Open access


Thu, April 5 – 10 Stories of The Day!

5 Apr,2018


1 – Routine Assessment and Promotion of Physical Activity in Healthcare Settings: A Scientific Statement From the American Heart Association (free PDF)

Commentary: Promoting Physical Activity in Routine Health Care: Time to Walk the Talk (free)

Top Ten Things to Know: Routine Assessment and Promotion of Physical Activity in Healthcare Settings (free PDF)


2 – Tax sugar, alcohol and tobacco to help the poor, say experts – The Guardian (free)

See also: To Improve Global Health, Tax the Things that are Killing Us (free policies, articles and commentaries)


3 – Preconception Blood Pressure Levels and Reproductive Outcomes in a Prospective Cohort of Women Attempting Pregnancy – Hypertension (link to abstract – $ for full-text)

Commentaries: Higher blood pressure before pregnancy may increase miscarriage risk – American Heart Association, via ScienceDaily (free) AND High blood pressure before pregnancy linked to heightened miscarriage risk – OnMedica (free) AND Slightly high blood pressure before pregnancy tied to miscarriage risk – Reuters (free) AND Higher Blood Pressure Before Conception Tied to Miscarriage – MedPage Today (free registration required)


4 – Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques – Science Translational Medicine (link to abstract – $ for full-text)

Commentaries: Monkey study suggests Zika infection in infancy could cause brain damage – STAT (free) AND Zika Exposure Even after Birth May Lead to Brain Damage – Scientific American (free)


5 – Associations of Bariatric Surgery With Changes in Interpersonal Relationship Status: Results From 2 Swedish Cohort Studies – JAMA Surgery (link to abstract – $ for full-text)

Commentaries: Relationship changes after bariatric surgery – University of Gothenburg, via EurekAlert (free) AND Big weight loss may bring big relationship changes – UPI (free)


6 – Time to Endovascular Treatment and Outcome in Acute Ischemic Stroke: MR CLEAN Registry Results – Circulation (link to abstract – $ for full-text)

Commentary: Time to endovascular therapy predicted functional outcome after stroke in registry study – ACP Hospitalist (free)

“Every hour of delay from stroke onset to the start of endovascular therapy resulted in a 5.3% decreased probability of functional independence” (from ACP Hospitalist)


7 – Change in Overweight from Childhood to Early Adulthood and Risk of Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Heavy kids who normalize weight in childhood can avoid extra diabetes risk – Reuters (free) AND Normalizing Weight By Puberty May Drop Diabetes Risk Later – Medscape (free registration required)


8 – Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma – NEJM (link to abstract – $ for full-text)

Quick Take Video Summary: Sunitinib or Nivolumab plus Ipilimumab for Renal-Cell Carcinoma (free)

Overall survival and objective response rates were significantly higher with nivolumab plus ipilimumab”.


9 – Review: Management of Left Main Coronary Artery Disease – Journal of the American Heart Association (free for a limited period)


10 – Socioeconomic status, non-communicable disease risk factors, and walking speed in older adults: multi-cohort population based study – The BMJ (free)

“New work in @bmj_latest shows poverty increases ageing. Measured by walking speed. 60 y.o. men of lower social class walk like 66 y.o. men of higher social class. As important as physical inactivity, obesity or diabetes. Worse than smoking”. (via @astaines see Tweet)


Wed, April 4 – 10 Stories of The Day!

4 Apr,2018


1 – Association of a Negative Wealth Shock With All-Cause Mortality in Middle-aged and Older Adults in the United States – JAMA (free for a limited period)

Commentaries: Financial Ruin Can Be Hazardous To Your Health – NPR (free) AND Losing your nest egg can kill you – Northwestern University, via ScienceDaily (free)

“People have a 50 percent higher risk of death if they suffer a shocking financial loss” (via ScienceDaily)


2 – Characteristics of Infant Deaths during Sleep While Under Nonparental Supervision – The Journal of Pediatrics (free)

Commentaries: Babies At Risk Of Being Put In Unsafe Sleep Positions By Babysitters And Relatives, Study Suggests – HuffPost (free) AND Infant death study reveals dangerous sleep practices among babysitters, relatives, others – University of Virginia Health System, via ScienceDaily (free)

Related Guideline: SIDS and Other Sleep-Related Infant Deaths: Updated 2016 Recommendations for a Safe Infant Sleeping Environment – Task Force on Sudden Infant Death Syndrome, American Academy of Pediatrics (free)


3 – Hospitals are germy, noisy places. Some acutely ill patients are getting treated at home instead – The Washington Post (a few articles per month are free)

