Thu, August 3 – 10 Stories of The Day!

1 – Correction of a pathogenic gene mutation in human embryos – Nature (free)

Nature News & Views: Biotechnology: At the heart of gene edits in human embryos (free)

Commentaries: Embryo Gene-Editing Experiment Reignites Ethical Debate – Scientific American (free) AND Scientists successfully used CRISPR to fix a mutation that causes disease. This is huge – VOX (free) AND U.S. scientists edit genome of human embryo, but cast doubt on possibility of ‘designer babies’ – STAT (free) AND Human embryos edited to stop disease – BBC (free) AND In Breakthrough, Scientists Edit a Dangerous Mutation From Genes in Human Embryos – The New York Times (10 articles per month are free)

2 – Choosing Wisely: An International Campaign to Combat Overuse, with new Top 10 recommendations (free) (RT @ChooseWiselyCA and @CADTH_ACMTS see Tweet with infographic)

See more on the Choosing Wisely initiative in our April 5 issue (see #6)

Choosing Wisely has prioritized 10 recommendations for limiting overuse internationally.

3 – Guidelines for Drinking-Water Quality: Fourth Edition Incorporating the First Addendum – World Health Organization (free)

4 – Neck Pain: Revision 2017 – Clinical Practice Guidelines Linked to the International Classification of Functioning, Disability and Health from the Orthopaedic Section of the American Physical Therapy Association (free)

5 – Subgroup analyses of the effectiveness of oral glucosamine for knee and hip osteoarthritis: a systematic review and individual patient data meta-analysis from the OA trail bank – Annals of Rheumatic Diseases (link to abstract – $ for full-text) (RT @PhysioMeScience see Tweet)

“Currently, there is no good evidence to support the use of glucosamine for hip or knee OA”

6 – Benefits and Harms of Treatment of Asymptomatic Bacteriuria: A Systematic Review and Meta-analysis by the European Association of Urology Urological Infection Guidelines Panel (free)

“For most people, treatment was not beneficial and may be harmful. Antibiotic treatment did appear to benefit women in pregnancy and those about to undergo urological surgery”.

7 – Antiemetics: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

Related guideline: NCCN Guidelines Insights: Antiemesis, Version 2.2017 (free)

Commentaries: Antipsychotic Added to ASCO Antiemetic Guide – MedPage Today (free registration required) AND New Antiemetic Guidelines Issued by ASCO – Medscape (free registration required)

8 – Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association (free)

9 – ESC Joint Working Groups on Cardiovascular Surgery and the Cellular Biology of the Heart Position Paper: Peri-operative myocardial injury and infarction in patients undergoing coronary artery bypass graft surgery (free)

Summary with 10 key points to remember: Perioperative Myocardial Injury and Infarction After CABG – American College of Cardiology, Latest in Cardiology (free)

10 – Canadian Urological Association-Pediatric Urologists of Canada (CUA-PUC) guideline for the diagnosis, management, and followup of cryptorchidism (free)