Open access


Tue, January 9 – 10 Stories of The Day!

9 Jan,2018


1 – Night Shift Work Increases the Risks of Multiple Primary Cancers in Women: A Systematic Review and Meta-analysis of 61 Articles – Cancer Epidemiology, Biomarkers & Prevention Online (link to abstract – $ for full-text)

Commentaries: Night shifts raise women’s cancer risk – Medical News Today (free) AND Night Shifts Increase Breast Cancer Risk, Especially for Nurses – Medscape (free registration required) AND Female Night Shift Workers May Have Increased Risk of Common Cancers – American Association for Cancer Research (free)


2 – Canadian HIV Pregnancy Planning Guidelines – Journal of Obstetrics and Gynaecology Canada (free)


3 – Obesity in the Workplace: Impact, Outcomes, and Recommendations – Journal of Occupational and Environmental Medicine (free)

Commentary: Managing Obesity in the Workplace: New Guidance from ACOEM – Wolters Kluwer Health, via NewsWise (free)


4 – State of the Art Review: The role of the gut microbiome in systemic inflammatory disease – The BMJ (free for a period)


5 – Evidence Based Medicine is Easy – First10EM (free)

A simplified guide to approaching the medical literature.


6 – Understanding and misunderstanding randomized controlled trials – Social Science & Medicine (free) (via @trishgreenhalgh see Tweet)

Evidence-based medicine is not so easy.


7 – Richard Lehman’s journal reviews, 8 January 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.


8 – Giving oxygen routinely after a stroke does not improve outcomes – NIHR Signal (free)

Original article: Effect of Routine Low-Dose Oxygen Supplementation on Death and Disability in Adults With Acute Stroke: The Stroke Oxygen Study Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Related guideline: BTS Guideline for oxygen use in healthcare and emergency settings – British Thoracic Society (free)


9 – Projections of temperature-related excess mortality under climate change scenarios – The Lancet Planetary Health (free)

Commentaries: Climate change adaptation: no one size fits all – The Lancet Planetary Health (free) AND Study of impact of climate change on temperatures suggests more deaths unless action taken – London School of Hygiene & Tropical Medicine, via ScienceDaily (free)


10 – Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial – The Lancet Infectious Diseases (link to abstract – $ for full-text)

Commentaries: Post Exposure Doxycycline in PReP Users May Reduce Risk of Syphilis and Chlamydiae – MedicalResearch (free) AND Doxycycline After Condomless Sex Lowers STI Risk in High-Risk Men – Physician’s First Watch (free) AND Antibiotics could dramatically reduce STIs, study says, raising tough new questions – STAT (free) AND Antibiotics could ‘dramatically reduce’ STIs, STAT says, though findings apply to small group of men – HealthNewsReview (free)


Mon, January 8 – 10 Stories of The Day!

8 Jan,2018


1 – New free online course: Antimicrobial Stewardship: A competency-based approach – World Health Organization (via @snahrgang)

See also other OpenWHO Courses


2 – 2018 Edition: Let’s Talk TB (free PDF chapters) (via @paimadhu and @Onisillos)

“Let’s Talk TB is a book on the current best practices on TB diagnosis and treatment available for free for all GPs and private practitioners in India and other high-burden countries”


3 – Guidelines for the Antibiotic Use in Adults with Acute Upper Respiratory Tract Infections – Korean Society of Infectious Diseases and Korean Society for Chemotherapy (free)


4 – Clinical Guidelines for the Antibiotic Treatment for Community-Acquired Skin and Soft Tissue Infection – Korean Society of Infectious Diseases and Korean Society for Chemotherapy (free)


5 – The Society for Vascular Surgery practice guidelines on the care of patients with an abdominal aortic aneurysm – The Journal of Vascular Surgery (free)


6 – Guidelines for the management of tracheal intubation in critically ill adults – British Journal of Anaesthesia (free)

Source: Critical Care Reviews Newsletter


7 – Too Many Older Patients Get Cancer Screenings – The New York Times (10 articles per month are free)


8 – Essay: What if sugar is worse than just empty calories? An essay by Gary Taubes – The BMJ (free)


9 – Best Diets – U.S. News & World Report rankings (Free)

News release: U.S. News Reveals Best Diets Rankings for 2018 (free)

