Open access

Fri, September 15 – 10 Stories of The Day!



1 – 2017 HIVMA of IDSA Clinical Practice Guideline for the Management of Chronic Pain in Patients Living With HIV – Clinical Infectious Diseases (free)


2 – Education and coronary heart disease: mendelian randomisation study – The BMJ (free)

Commentary: Going to university may cut your risk of heart disease – NHS Choices (free)


3 – Association Between More Intensive vs Less Intensive Blood Pressure Lowering and Risk of Mortality in Chronic Kidney Disease Stages 3 to 5: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Intensive blood pressure lowering linked to decreased mortality in patients with chronic kidney disease – 2 Minute Medicine (free) AND Intensive BP Lowering in Chronic Kidney Disease Associated with Lower Mortality – Physician’s First Watch (free) AND Is Strict BP Control a Good Bet for CKD Patients? – MedPage Today (free registration required)


4 – Pathophysiology, diagnosis and treatment of tachycardiomyopathy – Heart (free)

Source: Critical Care Review Newsletter


5 – Corticosteroid or Nonsteroidal Antiinflammatory Drugs for the Treatment of Acute Gout: A Systematic Review of Randomized Controlled Trials – The Journal of Rheumatology (free)

Source: EvidenceAlerts

Corticosteroids and NSAIDs did not have different effects on pain scores, but there was a higher risk of indigestion, nausea and vomiting with NSAIDs.


6 – New Series: The World Bank and financing global health – The BMJ

– World Bank’s financing, priorities, and lending structures for global health (free)

– Universal health coverage, health systems strengthening, and the World Bank (free)

– World Bank and the Global Financing Facility (free)

– Earmarking for global health: benefits and perils of the World Bank’s trust fund model (free)

– Health as a “global public good”: creating a market for pandemic risk (free)

– Baines and Babar: Why medical practitioners should be interested in the World Bank (free)


7 – The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis – The Lancet (free)

Commentaries: Sleep improvement by internet-based cognitive behavioural therapy might help prevent mental health disorders – The Lancet (free) AND Lack of sleep could contribute to mental health problems, researchers reveal – The Guardian (free) AND Tackling insomnia may be key to easing mental health issues – OnMedica (free)


8 – Protocol for the management of psychiatric patients with psychomotor agitation – BMC Psychiatry (free)


9 – A range of anti-epilepsy drugs are effective as first-line treatment – NIHR Signal (free)

Original article: Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data – Cochrane Library (link to abstract – $ for full-text)


10 – Osteoporosis drug treatment: duration and management after discontinuation. A position statement from the SVGO/ASCO – Swiss Medical Weekly (free)


Thu, September 14 – 10 Stories of The Day!



1 – Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016 – The Lancet (free)

Commentary: IHME releases second annual report on the Sustainable Development Goal indicators – Institute for Health Metrics and Evaluation (free)

See also: Health-related Sustainable Development Goals visualization tool, which allows users to compare and contrast between countries and among indicators, and the United Nations Sustainable Development Goals Website.


2 – Guideline: Prevention of Early-onset Neonatal Group B Streptococcal Disease – Royal College of Obstetricians and Gynaecologists (free)

News release: Group B Streptococcal Disease, Early-onset (free)

Commentaries: Antibiotics for women in early labour to combat Group B Strep – OnMedica (free) AND More pregnant women to get Group B Strep treatment – BBC News (free)


3 – Review article: Randomized, Controlled Trials in Health Insurance Systems – New England Journal of Medicine (free)

See also other articles in The Changing Face of Clinical Trials Series (all free)


4 – Benefit of Patent Foramen Ovale Closure Seen in Selected Patients with Cryptogenic Stroke – Journal Watch (free)

Original articles from the New England Journal of Medicine: Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke (link to abstract – $ for full-text) AND Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke (link to abstract – $ for full-text) AND Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke (link to abstract – $ for full-text)


5 – The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Treatment of Colon Cancer (free)


6 – Prevention of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline (free)


7 – European Respiratory Society guidelines for the management of adult bronchiectasis (free)


8 – Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: systematic review and meta-analysis of relapse prevention trials – The BMJ (free)

