Open access

Fri, July 21 – 10 Stories of The Day!



1 – Report: HIV drug resistance report 2017 – World Health Organization (free)

News release: WHO urges action against HIV drug resistance threat (free)

Commentaries: HIV drug resistance could undermine progress in AIDS battle: WHO – Reuters (free) AND Drug-Resistant HIV Is On the Rise – TIME (free)


2 – Report: Ending AIDS: Progress Towards the 90-90-90 Target – Joint United Nations Programme on HIV/AIDS (UNAIDS) (free PDF)

Fact Sheet: Latest Statistics on The Status of The Aids Epidemic – UNAIDS (free) (RT @greg_folkers see Tweet)

Related editorial: The global HIV/AIDS epidemic—progress and challenges – The Lancet (free)

Commentary: For first time in history, half of all people with HIV are getting treatment – Science (free) (source: GlobalHealthNOW newsletter)


3 – Parkinson’s disease in adults – National Institute for Health and Care Excellence (NICE) Guideline (free)


4 – Antiplatelet Regimen for Patients With Breakthrough Strokes While on Aspirin: A Systematic Review and Meta-Analysis – Stroke (link to abstract – $ for full-text)

Commentary: Adjusting Antiplatelet Regimen Could Decrease Risk For Stroke Patients on Aspirin Monotherapy – American College of Cardiology, Latest in Cardiology (free)

Meta-analysis of cohort studies: in patients who experienced an ischemic stroke or transient ischemic attack while on aspirin monotherapy, the addition of or a switch to another antiplatelet agent, versus aspirin monotherapy, was associated with a 32 percent reduction in the risk of major adverse cardiovascular events (HR 0.68; 0.54–0.85) and 30 percent reduction in recurrent strokes (HR, 0.70; 0.54–0.92). Additional randomized trials would better clarify the best antiplatet regimen for these patients.


5 – Antidepressants during pregnancy and autism in offspring: population based cohort study – The BMJ (free)

Editorial: Prenatal antidepressant use and risk of autism (free)

Commentaries: Antidepressants and pregnancy: study didn’t find they actually cause autism – The Conversation (free) AND Antidepressant use in pregnancy linked to autism in children – OnMedica (free) AND Study finds slight autism risk link to antidepressants in pregnancy – Reuters (free)


6 – Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials – The BMJ (free)

Editorial: Diet and exercise in pregnancy (free)

Commentaries: Risk of caesarean reduced by healthy diet and physical activity during pregnancy, study finds – NewsMedical (free) AND C-Section Risk Reduction Linked to Healthy Lifestyle – MedPage Today (free)


7 – The Effects of Public Access Defibrillation on Survival After Out-of-Hospital Cardiac Arrest: A Systematic Review of Observational Studies – Circulation (link to abstract – $ for full-text)

Commentary: Bystander CPR Best Hope for Out-of-Hospital Cardiac Arrest? – Medscape (free registration required)

See related article on Bystander Efforts and 1-Year Outcomes in Out-of-Hospital Cardiac Arrest in our May 4th issue (see #2)


8 – Report: Dementia prevention, intervention, and care – The Lancet (free registration required)

Commentaries: Experts: 1 in 3 cases of dementia preventable, nonmedical therapies ideal for dementia – University of Southern California, via EurekAlert (free) AND One Third of Dementia May Be Preventable With Lifestyle Change – Medscape (free registration required) AND Over a Third of Dementia Cases Tied to Modifiable Risk Factors – Physician’s First Watch (free) AND Living healthily, learning more could cut dementia cases by a third – Reuters (free) AND Lifestyle changes could prevent a third of dementia cases, report suggests – The Guardian (free)


9 – The Uncertain Future of Genetic Testing – The Atlantic (free)

“Bringing genetics into medicine leads to more accuracy, better diagnosis, and personalized treatment—but for some, gene testing has only resulted in unanswered questions”.


10 – An emergency department protocol to restore circulation doesn’t improve outcomes in septic shock – NIHR Signal (free)

Original article: Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis – New England Journal of Medicine (link to abstract – $ for full-text)


Thu, July 20 – 10 Stories of The Day!



