Randomized Trial: Piperacillin-Tazobactam vs for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance

Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Video Summary: Effect of Piperacillin-Tazobactam vs Meropenem on Mortality in Gram-Negative Bloodstream Infection – JAMA (free)

Commentaries: Combo antibiotic found inferior for MDR bloodstream infections – CIDRAP (free) AND Drug Combo No Better for Hard-to-Treat Bloodstream Infections – Medscape (free registration required)

“The results do not support the use of Pip/Tazo as 30 d mortality was 12.3% in Pip/Tazo vs 3.7% in Mero arms” (via @CarlosdelRio7 see Tweet)