Source: STAT Newsletter


4 – Paying Hospitals To Keep People Out Of Hospitals? It Works In Maryland – Kaiser Health News (free)


5 – Serum n–6 polyunsaturated fatty acids and risk of death: the Kuopio Ischaemic Heart Disease Risk Factor Study – American Journal of Clinical Nutrition (link to abstract – $ for full-text)

Commentaries: High omega-6 levels can protect against premature death – University of Eastern Finland, via EurekAlert (free) AND Could omega-6 fatty acids help us live longer? – MedicalNewsToday (free) AND Omega-6s in Nuts, Seeds and Vegetable Oils May Aid the Heart – The New York Times (10 articles per month are free)


6 – ‘Faith Healing’ And Chest Pain: Heart Controversy Points Up Confounding Power Of Reassurance – CommonHealth (free)

Related: More Controversy Over Major Cardiology Clinical Trial – Cardiobrief (free) AND Cardiology World Erupts Into Controversy Over Change In Major Clinical Trial – Cardiobrief (free) AND Moving the Goalposts Into Unblinded Territory – Circulation: Cardiovascular Quality and Outcomes (free)


7 – Richard Lehman’s journal reviews, 3 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.


8 – Acute chest pain evaluation using coronary computed tomography angiography compared with standard of care: a meta-analysis of randomised clinical trials – Heart (link to abstract – $ for full-text)

See commentary in: Articles of the month (March 2018) – First10EM (free)

Se related meta-analysis with similar results: Outcomes of non-invasive diagnostic modalities for the detection of coronary artery disease: network meta-analysis of diagnostic randomised controlled trials – The BMJ (free)

“Bottom line: In the RCTs we have to date, CCTA demonstrate no benefit, but leads to an increase in unnecessary invasive procedures” (from First10EM).


9 – Migraine and the risk of cardiovascular and cerebrovascular events: a meta-analysis of 16 cohort studies including 1 152 407 subjects – BMJ Open (free)

Commentary: Migraines tied to higher risk for stroke, MI in large meta-analysis – Univadis (free registration required)


10 – Effects of supplemental oxygen therapy in patients with suspected acute myocardial infarction: a meta-analysis of randomised clinical trials – Heart (link to abstract – $ for full-text)

Related guideline: BTS Guideline for oxygen use in healthcare and emergency settings – British Thoracic Society (free)

“These findings from eight RCTs support departing from the usual practice of administering oxygen in normoxaemic patients”.


Tue, April 3 – 10 Stories of The Day!

3 Apr,2018


1 – Guideline Summary: Cardiovascular Disease and Risk Management: Review of the American Diabetes Association Standards of Medical Care in Diabetes 2018 – Annals of Internal Medicine (free)


2 – Association Between Use of Acid-Suppressive Medications and Antibiotics During Infancy and Allergic Diseases in Early Childhood – JAMA Pediatrics (free for a limited period)

Author interview: Association Between Use of Acid-Suppressive Medications and Antibiotics During Infancy And Allergic Diseases in Early Childhood (free)

Commentaries: Antacids, antibiotics for infants linked to later allergies – STAT (free) AND Antacids, antibiotics for infants linked to later allergies – Associated Press (free) AND Giving Babies Antibiotics or Antacids May Increase Allergy Risk – The New York Times (10 articles per month are free)


3 – ‘Aggressive’ New Advance Directive Would Let Dementia Patients Refuse Food – Kaiser Health News (free)

See website: End of Life Choices

Related initiatives: This Startup Makes End-Of-Life Planning A Piece Of Cake (free) AND New Document for Patients: Advanced Health Directive for Dementia (free document and commentaries)


4 – Quantifying population-level health benefits and harms of e-cigarette use in the United States – PLOS One (free)

Commentaries: Study Suggests E-cigarettes Cause More Harm Than Good – AAFP News (free)

“Some Adults May Quit Smoking Traditional Cigarettes, But More Teens and Young Adults Will Start” (from AAFP)


5 – Mindfulness-based intervention to increase resilience to stress in university students (the Mindful Student Study): a pragmatic randomised controlled trial – The Lancet (free)

Commentaries: Mindfulness training in higher education students – The Lancet (free) AND Mindfulness may help university students reduce stress – The Mental Elf (free)


6 – 2018 European Thyroid Association (ETA) Guidelines for the Management of Amiodarone-Associated Thyroid Dysfunction – European Thyroid Journal (free)


7 – Summary: Clinician Guide to the ABCs of Primary and Secondary Prevention of Atherosclerotic Cardiovascular Disease – American College of Cardiology (free)


