Wed, Mar 22 – Top 10 Medical News Stories

1 -Effect of Intensive vs Moderate Alveolar Recruitment Strategies Added to Lung-Protective Ventilation on Postoperative Pulmonary Complications: A Randomized Clinical Trial – JAMA (free)

Editorial: Optimizing the Settings on the Ventilator Settings: High PEEP for All? (free)

In patients with hypoxemia after cardiac surgery, a more intensive alveolar recruitment strategy applied postoperatively was associated with reduced severity of pulmonary complications.

2 – Association of Suicidality and Depression With 5α-Reductase Inhibitors – JAMA Internal Medicine (free)

Invited Commentary: The Risk of Suicidality and Depression From 5-α Reductase Inhibitors (free)

“5-alpha reductase inhibitors in older men are associated with increased risk of self-harm and depression”

3 – Sleep Apnea: Types, Mechanisms, and Clinical Cardiovascular Consequences – Journal of the American College of Cardiology (free)

Source: Medscape Week in Review Newsletter (free registration required)

4 – Early, Goal-Directed Therapy for Septic Shock – A Patient-Level Meta-Analysis – New England Journal of Medicine (free)

Contradicting earlier studies and guidelines, “Early, Goal-Directed Therapy” did not improve results in septic shock and was associated with higher hospitalization costs.

5 – Oral Direct-Acting Agent Therapy for Hepatitis C Virus Infection: A Systematic Review – Annals of Internal Medicine (free) (RT @greg_folkers)

See also: Hepatitis C drugs remain unaffordable in many countries, says WHO study – STAT News (free)

6 – The Power of Conferences in a Social-Media Age: A guide to using technology to make face-to-face gatherings even more valuable – The Wall Street Journal (a few articles per month are free)

This new trend is here to stay. In the past few days we could all follow #ACC17 very closely through twitter. The numbers of the meeting: 237,217,427 Impressions; 43,678 tweets; and 15,970 participants (RT @CMichaelGibson see Tweet)

7 – Can science rob snakes of their deadliest weapon? – STAT News (free)

“Snakebites claim so many more victims than such high-profile threats as Ebola and many other tropical diseases” (RT @ininteraction see Tweet)

8 – Intradiscal Steroid Injection of “Questionable” Benefit for Low Back Pain with Discopathy – Physician’s First Watch (free)

Original article abstract ($ required for full-text): Intradiscal Glucocorticoid Injection for Patients With Chronic Low Back Pain Associated With Active Discopathy: A Randomized Trial – Annals of Internal Medicine

9 – Just Started: Global Health at the Human-Animal-Ecosystem Interface – Free Online Course from the University of Geneva and Coursera

Watch teaser: https://youtu.be/rkiJTwBud2o

10 – Peer Into the Post-Apocalyptic Future of Antimicrobial Resistance – WIRED (free) (RT @PreetiNMalani)

See also: LinksMedicus Selection of news and education resources on #AntibioticResistance (Published Sep 21, 2016)

“if left unchecked, in the next 35 years antimicrobial resistance could kill 300,000,000 people worldwide and stunt global economic output by $100 trillion”