Open access

Mon, September 18 – 10 Stories of The Day!



1 – Life, death, and disability in 2016: latest estimates from The Global Burden of Disease Study – The Lancet

Editorial: Life, death, and disability in 2016 (free)

– Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016 (free)

– Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016 (free)

– Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016 (free)

– Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016 (free)

– Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2016 (free)

– Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries (free)

Commentaries: New global study finds countries saving more lives, despite a ‘triad of troubles’ in obesity, violence, and mental illness – Institute of Health Metrics and Evaluation (free) AND Smoking And Poor Diet Still Leading Killers Worldwide – Pursuit (free)

See also: GBD Compare Interactive Tool – Explore which causes & risk factors are causing the most death & disability in your country over time (free tool)


2 – Guideline: Type 2 diabetes: prevention in people at high risk – National Institute for Health and Care Excellence (NICE) (free)


3 – Guideline: Depression in children and young people: identification and management – National Institute for Health and Care Excellence (NICE) (free)


4 – Percutaneous Coronary Intervention vs Coronary Artery Bypass Grafting in Patients With Left Main Coronary Artery Stenosis: A Systematic Review and Meta-analysis – JAMA Cardiology (free)

Commentary: CABG, PCI show similar long-term outcomes – Cardiovascular Business (free)


5 – Meat, Dietary Heme Iron, and Risk of Type 2 Diabetes Mellitus: The Singapore Chinese Health Study – American Journal of Epidemiology (link to abstract – $ for full-text)

Commentary: Eating meat linked to higher risk of diabetes – DukeNUS Medical School, via EurekAlert (free)

Related articles: Meat Consumption as a Risk Factor for Type 2 Diabetes – Nutrients (free) AND Meat consumption and the risk of type 2 diabetes: a systematic review and meta-analysis of cohort studies – Diabetologia (free) AND Red meat consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis – American Journal of Clinical Nutrition (free)

“The Singapore Chinese Health Study reveals increased risk of diabetes with higher intake of red meat and poultry, partially attributed to the dietary iron content in these meats” (from EurekAlert)


6 – How Big Business Got Brazil Hooked on Junk Food – The New York times (10 articles per month are free) (RT @glassmanamanda see Tweet)

“As growth slows in wealthy countries, Western food companies are aggressively expanding in developing nations, contributing to obesity and health problems”.


7 – Evaluation of a Rapid Molecular Drug-Susceptibility Test for Tuberculosis – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Detecting Tuberculosis Resistance (free)

Commentary: New rapid molecular test for MDR-TB shows promise – CIDRAP (free)


8 – European guidelines on perioperative venous thromboembolism prophylaxis: Surgery in the elderly – European Journal of Anaesthesiology (free PDF)


9 – Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentary: Sulfonylureas, Pioglitazone Similarly Safe for Add-On Therapy in Type 2 Diabetes – Physician’s First Watch (free)


10 – Review: Drug-induced liver injury: recent advances in diagnosis and risk assessment – Gut (free)


Fri, September 15 – 10 Stories of The Day!



1 – 2017 HIVMA of IDSA Clinical Practice Guideline for the Management of Chronic Pain in Patients Living With HIV – Clinical Infectious Diseases (free)


2 – Education and coronary heart disease: mendelian randomisation study – The BMJ (free)

Commentary: Going to university may cut your risk of heart disease – NHS Choices (free)


3 – Association Between More Intensive vs Less Intensive Blood Pressure Lowering and Risk of Mortality in Chronic Kidney Disease Stages 3 to 5: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Intensive blood pressure lowering linked to decreased mortality in patients with chronic kidney disease – 2 Minute Medicine (free) AND Intensive BP Lowering in Chronic Kidney Disease Associated with Lower Mortality – Physician’s First Watch (free) AND Is Strict BP Control a Good Bet for CKD Patients? – MedPage Today (free registration required)


4 – Pathophysiology, diagnosis and treatment of tachycardiomyopathy – Heart (free)

Source: Critical Care Review Newsletter


5 – Corticosteroid or Nonsteroidal Antiinflammatory Drugs for the Treatment of Acute Gout: A Systematic Review of Randomized Controlled Trials – The Journal of Rheumatology (free)

Source: EvidenceAlerts

Corticosteroids and NSAIDs did not have different effects on pain scores, but there was a higher risk of indigestion, nausea and vomiting with NSAIDs.


6 – New Series: The World Bank and financing global health – The BMJ

– World Bank’s financing, priorities, and lending structures for global health (free)

– Universal health coverage, health systems strengthening, and the World Bank (free)

– World Bank and the Global Financing Facility (free)

– Earmarking for global health: benefits and perils of the World Bank’s trust fund model (free)

– Health as a “global public good”: creating a market for pandemic risk (free)

– Baines and Babar: Why medical practitioners should be interested in the World Bank (free)


7 – The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis – The Lancet (free)

Commentaries: Sleep improvement by internet-based cognitive behavioural therapy might help prevent mental health disorders – The Lancet (free) AND Lack of sleep could contribute to mental health problems, researchers reveal – The Guardian (free) AND Tackling insomnia may be key to easing mental health issues – OnMedica (free)


8 – Protocol for the management of psychiatric patients with psychomotor agitation – BMC Psychiatry (free)


9 – A range of anti-epilepsy drugs are effective as first-line treatment – NIHR Signal (free)

Original article: Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data – Cochrane Library (link to abstract – $ for full-text)


10 – Osteoporosis drug treatment: duration and management after discontinuation. A position statement from the SVGO/ASCO – Swiss Medical Weekly (free)


Thu, September 14 – 10 Stories of The Day!