8 – Review: Diagnosis and Management of Acute Ischemic Stroke – Mayo Clinic Proceedings (free)

Related guideline: 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association / American Stroke Association (free PDF) AND Summary for ED-relevant care: 2018 AHA/ASA Ischemic Stroke Updates – emDocs (free)


9 – Review: Mechanisms and Management of Acute Pancreatitis – Gastroenterology Research and Practice (free)

Source: Critical Care Reviews Newsletter


10 – Increased coronary heart disease and stroke hospitalisations from ambient temperatures in Ontario – Heart (free)

Related study: Big Swings in Daily Temperatures Linked to Spikes in MI Rates – TCTMD (free)

“Cold and hot weather associated with risk of cardiovascular disease hospitalization” (via @kamleshkhunti see Tweet)


Mon, April 2 – 10 Stories of The Day!

2 Apr,2018


1 – Moderate‐to‐Vigorous Physical Activity and All‐Cause Mortality: Do Bouts Matter? – Journal of the American Heart Association (free for a limited period)

Editorial: Accumulation of Moderate‐to‐Vigorous Physical Activity and All‐Cause Mortality (free)

Commentaries: Whether sustained or sporadic, exercise offers same reductions in premature death risk – Duke University Medical Center, via ScienceDaily (free) AND Get 150 minutes/week of moderate physical activity: It doesn’t matter how – National Cancer Institute (free) AND Every bit of exercise counts in reducing risk of early death: Study – CBC (free) AND Those 2-Minute Walk Breaks? They Add Up – The New York Times (10 articles per month are free) 


2 – Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance – Hepatology (free)


3 – Treating Subthreshold Depression in Primary Care: A Randomized Controlled Trial of Behavioral Activation With Mindfulness – Annals of Family Medicine (free)

Commentaries: Mindfulness Intervention Can Prevent Depression, Study Finds – Mad in America (free) AND Could mindfulness prevent major depression? – Medical News Today (free) AND Meditation May Reduce Depression in Primary Care – Medscape (free registration required)


4 – Viewpoint: Charter on Physician Well-being – JAMA (free)


5 – To Combat Physician Burnout and Improve Care, Fix the Electronic Health Record – Harvard Business Review (a few articles per month are free)

Related: Care-Centered Clinical Documentation in the Digital Environment: Solutions to Alleviate Burnout – National Academy of Medicine (free) AND Date Night with the EHR – NEJM Catalyst (free) AND Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free) AND Putting Patients First by Reducing Administrative Tasks in Health Care: A Position Paper of the American College of Physicians (free)


5 – The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines – Gut (free)


6 – Report: Securing safe roads: the politics of change – World Resources Institute Ross Center for Sustainable Cities (free news release and PDF)

Commentary: Death Toll On World’s Roads Grows, But Not Will To Stop It, New Report Finds – Forbes (free)

Related World Bank Report: The High Toll of Traffic Injuries : Unacceptable and Preventable – The World Bank (free PDF)

Related WHO Report: Save LIVES: a road safety technical package (free)

Source: International Health Policies Newsletter (free PDF)


7 – Mapped: the global epidemic of ‘lifestyle’ disease in charts – The Telegraph (free) (via @kamleshkhunti see Tweet)


8 – Illustrative Teaching Case: Oral Contraceptives and Ischemic Stroke Risk – Stroke (free for a limited period)

Key points: Oral Contraceptives and Ischemic Stroke Risk – American College of Cardiology (free)


9 – Macrolide antibiotics for bronchiectasis – Cochrane Library (link to abstract – $ for full-text)

Summary: Macrolide antibiotics for bronchiectasis – Cochrane Library (free)

Long-term macrolide therapy may reduce the frequency of exacerbations and improve quality of life, although supporting evidence is derived mainly from studies of azithromycin, rather than other macrolides, and predominantly among adults rather than children. However, macrolides should be used with caution, as limited data indicate an associated increase in microbial resistance”.


10 – The most affected health domains after ischemic stroke – Neurology (link to abstract – $ for full-text)

Commentaries: Stroke affects more than just the physical – American Academy of Neurology, via EurekAlert (free) AND Physical, Executive Function Most Affected After Ischemic Stroke – Physician’s Weekly (free) AND Nonphysical Problems Common After Stroke – Medscape (free registration required) AND Mild Stroke Alters Far More Than the Physical – MedPage Today (free)

“Mild disability still comes with social, cognitive impact, study suggests” (from MedPage Today)


Fri, March 30 – 10 Stories of The Day!

