Open access


Fri, July 6 – 10 Stories of The Day!

6 Jul,2018


1 – Report: Delivering quality health services: A global imperative for universal health coverage – World Health Organization (free)

News Release: Low quality healthcare is increasing the burden of illness and health costs globally (free)

Commentary: Universal quality healthcare coverage—a commitment to building a healthier and more productive society – The BMJ Opinion (free)

Related: Handbook for national quality policy and strategy: A practical approach for developing policy and strategy to improve quality of care – World Health Organization (free)


2 – Hypothalamic–Pituitary and Growth Disorders in Survivors of Childhood Cancer: An Endocrine Society Clinical Practice Guideline – The Journal of Clinical Endocrinology & Metabolism (free PDF)

Commentaries: Up to half of childhood cancer survivors will develop hormone disorders – The Endocrine Society, via ScienceDaily (free) AND Guideline Addresses Endocrine Effects After Childhood Cancer – Medscape (free registration required)


3 – Cost-effectiveness and Benefit-to-Harm Ratio of Risk-Stratified Screening for Breast Cancer: A Life-Table Model – JAMA Oncology (free)

Editorial: Implementation Challenges for Risk-Stratified Screening in the Era of Precision Medicine (free)

Author Interview: Cost-effectiveness and Benefit-to-Harm Ratio of Risk-Stratified Breast Cancer Screening (free)

Commentaries: New approach to breast cancer screening — tailoring guidelines for each patient — may save lives and money, study says – STAT (free) AND No screening is better for women with low breast cancer risk, finds study – Guardian (free) AND Breast Cancer Screening Only for Women at Higher Risk – Medscape (free registration required)


4 – Review: Heart failure with preserved ejection fraction: from mechanisms to therapies – European Heart Journal (free)


5 – Review: Anemia and Iron Deficiency in Heart Failure: Current Concepts and Emerging Therapies – Circulation (free)


6 – Hidden conflicts? – Science Magazine (free)

““Pay-later conflicts of interest” have gone largely unnoticed & entirely unpoliced”. (via @cpiller see Tweet)


7 – Clinical practice guidelines for the management of non-specific low back pain in primary care: an updated overview – European Spine Journal (free)


8 – Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care – The BMJ (free)

Commentary: Analysis Finds Less Bleeding — But Potentially Greater Mortality Risk — with Some Newer Anticoagulants – NEJM Physician’s First Watch (free)


9 – Species-specific activity of antibacterial drug combinations – Nature (link to abstract – $ for full-text)

Commentaries: Study: For antibiotics, good things may come in pairs – CIDRAP (free) AND Combining antibiotics alters effectiveness, study says – UPI (free) AND As drug resistance grows, combining antibiotics could turn up new treatments – STAT (free)


10 – Continuous low-dose antibiotic prophylaxis for adults with repeated urinary tract infections (AnTIC): a randomised, open-label trial – The Lancet Infectious Diseases (free)

Invited Commentary: Preventing urinary tract infections in patients with neurogenic bladder (free)


Thu, July 5 – 10 Stories of The Day!

5 Jul,2018


1 – Guideline for Antibiotic Use in Adults with Community-acquired Pneumonia – The Korean Society of Infectious Disease (free)

Related Guideline: Pneumonia: Diagnosis and Management of Community- and Hospital-Acquired Pneumonia in Adults – National Institute for Health and Care Excellence (free)


2 – An evidence-based approach to evaluation and management of the febrile child in Indian emergency department – International Journal of Critical Illness & Injury Science (free)


3 – Pathophysiology, diagnosis and management of MINOCA: an update – European Heart Journal: Acute Cardiovascular Care (free)


4 – Presentation, Clinical Profile, and Prognosis of Young Patients With Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): Results From the VIRGO Study – Journal of the American Heart Association (free)

Editorial: Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): It’s Time to Face Reality! (free)


5 – Treatment of Angina: Where Are We? – Cardiology (free)

Source: Critical Care Reviews Newsletter


6 – Adverse effect of long work hours on incident diabetes in 7065 Ontario workers followed for 12 years – BMJ Open Diabetes Research & Care (free)

Commentaries: Clocking up 45+ working hours/week linked to heightened risk of diabetes in women – BMJ, via ScienceDaily (free) AND Greater Risk of Diabetes in Women With Longer Work Week – MedicalResearch.com (free)

Related Study: Effect of Work Stressors on the Risk of Type 2 Diabetes (link to abstract and commentary)


7 – Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates – Nature Medicine (link to abstract – $ for full-text)

Commentaries: Pregnancy loss occurs in 26 percent of Zika-infected monkeys – NIH News Releases (free) AND Monkey studies suggest Zika role in miscarriage may be higher than thought – CIDRAP (free)


8 – Alarming polio outbreak spreads in Congo, threatening global eradication efforts – Science (free)