1 – Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016 – The Lancet (free)

Commentary: IHME releases second annual report on the Sustainable Development Goal indicators – Institute for Health Metrics and Evaluation (free)

See also: Health-related Sustainable Development Goals visualization tool, which allows users to compare and contrast between countries and among indicators, and the United Nations Sustainable Development Goals Website.


2 – Guideline: Prevention of Early-onset Neonatal Group B Streptococcal Disease – Royal College of Obstetricians and Gynaecologists (free)

News release: Group B Streptococcal Disease, Early-onset (free)

Commentaries: Antibiotics for women in early labour to combat Group B Strep – OnMedica (free) AND More pregnant women to get Group B Strep treatment – BBC News (free)


3 – Review article: Randomized, Controlled Trials in Health Insurance Systems – New England Journal of Medicine (free)

See also other articles in The Changing Face of Clinical Trials Series (all free)


4 – Benefit of Patent Foramen Ovale Closure Seen in Selected Patients with Cryptogenic Stroke – Journal Watch (free)

Original articles from the New England Journal of Medicine: Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke (link to abstract – $ for full-text) AND Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke (link to abstract – $ for full-text) AND Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke (link to abstract – $ for full-text)


5 – The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Treatment of Colon Cancer (free)


6 – Prevention of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline (free)


7 – European Respiratory Society guidelines for the management of adult bronchiectasis (free)


8 – Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: systematic review and meta-analysis of relapse prevention trials – The BMJ (free)

Commentary: Researchers: Antidepressants for Anxiety Should Be Continued for at Least a Year After Treatment Response – Physician’s First Watch (free)


9 – Association Between Laparoscopic Antireflux Surgery and Recurrence of Gastroesophageal Reflux – JAMA (link to abstract – $ for full-text)

Commentaries: Laparoscopic Antireflux Surgery Associated With High Rate of Recurrence of GERD – The JAMA Network (free) AND GERD Recurrence Fairly Common Following Laparoscopic Antireflux Surgery – Physician’s First Watch (free) AND High recurrence of gastroesophageal reflux disease in patients treated with laparoscopic antireflux surgery – 2 Minute Medicine (free)


10 – Differential blood pressure effects of ibuprofen, naproxen, and celecoxib in patients with arthritis: the PRECISION-ABPM (Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen Ambulatory Blood Pressure Measurement) Trial – European Heart Journal (free)

Commentaries: Under Pressure: PRECISION Substudy Shows Adverse BP Effects of Ibuprofen – TCTMD (free) AND Increases in BP, Hypertension Incidence Linked to Certain NSAIDs – MPR (free) AND Ibuprofen Ups Systolic BP, New-Onset Hypertension Risk – Medscape (free registration required)


Wed, September 13 – 10 Stories of The Day!



1 – International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia (free) (RT @CritCareReviews see Tweet)


2 – Report: Preventing noncommunicable diseases (NCDs) by reducing environmental risk factors – World Health Organization (free)

We welcome new @WHO report, showing 23% of all deaths can be prevented through healthier environments” (RT @HealthandEnv see Tweet)


3 – Draft Recommendation Statement: Cervical Cancer: Screening – U.S. Preventive Services Task Force (free)

Commentaries: USPSTF Draft Recommendation Eliminates Cervical Cytology-HPV Cotesting for Women Over 30 – Physician’s First Watch (free) AND USPSTF: Pap Test or HPV Test, Not Both, For Most Cervical Ca Screening – MedPage Today (free registration required) AND USPSTF Has New Draft Guidance for Cervical Cancer Screening – Medscape (free registration required) AND Age matters when it comes to screening for cervical câncer – STAT (free)


4 – Research and Development Spending to Bring a Single Cancer Drug to Market and Revenues After Approval – JAMA Internal Medicine (free)

Author interview: Cost of Developing a Single Cancer Drug (free audio)

Invited commentary: A Much-Needed Corrective on Drug Development Costs (free)

Commentaries: R&D Costs For Cancer Drugs Are Likely Much Less Than Industry Claims, Study Finds – NPR (free) AND A new study undermines Big Pharma’s justification for charging high drug prices – Business Insider (free) AND What Does It Cost to Create a Cancer Drug? Less Than You’d Think – The New York Times (10 articles per month are free)


5 – Antiretroviral therapy in pregnant women living with HIV: a clinical practice guideline – The BMJ (free guideline and infographic)


6 – Menopausal Hormone Therapy and Long-term All-Cause and Cause-Specific Mortality: The Women’s Health Initiative Randomized Trials – JAMA (link to abstract – $ for full-text)

