Open access


Wed, October 3 – 10 Stories of The Day!

3 Oct,2018


1 – Ten Principles for More Conservative, Care-Full Diagnosis – Annals of Internal Medicine (free) (via @EricTopol)


2 – Management of Malignant Pleural Effusions. An Official ATS/STS/STR Clinical Practice Guideline – American Journal of Respiratory and Critical Care Medicine (free)

Related Guideline: ERS/EACTS statement on the management of malignant pleural effusions – European Respiratory Journal (free)


3 – Effect of Early Surgery vs Physical Therapy on Knee Function Among Patients With Nonobstructive Meniscal Tears: The ESCAPE Randomized Clinical Trial – JAMA (free for a limited period)

Commentary: PT an Alternative to Surgery for Some Meniscal Tears – Physician’s First Watch (free)

Related: Adverse Outcomes After Arthroscopic Partial Meniscectomy (free study, commentary and guideline on the subject)

 “Our Dutch multi center RCT demonstrates noninferiority of physical therapy compared with early surgery with arthroscopic partial meniscectomy for improving self-reported knee function in patients with nonobstructive meniscal tears.” (via @RudolfPoolman see Tweet)


4 – Association of Thyroid Hormone Therapy With Quality of Life and Thyroid-Related Symptoms in Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)

Commentaries: Most Patients With Subclinical Hypothyroidism May Not Require Thyroid Medication – MedicalResearch.com (free) AND Hormone Tx May Not Benefit Subclinical Hypothyroidism – MedPage Today (free registration required) AND Treating Subclinical Hypothyroidism Is of Little Benefit – Medscape (free registration required)


5 – A systematic review into the incidence, severity and duration of antidepressant withdrawal effects: Are guidelines evidence-based? – Addictive Behaviours (free PDF)

Commentaries: Antidepressant withdrawal ‘hits millions’ – BBC (free) AND Antidepressant withdrawal symptoms severe, says new report – The Guardian (free)

Related: Antidepressant Withdrawal Syndrome (free review and NYT article)


6 – Association is not causation: treatment effects cannot be estimated from observational data in heart failure – European Heart Journal (free)


7 – Fracture Prevention with Zoledronate in Older Women with Osteopenia – New England Journal of Medicine (free)

Editorial: A Not-So-New Treatment for Old Bones (free)

Commentary: Study Suggests More Older Women May Benefit From Bone Drugs – The Associated Press (free)


8 – Review: Neuro-Ophthalmology at the bedside: A clinical guide – Journal of Neurosciences in Rural Practice (free)


9 – Efficacy of Low-Dose Amitriptyline for Chronic Low Back Pain: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Low-dose antidepressants ease back pain – Australian Hospital + Healthcare Bulletin (free) AND Antidepressant Amitriptyline Might Help Ease Low Back Pain – Physician’s First Watch (free)


10 – Six months versus 12 months dual antiplatelet therapy after drug-eluting stent implantation in ST-elevation myocardial infarction (DAPT-STEMI): randomised, multicentre, non-inferiority trial – The BMJ (free)

Related Research: 6-month versus 12-month or longer dual antiplatelet therapy after percutaneous coronary intervention in patients with acute coronary syndrome (link to abstract and commentaries)

In this study, DAPT for 6 months was non-inferior to DAPT for 12 months after drug-eluting stent implantation in ST-elevation myocardial infarction.


Tue, October 2 – 10 Stories of The Day!