9 – Carbohydrate Replacement of Rice or Potato with Lentils Reduces the Postprandial Glycemic Response in Healthy Adults in an Acute, Randomized, Crossover Trial – The Journal of Nutrition (link to abstract – $ for full-text)

Commentaries: Lentils significantly reduce blood glucose levels – University of Guelph, via ScienceDaily (free) AND Replace Carbs With Lentils to Blunt Glucose Spike After Meals – Medscape (free registration required)


10 – Hypertensive Disorders of Pregnancy and Maternal Cardiovascular Disease Risk Factor Development: An Observational Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Hypertensive disorders during pregnancy associated with increased rates of later CVD – ACP Internist (free) AND High blood pressure in pregnancy tied to heart disease risk afterward – Reuters (free) AND Women who experience hypertensive disorders during pregnancy are at high risk for developing high blood pressure, diabetes, and high cholesterol later in life – 2 Minute Medicine (free)

Related Studies: All Hypertensive Disorders of Pregnancy Increase the Risk of Future Cardiovascular Disease (free PDF and commentaries) AND Hypertensive Disorders in Pregnancy and the Risk of Subsequent Cardiovascular Disease (link to abstract and free commentaries) AND Gestational Hypertension and Future Risk of Cardiovascular Disease (free research and editorial)


Wed, July 4 – 10 Stories of The Day!

4 Jul,2018


1 – Anticonvulsants in the treatment of low back pain and lumbar radicular pain: a systematic review and meta-analysis – Canadian Medical Association Journal (free)

Commentaries: Class of drugs used as alternative to opioids for back pain are ineffective, have potentially serious side effects: report – The Globe and Mail (free) AND Anticonvulsant drugs ineffective for low back pain and can cause harm, despite increased prescribing – CMAJ, via EurekAlert (free)

Related Meta-Analysis: Benefits and safety of gabapentinoids in chronic low back pain (free research and commentaries)


2 – The Carbohydrate-Insulin Model of Obesity: Beyond “Calories In, Calories Out” – JAMA Internal Medicine (free for a limited period)


3 – Epinephrine Versus Norepinephrine for Cardiogenic Shock After Acute Myocardial Infarction – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Epinephrine vs. Norepinephrine for Cardiogenic Shock – American College of Cardiology (free) AND Norepinephrine Bests Epinephrine in Battle of the Vasopressors in Cardiogenic Shock – TCTMD (free)


4 – Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Related Perspective: Metastasis-free Survival — A New End Point in Prostate Cancer Trials – New England Journal of Medicine (free)

Commentaries: Enzalutamide: Now Also for Earlier Use in Prostate Cancer? – Medscape (free registration required) AND Enzalutamide Improves Outcomes for Aggressive Prostate Cancer – MPR (free) AND Enzalutamide Postpones Metastasis for a Subset of High-Risk Patients With Prostate Cancer – Cancer Therapy Advisor (free)


5 – Editorial: Immunotherapy: hype and hope – The Lancet Oncology (free) (via @OphiraG)

Related: What Precisely Is Precision Oncology—and Will It Work? – The ASCO Post (free) AND Hope and hype around cancer immunotherapy – CNN (free)


6 – Fertility Preservation for Patients with Malignant Disease. Guideline of the DGGG, DGU and DGRM – Recommendations and Statements for Girls and Women – Geburtshilfe Frauenheilkd (free)

Related guidelines: Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update – Journal of Clinical Oncology (free) AND Fertility preservation for patients with gynecologic malignancies: The Korean Society for Fertility Preservation clinical guidelines – Clinical and Experimental Reproductive Medicine (free) AND Fertility preservation for medical reasons in girls and women: British fertility society policy and practice guideline – Human Fertility (free)


7 – Influenza vaccine for chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)

Summary: Influenza vaccine for people with chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)


8 – Maternal and infant outcomes associated with lithium use in pregnancy: an international collaborative meta-analysis of six cohort studies – The Lancet (link to abstract – $ for full-text)

Commentaries: Increased risk of birth defects in babies after first-trimester exposure to lithium – Mount Sinai School of Medicine, via ScienceDaily (free) AND Lithium in Pregnancy Tied to Infant Morbidity, Malformation Risk – Medscape (free)


9 – Metformin exposure in first trimester of pregnancy and risk of all or specific congenital anomalies: exploratory case-control study – The BMJ (free)

In this large international, population-based database, no evidence was found of an overall increased risk of congenital anomalies after first trimester metformin exposure.


10 – Australia wins landmark WTO ruling on plain tobacco packaging – Reuters (free)

Other commentaries: WTO Tobacco Ruling Opens Door to New Plain-Packaging Laws – Bloomberg (free) AND ‘Resounding victory’: Australia wins tobacco plain packaging dispute – The Guardian (free) AND Australian Tobacco Plain Packaging Upheld In Decision At WTO – Intellectual Property Watch (free)

Source: International Health Policies Newsletter


Tue, July 3 – 10 Stories of The Day!