Commentaries: DASH ranked Best Diet Overall for eighth year in a row by U.S. News and World Report – NIH (free) AND DASH and Mediterranean Diets Tie for Best Overall Diet – Physician’s First Watch (free) AND What are the best diets for 2018? – Medical News Today (free) AND From Vegan To ‘Keto’ And Mediterranean: Experts Rank 2018’s Best Diets – NPR (free)


10 – Association of Noncigarette Tobacco Product Use With Future Cigarette Smoking Among Youth in the Population Assessment of Tobacco and Health (PATH) Study, 2013-2015 – JAMA Pediatrics (free)

Commentaries: Youth Use of Cigarette Alternatives May Raise Risk of Trying the Real Thing – TCTMD (free) AND Noncigarette tobacco product use is associated with future cigarette smoking – 2 Minute Medicine (free) AND Electronic Cigarette Use and Smoking Among Adolescents – The ASCO Post (free)


Fri, January 5 – 10 Stories of The Day!

5 Jan,2018


1 – Practice guideline update summary: Mild cognitive impairment – American Academy of Neurology (free PDF)

Commentary: Mild cognitive impairment: a practice guideline update – Clinical Advisor (free)

 “For patients diagnosed with MCI, clinicians may choose NOT to offer cholinesterase inhibitors”.

“If clinicians choose to offer cholinesterase inhibitors, they must first discuss with patients the fact that this is an off-label prescription not currently backed by empirical evidence”.


2 – Association of Cardiovascular Risk With Inhaled Long-Acting Bronchodilators in Patients With Chronic Obstructive Pulmonary Disease: A Nested Case-Control Study – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Starting new COPD inhaler tied to heart attack risk – Reuters (free) AND New Use of Long-Acting Bronchodilators in COPD Tied to Increased Cardiovascular Risk – Physician’s First Watch (free) AND COPD patients beginning inhaler therapy at greater short-term risk for CVD – Cardiovascular Business (free)


3 – Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma – The New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Stem Cell Transplant for Severe Scleroderma Improves Survival, Quality of Life – NIH (free) AND Stem Cell Transplantation Offers Hope For Severe Scleroderma – MedicalResearch (free)


4 – Updated WHO Recommendation on Tranexamic Acid for the Treatment of Postpartum Haemorrhage (free PDF)

Commentary: Updated WHO recommendation on intravenous tranexamic acid for the treatment of post-partum haemorrhage – The Lancet Global Health (free)


5 – Interventions to Address Sexual Problems in People With Cancer: American Society of Clinical Oncology Clinical Practice Guideline Adaptation Summary – Journal of Oncology Practice (free)


6 – Potentially Modifiable Risk Factors for Long-Term Cognitive Impairment After Critical Illness: A Systematic Review – Mayo Clinic Proceedings (free)


7 – Impact of Financial Incentives on Early and Late Adopters among US Hospitals: observational study – The BMJ (free)

Commentaries: ACA Pay-For-Performance Programs Not Living Up To Expectations – MedicalResearch (free) U.S. Researchers: Change or End the Current Pay-for-Performance System – Physician’s First Watch (free) AND Impact of US Pay for Performance Programs ‘Limited And Disappointing’ Say Experts – ScienceNewsline (free)

Related: The Effects of Pay-for-Performance Programs on Health, Health Care Use, and Processes of Care: A Systematic Review – Annals of Internal Medicine (free) AND Pay-for-performance fails to perform – Harvard Medical School, via ScienceDaily (free) AND Value-Based Purchasing: Time for Reboot or Time to Move On? by Ashish K. Jha, MD – The JAMA Forum (free)


8 – Association of the Hospital Readmissions Reduction Program Implementation With Readmission and Mortality Outcomes in Heart Failure – JAMA (link to abstract – $ for full-text)

Commentaries: To Fix the Hospital Readmissions Program, Prioritize What Matters – JAMA Forum (free) AND Readmissions reduction program linked to increased mortality for heart failure patients – Cardiovascular Business (free) AND Going the Wrong Way: ACA’s Readmission Reduction Program Linked To Increased Heart Failure Deaths – MedicalResearch (free) AND Hospital quality-control program tied to rise in heart failure deaths – Reuters (free)

Related: The data are in, but debate rages: Are hospital readmission penalties a good idea? – STAT (free)


9 – Report: Strategies to Limit Sugar-Sweetened Beverage Consumption in Young Children – The National Academies Press (free PDF)


10 – A strategy of ‘delayed antibiotic prescribing’ for respiratory infections may reduce antibiotic use – NIHR Signal (free)

Original article: Delayed antibiotic prescriptions for respiratory infections – Cochrane Library (free) AND Summary: Delayed antibiotic prescriptions for respiratory tract infections – Cochrane Library (free)


Thu, January 4 – 10 Stories of The Day!