30 Mar,2018


1 – Duration of Adjuvant Chemotherapy for Stage III Colon Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Duration of Chemotherapy for Colon Cancer (free)

Commentaries: Colon cancer chemo could be halved after surgery – Cancer Research UK, via MedicalXpress (free) AND Global cancer trial sets new standard for post-surgery chemotherapy – National Cancer Institute, via MedicalXpress (free)


2 – Long-term Thromboembolic Risk in Patients With Postoperative Atrial Fibrillation After Coronary Artery Bypass Graft Surgery and Patients With Nonvalvular Atrial Fibrillation – JAMA Cardiology (free for a limited period)

Commentaries: Postoperative A-fib Not as Bad as Nonsurgical A-fib for Thromboembolism – TCTMD (free) AND Fib after CABG linked to minimal long-term stroke risk – Cardiovascular Business (free)


3 – Venous Thromboembolism Prevention in Emergency General Surgery: A Review – JAMA Surgery (free for a limited period)

Commentary: VTE Risk Up in Most Emergency General Surgery Patients – Physician’s Weekly (free)


4 – Behavioral interventions as a treatment for epilepsy: A multicenter randomized controlled trial – Neurology (link to abstract – $ for full-text)

Commentaries: Can Learning Stress-Reducing Techniques Help Reduce Seizures? – American Academy of Neurology, via NewsWise (free) AND Stress Reduction Techniques Cut Seizure Rate in Severe Epilepsy – Medscape (free registration required) AND Stress-Reducing Techniques Lead to Fewer Seizures – MedPage Today (free registration required)


5 – IOC consensus statement: dietary supplements and the high-performance athlete – British Journal of Sports Medicine (free)


6 – What We Know (and Don’t Know) About How to Lose Weight – The New York Times (10 articles per month are free)

“One conclusion from a much-discussed study: The best diet is the one you can stick to”.


7 – High red and processed meat consumption is associated with non-alcoholic fatty liver disease and insulin resistance – Journal of Hepatology (link to abstract – $ for full-text) (via @kamleshkhunti see Tweet)

Commentaries: High Consumption Of Red And Processed Meat Linked to Non-Alcoholic Fatty Liver Disease And Insulin Resistance – EASL (free) AND More People Can Afford Meat Now, And Hepatologists Claim That Is Causing Liver Disease – Science 2.0 (free)


8 – Patent foramen ovale closure vs. medical therapy for cryptogenic stroke: a meta-analysis of randomized controlled trials – European Heart Journal (free)

“5-study EHJ meta analysis confirms value of PFO closure after cryptogenic stroke. “Number Needed to Close”: 178 pts to prevent one stroke over 1 year. Size matters (no effect for small shunts, “NNC” 96 for large shunts)” (via @Steph_Achenbach see Tweet)


9 – Report: Multi-drug resistant gonorrhoea in England: 2018 – Public Health England (free)

Commentaries:  In world first, UK reports high-level gonorrhea resistance – CIDRAP (free) AND First case of super-resistant gonorrhea reported – CNN (free)

Related: Scientists warn that antibiotic-resistant gonorrhoea is on the rise – World Health Organization (free) AND Untreatable Gonorrhea Is Rapidly Spreading. Here’s What You Need to Know – TIME Health (free)


10 – The Effect of Door-to-Diuretic Time on Clinical Outcomes in Patients With Acute Heart Failure – JACC Heart Failure (free)

Commentaries: Quicker Diuretics Not Associated With Better Outcomes in Acute Heart Failure – TCTMD (free) AND Door-to-Diuretic Time in Acute Heart Failure – American College of Cardiology, Latest in Cardiology (free) AND Door-to-diuretic time didn’t affect mortality from heart failure in Korean registry – ACP Hospitalist (free)

“Overall, there isn’t strong evidence of benefit from early use of diuretics and “the overriding consideration should remain ‘get it right’ rather than ‘do it fast,’” the editorial concluded”. (from ACP)


Thu, March 29 – 10 Stories of The Day!

29 Mar,2018


1 – Guideline: Otitis media (acute): antimicrobial prescribing – National Institute for Health and Care Excellence (NICE) (free)

Commentaries: Most common ear infections should not be treated with antibiotics, says NICE (free) AND Common ear infections don’t need antibiotics, health watchdog says – The Guardian (free) AND Antibiotics not recommended for acute otitis, says NICE – OnMedica (free)

Related guideline: Clinical Practice Guideline: Otitis Media with Effusion (Update) – Otolaryngol Head Neck Surg (free) AND Executive Summary – Otolaryngol Head Neck Surg (free)


2 – Guideline: Stop smoking interventions and services – National Institute for Health and Care Excellence (NICE) (free)