3 Jul,2018


1 – A Multicenter Study of Patient-Reported Infectious and Noninfectious Complications Associated With Indwelling Urethral Catheters – JAMA Internal Medicine (free)

Commentary: Foleys Aren’t Fun: Patient Study Shows Catheter Risks – University of Michigan, via NewsWise (free)

“More than half of patients surveyed while they had a urinary catheter, and again weeks later, reported a complication – and infections were only part of the problem” (from NewsWise)


2 – Out-of-hours discharge from intensive care, in-hospital mortality and intensive care readmission rates: a systematic review and meta-analysis – Intensive Care Medicine (free)

Source: Critical Care Reviews Newsletter

“Out-of-hours discharge from an ICU is strongly associated with both in-hospital death and ICU readmission. Whether these increases in mortality and readmission result from patient differences, differences in care, or a combination remains unclear”.


3 – Review: Chronic hyperkalemia in non-dialysis CKD: controversial issues in nephrology practice – Journal of Nephrology (free)


4 – Opinion: Endless Gaming May Be a Bad Habit. That Doesn’t Make It a Mental Illness – The New York Times (10 articles per month are free)

Related: Gaming addiction as a mental disorder: it’s premature to pathologise players – The Conversation (free)

“The World Health Organization has made “internet gaming” a diagnosable disorder. But many experts aren’t even sure it exists”.


5 – Richard Lehman’s journal review, 2 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.


6 – Outbreak of Ebola virus disease in the Democratic Republic of the Congo, April–May, 2018: an epidemiological study – The Lancet (free)

Invited Commentary: Ebola virus disease: 11 323 deaths later, how far have we come? (free)

Related: Ebola Outbreak in Congo ‘Largely Contained’, says WHO (free statement and commentary)


7 – Management of multimorbidity using a patient-centred care model: a pragmatic cluster-randomised trial of the 3D approach – The Lancet (free)

Commentaries: Patient-centred care for multimorbidity: an end in itself? – The Lancet (free) AND Results of the largest ever multimorbidity trial in primary care challenge current thinking -NIHR News (free)

Related: Designing a High-Performing Health Care System for Patients with Complex Needs: Ten Recommendations for Policymakers (series of free articles on the topic) AND Multimorbidity: A Priority for Global Health Research (free report and commentaries)

“In the largest ever trial of an intervention to treat people with multiple long-term conditions (multimorbidity) in primary care, NIHR-researchers found that the patient-centred approach taken improved patients’ experience of their care but did not improve their health-related quality of life. This is a challenge to current thinking on which UK and international guidelines are based”. (from NIHR News)


8 – Association of Coffee Drinking With Mortality by Genetic Variation in Caffeine Metabolism: Findings From the UK Biobank – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Expert reaction to research association between coffee and lower risk of death – Science Media Centre (free) AND Fresh grounds for coffee: Study shows it may boost longevity – Associated Press (free) AND Coffee Drinkers Are More Likely To Live Longer. Decaf May Do The Trick, Too – NPR (free)

Related Studies: Meta-Analysis: Coffee consumption and health (free research and commentaries) AND Coffee Drinking and Mortality Studies (link to abstract and commentaries)

Another observational study showing possible benefits from drinking coffee.


9 – Endocrine Late Effects in Survivors of Cancer in Adolescence and Young Adulthood: A Danish Population-Based Cohort Study – JAMA Network Open (free)

Invited Commentary: Unmet Survivorship Care Needs of Adolescent and Young Adult Cancer Survivors (free)

Related Reviews: Endocrine late-effects of childhood cancer and its treatments – European Journal of Endocrinology (free) AND Metabolic syndrome induced by anticancer treatment in childhood cancer survivors – Annals of Pediatric Endocrinology & Metabolism (free) AND Screening and management of adverse endocrine outcomes in adult survivors of childhood and adolescent cancer – The Lancet Diabetes & Endocrinology (free)


10 – Cardiovascular Toxicity in Cancer Survivors: Current Guidelines and Future Directions – American College of Cardiology (free)

Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Cardio-Onco-Hematology in Clinical Practice. Position Paper and Recommendations – Revista Espanola de Cardiologia (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)


Mon, July 2 – 10 Stories of The Day!