4 Jan,2018


1 – Draft Recommendation Statement: Cardiovascular Disease Risk: Screening With Electrocardiography – U.S. Preventive Services Task Force (free)

Commentaries: USPSTF Examines ECG Screening to Prevent CVD Events, AFib – AAFP (free) AND USPSTF Doesn’t Endorse Routine ECG for Atrial Fibrillation Detection or CVD Prevention – Physician’s First Watch (free) AND USPSTF Releases Draft Recommendations on ECG Screening for CVD, A-fib – TCTMD (free)


2 – Association of Broad- vs Narrow-Spectrum Antibiotics With Treatment Failure, Adverse Events, and Quality of Life in Children With Acute Respiratory Tract Infections – JAMA (link to abstract – $ for full-text)

Commentaries: Study: For kids with respiratory infections, broader isn’t better – CIDRAP (free) AND Treatment Failure, or is Treatment the Failure? – Emergency Medicine Literature of Note Blog (free)


3 – Endoscopic Treatment versus Shunting for Infant Hydrocephalus in Uganda – The New England Journal of Medicine (free)

Commentaries: Two surgical approaches equal in treating infection-caused hydrocephalus – PennState Health News (free) AND Surgery For Saving Babies From ‘Water On The Brain’ Developed in Uganda – NPR Goats and Soda (free)


4 – Childhood and Adolescent Adversity and Cardiometabolic Outcomes: A Scientific Statement From the American Heart Association – Circulation (free PDF )

News release: Abuse and adversity in childhood linked to more cardiovascular risk in adulthood (free)

Commentaries: Distressing experiences as a kid impact cardiovascular health later in life – AHA News (free) AND Adversity In Childhood and Adolescence Sets Stage for Cardiometabolic Outcomes – AHA Centers for Health Metrics and Evaluation (free)


5 – Association of Long-term Exposure to Airborne Particulate Matter of 1 μm or Less With Preterm Birth in China – JAMA Pediatrics (free)

Commentary: Exposure to fine particulate pollution linked to increase in early births: study – The Sidney Morning Herald (free)

Source: Global Health NOW Newsletter

See related news and commentaries on The Impact of the Environment on Children’s Health and on Air Pollution and Mortality


6 – Association of Short-term Exposure to Air Pollution With Mortality in Older Adults – JAMA (link to abstract – $ for full-text)

Commentaries: Short-term exposure to low levels of air pollution linked with premature death among US seniors – Harvard T.H. Chan School of Public Health, via EurekAlert (free) AND Even ‘Safe’ Levels of Air Pollution Tied to Higher Mortality – Medscape (free registration required) AND Low-Level Pollution Exposures Increase Death Risk Among Elderly – MedPage Today (free registration required)

See related news and commentaries on The Impact of the Environment on Children’s Health and on Air Pollution and Mortality


7 – Tackling the High Cost of Cancer Care – The ASCO Post (free)

Original abstract: A prospective international randomized phase II study evaluating the food effect on the pharmacokinetics (PK) and pharmacodynamics (PD) of abiraterone acetate (AA) in men with castration-resistant prostate cancer (CRPC) (free) AND Commentary: A group of cancer doctors discovered a way to slash the cost of expensive pills by up to 75%, but they’ve hit a wall – Business Insider (free)

Related Website (news section): Value in Cancer Care Consortium (free resources)

See also other articles and commentaries on financial toxicity of cancer treatments


8 – Whole-system approaches to improving the health and wellbeing of healthcare workers: A systematic review – PLOS One (free)


9 – Suicide Risk Behaviors Among Sexual Minority Adolescents in the United States, 2015 – JAMA (link to abstract – $ for full-text)

Commentaries: LGBQ teens face serious suicide risk, research finds – CNN (free) AND LGBQ Adolescents at Much Greater Risk of Suicide than Heterosexual Counterparts – MyScience (free) AND Suicide Risk Rife in Sexual Minority Teens – Medscape (free registration required) AND Sexual minority young people are at a higher risk for suicide – San Diego State University, via EurekAlert (free)


10 – Safety of Magnetic Resonance Imaging in Patients with Cardiac Devices – The New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: MRI scan safe for most people with older pacemakers, defibrillators – Reuters (free) AND Even Thoracic MRI Safe for ‘Legacy’ ICDs, Pacemaker Systems: Large Cohort Study – Medscape (free registration required) AND MRIs safe with older pacemakers, study finds – MedicalXpress (free)


Wed, January 3 – 10 Stories of The Day!