1 – WHO report on the global tobacco epidemic 2017 – World Health Organization (free)

Full report: WHO Report on The Global Tobacco Epidemic: 2017 Monitoring tobacco use and prevention policies (free PDF)

Press release: WHO report finds dramatic increase in life-saving tobacco control policies in last decade (free)

Infographics: Protecting people from tobacco (free)

Commentaries: Taxation: Most effective but still the least-used tobacco control measure, by Patricio V. Marquez via The World Bank Blogs (free) AND Tobacco industry blocking anti-smoking moves: WHO – Reuters (free) AND Tobacco firms ‘hamper anti-smoking push’ – BBC News (free) AND Tobacco companies interfere with health regulations, WHO reports – The Guardian (free)

See also our coverage of World No Tobacco Day in our May 31 issue (see #1).


2 – Enhanced Prophylaxis plus Antiretroviral Therapy for Advanced HIV Infection in Africa – New England Journal of Medicine (free)

Editorial: The Enduring Challenge of Advanced HIV Infection (free)

Among HIV-infected patients with advanced immunosuppression (CD4+ count < 100 cells/mm3), enhanced antimicrobial prophylaxis combined with ART resulted in reduced rates of death.


3 – Efficacy and Safety of Spironolactone in Acute Heart Failure: The ATHENA-HF Randomized Clinical Trial – JAMA Cardiology (link to abstract – $ for full-text)

Commentaries: High-dose spironolactone didn’t affect acute heart failure outcomes – ACP Hospitalist (free) AND High-Dose Spironolactone in Acute Heart Failure – American College of Cardiology, Latest in Cardiology (free)


4 – Use of antibiotics during pregnancy and the risk of major congenital malformations: A population based cohort study – British Journal of Pharmacology (link to abstract – $ for full-text)

Commentary: New study finds link between certain antibiotics during pregnancy and risk for birth defects – News Medical (free)

Related article: Use of antibiotics during pregnancy and risk of spontaneous abortion – Canadian Medical Association Journal (free)

In this large canadian cohort clindamycin, doxycycline, quinolones, macrolides, and phenoxymethylpenicillin were associated with congenital malformations. Amoxicillin, cephalosporins, and nitrofurantoin were not associated with birth defects.


5 – Position statement: American Society of Clinical Oncology Position Statement On Addressing the Affordability of Cancer Drugs (free PDF)

Commentaries: ASCO Offers Path to Addressing Affordability of Cancer Drugs in New Position Statement – ASCO Post (free) AND ASCO Tackles Affordability of Cancer Drugs – Physician’s First Watch (free) AND ASCO Advocates Value in Drug Pricing – MedPage Today (free registration required) AND ASCO Addresses High Cost of Cancer Drugs – Medscape (free registration required)


6 – Treating axial spondyloarthritis and peripheral spondyloarthritis, especially psoriatic arthritis, to target: 2017 update of recommendations by an international task force – Annals of Rheumatic Diseases (free)

Commentary: International Guidelines Say Use Treat-to-Target for SpA, PsA – Medscape (free registration required)


7 – Clinical Review: Community-associated methicillin-resistant Staphylococcus aureus infection: Literature review and clinical update – Canadian Family Physician (free)


8 – The Aging Physician and the Medical Profession: A Review – JAMA Sugery (free) (RT @EricTopol see Tweet)


9 – New Choosing Wisely Canada List: Hepatology: Five Things Physicians and Patients Should Question (free) (RT @ChooseWiselyCA see Tweet)

See more on the Choosing Wisely initiative in our April 5 issue (see #6).


10 – Improving people’s health through spatial planning – Public Health England (free) (RT @pash22 see Tweet)

Related reports: Spatial planning for health: evidence review – Public Health England (free) AND Healthy people healthy places evidence tool: Evidence and practical linkage for design, planning and health – University of the West of England (free)

Related WHO Report: Preventing disease through healthy environments: a global assessment of the burden of disease from environmental risks (free) AND News release: An estimated 12.6 million deaths each year are attributable to unhealthy environments (free)


Wed, July 19 – 10 Stories of The Day!



1 – Healthful and Unhealthful Plant-Based Diets and the Risk of Coronary Heart Disease in U.S. Adults – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Some Plant-Based Diets May Increase Heart Disease Risk –American College of Cardiology, Latest in Cardiology (free) AND Not All Vegetarian, Plant-Based Diets Equal for CHD Risk – Medscape (free registration required) AND Not all plant-based diets are created equal – American College of Cardiology, via ScienceDaily (free)


2 – Screening Criteria for Ophthalmic Manifestations of Congenital Zika Virus Infection – JAMA Pediatrics (free)

Commentaries: Zika: Check All Potentially Exposed Infants for Eye Damage – Medscape (free registration required) AND Which Infants Exposed to Zika Virus Infection in Pregnancy Should Have Eyes Examined? – The JAMA Network (free)