2 Jul,2018


1 – Continuity of care with doctors—a matter of life and death? A systematic review of continuity of care and mortality – BMJ Open (free)

Commentaries: Seeing same doctor every time ‘reduces risk of death’ – NHS Choices (free) AND Sticking with 1 doctor could have health benefits: Study – UPI (free)


2 – Opinion: Why do-it-yourself blood tests are a bad idea – Common Sense Family Doctor (free)

Related: Benjamin Mazer: Theranos’ dystopian vision lives on – The BMJ Opinion (free)

“Routine blood testing in healthy people has numerous downsides that Holmes never mentioned, including poor predictive value, false positives, and overdiagnosis” (from Common Sense Family Doctor)

“When you go about testing everyone for everything, you don’t create a world of healthy people….you create a nightmare where everyone is sick” (from The BMJ Opinion)


3 – Scientists on Twitter: Preaching to the choir or singing from the rooftops? – Facets (free)

Related: Rise of the Tweetorial – Precious Bodily Fluids (free) AND Social Medicine: Twitter in Healthcare – Journal of Clinical Medicine (free) AND University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC (free) AND Twitter-Based Medicine: How Social Media is Changing the Public’s View of Medicine – The Health Care Blog (free) AND What’s your doctor reading? How social media is disrupting medical education – National Post (free)

“Great new study about science outreach via Twitter: Initially, scientists mostly tweet to each other. But after accumulating about 1000 followers, scientists reach an increasing number of journalists, policy makers, and other members of the public”. (via @JSheltzer see Tweet)


4 – Four principles to make evidence synthesis more useful for policy – Nature (free)

Related: A fresh approach to evidence synthesis – Nature (free)

“Reward the creation of analyses for policymakers that are inclusive, rigorous, transparent and accessible, urge Christl A. Donnelly and colleagues”.


5 – American College of Gastroenterology Monograph on Management of Irritable Bowel Syndrome – American Journal of Gastroenterology (free for a limited period)

Related guidelines: Irritable bowel syndrome in adults: diagnosis and management – National Institute for Health and Care Excellence (free) AND Clinical Practice Guidelines for Irritable Bowel Syndrome in Korea, 2017 Revised Edition – Journal of Neurogastroenterology and Motility (free) AND Evidence-based clinical practice guidelines for irritable bowel syndrome – Journal of Gastroenterology (free)

Source: NewsWise


6 – Update of Recommendations for Use of Once-Weekly Isoniazid-Rifapentine Regimen to Treat Latent Mycobacterium tuberculosis Infection – Centers for Disease Control and Prevention (free)

Commentary: CDC Updates Guidelines on Weekly Therapy for Latent TB Infection – Physician’s First Watch (free)

Related WHO Guideline: Latent TB Infection (free guideline and news release)


7 – The plateau of human mortality: Demography of longevity pioneers – Science (link to abstract – $ for full-text)

Commentaries: There’s no limit to longevity, says study that revives human lifespan debate – Nature News (free) AND Italian study suggests human lifespan could continue increasing – NHS Choices (free) AND Age 105? Then you’ve a better chance of living even longer – The Guardian (free) AND How Long Can We Live? The Limit Hasn’t Been Reached, Study Finds – The New York Times (free)


8 – Editorial: HPV vaccination: balancing facts – Cochrane Library (free)

Related Cochrane Review: Prophylactic Vaccination Against HPV to Prevent Cervical Cancer (link to review and commentaries)


9 – Beta-blockers and inhibitors of the renin-angiotensin aldosterone system for chronic heart failure with preserved ejection fraction – Cochrane Library (free)

Summary: Beta-blockers and inhibitors of the renin-angiotensin aldosterone system for chronic heart failure with preserved ejection fraction – Cochrane Library (free)

Related Meta-Analysis: Drug treatment effects on outcomes in heart failure with preserved ejection fraction: a systematic review and meta-analysis – Heart (free)

This Cochrane review suggests mineralocorticoid receptor antagonists may be of benefit to reduce hospitalizations, while the meta-analysis in Heart suggests beta-blockers may improve all-cause and cardiovascular mortality…


10 – The 2016 global and national burden of diabetes mellitus attributable to PM2·5 air pollution – The Lancet Planetary Health (free)

Commentaries: Air pollution and diabetes: it’s time to get active! – The Lancet Planetary Health (free) AND Air pollution linked to 3.2 million new diabetes cases in one year – CNN (free) AND Air pollution contributes significantly to diabetes globally – Washington University School of Medicine (free)

Related: WHO Report: 9 out of 10 People Worldwide Breathe Polluted Air (free report and commentaries) AND Ambient Air Pollution in Relation to Diabetes (free research) AND The Lancet Commission on pollution and health (free resources) AND Air Pollution and Mortality (free research and commentaries) AND Global burden of disease attributable to ambient air pollution (free report and commentaries) AND 5.5 million lives were lost in 2013 to diseases associated with Air Pollution (free report and infographic)


Fri, June 29 – 10 Stories of The Day!