2 Oct,2018


1 – Press Release: The Nobel Prize in Physiology or Medicine 2018 – The Nobel Prize (free)

Commentaries: Cancer immunologists scoop medicine Nobel prize – Nature (free) AND Nobel Prize in medicine awarded to two cancer researchers for immune system breakthrough – STAT (free) AND 2018 Nobel Prize in Medicine Awarded to 2 Cancer Immunotherapy Researchers – The New York Times (10 articles per month are free)


2 – Effect of Increased Daily Water Intake in Premenopausal Women With Recurrent Urinary Tract Infections: A Randomized Clinical Trial – JAMA Internal Medicine (free)

Editorial: Drinking More Water for Prevention of Recurrent Cystitis (free)

Commentaries: Drinking more water reduces bladder infections in women – UT Southwestern Medical Center (free) AND Drinking more water linked to fewer bladder infections in women – UPI (free)


3 – Report: Taking action on childhood obesity report – World Health Organization (free PDF) (via @equitylist)


4 – Supplement: Practical guide for allergy and immunology in Canada 2018 – Allergy, Asthma & Clinical Immunology (free reviews)

– Homepage

– Introduction from the Editors

– An introduction to immunology and immunopathology

– Asthma

– Allergic rhinitis

– Atopic dermatitis

– Allergen-specific immunotherapy

– Anaphylaxis

– IgE-mediated food allergy

– Non-IgE-mediated food hypersensitivity

– Early introduction of foods to prevent food allergy

– Eosinophilic esophagitis

– Urticaria and angioedema

– Drug allergy

– Primary immunodeficiency


5 – Perspective: Failing the Public Health — Rofecoxib, Merck, and the FDA – New England Journal of Medicine (free)


6 – Zackary Berger’s journal reviews, 1 October 2018 – The BMJ Opinion (free)


7 – Standards for Neurologic Critical Care Units: A Statement for Healthcare Professionals from The Neurocritical Care Society – Neurocritical Care (free)

Source: Critical Care Reviews Newsletter


8 – Review: Pulmonary vasculitis – Journal of Thoracic Disease (free)

Source: Critical Care Reviews Newsletter


9 – Over 80,000 Americans Died of Flu Last Winter, Highest Toll in Years – The New York Times (10 articles per month are free)

Related: 80,000 people died of flu last winter in US – Associated Press (free)


10 – Language Experience in the Second Year of Life and Language Outcomes in Late Childhood – Pediatrics (free)

Commentaries: Early Language Exposure and Middle School Language and IQ: Implications for Primary Prevention – Pediatrics (free) AND Conversations Between Parents and Toddlers Help Build Intelligence and Vocabulary – Journal Watch (free)


Mon, October 1 – 10 Stories of The Day!

1 Oct,2018


1 – WHO launches SAFER alcohol control initiative to prevent and reduce alcohol-related death and disability – World Health Organization (free)

See also: SAFER High Impact Strategies (free)

Related: WHO Global Status Report on Alcohol and Health 2018 (free report and commentaries)


2 – Guideline: Placenta Praevia and Placenta Accreta: Diagnosis and Management – British Journal of Obstetrics and Gynaecology (free)


3 – Guideline: Vasa Praevia: Diagnosis and Management – British Journal of Obstetrics and Gynaecology (free)


4 – Video: KHN Conversation on Overtreatment – Kaiser Health News (free)

Commentary: Changing Healthcare’s Culture of Overtreatment a Challenge – MedPage Today (free registration required)

Related KHN Series: Treatment Overkill (free articles)


5 – WCLC 2018: NELSON Study: CT Screening for Early Lung Cancer Reduces Lung Cancer Mortality – The ASCO Post (free)

Related: NELSON lung cancer study encourages widespread screening, Medicare reimbursement – Health Imaging (free) AND Second Large Study Shows That Lung Cancer Screening Works – Medscape (free registration required)


6 – Perspective: More Evidence That Nutrition Studies Don’t Always Add Up – The New York Times (10 articles per month are free)


7 – Podcast: #116 Geriatric Psychiatry: Sleep, Dementia, and Behavioral Disturbances – Curbsiders Internal Medicine Podcast (free)

Related Podcast: #115 Geriatric Depression – The Curbsiders Internal Medicine Podcast (free)


8 – Effects of Coenzyme Q10 on Statin‐Induced Myopathy: An Updated Meta‐Analysis of Randomized Controlled Trials – Journal of the American Heart Association (free)