3 Jan,2018


1 – Association Between Calcium or Vitamin D Supplementation and Fracture Incidence in Community-Dwelling Older Adults: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)

Commentaries: Calcium and vitamin D supplements not associated with lower risk of fractures – OnMedica (free) AND Do Vitamin D, Calcium Supplements Cut Fracture Risk in Older Patients? – MPR (free) AND Vitamin D and Calcium Don’t Prevent Bone Fractures – The New York Times (10 articles per month are free) AND Calcium And Vitamin D Supplements Still Do Not Prevent Fractures – American Council on Science and Health (free)


2 – The use of probiotics to prevent Clostridium difficile diarrhea associated with antibiotic use – Cochrane Library (free)

See related meta-analysis: Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection (free)

“Based on this systematic review and meta-analysis of 31 randomized controlled trials including 8672 patients, moderate certainty evidence suggests that probiotics are effective for preventing C. difficile-associated diarrhea”


3 – Mandrola’s Top 10 Cardiology Stories of 2017 – Medscape (free registration required)


4 – Top nephrology-related stories of 2017 – NephJC (free)


5 – Regional Variation of Computed Tomographic Imaging in the United States and the Risk of Nephrectomy – JAMA Internal Medicine (link to abstract – $ for full-text)

Editorial: Use of Advanced Imaging Tests and the Not-So-Incidental Harms of Incidental Findings (link to abstract – $ for full-text)

Commentary: Trunk Imaging Tied to Higher Nephrectomy Risk – MedPage Today (free registration required)

“The remarkable number of unnecessary CT scans and their downstream risk from incidental findings” (via @EricTopol see Tweet)


6 – Overdiagnosis across medical disciplines: a scoping review – The BMJ Open (free) (via @brooke_nickel)


7 – Prevalence of Work-Related Musculoskeletal Disorders Among Surgeons and Interventionalists: A Systematic Review and Meta-analysis – JAMA Surgery (free)

Author Interview: Work-Related Musculoskeletal Disorders Among Surgeons and Interventionalists (free)

Commentary: Work-Related Musculoskeletal Injury Common in Surgeons, Interventionalists – Medscape (free registration required)


8 – Richard Lehman’s journal review, 2 January 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.


9 – Infographic: Date Night with the EHR – NEJM Catalyst (free)

Related Guideline: Putting Patients First by Reducing Administrative Tasks in Health Care: A Position Paper of the American College of Physicians (free)

Related Commentary: Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free)


10 – Comparative Effectiveness of Implementation Strategies for Blood Pressure Control in Hypertensive Patients: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Meta-Analysis: It Takes a Team to Optimize Hypertension Tx – MedPage Today (free registration required) AND Blood pressure control best achieved with a multilevel, multicomponent approach – American College of Physicians, via EurekAlert (free)


Tue, January 2 – 10 Stories of The Day!

2 Jan,2018


1 – 2017 year in review: key health issues – World Health Organization (free)

Review the biggest health stories from WHO in 2017.


2 – Biggest global health moments of 2017 – Devex (free)


3 – No interventions proven to prevent late-life dementia, systematic reviews find – ACP Internist (free)

Other Commentaries: No Magic Bullet for Preventing Late-Life Dementia – Physician’s Weekly (free) AND No interventions proven to prevent late-life dementia – MedicalXpress (free)

Original Articles:

– Physical Activity Interventions in Preventing Cognitive Decline and Alzheimer-Type Dementia: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)

– Pharmacologic Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)

– Does Cognitive Training Prevent Cognitive Decline?: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)

– Over-the-Counter Supplement Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)


4 – Best 10 ICU Trials of 2017 – from The Bottom Line (free)

(via @azevedo_lcp and @Gas_Craic see Tweet with infographic summarizing the review)


