vatican? Not From Cigarettes – The New York Times (10 articles per month are free)

Related: No more Holy Smokes – Vatican bans sale of cigarettes – Reuters (free) AND Holy smoke: Vatican bans duty-free cigarette sales – BBC (free)

“WHO welcomes the Vatican’s decision to ban the sale of cigarettes as of next year. Tobacco kills more than 7 million people every year” (RT @WHO see Tweet)


7 – Exercise for the Prevention of Low Back Pain: Systematic Review and Meta-Analysis of Controlled Trials – American Journal of Epidemiology (link to abstract – $ for full-text)

Commentary: Exercise may help prevent low back pain or make it less severe – Reuters (free)

Related meta-analysis: Prevention of Low Back Pain: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free)


8 – How to survive the medical misinformation mess – European Journal of Clinical Investigation (free) (RT @RasoiniR see Tweet)


9 – Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study – The BMJ (free)

Commentary: Vitamin D level not associated with cancer risk – Clinical Adviser (free)

“These results, in combination with previous literature, provide evidence that population-wide screening for vitamin D deficiency and subsequent widespread vitamin D supplementation should not currently be recommended as a strategy for primary cancer prevention”.


10 – Long-term Sustainability of Diabetes Prevention Approaches: A Systematic Review and Meta-analysis of Randomized Clinical Trials – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Lifestyle Modifications Slow Progression To Diabetes As Effectively As Medications – Medical Research (free) AND Lifestyle changes successfully reduce incidence of diabetes – MedicalXpress (free) AND Lifestyle changes—not medications—linked to sustained risk reduction for diabetes – Cardiovascular Business (free)


Fri, November 10 – 10 Stories of The Day!



1 – Book: Major Infectious Diseases: Disease Control Priorities, Third Edition (free)

Press Release: Disease Control Priorities, 3rd Edition Launches Major Infectious Diseases Volume (free)

Previous volumes: 1 – Essential Surgery / 2 – Reproductive, Maternal, Newborn, and Child Health / 3 – Cancer / 4 – Mental, Neurological, and Substance Use Disorders / 5 – Injury Prevention and Environmental Health (all free)


2 – Inflammatory Bowel Disease, 4th Edition – Australian Guidelines for General Practitioners and Physicians (free PDF)

Source: Gastroenterology Research Review Australia


3 – Symptomatic treatment of uncomplicated lower urinary tract infections in the ambulatory setting: randomised, double blind trial- The BMJ (free)

Editorial: Antibiotics or NSAIDs for uncomplicated urinary tract infection? (free)

Commentary: NSAID Compared to Antibiotic for Symptomatic Treatment of UTI – MPR (free)


4 – Regeneration of the entire human epidermis using transgenic stem cells – Nature (link to abstract – $ for full-text)

Commentaries: A Dying Boy Gets a New, Gene-Corrected Skin – The Atlantic (free) Gene Therapy Creates Replacement Skin to Save a Dying Boy – The New York Times (10 articles per month are free) AND ‘Extraordinary’ tale: Stem cells heal a young boy’s lethal skin disease – STAT (free) AND Scientists grow replacement skin for boy suffering devastating genetic disorder – The Guardian (free) Boy with rare disease gets brand new skin with gene therapy – Associated Press (free)


5 – International variations in primary care physician consultation time: a systematic review of 67 countries – BMJ Open (free)

Commentary: Primary care consultations last less than 5 minutes for half the world’s population – BMJ, via ScienceDaily (free)

“Global assessment of the length of doctor visits (primary care): range of 48 seconds to 22 minutes” (RT @EricTopol see Tweet)


6 – The case against hospital beds – Politico (free)


7 – Pre-exposure prophylaxis for HIV-negative persons with partners living with HIV: uptake, use, and effectiveness in an open-label demonstration project in East Africa – Gates Open Research (free)


8 – Medications That Cause Dry Mouth As an Adverse Effect in Older People: A Systematic Review and Metaanalysis – Journal of The American Geriatrics Society (free)