Commentary: Coenzyme Q10 reduces statin-induced myopathy symptoms – Univadis (free registration required)


9 – Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing – New England Journal of Medicine (free)

Editorial: The Coming of Age of Drug-Susceptibility Testing for Tuberculosis (free)

Commentaries: Study heralds genetic era of TB drug susceptibility testing – CIDRAP (free) AND UK-led study marks shift towards genetic era in tackling TB – NIHR Oxford Biomedical Research Centre (free)


10 – 2018 IDSA Guidelines for Clostridium Difficile Infection: fecal transplant gets its moment in the sun – PulmCCM (free)

Related Guidelines: Clinical Practice Guidelines for Clostridium difficileInfection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) – Clinical Infectious Diseases (free) AND The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines – GUT (free)


Fri, September 28 – 10 Stories of The Day!

28 Sep,2018


1 – Editorial: We Know How to Conquer Tuberculosis – The New York Times (10 articles per month are free)

Related: Tuberculosis experts hail historic week in the fight against TB – London School of Hygiene & Tropical Medicine (free) AND You Can’t Treat Tuberculosis With Platitudes – Foreign Policies (a few articles are free) AND Tuberculosis is a disease the world could control. But will it? – STAT (free) AND Addressing the Tuberculosis Epidemic: 21st Century Research for an Ancient Disease – JAMA (free)


2 – Potential effect of household contact management on childhood tuberculosis: a mathematical modelling study – The Lancet Global Health (free)

Invited Commentary: Preventing tuberculosis in household contacts crucial to protect children and contain epidemic spread (free)

Related: New roadmap to prevent and treat tuberculosis in children and adolescents – UNICEF (free)


3 – Doctor Referral of Overweight People to Low Energy total diet replacement Treatment (DROPLET): pragmatic randomised controlled trial – The BMJ (free)

Commentaries: Susan Jebb: Interventions to treat obesity work—so why am I not celebrating? – The BMJ Opinion (free) AND Expert reaction to study looking at total diet replacement programmes and obesity – Science Media Centre (free) AND Crash diets are highly effective – new evidence – The Conversation (free)


4 – Associations between 24 hour movement behaviours and global cognition in US children: a cross-sectional observational study – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)

Commentaries: Limiting children’s recreational screen time to less than 2 hours a day linked to better cognition – The Lancet (free) AND Limiting children’s screen time linked to better cognition, study says – CNN (free) AND Limiting children’s screen time linked to better cognition – BBC (free)

“Researchers said more work was now needed to better understand the effects of different types of screen use. However, they acknowledge that their observational study shows only an association between screen time and cognition and cannot prove a causal link.” (from BBC)


5 – Association of Same-Day Discharge After Elective Percutaneous Coronary Intervention in the United States With Costs and Outcomes – JAMA Network Open (free)

“Same day discharge after elective PCI used infrequently (3.5%), while safe + associated w/ reduced costs” (via @krychtiukmd see Tweet)


6 – Video: Understanding How Machine Learning Works – JAMA (free)


7 – Deprescribing recommendations: An essential consideration for clinical guideline developers – Research in Social and Administrative Pharmacy (free)

Related: Position Statement: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)

““Clinical guidelines often do not accommodate frailty or patients with multiple comorbid conditions. This can give rise to complex medication regimens and risk of medication harm. “Paper discusses the need to include deprescribing in clinical guidelines” (via @Deprescribing see Tweet)


8 – Opinion: No more first authors, no more last authors – Nature (free)

“The controversial suggestion that we “blow up” authorship conventions to foster team, collaborative science” (via @EricTopol see Tweet)


9 – Perspective: No One Knows Exactly What Would Happen If Mosquitoes Were to Disappear – The Atlantic (free)

Related: Mosquitoes Genetically Modified To Crash Species That Spreads Malaria – NPR (free) AND Scientists use gene drive to eradicate lab mosquitoes for the first time – STAT (free) AND Malaria mosquitoes wiped out in lab trials of gene drive technique – Reuters (free)


10 – Ethanol lock is effective on reducing the incidence of tunneled catheter-related bloodstream infections in hemodialysis patients: a systematic review and meta-analysis – International Urology and Nephrology (link to abstract – $ for full-text)

Commentary: Ethanol locks in catheters for dialysis may prevent sepsis – NIHR Signal (free)


Thu, September 27 – 10 Stories of The Day!