29 Jun,2018


1 – A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology – Clinical Infectious Diseases (free)

News Release: IDSA/ASM Lab Diagnosis Guide Helps Health Care Providers Navigate Rapidly Changing Landscape of Infectious Diseases Tests, Enabling Faster, Better Treatment – Infectious Diseases Society of America (free)


2 – Prospective external validation of the Predicting Out-of-OFfice Blood Pressure (PROOF-BP) strategy for triaging ambulatory monitoring in the diagnosis and management of hypertension: observational cohort study – The BMJ (free)

Commentary: Reducing the need for 24-hour blood pressure monitors in general practice – University of Oxford (free)

The tool: freely available online here 


3 – Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study – The BMJ (free)

Commentaries: Penicillin-allergic patients may run bigger risk of MRSA, C diff – CIDRAP (free) AND Patients believed allergic to penicillin have increased risks of MRSA and C. difficile – Massachusetts General Hospital (free) AND Patients with Documented Penicillin Allergy at Higher Risk for MRSA, C. difficile – NEJM Physician’s First Watch (free)


4 – Perspective: Potential Policy Approaches to Address Diet-Related Diseases – JAMA (free for a limited period)

Related: Fiscal policies for diet and the prevention of noncommunicable diseases – World Health Organization (free) AND To improve global health, tax the things that are killing us – Financial Times (free articles, commentaries and reports) AND The Lancet taskforce on NCDs and economics (free series and commentaries)


5 – Perspective: What’s the Best Way to Treat Normal-Weight People With Metabolic Abnormalities? – JAMA (free for a limited period)


6 – Guidelines for the management of osteoporosis and fragility fractures – Internal and Emergency Medicine (free)

Related Guidelines: UK clinical guideline for the prevention and treatment of osteoporosis – Archives of Osteoporosis (free) AND Treatment of Low Bone Density or Osteoporosis to Prevent Fractures in Men and Women: A Clinical Practice Guideline Update from the American College of Physicians – Annals of Internal Medicine (free)


7 – Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis – Allergy Asthma & Immunology Research (free)


8 – Midlife contributors to socioeconomic differences in frailty during later life: a prospective cohort study – The Lancet Public Health (free)

Commentaries: Frailty: from clinical syndrome to epidemiological construct? – The Lancet Public Health (free) AND Old before your time? Scientists have put together five warning signs middle-aged people will suffer from frailness in retirement – Daily Mail (free) AND Five modifiable risk factors found to help reach healthy old age – OnMedica (free)

Related Study: Impact of Healthy Lifestyle Factors on Life Expectancies (link to abstract and commentaries)


9 – Oncological outcome after MRI‐based selection for neoadjuvant chemoradiotherapy in the OCUM Rectal Cancer Trial – British Journal of Surgery (link to abstract – $ for full-text)

Commentaries: Many patients with rectal cancer may not need chemoradiotherapy – eCancer News (free) AND Limiting Chemo to High-Risk Rectal Cancer Called Feasible – MedPage Today (free registration required) AND OCUM Trial: Some Rectal Cancers Need Only Surgery – Medscape (free registration required)


10 – Study Guide: Rip Current Heroes Study Guide – National Geographic (free PDF)

News Release: Rip Current Heroes Study Guide (Free)

Videos: Rip Current Heroes (free)

Related Reports: Preventing drowning: an implementation guide – World Health Organization (free) AND Global report on drowning: preventing a leading killer – World Health Organization (free) AND Hidden Hazards: An Exploration of Open Water Drowning and Risks for Children – Safe Kids Worldwide (free PDF)

Source: Global Health NOW Newsletter

Each year they kill, on average, more lives in Australia than bushfires, floods, cyclones and sharks combined.
The global drowning prevention community is out to spread the word on identifying and escaping deadly rip currents with a public awareness campaign today. Check out a documentary and study guide focused on rip current science and survival strategies from National Geographic and Australia’s Rob Brander, a global expert in the field from UNSW Sydney”. (from Global Health NOW Newsletter)


Thu, June 28 – 10 Stories of The Day!

28 Jun,2018


1 – Heat-Stable Carbetocin versus Oxytocin to Prevent Hemorrhage after Vaginal Birth – New England Journal of Medicine (free)

Commentaries: Heat-stable drug could save thousands from post-childbirth bleeding: WHO – Reuters (free) AND Saving Moms’ Lives During Childbirth Just Got Easier – NPR (free)


2 – Clinical Report: The Prenatal Visit – The American Academy of Pediatrics (free)

News Release: What to cover during prenatal visit: AAP clinical report offers guidance – AAP News (free)

Commentaries: Urge expectant parents to have prenatal pediatrician visit – Pediatric News (free) AND AAP updates recommendations for prenatal visits – Healio (free registration required)


3 – Guideline Synopsis: Management of Ventricular Arrhythmias and Sudden Cardiac Death Risk Associated With Cardiac Channelopathies – JAMA Cardiology (free for a limited period)