“All infants with potential Zika virus exposure should have ophthalmic screening regardless of other abnormalities” (RT @PreetiNMalani see Tweet)


3 – The Association Between Vasectomy and Prostate Cancer: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Meta-Analysis: Vasectomy Likely Does Not Cause Prostate Cancer – Physician’s First Watch (free) AND Weak Link Between Vasectomy, Prostate Cancer – MedPage Today (free registration required)


4 – Draft Recommendation Statement: Ovarian Cancer: Screening – U.S. Preventive Services Task Force (free)

Commentaries: USPSTF Again Recommends Against Screening General Population for Ovarian Cancer – Physician’s First Watch (free) AND USPSTF Stays Course on Ovarian Cancer Screening: No screening for asymptomatic women – MedPage Today (free registration required)


5 – Review: Emerging arboviruses: Why today? – One Health (free) (RT @greg_folkers see Tweet)


6 – Cochrane What is the best medication for a fungal infection of the toenail? – Cochrane Library (free)

Full review: Oral antifungal medication for toenail onychomycosis – Cochrane Library (link to abstract – $ for full-text)

Terbinafine probably leads to better cure rates than azoles, with the same risk of adverse events. Griseofulvin is no better and has more adverse effects than azoles.


7 – Homepage – New European Society of Medical Oncology (ESMO) Updated Clinical Practice Guidelines

New available guidelines are:

– Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Chronic myeloid leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Newly diagnosed and relapsed mantle cell lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with leptomeningeal metastasis from solid tumours (free)

– Management of infusion reactions to systemic anticancer therapy: ESMO Clinical Practice Guidelines (free)

– Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)


8 – Patient Outcomes in Dose Reduction or Discontinuation of Long-Term Opioid Therapy: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Tapering long-term opioid therapy may improve outcomes in chronic pain, review finds – ACP Internist (free) AND Opioid Reduction Therapy Offers Some Benefits to Patients with Chronic Pain – Physician’s First Watch (free) AND How tapering off opioids can help people with chronic pain – CNN (free)

“Opioid tapering:

– less pain: 8 of 8 studies

– Improved function: 5 of 5 studies

– Improved QOL: 3 of 3 studies” (RT @DavidJuurlink see Tweet)


9 – As Workouts Intensify, a Harmful Side Effect Grows More Common – New York Times (10 articles per month are free)

Related practical review: Exercise-Induced Emergencies in the Heat: Rhabdomyolysis & Exertional Heat Stroke – emDocs (free)


10 – Randomized clinical trial of comprehensive geriatric assessment and optimization in vascular surgery – British Journal of Surgery (link to abstract – $ for full-text)

Source: ACP Journal Club ($ resource to find articles of interest)

In this RCT, a comprehensive preoperative geriatric assessment and optimization before vascular surgery was associated with shorter length of hospital stay, lower incidence of complications, and patients were less likely to be discharged to a higher level of dependency.


Tue, July 18 – 10 Stories of The Day!



1 – Report: Progress and Challenges with Achieving Universal Immunization Coverage: 2016 Estimates of Immunization Coverage – WHO / UNICEF (free PDF)  (RT @WHO see Tweet )

News Release: 1 in 10 infants worldwide did not receive any vaccinations in 2016 – World Health Organization (free)


2 – Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies – Canadian Medical Association Journal (free)

Commentaries: Artificial Sweeteners Not Tied to Lower BMI and May Even Increase It – Physician’s First Watch (free) AND Artificial Sweeteners Don’t Help People Lose Weight, Review Finds – NPR (free) AND The Irony Of Artificial Sweeteners – Forbes (free) AND Low-calorie sweeteners don’t help with weight loss — and may lead to gained pounds – STAT News (free)


3 – What proportion of health outcomes are attributable to health care – Sheffield DPH (free) (RT @gmacscotland and @felly500 see Tweet)


4 – The hidden truth about our prescription medications – Ideas.Ted.Com (free)

“Around half of the clinical trials that were done on the medicines we use today have never published their results…” (RT @Students4BE see Tweet)


5 – Why are these countries the most obese? Walking is just one reason – CNN (free) (RT @kamleshkhunti see Tweet)

Related studies: Health Effects of Overweight and Obesity in 195 Countries over 25 Years – New England Journal of Medicine (free) AND NIH-funded team uses smartphone data in global study of physical activity – NIH News Release (commentary, see original article$)


6 – Position Statement: American Association of Clinical Endocrinologists And American College Of Endocrinology Position Statement On Menopause – 2017 Update (free)

Related Position Statement: The 2017 hormone therapy position statement of The North American Menopause Society (free PDF)

Related Draft Recommendation Statement: Menopausal Hormone Therapy: Primary Prevention of Chronic Conditions – U.S. Preventive Services Task Force (free)


7 – Richard Lehman’s journal review, 17 July 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.