Commentaries: Dry mouth symptoms can be side effect of certain medications for older adults – American Geriatrics Society, via EurekAlert (free) AND Certain medication use associated with dry mouth in older adults – Clinical Advisor (free)


9 – Coronary Artery Calcium Score for Long-term Risk Classification in Individuals With Type 2 Diabetes and Metabolic Syndrome From the Multi-Ethnic Study of Atherosclerosis – JAMA (free)

Commentaries: Risk Classification by CAC Score in Diabetes and Metabolic Syndrome – American College of Cardiology, Latest in Cardiology (free) AND CAC Score Aids in CVD Risk Prediction in Diabetes – MedPage Today (free registration required)


10 – Viewpoint: Placebo Effect of the Heart – The Atlantic (free)

Related viewpoints: 12 Seconds of Placebo – An Outsider’s View of ORBITA – The HealthCare Blog (free) AND ORBITA Trial Puts Interventional Cardiologists On The Defensive – Cardiobrief (free) AND ORBITA: Another clinical trial demonstrating the need for sham controls in surgical trials – Science-Based Medicine (free) AND Coronary Stents Humbled Yet Again in Stable CAD – Medscape (free)

See original ORBITA trial and commentaries in our November 3rd issue (see #1)


Thu, November 9 – 10 Stories of The Day!



1 – European guidelines on perioperative venous thromboembolism prophylaxis – European Journal of Anaesthesiology (free PDF articles):

– Editorial

– Executive Summary

– Intensive care

– Mechanical prophylaxis

– Patients with preexisting coagulation disorders and after severe perioperative bleeding

– Inferior vena cava filters

– Cardiovascular and thoracic surgery

– Neurosurgery

– Surgery in the elderly

– Surgery in the obese patient

– Surgery during pregnancy and the immediate postpartum period

– Day surgery and fast-track surgery

– Chronic treatments with antiplatelet agents

– Aspirin


2 – Vancomycin Plus Piperacillin-Tazobactam and Acute Kidney Injury in Adults: A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)

Commentary: Vancomycin plus piperacillin-tazobactam associated with higher AKI risk – ACP Hospitalist (free)

Related article: Association of Acute Kidney Injury With Concomitant Vancomycin and Piperacillin/Tazobactam Treatment Among Hospitalized Children – JAMA Pediatrics (link to abstract – $ for full-text)


3 – 2017 Comprehensive Update of the Canadian Cardiovascular Society Guidelines for the Management of Heart Failure (free)


4 – Clinical Practice Guideline of Korean Diabetes Association (free articles):

– Antihyperglycemic Agent Therapy for Adult Patients with Type 2 Diabetes Mellitus 2017

– Insulin Therapy for Adult Patients with Type 2 Diabetes Mellitus

– Monotherapy in Patients with Type 2 Diabetes Mellitus

– Combination Therapy of Oral Hypoglycemic Agents in Patients with Type 2 Diabetes Mellitus


5 – 2017 Multimodality Appropriate Use Criteria for Noninvasive Cardiac Imaging: Expert Consensus of the Asian Society of Cardiovascular Imaging – Korean Journal of Cardiology (free)


6 – Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research – The Lancet Neurology (free registration required)


7 – Being overweight or obese is linked with heart disease even without other metabolic risk factors – NIHR Signal (free)

Original article: Separate and combined associations of obesity and metabolic health with coronary heart disease: a pan-European case-cohort analysis – European Heart Journal (free)


8 – Receipt of Warnings Regarding Potentially Impairing Prescription Medications and Associated Risk Perceptions in a National Sample of U.S. Drivers – Journal of Studies on Alcohol and Drugs (free)

Commentaries: Drivers not always told about their prescriptions’ potentially impairing effects – ACP Internist (free) AND Many People Prescribed Drugs That Could Impair Driving Aren’t Warned About Risk – Physician’s First Watch (free)


9 – Cardiovascular Effects of Long‐Term Exposure to Air Pollution: A Population‐Based Study With 900 845 Person‐Years of Follow‐up – Journal of The American Heart Association (free)

Commentaries: Air pollution as great a risk as hypertension, obesity, diabetes for CVD – Cardiovascular Business (free)


10 – Pulse oximetry screening for critical congenital heart defects: a European consensus statement – The Lancet Child & Adolescent Health (free)

Commentaries: All babies in Europe should be screened for heart defects at birth – OnMedica (free) AND Call for Europe-wide screening of babies for heart defects – MedicalXpress (free)


Wed, November 8 – 10 Stories of The Day!