Commentaries: Taking Hormones for Menopause Doesn’t Raise Early Death Risk – The New York Times (free) AND Menopause hormone therapy not linked to premature death – Reuters (free) AND Menopause hormones don’t shorten lives, long follow-up says – STAT (free)


7 – Patient-Clinician Communication: American Society of Clinical Oncology Consensus Guideline (free)

News release: New Guideline Aims to Improve Clinician Communication With Patients (free)


8 – Laparoscopic and robotic-assisted versus open radical prostatectomy for the treatment of localised prostate cancer – Cochrane Library (free)

Original article: Laparoscopic and robotic-assisted versus open radical prostatectomy for the treatment of localised prostate cancer – Cochrane Library (link to abstract – $ for full-text)

“Urinary and sexual quality of life-related outcomes appear similar”.


9 – LDL-Cholesterol Lowering for the Primary Prevention of Cardiovascular Disease Among Men with Primary Elevations of LDL-Cholesterol Levels of 190 mg/dL or Above: Analyses from the WOSCOPS 5-year Randomised Trial and 20-year Observational Follow-Up – Circulation (free)

Commentary: Statins cut heart deaths in men by 28% finds study – NHS Choices (free)


10 – Role of Total, Red, Processed, and White Meat Consumption in Stroke Incidence and Mortality: A Systematic Review and Meta‐Analysis of Prospective Cohort Studies – Journal of The American Heart Association (free)

Increased consumption of red and processed meat may be associated with higher risk of stroke.


Tue, September 12 – 10 Stories of The Day!



1 – Treatment of Type 1 Diabetes: Synopsis of the 2017 American Diabetes Association Standards of Medical Care in Diabetes – Annals of Internal Medicine (free)


2 – Recommendations on screening for abdominal aortic aneurysm in primary care – Canadian Task Force on Preventive Health Care (free)

See also: Summary of recommendations for clinicians and policy-makers (free) AND Abdominal Aortic Aneurysm (AAA): 1000-Person Tool (free)

“The number of men >65 needed to screen to prevent one AAA related death is 796 (95% confidence interval 621–1242) @ 3-5 yr follow-up” (RT @cantaskforce see Tweet)


3 – Clinical Practice Guideline: Evaluation of the Neck Mass in Adults – American Academy of Otolaryngology—Head and Neck Surgery Foundation (free)

See also: Executive Summary (free) AND News Release (free)

Commentaries: Neck Mass in Adults: Guideline for Evaluation Provides Framework for Timely Diagnosis – NewsWise (free) AND Guidelines Issued on Evaluating Neck Masses – Physician’s First Watch (free)


4 – A Comparison of Alkaline Water and Mediterranean Diet vs Proton Pump Inhibition for Treatment of Laryngopharyngeal Reflux – JAMA Otolaryngology Head Neck Surgery (free)

Commentaries: Could a Mediterranean diet be as good as drugs for acid reflux? – NHS Choices (free) AND Dietary Approach Found as Effective as Medications for Treating Type of Reflux Disease – The JAMA Network (free) AND Treating Reflux With Diet – The New York Times (10 articles per month are free)

A small retrospective cohort study suggests a plant-based, Mediterranean-style diet may be as effective as medication.


5 – The Joint Associations of Sedentary Time and Physical Activity With Mobility Disability in Older People: The NIH-AARP Diet and Health Study – The Journals of Gerontology (free)

Commentaries: Get Off The Couch Baby Boomers, Or You May Not Be Able To Later – NPR (free) AND Prospective Study Shows Just How Bad TV Can Be – Medscape (free registration required) AND Prolonged sitting and TV watching ‘dangerous’ for seniors – Medical News Today (free) AND TV viewing ‘a potent risk factor’ for disability – OnMedica (free)


6 – Guideline: National Partnership for Maternal Safety: Consensus Bundle on Severe Hypertension During Pregnancy and the Postpartum Period – Obstetrics & Gynecology (free)

Commentary: Management of Severe Maternal Hypertension During Pregnancy and Postpartum – Journal Watch (free)


7 – Hormonal contraceptive eligibility for women at high risk of HIV: Guidance Statement – World Health Organization (free PDF)

News release: Can women who are at high risk of acquiring HIV, safely use hormonal contraception? (free)

Frequently asked questions: Hormonal contraceptive eligibility for women at high risk of HIV (free)

Guideline Summary: Hormonal contraceptive eligibility for women at high risk of HIV: guidance statement – National Guideline Clearinghouse (free)


8 – Cardiovascular disease risk and androgen deprivation therapy in patients with localised prostate cancer: a prospective cohort study – British Journal of Cancer (link to abstract – $ for full-text)

Commentaries: Prostate cancer treatment associated with higher risk of heart failure – Cardiovascular Business (free) AND Hormone Treatment for Prostate Cancer Tied to Heart Risks – The New York Times (10 articles per month are free)


9 – Richard Lehman’s journal review, 11 September 2017 (free)

Richard Lehman reviews the latest research in the top medical journals.


10 – Adverse effects of proton-pump inhibitor use in older adults: a review of the evidence – Therapeutic Advances in Drug Safety (free)


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