8 – Evidence-based guidelines for fall prevention in Korea – The Korean Association of Internal Medicine and The Korean Geriatrics Society (free)


9 – Financing transformative health systems towards achievement of the health Sustainable Development Goals: a model for projected resource needs in 67 low-income and middle-income countries – The Lancet Global Health (free) (RT @LancetGH see Tweet)

Invited commentaries: Financing health systems to achieve the health Sustainable Development Goals (free) AND All roads lead to universal health coverage, by Tedros Adhanom Ghebreyesus, Director-General of WHO (free)

WHO News Release: WHO estimates cost of reaching global health targets by 2030 (free)

Commentaries: Global health price tag could be $371 billion a year by 2030, WHO says – Reuters (free)


10 – New research program and website: Access to Healthcare – Economist Intelligence Unit (all resources are free) (RT @anetrid see Tweet)

Report: Global access to healthcare: Building sustainable health systems – Economist Intelligence Unit report (free)

“This research programme, created by The Economist Intelligence Unit, examines the challenges and opportunities countries face as they attempt to improve access to high-quality healthcare that meets the needs of their populations. It consists of the Global Access to Healthcare Index, covering 60 countries with a diversity of income levels; a global report; an animated infographic introducing the key findings from the index; six infographics on the main domains of the index; and five regional summary papers”.


Mon, July 17 – 10 Stories of The Day!



1 – The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines – World Journal of Emergency Surgery (free)

Related guideline: The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection – Surgical Infections (free)


2 – Constipation in children and young people: diagnosis and management – National Institute for Health and Care Excellence (NICE) Guideline (free)


3 – High-flow nasal cannula oxygen therapy is superior to conventional oxygen therapy but not to noninvasive mechanical ventilation on intubation rate: a systematic review and meta-analysis – Critical Care (free)

Source: Hospital Medicine Virtual Journal Club (free resource to find articles of interest)


4 – Systematic review: Antiepileptic drug monotherapy (single drug treatment) for epilepsy – Cochrane Library (free)

Original article: Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data (link to summary – $ for full-text)


5 – Studies suggest apneic oxygenation reduces hypoxemia during emergency intubation:

Meta-analysis 1: Apneic oxygenation during intubation in the emergency department and during retrieval: A systematic review and meta-analysis – The American Journal of Emergency Medicine (link to abstract – $ for full-text)

Meta-analysis 2: Apneic oxygenation reduces the incidence of hypoxemia during emergency intubation: A systematic review and meta-analysis – The American Journal of Emergency Medicine (link to abstract – $ for full text)

Source: Apneic Oxygenation Prevents Desaturation During Intubation – Journal Watch ($ resource to find articles of interest)


6 – Risk of post-pregnancy hypertension in women with a history of hypertensive disorders of pregnancy: nationwide cohort study – The BMJ (free)

Related article: Lifestyle in progression from hypertensive disorders of pregnancy to chronic hypertension in Nurses’ Health Study II: observational cohort study – The BMJ (free)

Editorial: Hypertensive disorders of pregnancy – The BMJ (free)

Commentaries: Hypertensive Disorders of Pregnancy Tied to Increased Hypertension Risk Decades Later – Physician’s First Watch (free)


7 – How to spot a misleading graph, by Lea Gaslowitz – TED Talks (free YouTube video)

“How to spot a misleading graph – Great video by Lea Gaslowitz @TEDTalks” (RT @CochraneUK see Tweet)


8 – Opinion: Physicians need to openly discuss medical mistakes and near misses – STAT News (free) (RT @statnews see Tweet)


9 – “Pathologists debating their future in the era of #AI” (RT @EricTopol see Tweet)

Editorial 1: AlphaGo, Deep Learning, and the Future of the Human Microscopist – Archives of Pathology & Laboratory Medicine (free)

Editorial 2: Artificial Intelligence and the Pathologist: Future Frenemies? – Archives of Pathology & Laboratory Medicine (free)

See more on the impact of artificial intelligence in healthcare in our June 14th issue (see #2 and #3)


10 – A must read perspective on “Machine Learning and Prediction in Medicine — Beyond the Peak of Inflated Expectations” – Cross Invalidation (free) (RT @pash22 see Tweet)


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