Original Guideline: 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death – Circulation (free PDF)


4 – Sex‐Specific Associations Between Alcohol Consumption and Incidence of Hypertension: A Systematic Review and Meta‐Analysis of Cohort Studies – Journal of the American Heart Association (free for a limited period)

Related Study: Effects of Repeated Binge Drinking on Blood Pressure Levels and Other Cardiovascular Health Metrics in Young Adults: National Health and Nutrition Examination Survey, 2011‐2014 – Journal of the American Heart Association (free for a limited period)

Editorial: Alcohol Consumption, Hypertension, and Cardiovascular Health Across the Life Course: There Is No Such Thing as a One‐Size‐Fits‐All Approach (free)

Commentaries: Young binge drinkers may have higher heart risks – AHA Newsroom (free) AND Alcohol Intake Tied to Elevated Blood Pressure – NEJM Physician’s First Watch (free) AND Binge drinking may increase heart risks for younger people – UPI (free)


5 – Dietary Recommendations for Adults With Psoriasis or Psoriatic Arthritis From the Medical Board of the National Psoriasis Foundation: A Systematic Review – JAMA Dermatology (link to abstract- $ for full-text)

Commentaries: What is the Role of Diet in Psoriasis and Psoriatic Arthritis? – MedicalResearch.com (free) AND Dietary Changes Can Lessen Severity of Psoriatic Disease – Medscape (free registration required) AND Can Diet Help in Psoriasis? – MedPage Today (free registration required) AND NPF Dietary Recommendations for Psoriatic Disease – RheumNow (free)


6 – Perspective: FDA Repays Industry by Rushing Risky Drugs to Market – ProPublica (free)


7 – Society of Anesthesia and Sleep Medicine Guideline on Intraoperative Management of Adult Patients With Obstructive Sleep Apnea – Anesthesia & Analgesia (free PDF)


8 – Nutritional Considerations in Pediatric Pancreatitis: A Position Paper from the NASPHAN Pancreas Committee and ESPHAN Cystic Fibrosis/Pancreas Working Group – Journal of Pediatric Gastroenterology and Nutrition (free)

Commentary: Pediatric pancreatitis: nutritional care recommendations from ESPGHAN-NASPGHAN – Univadis (free registration required)


9 – Systemic Therapy for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: ASCO Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

Related Guideline: Recommendations on Disease Management for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer and Brain Metastases: ASCO Clinical Practice Guideline Update – Journal of Clinical Oncology (free)


10 – Association of Retinal Nerve Fiber Layer Thinning With Current and Future Cognitive Decline: A Study Using Optical Coherence Tomography – JAMA Neurology (free for a limited period)

Commentaries: Eye Sign of Dementia Risk? Thinning of Retinal Nerve Fiber Layer – MedicalResearch.com (free) AND Are the Eyes Windows to Early Dementia? – MedPage Today (free registration required)

“A thinner Retinal Nerve Fiber Layer is associated with worse cognitive function in individuals without a neurodegenerative disease as well as greater likelihood of future cognitive decline”.


Wed, June 27 – 10 Stories of The Day!

27 Jun,2018


1 – Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: Screening for Osteoporosis (free) AND Osteoporosis Screening—2 Steps May Be Too Much for Women Younger Than 65 Years (free)

Author Interview: USPSTF Recommendation Statement: Screening for Osteoporosis to Prevent Fractures (free)

See also: USPSTF Final Recommendation Statement (free)


2 – The Society for Vascular Surgery practice guidelines on follow-up after vascular surgery arterial procedures – Journal of Vascular Surgery (free)


3 – Recurrent Glioblastoma Treated with Recombinant Poliovirus – New England Journal of Medicine (free for a limited period)

Editorial: Exploiting Viruses to Treat Diseases (free for a limited period)

Commentaries: Doctors Try Genetically Modified Poliovirus As Experimental Brain Cancer Treatment – NPR (free) AND Poliovirus therapy shows early promise in patients with aggressive brain cancer but questions linger – STAT (free)


4 – Closed-Loop Insulin Delivery for Glycemic Control in Noncritical Care – New England Journal of Medicine (free for a limited period)

Commentaries: Improved Glycemic Control With Closed-Loop Insulin Delivery System – Endocrinology Advisor (free) AND Closed-Loop Diabetes Systems (Artificial Pancreas) Can Be Used For Inpatient Care – MedicalResearch.com (free)


5 – Different defibrillation strategies in survivors after out-of-hospital cardiac arrest – Heart (free)

Commentary: Onsite defibrillators helping to increase cardiac arrest survival – Reuters (free)