Commentaries: Help people make informed decisions when they want to quit smoking, says NICE and Public Health England – NICE News Release (free) AND Doctors should tell patients e-cigarettes ‘less harmful than smoking but not without risk’ – iNews (free)

Related guidelines and reports:  E-cigarettes and heated tobacco products: evidence review – Public Health England (free PDF) AND Public Health Consequences of E-Cigarettes – National Academies of Sciences, Engineering, and Medicine (free PDF) AND E-cigarettes: balancing risks and opportunities – British Medical Association (free PDF) AND Nicotine without smoke: Tobacco harm reduction – Royal College of Physicians (free summary and PDF) AND RCGP Position Statement on the use of electronic nicotine vapour products (E-Cigarettes) – Royal College of General Practitioners (free PDF)


3 – Safety and mosquitocidal efficacy of high-dose ivermectin when co-administered with dihydroartemisinin-piperaquine in Kenyan adults with uncomplicated malaria (IVERMAL): a randomised, double-blind, placebo-controlled trial – The Lancet Infectious Diseases (free registration required)

Commentaries: Ivermectin: repurposing an old drug to complement malaria vector control – The Lancet Infectious Diseases (free registration required) AND LSTM study shows drug that kills mosquitoes could be used to fight malaria – London School of Tropical Medicine (free) AND Common anti-parasitic could be new tool for malaria control – OnMedica (free)


4 – Psychosocial Effects of Parent-Child Book Reading Interventions: A Meta-analysis – Pediatrics (link to abstract – $ for full-text)

Commentaries: Reading programs may teach parents and kids more than literacy – Reuters (free) AND Parent-child reading interventions have positive psychosocial effects – 2 Minute Medicine (free)


5 – Pain Management in Cancer Center Inpatients: A Cluster Randomized Trial to Evaluate a Systematic Integrated Approach—The Edinburgh Pain Assessment and Management Tool – Journal of Clinical Oncology (free)

Commentaries: Cancer patients’ pain eased by simple bedside chart – University of Edinburgh, via ScienceDaily (free) AND Bedside Assessment Tool Improves Worst Pain in Patients With Cancer – Oncology Nurse Advisor (free) AND Effect of Integrated Assessment and Management Tool on Pain Management in Cancer Center Inpatients – The ASCO Post (free)


6 – Last Month in Oncology with Dr. Bishal Gyawali: February 2018 – eCancer News (free)


7 – Prevalence and causes of vision loss in high-income countries and in Eastern and Central Europe in 2015: magnitude, temporal trends and projections – British Journal of Ophthalmology (free)

Commentary: Half of vision impairment in first world is preventable – Cambridge Network (free)


8 – Life After Stroke: a round up of Cochrane evidence – Evidently Cochrane (free)


9 – Smoking and smoking cessation in relation to risk of diabetes in Chinese men and women: a 9-year prospective study of 0·5 million people – The Lancet Public Health (free)

Commentaries: Combating diabetes in China: a long-term perspective is needed – The Lancet Public Health (free) AND Smoking linked with higher risk of type 2 diabetes – University of Oxford (free)

“Among Chinese adults, smoking associated with 18-33% increased risk of diabetes” (via @kamleshkhunti see Tweet)


10 – A Comparison of the Quick-SOFA and Systemic Inflammatory Response Syndrome Criteria for the Diagnosis of Sepsis and Prediction of Mortality: A Systematic Review and Meta-Analysis – Chest (free)

Related meta-analysis and commentaries: Prognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in Patients With Suspected Infection: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text) AND For mortality prediction, qSOFA has poor sensitivity, moderate specificity, review finds – ACP Hospitalist (free) AND Systemic inflammatory response syndrome criteria may be more sensitive than quick sequential organ failure assessment for predicting mortality in patients with suspected infection – 2 Minute Medicine (free)

“The SIRS was significantly superior to the qSOFA for sepsis diagnosis, and the qSOFA was slightly better than the SIRS in predicting hospital mortality. The association of both criteria could provide a better model to initiate or escalate therapy in patients with sepsis”.


Wed, March 28 – 10 Stories of The Day!