27 Sep,2018


1 – Phase 2b Controlled Trial of M72/AS01E Vaccine to Prevent Tuberculosis – New England Journal of Medicine (free)

Editorial: New Promise for Vaccines against Tuberculosis (free)

Commentaries: New TB vaccine protects half of people with latent infection – NBC Health News (free) AND Experimental vaccine shows promise in preventing TB – MedicalXpress (free)


2 – Systematic review update of observational studies further supports aspirin role in cancer treatment: Time to share evidence and decision-making with patients? – PLOS One (free)

Commentaries: Aspirin could play key role in treating some cancers – UPI (free) AND Could aspirin play role in treatment of cancer? – Cardiff University (free)


3 – Two‐year results of the randomized clinical trial DILALA comparing laparoscopic lavage with resection as treatment for perforated diverticulitis – British Journal of Surgery (free)

Commentary: Comparing Laparoscopic Lavage vs Resection for Perforated Diverticulitis – Medscape (free registration required)


4 – Temporal trends in muscular fitness of English 10-year-olds 1998–2014: An allometric approach – Journal of Science and Medicine in Sport (link to abstract – $ for full-text)

Commentary: Fall in strength and fitness of 10-year-olds, study shows – BBC (free) AND Ten-Year-Olds Are Weaker Today Than They Were 16 Years Ago – HuffPost (free) AND British study reveals fall in muscle strength of 10-year-olds – The Guardian (free)


5 – STAT’s cheerleading coverage of prescription fish oil capsule lacks crucial context – Health News Review (free)

Original Commentary: Amarin fish oil capsule shows dramatic benefit for cardiovascular patients, potentially upending market – STAT (free)


6 – Conventional Autopsy versus Minimally Invasive Autopsy with Postmortem MRI, CT, and CT-guided Biopsy: Comparison of Diagnostic Performance – Radiology (free for a limited period) (via @EricTopol)

Commentary: Minimally invasive autopsy improves postmortem diagnoses – Radiology Society of North America (free)

Related Systematic Review: Non-invasive or minimally invasive autopsy compared to conventional autopsy of suspected natural deaths in adults  – European Radiology (free)


7 – Effect of Digital Cognitive Behavioral Therapy for Insomnia on Health, Psychological Well-being, and Sleep-Related Quality of Life: A Randomized Clinical Trial – JAMA Psychiatry (free for a limited period) (via @EricTopol)

Commentary: Insomnia symptoms, overall health improve with online insomnia program – Northwestern University (free)


8 – Association between physician US News & World Report medical school ranking and patient outcomes and costs of care: observational study – The BMJ (free)

“Overall, little or no relation was found between the USNWR ranking of the medical school from which a physician graduated and subsequent patient mortality or readmission rates.”


9 – Modifying the consistency of food and fluids for swallowing difficulties in dementia – Cochrane Library (free for a limited period)

Summary: Modifying the consistency of food and fluids for swallowing difficulties in dementia (free)

“We are uncertain about the immediate and long-term effects of modifying the consistency of fluid for swallowing difficulties in dementia”


10 – Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies – Molecular Psychiatry (link to abstract – $ for full-text)

Commentaries: Plant-rich diets may help prevent depression – new evidence – The Conversation (free) AND Eating a Mediterranean diet ‘may lower your risk of depression’ – NHS Choices (free) AND Expert reaction to observational studies on diet and depression – Science Media Centre (free) AND Mediterranean diet could prevent depression, new study finds – CNN (free)

“The current evidence is not sufficient to prove plant-rich diets can prevent depression as most of the evidence so far simply shows that those with poorer mental health eat worse, so it may be that those more prone to depression also choose less health” (from CNN)


Wed, September 26 – 10 Stories of The Day!

