Randomized Trial: Sertraline is Unlikely to Reduce Depressive Symptoms

The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA): a pragmatic, double-blind, placebo-controlled randomised trial – The Lancet Psychiatry (free)

Commentaries: Examining the antidepressant scattergun approach – The Lancet Psychiatry (free) AND Expert reaction to study on the clinical effectiveness of the antidepressant sertraline – Science Media Centre (free) AND Common antidepressant more effective for anxiety than depression – UPI (free) AND Antidepressants work, but just not how scientists thought they worked – The Conversation (free) AND Antidepressants may reduce anxiety more than depressive symptoms – University College London (free)

Related Commentary on Twitter (Thread – click for more)

Important new trial on the real-world effectiveness of antidepressants (sertraline) in primary care patients. Main finding: There is no evidence that antidepressants effectively treat depression symptoms in real-world patients (effect size: d<0.2) https://t.co/bq9atTwrdo

— Michael P. Hengartner, PhD (@HengartnerMP) September 20, 2019