Related Studies: Impact of Bystander Automated External Defibrillator Use on Outcomes (free study and commentaries) AND Use of public defibrillators linked to out-of-hospital cardiac arrest survival (link to abstract and commentaries) AND Bystander Efforts and 1-Year Outcomes in Out-of-Hospital Cardiac Arrest (link to abstract and commentaries)


6 – Deprescribing Proton Pump Inhibitors – Therapeutics Initiative (free)

Related guidelines: Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Deprescribing antihyperglycemic agents in older persons: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Deprescribing antipsychotics for behavioural and psychological symptoms of dementia and insomnia: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Deprescribing benzodiazepine receptor agonists – Canadian Family Physician (free)


7 – Intentional Weight Loss for Overweight and Obese Knee Osteoarthritis Patients: Is More Better? – Arthritis Care & Research (free PDF)

Commentaries: Long-term weight loss of at least 20% helps improve outcomes in overweight, obese patients with knee osteoarthritis – ACP Internist (free) AND When it comes to weight loss in overweight and obese adults with knee osteoarthritis, more is better – Wiley, via ScienceDaily (free) AND More weight loss tied to less knee pain for obese people – Reuters (free) AND More Weight Loss Linked To Greater Decrease in Knee Arthritis Pain – MedicalResearch.com (free)


8 – The economic cost of inadequate sleep – Sleep (free)

Commentaries: Inadequate sleep could cost countries billions – Oxford University Press USA, via EurekAlert (free) AND Wake-up call: Sleepiness ‘epidemic’ costing global economies billions – The Sidney Morning Herald (free)


9 – Donepezil for dementia due to Alzheimer’s disease – Cochrane Library (free)

Summary: Donepezil for people with dementia due to Alzheimer’s disease – Cochrane Library (free)


10 – Percutaneous Ablation Versus Partial and Radical Nephrectomy for T1a Renal Cancer: A Population-Based Analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Percutaneous ablation may be preferred to nephrectomy for selected patients with early-stage renal cancer – ACP Internist (free) AND New Findings Support Ablation for Small Renal Tumors – Renal & Urology News (free)

Related Meta-Analysis: Radiofrequency ablation versus partial nephrectomy for treatment of renal masses: A systematic review and meta-analysis – The Kaohsiung Journal of Medical Sciences (free) AND Radiofrequency Ablation Versus Partial Nephrectomy in Treating Small Renal Tumors: A Systematic Review and Meta-Analysis – Medicine (free)

“Percutaneous ablation for T1a renal cancer has similar 5-year survival rates to radical nephrectomy but with far fewer 30-day complications and less kidney failure (via @AnnalsofIM see Tweet)


Tue, June 26 – 10 Stories of The Day!

26 Jun,2018


1 – Association of a Bundled Hospital-at-Home and 30-Day Postacute Transitional Care Program With Clinical Outcomes and Patient Experiences – JAMA Internal Medicine (free for a limited period)

Editorial: Hospital-at-Home Care Programs—Is the Hospital of the Future at Home? (free for a limited period)

Author Interview: Association of a Bundled Hospital-at-Home Program With Clinical Outcomes and Patient Experiences (free)

Commentaries: Hospital-at-Home Bundled Program Associated With Better Clinical Outcomes, Patient Experiences – AJMC (free) AND Clinical outcomes and patient experiences vastly improved with hospital at home – The Mont Sinai Hospital, via MedicalXpress (free) AND Hospital-at-Home Care a Potential Alternative to Inpatient Care – Physician’s First Watch (free)


2 – Advance care planning in dementia: recommendations for healthcare professionals – BMC Palliative Care (free)

Related: New Document for Patients: Advanced Health Directive for Dementia (free document and commentaries) AND Alzheimer’s? Your Paperwork May Not Be in Order – The New York Times (10 articles per month are free)


3 – Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health – International Journal of Epidemiology (link to abstract – $ for full-text)

Commentaries: Accurate measurements of sodium intake confirm relationship with mortality – ScienceDaily (free) AND Better estimate of intake more firmly links salt, death – UPI (free)

Related Report: Sodium and Potassium Intake: Effects on Chronic Disease Outcomes and Risks – Agency for Healthcare Research and Quality (free)


4 – Saline irrigation for allergic rhinitis – Cochrane Library (free)

Summary: Nasal saline for allergic rhinitis – Cochrane Library (free)


5 – Richard Lehman’s journal review, 25 June 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.