Commentary: Researchers: Antidepressants for Anxiety Should Be Continued for at Least a Year After Treatment Response – Physician’s First Watch (free)


9 – Association Between Laparoscopic Antireflux Surgery and Recurrence of Gastroesophageal Reflux – JAMA (link to abstract – $ for full-text)

Commentaries: Laparoscopic Antireflux Surgery Associated With High Rate of Recurrence of GERD – The JAMA Network (free) AND GERD Recurrence Fairly Common Following Laparoscopic Antireflux Surgery – Physician’s First Watch (free) AND High recurrence of gastroesophageal reflux disease in patients treated with laparoscopic antireflux surgery – 2 Minute Medicine (free)


10 – Differential blood pressure effects of ibuprofen, naproxen, and celecoxib in patients with arthritis: the PRECISION-ABPM (Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen Ambulatory Blood Pressure Measurement) Trial – European Heart Journal (free)

Commentaries: Under Pressure: PRECISION Substudy Shows Adverse BP Effects of Ibuprofen – TCTMD (free) AND Increases in BP, Hypertension Incidence Linked to Certain NSAIDs – MPR (free) AND Ibuprofen Ups Systolic BP, New-Onset Hypertension Risk – Medscape (free registration required)


Wed, September 13 – 10 Stories of The Day!



1 – International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia (free) (RT @CritCareReviews see Tweet)


2 – Report: Preventing noncommunicable diseases (NCDs) by reducing environmental risk factors – World Health Organization (free)

We welcome new @WHO report, showing 23% of all deaths can be prevented through healthier environments” (RT @HealthandEnv see Tweet)


3 – Draft Recommendation Statement: Cervical Cancer: Screening – U.S. Preventive Services Task Force (free)

Commentaries: USPSTF Draft Recommendation Eliminates Cervical Cytology-HPV Cotesting for Women Over 30 – Physician’s First Watch (free) AND USPSTF: Pap Test or HPV Test, Not Both, For Most Cervical Ca Screening – MedPage Today (free registration required) AND USPSTF Has New Draft Guidance for Cervical Cancer Screening – Medscape (free registration required) AND Age matters when it comes to screening for cervical câncer – STAT (free)


4 – Research and Development Spending to Bring a Single Cancer Drug to Market and Revenues After Approval – JAMA Internal Medicine (free)

Author interview: Cost of Developing a Single Cancer Drug (free audio)

Invited commentary: A Much-Needed Corrective on Drug Development Costs (free)

Commentaries: R&D Costs For Cancer Drugs Are Likely Much Less Than Industry Claims, Study Finds – NPR (free) AND A new study undermines Big Pharma’s justification for charging high drug prices – Business Insider (free) AND What Does It Cost to Create a Cancer Drug? Less Than You’d Think – The New York Times (10 articles per month are free)


5 – Antiretroviral therapy in pregnant women living with HIV: a clinical practice guideline – The BMJ (free guideline and infographic)


6 – Menopausal Hormone Therapy and Long-term All-Cause and Cause-Specific Mortality: The Women’s Health Initiative Randomized Trials – JAMA (link to abstract – $ for full-text)

Commentaries: Taking Hormones for Menopause Doesn’t Raise Early Death Risk – The New York Times (free) AND Menopause hormone therapy not linked to premature death – Reuters (free) AND Menopause hormones don’t shorten lives, long follow-up says – STAT (free)


7 – Patient-Clinician Communication: American Society of Clinical Oncology Consensus Guideline (free)

News release: New Guideline Aims to Improve Clinician Communication With Patients (free)


8 – Laparoscopic and robotic-assisted versus open radical prostatectomy for the treatment of localised prostate cancer – Cochrane Library (free)

Original article: Laparoscopic and robotic-assisted versus open radical prostatectomy for the treatment of localised prostate cancer – Cochrane Library (link to abstract – $ for full-text)

“Urinary and sexual quality of life-related outcomes appear similar”.