5 – “Less is More”: The New paradigm in Critical Care – by Paul Marik, in EMCrit (free)


6 – What We Mean When We Say Evidence-Based Medicine – The New York Times (10 articles per month are free)


7 – Opinion: The evidence keeps piling up: e-cigarettes are definitely safer than smoking – The Guardian Science (free)

Related guidelines and reports: Balancing risks and opportunities – British Medical Association (free PDF) AND Nicotine without smoke: Tobacco harm reduction – Royal College of Physicians (free summary and PDF) AND RCGP Position Statement on the use of electronic nicotine vapour products (E-Cigarettes) – Royal College of General Practitioners (free PDF)

See related STAT News story addressing the question: “Should we settle for lesser harms?”.


8 – Medical News & Perspectives: Will the FDA’s New Tobacco Strategy Be a Game Changer? – JAMA (free)

See also related news about the new FDA regulatory plan to shift trajectory of tobacco-related disease and death


9 – 2017 ACC Expert Consensus Decision Pathway for Optimization of Heart Failure Treatment: Answers to 10 Pivotal Issues About Heart Failure With Reduced Ejection Fraction – Journal of the American College of Cardiology (free)

Commentaries: New Guidance Issued to Optimize Heart Failure Treatment – American College of Cardiology, Latest in Cardiology (free) AND Expert Consensus on Optimization of Heart Failure Treatment – American College of Cardiology, Latest in Cardiology (free) AND HFrEF Tx Guidelines Catch Up with New Therapies – MedPage Today (free registration required)


10 – Meta-Analysis of Culprit-Only Versus Multivessel Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction and Multivessel Coronary Disease – American Journal of Cardiology (link to abstract – $ for full-text)

Commentary: STEMI Patients With Multivessel Disease Best Served by a Single, Complete Procedure: Meta-analysis – TCTMD (free)

Related Systematic Review: Complete versus culprit-only revascularisation in ST elevation myocardial infarction with multi-vessel disease – Cochrane Library (free) AND Summary How should we deal with non-culprit lesions during a STEMI? A mid-night conundrum – Evidently Cochrane (free)


Fri, December 15 – 10 Stories of The Day!

15 Dec,2017


1 – Tracking Universal Health Coverage: 2017 Global Monitoring Report – Joint Report from the World Bank and the World Health Organization (free PDF)

Press Release: World Bank and WHO: Half the world lacks access to essential health services, 100 million still pushed into extreme poverty because of health expenses (free)

Infographic: Tracking Universal Health Coverage: 2017 Global Monitoring Report (free)

Commentaries: Healthcare costs are pushing millions into extreme poverty. This outrage must end – World Economic Forum (free) AND Almost 100 million people a year ‘forced to choose between food and healthcare’ – The Guardian (free)


2 – Is treatment with corticosteroids beneficial and safe for people with pneumonia? – The Cochrane Library (free)

Related: Corticosteroids for Pneumonia: Ready for Primetime? – emDocs (free)

“Corticosteroid therapy reduced mortality and morbidity in adults with severe CAP; the number needed to treat for an additional beneficial outcome was 18 patients (95% CI 12 to 49) to prevent one death. Corticosteroid therapy reduced morbidity, but not mortality, for adults and children with non-severe CAP”


3 – Estimates of global seasonal influenza-associated respiratory mortality: a modelling study – The Lancet (link to abstract – $ for full-text)

Commentaries: Respiratory diseases linked to seasonal flu claim thousands of lives every year – UN health agency (free) AND Up to 650 000 people die of respiratory diseases linked to seasonal flu each year – World Health Organization (free) AND CDC says more people die of influenza worldwide than some experts have estimated – PBS NewsHour (free)


4 – Effect of High-Intensity Treadmill Exercise on Motor Symptoms in Patients With De Novo Parkinson Disease: A Phase 2 Randomized Clinical Trial – JAMA Neurology (link to abstract – $ for full-text)

Commentaries: Exercise May Aid Parkinson’s Disease, but Make It Intense – The New York Times (10 articles per month are free) AND High-Intensity Exercise May Cut Parkinson’s Motor Symptoms – Medscape (free registration required) AND Vigorous Exercise May Hold Benefit in Early Parkinson’s – MedPage Today (free registration required) High-intensity exercise delays Parkinson’s progression – Northwestern University, via ScienceDaily (free)


