Thu, March 8 – 10 Stories of The Day!

1 – Association Between Estimated Cumulative Vaccine Antigen Exposure Through the First 23 Months of Life and Non–Vaccine-Targeted Infections From 24 Through 47 Months of Age – JAMA (link to abstract – $ for full-text)

Commentaries: Vaccines won’t overload your child’s immune system—or increase their risk of other infections – Science (free) AND Too Many Too Soon? No! – Science-Based Medicine (free) AND Study finds no immune overload for US kids’ vaccine schedule – CIDRAP (free)

2 – Frequency and level of evidence used in recommendations by the National Comprehensive Cancer Network guidelines beyond approvals of the US Food and Drug Administration: retrospective observational study – The BMJ (free)

Commentaries: Vinay Prasad on the NCCN’s cancer treatment guidelines: The US system needs an audit – The BMJ Opinion (free) AND US cancer network recommending expensive drugs based on weak evidence, study finds – The Guardian (free) AND New Study Questions Evidence for NCCN Recommendations – Medscape (free registration required)

3 – Digoxin and Mortality in Patients With Atrial Fibrillation – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Digoxin and Mortality in Patients With Atrial Fibrillation – American College of Cardiology, Latest in Cardiology (free) AND Digoxin Associated with Higher Mortality in Patients with Atrial Fibrillation – NEJM Physician’s First Watch (free)

4 – Effect of β‐Blockers Beyond 3 Years After Acute Myocardial Infarction – Journal of the American Heart Association (free for a limited period)

Related article: B-Blockers and Mortality After Acute Myocardial Infarction in Patients Without Heart Failure or Ventricular Dysfunction – Journal of The American College of Cardiology (free)

5 – Cancer screening recommendations: an international comparison of high income countries – Public Health Reviews (free) (via @hildabast see Tweet)

6 – Fluid therapy in neurointensive care patients: ESICM consensus and clinical practice recommendations – Intensive Care Medicine (free for a limited period) (via @luiscamacho02)

7 – Factor Xa inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in patients with atrial fibrillation – Cochrane Library (free)

Summary: Comparing two types of blood-thinning drugs, factor Xa inhibitors and vitamin K antagonists, to prevent blood clots in people with atrial fibrillation – Cochrane Library (free)

When available, Factor Xa inhibitors seem to be a better choice for treating these patients.

8 – The Science of Obesity Management: An Endocrine Society Scientific Statement – Endocrine Reviews (free)

Commentary: Research Finds Little Difference Among Diet Plans’ Long-Term Effectiveness – Endocrine Society, via NewWise (free)

9 – Cough Due to TB and Other Chronic Infections – CHEST Guideline and Expert Panel Report (free)

See also other recent CHEST guidelines on the management of cough in specific populations: Classification of Cough as a Symptom in Adults and Management Algorithms (free) AND Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold (free) AND Chronic Cough Due to Gastroesophageal Reflux in Adults (free) AND Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer (free) AND Cough in the athlete (free) AND Occupational and Environmental Contributions to Chronic Cough in Adults (free) AND Treatment of Unexplained Chronic Cough (free) AND Use of Management Pathways or Algorithms in Children With Chronic Cough (free) AND Management of Children With Chronic Wet Cough and Protracted Bacterial Bronchitis (free)

10 – Effect of Offering Same-Day ART vs Usual Health Facility Referral During Home-Based HIV Testing on Linkage to Care and Viral Suppression Among Adults With HIV in Lesotho: The CASCADE Randomized Clinical Trial – JAMA (free)

Editorial: The Global HIV Epidemic: What Will It Take to Get to the Finish Line? (free)

Commentary: HIV in sub-Sahara Africa: Testing and treatment start at home improves therapy – Swiss Tropical and Public Health Institute, via EurekAlert (free)

Related: Starting antiretroviral therapy immediately after HIV diagnosis reduces transmission of the virus – NIHR Signal (free)