1 – News Release and Summary: More Cardiac Arrest Victims Could Survive with Dispatcher CPR Instruction, Rescue Breaths for Children (free)

See Guidelines: 2017 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations Summary (free PDF) AND 2017 American Heart Association Focused Update on Adult Basic Life Support and Cardiopulmonary Resuscitation Quality (free PDF) AND 2017 American Heart Association Focused Update on Pediatric Basic Life Support and Cardiopulmonary Resuscitation Quality (free PDF)

Top Ten Things to Know: AHA Focused Update on Adult and Pediatric Basic Life Support and CPR Quality (free PDF)


2 – WHO guidelines on use of medically important antimicrobials in food-producing animals – World Health Organization (free)

News release: Stop using antibiotics in healthy animals to prevent the spread of antibiotic resistance (free)

Related Article: Restricting the use of antibiotics in food-producing animals and its associations with antibiotic resistance in food-producing animals and human beings: a systematic review and meta-analysis – The Lancet Planetary Health (free) and Editorial: Antimicrobial use and resistance in animals and human beings (free)

Commentaries: WHO calls for restrictions on use of antibiotics in food animal production – STAT (free) AND WHO Moves to Contain Superbugs on the Farm – Scientific American (free) WHO calls for an end to antibiotic use in healthy animals – CIDRAP (free)


3 – Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients – The Lancet (free)

Commentaries: Tranexamic acid: is it about time? – The Lancet (free) Rapid use of blood drug could save thousands of lives, study finds – The Guardian (free) AND Severely bleeding patients must receive lifesaving drug within minutes, not hours – London School of Hygiene & Tropical Medicine, via EurekAlert (free)


4 – Draft Recommendation Statement: Osteoporosis to Prevent Fractures: Screening – U.S. Preventive Services Task Force (free)

Commentary: New USPSTF Draft Recommendations for Osteoporosis Screening – Medscape (free registration required)


5 – Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: No Significant Difference in Pain Relief for Opioids vs Non-Opioid Analgesics for Treating Arm or Leg Pain – The JAMA Network (free) AND Acetaminophen plus Ibuprofen Noninferior to Low-Dose Oral Opioids for Acute Extremity Pain – Journal Watch (free)


6 – Comparisons of Interventions for Preventing Falls in Older Adults: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)

Commentaries: Exercise, Vision Testing and Osteoporosis Evaluation Are Keys To Fall Prevention – Medical Research (free) AND Exercise may be best intervention to prevent falls among elderly, according to new study – MedicalXpress (free) AND Adding other therapy to exercise may be best for fall prevention – Reuters (free) AND How to Prevent Falls in Older Adults – Consumer Reports (free)


7 – Alcohol and Cancer: A Statement of the American Society of Clinical Oncology – Journal of Clinical Oncology (free)

Commentaries: Cancer Doctors Cite Risks of Drinking Alcohol – The New York Times (10 articles per month are free) AND Cutting back on alcohol can prevent cancers: experts – Reuters (free) ASCO links alcohol to cancer, calls for reduced consumption – eCancer News (free)


8 – The Growing Value of Digital Health: Evidence and Impact on Human Health and the Healthcare System – IQVIA Institute (free)

Commentary: Study Names Top Apps for Patients to Manage Illnesses – Medscape (free registration required)

“An impressive, in-depth report on digital health, shows how the field is taking hold” (RT @EricTopol see Tweet)


9 – Clinical Guidelines Synopsis: Screening for Chronic Obstructive Pulmonary Disease – JAMA (free)