5 – Associations between fast food and physical activity environments and adiposity in mid-life: cross-sectional, observational evidence from UK Biobank – The Lancet Public Health (free)

Commentaries: The built environment and obesity in UK Biobank: right project, wrong data? – The Lancet Public Health (free) AND Living near exercise facilities linked to lower BMI and smaller waists – OnMedica (free) Living near physical activity facilities linked to smaller waistline, lower BMI and lower body fat percentage – London School of Hygiene & Tropical Medicine (free)


6 – Association between microcephaly, Zika virus infection, and other risk factors in Brazil: final report of a case-control study – The Lancet Infectious Diseases (link to abstract – $ for full-text) (via @Onisillos)

Commentaries: Zika virus, not vaccine or insecticide, linked to birth defects in Brazil – STAT (free) AND Study bolsters Zika-microcephaly link, rules out others – CIDRAP (free)


7 – Healthcare-acquired infections: prevention strategies – Internal Medicine Journal (free)

Source: Hospital Medicine Virtual Journal Club


8 – Association Between Methylphenidate and Amphetamine Use in Pregnancy and Risk of Congenital Malformations: A Cohort Study From the International Pregnancy Safety Study Consortium – JAMA Psychiatry (free)

Editorial: Shedding Light on the Risks of Methylphenidate and Amphetamine in Pregnancy (free)

Commentary: ADHD med use during pregnancy and risk of birth defects – Brigham and Women’s Hospital, via ScienceDaily (free) AND Class of ADHD medication linked to increased risk of congenital heart defects – Cardiovascular Business (free)

“Researchers find small increase in the risk of heart defects following first-trimester exposure to methylphenidate but not to amphetamines” (from ScienceDaily)


9 – The Surprising Effects of Loneliness on Health – The New York Times (10 articles per month are free)


10 – Individualized Glycemic Control for U.S. Adults With Type 2 Diabetes: A Cost-Effectiveness Analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Individualized Glycemic Control Could Safely Cut Costs in Type 2 Diabetes – Physician’s First Watch (free) AND Individualized HbA1c Targets for Diabetes Drop Cost, Improve QoL – Medscape (free registration required) AND Personalized Blood Sugar Goals Can Save Diabetes Patients Thousands – University of Chicago Medical Center, via NewsWise (free)


Thu, December 14 – 10 Stories of The Day!

14 Dec,2017


1 – The BMJ Christmas Issue – “The soul of the Christmas issue is originality. We don’t want to publish anything that resembles anything we’ve published before” (see details).


Original Article 1: Does Peppa Pig encourage inappropriate use of primary care resources? (free) AND Commentary: Peppa Pig might inspire unrealistic expectations of GPs – OnMedica (free)

Original Article 2 The science behind “man flu” (free) AND Commentary: Of mice and “man flu” – HealthNewsReview (free)

See also: The top six BMJ Christmas papers – Medical News Today (free) AND The BMJ Holiday Issue: Rain Doesn’t Mean More Joint Pain; Wine Glasses Getting Bigger – Physician’s First Watch (free)


2 – The Less-Is-More Crusade — Are We Overmedicalizing or Oversimplifying? – New England Journal of Medicine (free)


3 – Noninvasive Cardiac Radiation for Ablation of Ventricular Tachycardia – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: A ‘Game Changer’ for Patients With Irregular Heart Rhythm – The New York Times (10 articles per month are free)

“The use of stereotactic radiotherapy in five patients with refractory ventricular tachycardia (VT) showed a 99.9% reduction in VT burden”. (via @NEJM see Tweet with infographic)


4 – The American Society of Colon and Rectal Surgeons Clinical Practice Guideline for the Prevention of Venous Thromboembolic Disease in Colorectal Surgery – Diseases of The Colon & Rectum (free)


5 – AAFP Decides to Not Endorse AHA/ACC Hypertension Guideline – American Academy of Family Physicians (free) (via @kennylinafp see Tweet)

Commentary: New Hypertension Guideline: A Case of Guideline Creep? – Medscape (free registration required)


6 – Artificial Intelligence Promising for CA, Retinopathy Diagnoses – Physician’s Weekly (free)

Original Article 1: Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer – JAMA (link to abstract – $ for full-text) AND Commentary: Findings Show Potential Use of Artificial Intelligence in Detecting Spread of Breast Cancer – The JAMA Network (free)