28 Mar,2018


1 – Special Report: The IARC Perspective on Colorectal Cancer Screening – New England Journal of Medicine (free)

Commentaries: The IARC perspective on colorectal cancer screening – eCancer News (free) AND WHO Group Says Evidence Favors Most Forms of Colorectal Cancer Screening – NEJM Physician’s First Watch (free)


2 – European evidence-based guidelines on pancreatic cystic neoplasms – Gut (free)


3 – The Assessment of Pain in Older People: UK National Guidelines – Age and Ageing (free)


4 – Fast and accurate view classification of echocardiograms using deep learning – npj Digital Medicine (free)

Commentaries: AI is Quicker, More Effective Than Humans in Analyzing Heart Scans – University of California San Francisco (free) AND Study: AI faster, more accurate than humans at analyzing heart scans – UPI (free) AND AI model 98% accurate in ECG classification—outperforming cardiologists – Health Imaging (free)


5 – Efficacy of foot orthoses for the treatment of plantar heel pain: a systematic review and meta-analysis – British Journal of Sports Medicine (link to abstract – $ for full-text)

Commentaries: Pricey orthotic insoles aren’t worth the cost – UPI (free) AND Custom-Made Foot Orthotics No Benefit for Plantar Heel Pain – Physician’s Briefing (free) AND Custom-made foot orthoses appear to be no better than over-the-counter insoles or other treatments – MedicalXpress (free) AND Foot orthotics may not be superior to conservative treatment for relieving plantar heel pain – ACP Internist (free)


6 – Electronic Health Record Usability Issues and Potential Contribution to Patient Harm – JAMA (link to abstract – $ for full-text)

Commentaries: EHR Usability Linked to Possible Patient Harms, Study Finds – AJMC (free) AND EHRs May Be Tied to Potential Patient Harm, Study Suggests – Medscape (free registration required)


7 – The human microbiome: why our microbes could be key to our health – The Guardian (free) (via @trished see Tweet)


8 – The Truth Wears Off: Is there something wrong with the scientific method? – The New Yorker (free)

“An excellent New Yorker article on regression to the mean. Extremely relevant to the practice of evidence-based medicine” (via @rajshekharucms see Tweet)


9 – Tele-Monitoring Can Reduce Medical Appointments For Low-Risk Pregnancies – Kaiser Health News (free)

Related commentary: How Mayo Clinic Is Simplifying Prenatal Care for Low-Risk Patients – Harvard Business Review (a few articles per month are free)

Related articles: Effectiveness of Telemonitoring in Obstetrics: Scoping Review – Journal of Medical Internet Research (free) AND Assessing the Effect of mHealth Interventions in Improving Maternal and Neonatal Care in Low- and Middle-Income Countries: A Systematic Review – PLOS One (free)


10 – Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study – The Lancet Gastroenterology & Hepatology (free registration required)

Commentaries: Delineating the global challenges of hepatitis B virus infection – The Lancet Gastroenterology & Hepatology (free registration required) AND 1 in 20 people with hepatitis B receive care worldwide, study says – UPI (free) AND Scientists warn 90% of hepatitis B sufferers remain unaware of silent killer – The Guardian (free)


Tue, March 27 – 10 Stories of The Day!

27 Mar,2018


1 – Global increase and geographic convergence in antibiotic consumption between 2000 and 2015 – Proceedings of the National Academy of Sciences (free)

Commentaries: Calls to rein in antibiotic use after study shows 65% increase worldwide – The Guardian (free) AND Global antibiotic use rises, fueled by economic growth – CIDRAP (free) AND Surge In Antibiotics Is A Boon For Superbugs – NPR (free) AND As antibiotics fail, global consumption of antibiotics skyrockets, further driving drug resistance – MedicalXpress (free)


2 – Newly Revised: Curriculum for Educators and Residents (Version 4.0) – American College of Physicians (free)

News release: ACP introduces updated High Value Care Curriculum for educators and residents – ACP Internist (free)

“The High Value Care Curriculum (HVC) was jointly developed by ACP and the Alliance for Academic Internal Medicine (AAIM) to train physicians to be good stewards of limited health care resources”.


3 – Ethical Obligations Regarding Short-Term Global Health Clinical Experiences: An American College of Physicians Position Paper – Annals of Internal Medicine (free)

Commentaries: Ethical Guidance for Volunteer Medical Trips Issued by ACP – Medscape (free registration required) AND Ethical Duties ID’d for Short-Term Global Health Experiences – Physician’s Briefing (free)


4 – Viewpoint: Driving Under the Influence of Cannabis: An Increasing Public Health Concern – JAMA (free for a limited period)


5 – Antibiotic Therapy Duration in US Adults With Sinusitis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Sinus Infections: Majority of Antibiotics Prescriptions Longer Than Recommended – MedicalResearch.com (free) AND CDC Study Says Sinus Infections Are Treated With Antibiotics Longer Than Necessary – AJMC (free) AND Most Courses of Antibiotics for Sinusitis Are Too Long – NEJM Physician’s First Watch (free)

Related Guideline: IDSA Clinical Practice Guideline for Acute Bacterial Rhinosinusitis in Children and Adults – Clinical Infectious Diseases (free)


6 – Clinical Updates: Palliative radiotherapy – The BMJ (free)

Clinical Update for non-specialists on the benefits, practicalities, and side effects of palliative radiotherapy.