Original Guideline: GOLD 2017  Global Strategy for the Diagnosis, Management and Prevention of COPD (free PDF)

Related Guidelines: Final Recommendation Statement: Chronic Obstructive Pulmonary Disease: Screening – U.S. Preventive Services Task Force (free) AND Diagnosis and Management of Stable Chronic Obstructive Pulmonary Disease: A Clinical Practice Guideline Update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society (free)


10 – Projecting the impact of a nationwide school plain water access intervention on childhood obesity: a cost–benefit analysis – Pediatric Obesity (link to abstract – $ for full-text)

Commentaries: Making water available to school chilren at lunch may save $13B in health costs – UPI (free) AND Serving water with school lunches could curb obesity, save billions – Cardiovascular Business (free) AND Serving water with school lunches could prevent child, adult obesity: study – MedicalXpress (free)


Tue, November 7 – 10 Stories of The Day!



1 – The Burden of Group B Streptococcus Worldwide for Pregnant Women, Stillbirths, and Children – Clinical Infectious Diseases Supplement (free articles)

Commentaries: Group B Streptococcus infection causes an estimated 150,000 preventable stillbirths and infant deaths every year – London School of Hygiene & Tropical Medicine (free) AND Streptococcus vaccine ‘could prevent over 100,000 baby deaths worldwide’ – The Guardian (free)


2 – Effectiveness of β-Lactam Monotherapy vs Macrolide Combination Therapy for Children Hospitalized With Pneumonia – JAMA Pediatrics (link to abstract – $ for full-text)

Commentaries: Study: Azithromycin overprescribed for kids’ pneumonia – CIDRAP (free) AND Vanderbilt study shows azithromycin overprescribed for childhood pneumonia – Vanderbilt University Medical Center, via EurekAlert (free)


3 – Position Paper: Patient Safety in the Office-Based Practice Setting – American College of Physicians (free PDF)

Commentaries: ACP says patient safety must be improved in office-based practice setting – American College of Physicians, via EurekAlert (free) AND ACP: Recommendations for Improving Patient Safety in Ambulatory Settings – MPR (free)


4 – Debate: the case for and against screening for breast cancer with mammography:

The case for mammography: Routine mammograms do save lives: The Science – The Conversation (free)

The case against mammography: Routine mammograms do not save lives: The research is clear – The Conversation (free)

Related: Make Screening Mammography Personal, Say the French – Medscape (free registration required)

“The debate over breast cancer screening continues, with disagreements about the start age, frequency, mortality effect, overdiagnosis, and overtreatment” (from Medscape)


5 – ORBITA: Another clinical trial demonstrating the need for sham controls in surgical trials – Science-Based Medicine (free) (via @gorskon)


6 – Viewpoint: Advance Directives for Dementia: Meeting a Unique Challenge – JAMA (free)


7 – Richard Lehman’s journal reviews, 6 November 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.


8 – Last Month in Oncology with Dr. Bishal Gyawali: October 2017 – eCancer News (free)


9 – Association of Warfarin Use With Lower Overall Cancer Incidence Among Patients Older Than 50 Years – JAMA Internal Medicine (free)

“In this population-based cohort study of 1.256.725 persons, there was a significantly lower age- and sex-adjusted incidence rate ratio of cancer among warfarin users vs nonusers”.


10 – The Value of Preoperative Assessment Before Noncardiac Surgery in the Era of Value-Based Care – Circulation (free)

Related guidelines: 2014 ACC/AHA Guideline on Perioperative Cardiovascular Evaluation and Management of Patients Undergoing Noncardiac Surgery (free) AND 2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management (free) AND Routine preoperative tests for elective surgery – NICE Guideline (free) AND Canadian Cardiovascular Society Guidelines on Perioperative Cardiac Risk Assessment and Management for Patients Who Undergo Noncardiac Surgery (free) AND 3rd Guideline for Perioperative Cardiovascular Evaluation of the Brazilian Society of Cardiology (free)


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