Original Article 2: Development and Validation of a Deep Learning System for Diabetic Retinopathy and Related Eye Diseases Using Retinal Images From Multiethnic Populations With Diabetes – JAMA (link to abstract – $ for full-text) AND Commentary: Artificial Intelligence Detects Diabetic Retinopathy and Related Eye Diseases among Patients with Diabetes – The JAMA Network (free)


7 – People Don’t Take Their Pills. Only One Thing Seems to Help. – The New York Times (10 articles per month are free)

“High-tech approaches and “reminder” packaging don’t work well. Reducing prices does”.


8 – Supplement: The Economics of Hypertension and Cardiovascular Disease – American Journal of Preventive Medicine (free editorials, reviews and research articles)

Source: EvidenceAlerts


9 – Phone Addiction Is Real — And So Are Its Mental Health Risks – Forbes (free)

Related commentaries: We Need to Talk About Kids and Smartphones – TIME (free) AND Have Smartphones Destroyed a Generation? – The Atlantic (free) How Smartphones Hijack Our Minds – The Wall Street Journal (a few articles per month are free)


10 – Atraumatic versus conventional lumbar puncture needles: a systematic review and meta-analysis – The Lancet (link to abstract – $ for full-text)

Commentaries: Atraumatic needles associated with fewer side effects for lumbar puncture – ACP Hospitalist Weekly (free) AND Atraumatic Lumbar Puncture Needles Show Major Benefit in Meta-Analysis – Physician’s First Watch (free)


Wed, December 13 – 10 Stories of The Day!

13 Dec,2017


1 – The Altmetric TOP 100 Articles. What academic research caught the public imagination in 2017? (free)


2 – Universal Health Coverage Day, 12 December 2017 – World Health Organization (free resources)

Fact Sheet: Universal Health Coverage (UHC) – World Health Organization (free)

Related: Opinion: 5 ways to make progress towards universal health coverage – Devex (free)


3 – Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Women: US Preventive Services Task Force Recommendation Statement – JAMA (free)

JAMA Editorials: Menopausal Hormone Therapy for Primary Prevention of Chronic Disease (free) AND Evidence for Postmenopausal Hormone Therapy to Prevent Chronic Conditions: Success, Failure, and Lessons Learned (free) AND Menopausal Hormone Therapy for the Primary Prevention of Chronic Conditions: Unfulfilled Expectations (free)

Audio Interview: USPSTF Recommendation Statement: Hormone Therapy After Menopause (free)

Summary: Hormone Therapy Not Recommended for Prevention of Chronic Conditions in Postmenopausal Women – The JAMA Network (free)

“The U.S. Preventive Services Task Force (USPSTF) recommends against the use of combined estrogen and progestin in postmenopausal women, or estrogen alone in postmenopausal women who have had a hysterectomy, to prevent chronic conditions such as heart disease, dementia and stroke”.


4 – CAR T-Cell Therapies Drive Outcomes in Lymphoma, Myeloma: Treatments Hold Promise for People with Hard-to-Treat Blood Cancers – 2017 American Society of Hematology Annual Meeting (free)

Related commentary: CAR T-Cell Therapy Makes Further Inroads in Lymphoma and Myeloma – ASCO Post (free)

Related Study: Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas – New England Journal of Medicine (free), Editorial: A Milestone for CAR T Cells (free) AND Visual Abstract (free)


5 – Topical Tranexamic Acid Compared With Anterior Nasal Packing for Treatment of Epistaxis in Patients Taking Antiplatelet Drugs: Randomized Controlled Trial – Academic Emergency Medicine (link to abstract – $ for full-text)

Commentary: Topical TXA in Epistaxis – R.E.B.E.L.em (free)


6 – Get Ready For A Tsunami Of ECGs – Cardiobrief (free)

Related: Thoughts on the Apple Watch and Mobile ECG, by Dr John Mandrola (free) AND Overdiagnosis Only a Matter of Time With ECG Watches – Medscape (free registration required)


7 – State of The Art Review: Recent advances in pre-exposure prophylaxis for HIV – The BMJ (free fo 2 weeks)

Related Guidelines: WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection – World Health Organization (free) AND Summary: WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection (free PDF)