7 – Richard Lehman’s journal reviews, 26 March 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.


8 – The dark truth about chocolate – The Guardian (free)

Related: Dark chocolate is now a health food. Here’s how that happened – VOX (free)

“Grand health claims have been made about chocolate, but while it gives us pleasure, can it really be good for us?”


9 – Viewpoint: Individualizing Blood Pressure Targets for People With Diabetes and Hypertension: Comparing the ADA and the ACC/AHA Recommendations – JAMA (free for a limited period)


10 – Association of E-Cigarette Use With Smoking Cessation Among Smokers Who Plan to Quit After a Hospitalization: A Prospective Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Some e-cigarette users may struggle to quit smoking – Reuters (free) AND Expert reaction to ecigs and smoking cessation – Science Media Centre (free) AND Could E-Cigarettes Foil Smoking Cessation Efforts After Hospital Discharge? – NEJM Physician’s First Watch (free)

“The study is consistent with the hypothesis that smokers need to use e-cigarettes regularly and daily and switch completely from cigarettes to e-cigarettes for them to have the greatest chance of help” (from Reuters)


Mon, March 26 – 10 Stories of The Day!

26 Mar,2018


1 – #WorldTBDay (March 24, 2018) – 1 – World TB Day, 24 March 2018 – World Health Organization (free resources)

See also: WHO publications on tuberculosis


2 – #WorldTBDay (March 24, 2018) – The World Health Organization standards for tuberculosis care and management – European Respiratory Journal (free)

Original Guideline: Compendium of WHO guidelines and associated standards: ensuring optimum delivery of the cascade of care for patients with tuberculosis (free PDF)

“My dream of placing all recent and still valid older WHO TB guidelines into a short compendium, to facilitate life of users, is now accomplished. With this booklet, one can access immediately all WHO standards of TB care”. (via @M_Raviglione see Tweet)


3 – #WorldTBDay (March 24, 2018) – The impact of social protection and poverty elimination on global tuberculosis incidence: a statistical modelling analysis of Sustainable Development Goal 1 – The Lancet Global Health (free)

Commentaries: Predicting the effect of improved socioeconomic health determinants on the tuberculosis epidemic – The Lancet Global Health (free) AND Eradicating poverty would dramatically reduce TB cases, study finds – The Guardian (free)

Ending extreme poverty and expanding social protection is estimated to reduce the incidence of tuberculosis by 84.3%.


4 – Guideline: Physical activity and the environment – National Institute for Health and Care Excellence (NICE) (free)


5 – Richard Smith: The dangers of textbooks – The BMJ Opinion (free)

Related: Authors of premier medical textbook didn’t disclose $11 million in industry payments – STAT (free)


6 – The fraction of cancer attributable to modifiable risk factors in England, Wales, Scotland, Northern Ireland, and the United Kingdom in 2015 – British Journal of Cancer (free)

Commentaries: New calculations confirm lifestyle changes could prevent 4 in 10 cancer cases – Cancer Research UK (free) AND More than 2,500 cancer cases a week could be avoided – Cancer Research UK (free) AND Four in 10 cancer cases could be prevented by lifestyle changes – The Guardian (free)


7 – Vaccine waning and mumps re-emergence in the United States – Science Translational Medicine (link to abstract – $ for full-text)

Commentaries: Mumps resurgence likely due to waning vaccine-derived immunity – Harvard T.H. Chan School of Public Health (free) AND Mumps Vaccine Effectiveness Declines Over Time. But There’s A Solution – Forbes (free) AND Mumps Vaccine Protection Wanes Over Time, Study Finds – CommonHealth (free) AND Mumps Is On the Rise. A Waning Vaccine Response May Be Why – The New York Times (10 articles per month are free)

“a booster dose at age 18 should be a straight-forward solution to the problem based on models of how mumps spreads” (from Forbes)


8 – Facing the Shortage of IV Fluids — A Hospital-Based Oral Rehydration Strategy – New England Journal of Medicine (free)

Commentary: Boston Hospital May Have a Solution to IV Bag Shortage – Medscape (free registration required)


9 – Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging – Cell Metabolism (free for a limited period)

Commentaries: Reduced-calorie diet shows signs of slowing ageing in people – Nature News (free) AND Will Cutting Calories Make You Live Longer? – Wired (free) AND Calorie restriction trial in humans suggests benefits for age-related disease – Cell Press, via ScienceDaily (free)


10 – Myocarditis in Patients Treated With Immune Checkpoint Inhibitors – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Myocarditis a Risk with Checkpoint Inhibitors – CRTOnline.org (free) AND Myocarditis in Patients Treated With Immune Checkpoint Inhibitors – American College of Cardiology, Latest in Cardiology (free)

Related Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)


Fri, March 23 – 10 Stories of The Day!