9 – LDL-Cholesterol Lowering for the Primary Prevention of Cardiovascular Disease Among Men with Primary Elevations of LDL-Cholesterol Levels of 190 mg/dL or Above: Analyses from the WOSCOPS 5-year Randomised Trial and 20-year Observational Follow-Up – Circulation (free)

Commentary: Statins cut heart deaths in men by 28% finds study – NHS Choices (free)


10 – Role of Total, Red, Processed, and White Meat Consumption in Stroke Incidence and Mortality: A Systematic Review and Meta‐Analysis of Prospective Cohort Studies – Journal of The American Heart Association (free)

Increased consumption of red and processed meat may be associated with higher risk of stroke.


Tue, September 12 – 10 Stories of The Day!



1 – Treatment of Type 1 Diabetes: Synopsis of the 2017 American Diabetes Association Standards of Medical Care in Diabetes – Annals of Internal Medicine (free)


2 – Recommendations on screening for abdominal aortic aneurysm in primary care – Canadian Task Force on Preventive Health Care (free)

See also: Summary of recommendations for clinicians and policy-makers (free) AND Abdominal Aortic Aneurysm (AAA): 1000-Person Tool (free)

“The number of men >65 needed to screen to prevent one AAA related death is 796 (95% confidence interval 621–1242) @ 3-5 yr follow-up” (RT @cantaskforce see Tweet)


3 – Clinical Practice Guideline: Evaluation of the Neck Mass in Adults – American Academy of Otolaryngology—Head and Neck Surgery Foundation (free)

See also: Executive Summary (free) AND News Release (free)

Commentaries: Neck Mass in Adults: Guideline for Evaluation Provides Framework for Timely Diagnosis – NewsWise (free) AND Guidelines Issued on Evaluating Neck Masses – Physician’s First Watch (free)


4 – A Comparison of Alkaline Water and Mediterranean Diet vs Proton Pump Inhibition for Treatment of Laryngopharyngeal Reflux – JAMA Otolaryngology Head Neck Surgery (free)

Commentaries: Could a Mediterranean diet be as good as drugs for acid reflux? – NHS Choices (free) AND Dietary Approach Found as Effective as Medications for Treating Type of Reflux Disease – The JAMA Network (free) AND Treating Reflux With Diet – The New York Times (10 articles per month are free)

A small retrospective cohort study suggests a plant-based, Mediterranean-style diet may be as effective as medication.


5 – The Joint Associations of Sedentary Time and Physical Activity With Mobility Disability in Older People: The NIH-AARP Diet and Health Study – The Journals of Gerontology (free)

Commentaries: Get Off The Couch Baby Boomers, Or You May Not Be Able To Later – NPR (free) AND Prospective Study Shows Just How Bad TV Can Be – Medscape (free registration required) AND Prolonged sitting and TV watching ‘dangerous’ for seniors – Medical News Today (free) AND TV viewing ‘a potent risk factor’ for disability – OnMedica (free)


6 – Guideline: National Partnership for Maternal Safety: Consensus Bundle on Severe Hypertension During Pregnancy and the Postpartum Period – Obstetrics & Gynecology (free)

Commentary: Management of Severe Maternal Hypertension During Pregnancy and Postpartum – Journal Watch (free)


7 – Hormonal contraceptive eligibility for women at high risk of HIV: Guidance Statement – World Health Organization (free PDF)

News release: Can women who are at high risk of acquiring HIV, safely use hormonal contraception? (free)

Frequently asked questions: Hormonal contraceptive eligibility for women at high risk of HIV (free)

Guideline Summary: Hormonal contraceptive eligibility for women at high risk of HIV: guidance statement – National Guideline Clearinghouse (free)


8 – Cardiovascular disease risk and androgen deprivation therapy in patients with localised prostate cancer: a prospective cohort study – British Journal of Cancer (link to abstract – $ for full-text)

Commentaries: Prostate cancer treatment associated with higher risk of heart failure – Cardiovascular Business (free) AND Hormone Treatment for Prostate Cancer Tied to Heart Risks – The New York Times (10 articles per month are free)


9 – Richard Lehman’s journal review, 11 September 2017 (free)

Richard Lehman reviews the latest research in the top medical journals.


10 – Adverse effects of proton-pump inhibitor use in older adults: a review of the evidence – Therapeutic Advances in Drug Safety (free)


Mon, September 11 – 10 Stories of The Day!



1 – Coursera – Free Online Health & Medicine Courses Starting Today!