26 Sep,2018


1 – Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Podcast: Treating Appendicitis Without Surgery – 5-Year Follow-up from a Randomized Clinical Trial of Antibiotic Treatment (free)

Video Summary: Five-Year Follow-up of Patients Given Antibiotic Therapy for Uncomplicated Acute Appendicitis (free)

Commentaries: Pills for appendicitis? Surgery often not needed, study says – STAT (free) AND Antibiotics Alone Seem Reasonable for Uncomplicated Appendicitis in Adults – Physician’s First Watch (free) AND Appendicitis? Antibiotics May Be All You Need – The New York Times (10 articles per month are free)

Related: Randomized clinical trial of antibiotic therapy for uncomplicated appendicitis (link to abstract and commentaries) AND Antibiotics Versus Surgical Therapy for Uncomplicated Appendicitis (link to abstract and commentaries) AND Antibiotic Therapy versus Appendectomy for Acute Uncomplicated Appendicitis (free study and commentaries) AND New appendicitis guideline incorporates the possibility of non-operative treatment for uncomplicated disease (free guideline)


2 – Type 1 Diabetes in Children and Adolescents: A Position Statement by the American Diabetes Association – Diabetes Care (free)


3 – Recovery of Over-Ground Walking after Chronic Motor Complete Spinal Cord Injury – New England Journal of Medicine (free)

Commentaries: Technology and therapy help individuals with chronic spinal cord injuries take steps – University of Louisville (free) AND Epidural Stimulation Helps Patients Walk After Total Paralysis – MedPage Today (free registration required) AND Paralyzed Patients Able to Walk Following Epidural Stimulation, Intense Rehab – Physician’s First Watch (free)


4 – Prevalence of drug–herb and drug–supplement interactions in older adults: a cross-sectional survey – British Journal of General Practice (free)

Commentaries: New study finds concurrent use of prescription drugs and dietary supplements could pose health risks – University of Hertfordshire (free) AND Concerns raised about older adults mixing prescription drugs and herbal remedies – NHS Choices (free)


5 – Development and Validation of Deep Learning–based Automatic Detection Algorithm for Malignant Pulmonary Nodules on Chest Radiographs – Radiology (link to abstract – $ for full-text)

Commentary: Deep learning algorithm detects malignant pulmonary nodules better than radiologists – Radiology Business (free)

Related Studies: Deep Learning for the Diagnosis of Fibrotic Lung Disease (link to abstract and commentaries) AND Can Artificial Intelligence Reliably Report Chest X-Rays? (free study and commentaries) AND Artificial Intelligence Can Determine Lung Cancer Type (link to abstract and commentaries)


6 – Measuring human capital: a systematic analysis of 195 countries and territories, 1990–2016 – The Lancet (free)

Commentary: Unprecedented study finds nations failing to invest in education and health care at risk of slow economic growth – Institute for Health Metrics and Evaluation (free)

Infographic: What is human capital and why is it relevant? – Institute for Health Metrics and Evaluation (free)

The first-ever study ranking countries by human capital has been published in @TheLancet. This novel approach looks at nations’ investments in health and education and their relation to GDP growth” (via @IHME_UW see Tweet)


7 – Pharmacokinetics–pharmacodynamics issues relevant for the clinical use of beta-lactam antibiotics in critically ill patients – Critical Care (free)

Related: Extended Antibiotic Infusions Could Save Lives: Here’s How to Do It (free commentary) AND Mortality lower with prolonged vs. short-term IV infusion of antipseudomonal beta-lactams (link to abstract and free commentary)


8 – Ebola response faces ‘grave obstacles’ as count hits 150 – CIDRAP (free)