6 – Update on difficult airway management with a proposal of a simplified algorithm, unified and applied to our daily clinical practice – Colombian Journal of Anesthesiology (free)

Related Guidelines: Difficult Airway Society 2015 guidelines for management of unanticipated difficult intubation in adults – British Journal of Anaesthesia (free) AND Practice Guidelines for Management of the Difficult Airway: An Updated Report by the American Society of Anesthesiologists Task Force on Management of the Difficult Airway – Anesthesiology (free)

Source: Critical Care Reviews Newsletter


7 – Robot-assisted radical cystectomy versus open radical cystectomy in patients with bladder cancer (RAZOR): an open-label, randomised, phase 3, non-inferiority trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Robotic, Open Cystectomy Offer Comparable Bladder Cancer Outcomes – Renal & Urology News (free) AND RAZOR study: No differences in robotic vs open surgery for bladder cancer – Coloproctology News (free) AND Robotic surgery is no better than traditional surgery, bladder cancer study finds – The Washington Post (free)


8 – A Randomized Controlled Trial of Parent-Child Psychotherapy Targeting Emotion Development for Early Childhood Depression – The American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Parent-Child Psychotherapy Leads to Improvements in Young Children With Depression – Psychiatric News Alert (free) AND Psychotherapeutic intervention shows promise for treating depression in preschool-aged children – NIH News Releases (free) AND Parent-child therapy helps young children with depression – Washington University School of Medicine, via ScienceDaily (free)

Related Study: Talking therapy given by parents shows promise for childhood anxiety disorders (free research, editorial and commentaries)


9 – Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration – JAMA (link to abstract – $ for full-text)

Commentaries: Oxygen for preterm infants, what dose of this toxic drug is the right dose? #NeoEBM – Neonatal Research (free) AND Lower and higher oxygen saturation targets result in equal but contrasting outcomes for extremely preterm infants – 2 Minute Medicine (free)


10 – Association Between Portable Music Player Use and Hearing Loss Among Children of School Age in the Netherlands – JAMA Otolaryngology-Head & Neck Surgery (link to abstract – $ for full-text)

Commentaries: Portable music players tied to hearing loss in kids – Reuters (free) AND Portable Music Player Use Linked to Hearing Loss in Children – MPR (free)


Mon, June 25 – 10 Stories of The Day!

25 Jun,2018


1 – Diarrhoea in adult cancer patients: ESMO Clinical Practice Guidelines – Annals of Oncology (free)


2 – Neonatal interventions for preventing cerebral palsy: an overview of Cochrane Systematic Reviews – Cochrane Library (free)

Summary: Interventions for babies from birth to one month of life for preventing cerebral palsy: an overview of Cochrane Systematic Reviews (free)


3 – Prophylactic abdominal drainage for pancreatic surgery – Cochrane Library (free)

Summary: Drain use after pancreatic surgery – Cochrane Library (free)


4 – Resuscitation Education Science: Educational Strategies to Improve Outcomes From Cardiac Arrest: A Scientific Statement From the American Heart Association – Circulation (free PDF)

See also: Highlights (free PDF) AND FAQs (free PDF) AND Infographic (free PDF)


5 – Perspective: Breathing Tubes Fail to Save Many Older Patients – The New York Times (10 articles per month are free)

“One-third of patients over age 65 die in the hospital after they are put on ventilators. Doctors are beginning to wonder if the procedure should be used so often”.


6 – Core Competencies in Evidence-Based Practice for Health Professionals: Consensus Statement Based on a Systematic Review and Delphi Survey – JAMA Network Open (free)

Editorial: Interprofessional Evidence-Based Practice Competencies: Equalizing the Playing Field (free)

“68 core competencies for evidence-based practice for health professionals, developed using systematic review & Delphi consensus process” (via @hildabast see Tweet)


7 – Association of Initiation of Basal Insulin Analogs vs Neutral Protamine Hagedorn Insulin With Hypoglycemia-Related Emergency Department Visits or Hospital Admissions and With Glycemic Control in Patients With Type 2 Diabetes – JAMA (free for a limited period)

Editorial: Revisiting NPH Insulin for Type 2 Diabetes: Is a Step Back the Path Forward? (free for a limited period)

Clinical Review Audio: Health Care Spending Gone Wild: Using Expensive Insulin Analogs With Few Clinical Advantages (free)

“Long-acting insulin analogs not associated with reduced hypoglycemia-related ED visits or hospital admissions when compared with NPH insulin, despite costing 5-10x as much” (via @jsross119 see Tweet)


8 – Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial – The Lancet (link to abstract – $ for full-text)

Commentary: Spotlight on albumin in cirrhosis – ACP Gastroenterology (free)


9 – Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Commentary: BICAR-ICU – The Bottom Line (free)

This study will reassure clinicians that already use sodium bicarbonate for correcting metabolic acidaemia, that this may delay and/or reduce the requirement for RRT. Equally, for those that opt to avoid sodium bicarbonate, there is no compelling evidence to change practice” (from The Bottom Line)


10 – Determinants of long-term clinical outcomes in patients with angina but without obstructive coronary artery disease: a systematic review and meta-analysis – European Heart Journal (free)

Commentaries: Outcomes in Patients With Angina but Without Obstructive CAD – American College of Cardiology (free)


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