23 Mar,2018


1 – Guideline: Venous thromboembolism in over 16s: reducing the risk of hospital-acquired deep vein thrombosis or pulmonary embolism – National Institute for Health and Care Excellence (NICE) (free)


2 – New Tool: Sustainable Development Goal (SDG) Tracker – Our World in Data (free)

Commentary: The U.N. Set 17 Goals To Make The World A Better Place. How’s It Doing? – NPR (free)

“The United Nations Sustainable Development Goals (SDGs) are targets for global development adopted in September 2015, set to be achieved by 2030. Here we present data across all available indicators from the Our World in Data database tracking progress towards these goals around the world”.


3 – When antibiotics turn toxic – Nature News (free)

“Commonly prescribed drugs called fluoroquinolones cause rare, disabling side effects. Researchers are struggling to work out why”.


4 – Associations of Monounsaturated Fatty Acids From Plant and Animal Sources With Total and Cardiovascular Mortality Risk – Circulation (link to abstract – presented at the American Heart Association’s Epidemiology and Prevention | Lifestyle and Cardiometabolic Health Scientific Sessions 2018)

Commentaries: Mono-unsaturated fats from plants, not animals may reduce risk of death from heart disease and other causes – AHA / ASA Newsroom (free) AND These plant-based fats could help you live longer – Medical News Today (free)


5 – Report: Violence and Mental Health: Opportunities for Prevention and Early Detection – National Academies Press (free PDF)


6 – A Randomized Trial of High-Flow Oxygen Therapy in Infants with Bronchiolitis – New England Journal of Medicine (free)

Commentaries: Efficacy of High-Flow O2 Tx Test Outside ICU for Infants With Bronchiolitis? – MPR (free) AND High-flow O2 therapy feasible for infants with bronchiolitis – MedicalXpress (free) AND High-Flow Oxygen Improves Infant Bronchiolitis Outcomes – MedPage Today (free)


7 – FDA In Brief: FDA updates public information about known risk of lymphoma from breast implants (free) AND Breast Implant-Associated Anaplastic Large Cell Lymphoma – FDA Update (free)

Commentaries: More Cases Are Reported of Unusual Cancer Linked to Breast Implants – The New York Times (10 articles per month are free) AND Implant-Related Lymphoma Cases Rise – More than 400 cases reported to FDA – MedPage Today (free)

Some 400 to 500 women worldwide have an unusual type of lymphoma linked to breast implants with textured surfaces. Experts say women considering implants should be told”. (via @NYTHealth see Tweet)


8 – Viewpoint: The Proposal to Lower P Value Thresholds to .005 – JAMA (free) (via @VinayPrasad82 see Tweet)

Related: What a nerdy debate about p-values shows about science — and how to fix it – VOX (free) AND Big names in statistics want to shake up much-maligned P value – Nature News (free) AND ‘One-size-fits-all’ threshold for P values under fire – Nature News (free) AND Statisticians issue warning over misuse of P values – Nature News (free) AND Understanding common misconceptions about p-values – The 20% Statistician (free) AND Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations – European Journal of Epidemiology(free)


9 – Effect of tai chi versus aerobic exercise for fibromyalgia: comparative effectiveness randomized controlled trial – The BMJ (free)

Commentaries: Time to rethink exercise for fibromyalgia care – The BMJ Opinion (free) AND The unintended consequences of tai chi for fibromyalgia – The BMJ Opinion (free) AND Tai chi may be as effective for fibromyalgia as standard exercise – NHS Choices (free) AND Tai chi at least as beneficial as aerobic exercise for fibromyalgia – OnMedica (free)


10 – Efficacy of a single-dose regimen of inactivated whole-cell oral cholera vaccine: results from 2 years of follow-up of a randomised trial – The Lancet Infectious Diseases (free)

Invited commentary: Cholera control: one dose at a time (free)

“Our results indicate that when such emergencies occur in populations with endemic cholera, the challenges of successfully completing a two-dose regimen should not deter deployment of OCV, because older children and adults will be protected for at least 2 years by a single dose”. (via @Onisillos see Tweet)


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