Related: WHO warns of ‘perfect storm’ for Ebola in eastern Congo – STAT (free) AND WHO extremely concerned about Ebola ‘perfect storm’ in Congo – Reuters (free)


9 – Adverse outcomes after arthroscopic partial meniscectomy: a study of 700 000 procedures in the national Hospital Episode Statistics database for England – The Lancet (free)

Invited Commentary: Potential harms of isolated arthroscopic partial meniscectomy (free)

Related: Needless procedures: knee arthroscopy is one of the most common but least effective surgeries – The Conversation (free) AND Arthroscopic surgery for degenerative knee arthritis and meniscal tears: a clinical practice guideline (free guideline and commentary)


10 – Effect of Algorithm-Based Therapy vs Usual Care on Clinical Success and Serious Adverse Events in Patients with Staphylococcal Bacteremia: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Treatment Algorithms for Staphylococcal Bacteremia: Improving Clinical Care and Enhancing Antimicrobial Stewardship (free for a limited period)

Commentary: Algorithm may reduce antibiotics for staph bloodstream infections – CIDRAP (free)


Tue, September 25 – 10 Stories of The Day!

25 Sep,2018


1 – Noncommunicable Diseases Country Profiles 2018 – World Health Organization (free PDF)

See also: NCDs profile by country (free)


2 – Transcatheter Mitral-Valve Repair in Patients with Heart Failure – New England Journal of Medicine (free)

Commentary: COAPT: MitraClip Reduces Repeat Hospitalizations, Mortality in Functional MR Patients With Severe HF – TCTMD (free)

Related MITRA-FR trial: Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation – New England Journal of Medicine (free)

“Physicians responded with shock and excitement to findings, but struggled to reconcile the results with the MITRA-FR trial.” (from TCTMD)


3 – Effect of Variation in Published Stroke Rates on the Net Clinical Benefit of Anticoagulation for Atrial Fibrillation – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: Benefit of anticoagulation for stroke prevention may vary in patients with afib, study finds – ACP Internist (free)


4 – Review: Streptococcal toxic shock syndrome in the intensive care unit – Annals of Intensive Care (free)

Source: Critical Care Reviews Newsletter


5 – Targeted temperature management in patients with intracerebral haemorrhage, subarachnoid haemorrhage, or acute ischaemic stroke: consensus recommendations – British Journal of Anaesthesia (free)

Source: Critical Care Reviews Newsletter


6 – Podcast: #115 Geriatric Depression – The Curbsiders Internal Medicine Podcast (free)

Summary: #115 Geriatric Depression: Diagnosis, Antidepressants, and More (free)


7 – Ann Robinson’s research reviews, 24 September 2018 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.


8 – Congratulations. Your Study Went Nowhere – The New York Times (10 articles per month are free) (via @kennylinafp)

“Researchers should embrace negative results instead of accentuating the positive, which is one of several biases that can lead to bad science.”


9 – Just Started! Free Online Course: Antibiotic Stewardship – Stanford University and Coursera (via @classcentral)


10 – Double check patients with ‘penicillin allergy’ to avoid increased MRSA risk – NICE News and Features (free)

Related Study: Risk of Meticillin Resistant Staphylococcus Aureus and Clostridium Difficile in Patients with a Documented Penicillin Allergy (free article and commentaries)


Mon, September 24 – 10 Stories of The Day!

24 Sep,2018


1 – Global status report on alcohol and health 2018 – World Health Organization (free PDF)

News Release: Harmful use of alcohol kills more than 3 million people each year, most of them men (free)

Commentaries: Alcohol abuse kills 3 million a year, most of them men: WHO – Reuters (free) AND 1 in 20 deaths globally is a result of alcohol use – CNN (free) AND Alcohol causes one in 20 deaths worldwide, says WHO – The Guardian (free)


2 – NCD Countdown 2030: worldwide trends in non-communicable disease mortality and progress towards Sustainable Development Goal target 3.4 – The Lancet (free registration required)