– Easing the burden of obesity, diabetes and cardiovascular disease – University of Sidney

– Leading Healthcare Quality and Safety – The George Washington University

– Introduction to the Biology of Cancer – Johns Hopkins University

– Understanding Clinical Research: Behind the Statistics – University of Cape Town

– Health Across the Gender Spectrum – Stanford University

– Public Health in Humanitarian Crises – Johns Hopkins University

– Major Depression in the Population: A Public Health Approach – Johns Hopkins University

– Genomics: Decoding the Universal Language of Life – University of Illinois at Urbana-Champaign

– Living with Dementia: Impact on Individuals, Caregivers, Communities and Societies – Johns Hopkins University

– Health Care IT: Challenges and Opportunities – Icahn School of Medicine at Mount Sinai

– The People, Power, and Pride of Public Health – Johns Hopkins University

– The Science of Health Care Delivery – Arizona State University

– PrEParing: PrEP for Providers and Patients – Johns Hopkins University


2 – Management of Cardiac Involvement Associated With Neuromuscular Diseases: A Scientific Statement From the American Heart Association (free PDF)

News release: Experts aim to improve treatment for heart complications in people with neuromuscular disorders (free)

Top Ten Things to Know: Management of Cardiac Involvement Associated With Neuromuscular Diseases (free PDF)

Commentary: Statement on the Management of Cardiac Involvement Associated With Neuromuscular Diseases – Practice Update (free registration required)


3 – Comprehensive primary prevention of cardiovascular disease in women – Clinical Cardiology (free)


4 – Opinion: Cardiology Is Dead. Long Live Public Health – Cardiobrief (free)


5 – 11 Drugs You Should Seriously Consider Deprescribing – Medscape Slideshow (free registration required)

Related: Canadian Deprescribing Network (CaDeN) (free) AND CaDeN Deprescribing Guidelines and Algorithms (free) AND Deprescribing guidelines for the elderly – Ontario Pharmacy Evidence Network (free) AND Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Too Many Meds? America’s Love Affair With Prescription Medication – Consumer Reports (free) AND Patient often prescribed potentially futile drugs in their final months of life – Science Daily AND The Challenge of Polypharmacy: From Rhetoric to Reality – Royal Pharmaceutical Society and Royal College of General Practitioners Partnership (free PDF) Current and future perspectives on the management of polypharmacy – BMC Family Practice (free)


6 – Educating Girls, Ending Child Marriage – World Bank (free)

Related infographic and report: Putting a Price Tag on Child Marriage

“By keeping girls in school, girls would have a better chance for safety and security, to health and education, and to make their own life choices and decisions”.

“Being born to a mother younger than 18 increases the risk dying by the age of 5” (RT @WBG_Health see Tweet)


7 – Guidance on Forgoing Life-Sustaining Medical Treatment – Pediatrics (free)

News Release: Balancing act: Weighing the decision to withhold life-sustaining medical treatment (free)


8 – Palliative Care in Heart Failure: The PAL-HF Randomized, Controlled Clinical Trial – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Palliative Care Intervention Improves Quality of Life in Advanced Heart Failure Patients – American College of Cardiology, Latest in Cardiology (free) AND Palliative Care & CHF: PAL-HF trial – Pallimed (free)


9 – Development and risk factors of type 2 diabetes in a nationwide population of women with polycystic ovary syndrome – The Journal of Clinical Endocrinology & Metabolism (link to abstract – $ for full-text)

Commentaries: Type 2 diabetes risk four times higher in women with PCOS – Medical News Today (free) AND Researchers reveal link between PCOS, type 2 diabetes – The Endocrine Society, via EurekAlert (free)


10 – Addressing the Social Needs of Hypertensive Patients: The Role of Patient–Provider Communication as a Predictor of Medication Adherence – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Hypertension Medication Adherence May Be Improved by Collaborate Communication – Cardiology Advisor (free) AND Better Provider Communication Might Improve Medication Adherence – Medscape (free registration required) AND Talk Why, Not What for Better Antihypertensive Adherence – MedPage Today (free)

“Odds of poor med adherence 6x greater when patient-provider interactions don’t address patients’ unmet social needs” (RT @CircOutcomes see Tweet)


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