Related Commentary: Why PrEP takers should still use condoms with HIV+ partners – The Conversation (free)


8 – All-cause mortality and major cardiovascular outcomes comparing percutaneous coronary angioplasty versus coronary artery bypass grafting in the treatment of unprotected left main stenosis: a meta-analysis of short-term and long-term randomised trials – OpenHeart (free)

“PCI is associated with a reduction in the risk of major cardiovascular outcomes at short-term follow-up in patients with LMCA stenosis; but at long term, MACCE rate is increased for PCI”


9 – Pediatric Injuries Related to Window Blinds, Shades, and Cords – Pediatrics (free)

Commentaries: Researchers: Window Blind Cords as Dangerous to Young Children as Bodies of Water – Physician’s First Watch (free) AND Kids continue to die in window-blind accidents, despite safety warnings – Reuters (free)


10 – Severe COPD and the transition to a palliative approach – Breathe (free)

See more on palliative care in chronic respiratory disorders in our Decembe 6th issue (see #10)


Tue, December 12 – 10 Stories of The Day!

12 Dec,2017


1 – The other big drug problem: Older people taking too many pills – The Washington Post (free)

Related Articles and Commentaries: Current and future perspectives on the management of polypharmacy – BMC Family Medicine (free) 11 Drugs You Should Seriously Consider Deprescribing – Medscape Slideshow (free registration required) AND Too Many Meds? America’s Love Affair With Prescription Medication – Consumer Reports (free) AND Common ED Medication Errors: Polypharmacy – emDocs (free)

Related Website and Guidelines: Canadian Deprescribing Network (CaDeN) (free) AND CaDeN Deprescribing Guidelines and Algorithms (free) AND Deprescribing guidelines for the elderly – Ontario Pharmacy Evidence Network (free)


2 – Treated Incidence of Psychotic Disorders in the Multinational EU-GEI Study – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Environment May Play Major Role in Psychosis – PsychCentral (free) AND Psychosis incidence highly variable internationally – University College London, via EurekAlert (free)


3 – Mortality Associated with Metformin Versus Sulfonylurea Initiation: A Cohort Study of Veterans with Diabetes and Chronic Kidney Disease – Journal of General Internal Medicine (link to abstract – $ for full-text)

Commentaries: Metformin appears better than sulfonylureas as first-line therapy for patients with CKD – ACP Diabetes (free) AND Metformin May Up Survival in Older Men With Moderate CKD – Medscape (free registration required)


4 – Diet quality is associated with disability and symptom severity in multiple sclerosis – Neurology (link to abstract – $ for full-text)

Commentaries: Healthy diet may be linked to less disability, fewer symptoms for people with MS – News Medical (free) AND High-quality Diet, Healthy Lifestyle May Reduce MS Disability – Medscape (free registration required) AND Healthy Diet Tied to Less MS Disability – MedPage Today (free registration required)


5 – Review: Lung Manifestations in the Rheumatic Diseases – Chest (free)

Source: Critical Care Reviews Newsletter


6 – Review: Diagnosis and treatment of hyperkalemia – Cleveland Clinic Journal of Medicine (free)

Source: Critical Care Reviews Newsletter


7 – Viewpoint: Disclosures in Nutrition Research: Why It Is Different – JAMA (free)

“Medical researchers must disclose financial conflicts of interest. An article in @JAMA_current says nutrition researchers should also be obliged to disclose their food-related religious beliefs, comments to the public and personal diet”. (via @davidludwigmd see Tweet)


Expert consensus document: Advances in the physiological assessment and diagnosis of GERD – Nature Reviews Gastroenterology & Hepatology (free)

Commentary: Expert Consensus on the Assessment and Diagnosis of GERD – PracticeUpdate (free registration required)


9 – Intrauterine insemination with ovarian stimulation versus expectant management for unexplained infertility (TUI): a pragmatic, open-label, randomised, controlled, two-centre trial – The Lancet (link to abstract – $ for full-text)

Commentary: Fertility study shows cheaper treatment is effective – MedicalXpress (free)


10 – Caesarean section is better for extremely premature breech babies but not necessarily for their mothers – NIHR Signal (free)

“Delivering extremely preterm breech babies (23 to 27 weeks) by caesarean reduced the risk of infant death or brain bleeds by around 40%, compared with vaginal delivery”. (RT @NIHR_DC see Tweet)


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