Commentaries: Most nations falling short of targets to cut early deaths from chronic disease – Imperial College London (free) AND New Data Suggest More Than Half of Countries Not on Track to Meet Global NCD Goals – American College of Cardiology (free) AND Globally, losing the fight against cancer and other chronic diseases – CNN (free)


3 – Residual vein occlusion in relation to immediate compression and postthrombotic syndrome in deep vein thrombosis – Blood (free PDF)

Commentary: Immediate compression could help prevent complications after deep-vein thrombosis – American Society of Hematology (free)

“Study supports use of this simple, low-cost intervention even for patients without symptoms” (from American Society of Hematology)


4 – Clinical Update: Management of Chronic Wounds—2018 – JAMA (free for a limited period)


5 – Diagnostic Test Interpretation: Diagnostic Testing for Elevated Cortisol in the Setting of an Adrenal Mass – JAMA (free for a limited period)


6 – ‘Latent’ Tuberculosis? It’s Not That Common, Experts Find – The New York Times (1o articles per month are free)

Related Analysis: Revisiting the timetable of tuberculosis – The BMJ (free analysis and commentary)


7 – The cost of persuasive design: digital media use and ADHD – The Mental Elf (free)

Original Study: Association of Digital Media Use with ADHD Among Adolescents (link to abstract and free commentaries)


8 – Amazing ways artificial intelligence is used in healthcare – World Economic Forum (free)


9 – Global epidemiology and outcomes of acute kidney injury – Nature Reviews Nephrology (free for a limited period) (via @Abraham_RMI)


10 – Racial and ethnic estimates of Alzheimer’s disease and related dementias in the United States (2015–2060) in adults aged ≥65 years – Alzheimer’s & Dementia (free for a limited period)

Commentaries: Alzheimer’s and dementia cases will double by 2060 -HealthExec (free) AND Alzheimer’s Burden Projected to Double by 2060 – Physician’s First Watch (free) AND Alzheimer’s Disease Burden to Double by 2060 – MedPage Today (free registration required)


Fri, September 21 – 10 Stories of The Day!

21 Sep,2018


1 – Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet Infectious Diseases (free)

Invited Commentary: The global burden of lower respiratory infections: making progress, but we need to do better (free)


2 – Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet Infectious Diseases (free)

Invited Commentary: Old and new challenges related to global burden of diarrhea (free)

Related Report: Variation in Childhood Diarrheal Morbidity and Mortality in Africa (free article and commentaries)


3 – Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits – Nature Genetics (link to abstract – $ for full-text)

Commentaries: World’s biggest study of blood pressure genetics – Queen Mary University of London (free) AND Researchers find 535 new gene regions that influence blood pressure – UPI (free) AND High blood pressure breakthrough: Over 500 genes uncovered – Medical News Today (free)


4 – Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030 – Journal of Hepatology (free)

Editorial: Predicting the future burden of NAFLD and NASH (free)


5 – Incidence of cardiovascular disease up to 13 year after cancer diagnosis: A matched cohort study among 32 757 cancer survivors – Cancer Medicine (free)


6 – The preventable proportion of healthcare-associated infections 2005–2016: Systematic review and meta-analysis – Infection Control & Hospital Epidemiology (link to abstract – $ for full-text)

Commentary: Even the best healthcare facilities can do more to prevent infections – Society for Healthcare Epidemiology of America (free)

“Multifaceted tactics for infection control reduce healthcare-associated infections 35-55 percent”


7 – Analysis: Diagnostic expansion in clinical trials: myocardial infarction, stroke, cancer recurrence, and metastases may not be the hard endpoints you thought they were – The BMJ (free)


8 – Perspective: The Case For Expensive Antibiotics – Wired (a few articles per month are free) (via @CarlosdelRio7)


9 – Opinion: Everything You Know About Obesity Is Wrong – HuffPost (free) (via @cardiobrief)

“For decades, the medical community has ignored mountains of evidence to wage a cruel and futile war on fat people, poisoning public perception and ruining millions of lives.”


