1 – Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes – New England Journal of Medicine (free)

Commentary: CANVAS: Canagliflozin Reduces CV Events, but at Cost of Amputations – Medscape (free registration required)

Patients treated with canagliflozin had a lower risk of cardiovascular events than those who received placebo but a greater risk of amputation and fractures. The benefits and harms were likely small. See interesting commentaries on the trade-offs by @AnilMakam, see Tweet 1; Tweet 2; Tweet 3; Tweet 4; Tweet 5; Tweet 6; Tweet 7; Tweet 8; and Tweet 9.

 

2 – The End of Human Doctors – The Bleeding Edge of Medical AI Research (Part 1) – By Luke Oakden-Rayner (RT @pash22 see Tweet)

Original article: Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs – JAMA (free)

See more on the impact of artificial intelligence in healthcare in our April 28th issue, see #1, and in our April 10th issue, see #8

 

3 – The End of Human Doctors – The Bleeding Edge of Medical AI Research (Part 2) – By Luke Oakden-Rayner (RT @pash22 see Tweet)

Original article: Dermatologist-level classification of skin cancer with deep neural networks – Nature (link to abstract – $ for full-text)

See more on the impact of artificial intelligence in healthcare in our April 28th issue, see #1, and in our April 10th issue, see #8

 

4 – Association of Adverse Events With Antibiotic Use in Hospitalized Patients – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Antibiotic-Associated Adverse Events Common – Medscape (free registration required)

“20% of hospitalized patients receiving antibiotics had adverse drug event. Of those, 20% of regimens inappropriate” (RT @PeterPronovost see Tweet)

 

5 – Medical News & Perspectives: More Treatments on Deck for Alcohol Use Disorder – JAMA (free)

 

6 – Association Between Persistent Pain and Memory Decline and Dementia in a Longitudinal Cohort of Elders – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Persistent Pain May Increase Dementia Risk – The New York Times (10 articles per month are free)

Cohort of community-dwelling older adults suggests there might be a link.

 

7 – Snakebite finally makes a WHO list of top global health priorities – STAT News (free)

 

8 – How to fall to your death and live to tell the tale – Mosaic Science (free)

“Falls—such as slipping in the shower or tripping down stairs—kill over 420,000 people worldwide each year” (RT @ghn_news see Tweet)

 

9 – A Test in Context: Fractional Flow Reserve: Accuracy, Prognostic Implications, and Limitations – Journal of The American College of Cardiology (link to abstract – $ for full-text)

10 key points to remember: FFR: Accuracy, Prognostic Implications, and Limitations – American College of Cardiology, Latest in Cardiology (free)

 

10 – Combination inhaler treatment in emergency departments may reduce admissions for asthma attacks – NIHR Signal (free)

Original article: Combined inhaled beta-agonist and anticholinergic agents for emergency management in adults with asthma – Cochrane Library (link to abstract – $ for full-text)

 

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