10 – Association between maternal gluten intake and type 1 diabetes in offspring: national prospective cohort study in Denmark – The BMJ (free)

Editorial: Dietary gluten and type 1 diabetes (free for a limited period)

Commentaries: Expert reaction to research on high gluten intake during pregnancy and type 1 diabetes in children – Science Media Centre (free) AND Higher Gluten Intake in Pregnancy Tied to Increased Diabetes Risk in Offspring – Physician’s First Watch (free) AND High gluten intake during pregnancy associated with diabetes – OnMedica (free)

“As such these results, whilst well executed and very interesting, would need to be confirmed within independent similarly sized or bigger studies as stated by the authors themselves.” (from Science Media Centre)


Thu, September 20 – 10 Stories of The Day!

20 Sep,2018


1 – Variation in Childhood Diarrheal Morbidity and Mortality in Africa, 2000–2015 – New England Journal of Medicine (free)

News Release: Discomfort or death? New study maps hot spots of child mortality from diarrhea across Africa – Institute for Health Metrics and Evaluation (free)

Quick Take Video Summary: Variation in Childhood Diarrheal Morbidity and Mortality in Africa (free)


2 – Refractory septic shock: our pragmatic approach – Critical Care (free)


3 – Intensification of older adults’ outpatient blood pressure treatment at hospital discharge: national retrospective cohort study – The BMJ (free)

Commentaries: Study: Hospitals may overprescribe blood pressure meds – UPI (free) AND Veterans overtreated for blood pressure on leaving hospital – MedicalXpress (free) AND Antihypertensive treatment intensified at discharge regardless of outpatient blood pressure history – ACP Hospitalist (free)


4 – Meta-analyses were supposed to end scientific debates. Often, they only cause more controversy – Science (free) (via @Onisillos)


5 – Oral Fluoroquinolone and the Risk of Aortic Dissection – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: The Fluoroquinolone/Aortic Dissection Association – Emergency Medicine Literature of Note (free)

Related observational studies with similar conclusions: Fluoroquinolone use and risk of aortic aneurysm and dissection (free articles)


6 – Deep learning for classifying fibrotic lung disease on high-resolution computed tomography: a case-cohort study – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

Related Audio: Deep learning and fibrotic lung disease (free)

Commentary: Machine Tops Humans in Fibrotic Lung Disease Classification – Medical Health News (free)


7 – Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial – Journal of Clinical Oncology (free)

Commentary: Neoadjuvant Chemoradiotherapy in Locally Advanced Esophageal Cancer – The ASCO Post (free)

Source: EvidenceAlerts


8 – Are noise and air pollution related to the incidence of dementia? A cohort study in London, England – BMJ Open (free)

Commentaries: Air pollution linked to dementia risk – NHS Choices (free) AND Expert reaction to air pollution and risk of dementia – Science Media Centre (free) AND Air pollution may be linked to heightened dementia risk – OnMedica (free) AND Is air pollution tied to higher dementia risk? – CNN (free)


9 – Nutritional quality of food as represented by the FSAm-NPS nutrient profiling system underlying the Nutri-Score label and cancer risk in Europe: Results from the EPIC prospective cohort study – PLOS Medicine (free)

Commentaries: Expert reaction to study looking at nutritional quality of food and risk of cancer – Science Media Centre (free) AND Foods with low nutritional quality tied to higher cancer risk – Medical News Today (free)


10 – Association of Medical Scribes in Primary Care With Physician Workflow and Patient Experience – JAMA Internal Medicine (free for a limited period)

Commentaries: Use of Medical Scribes to Reduce Documentation Burden: Are They Where We Need to Go With Clinical Documentation? – JAMA Internal Medicine (free for a limited period) AND Scribes improve physician workflow, patient interaction – MedicalXpress (free) AND Scribes ease physician administrative burden and boost patient experience, JAMA study says – Healthcare Finance (free)


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