Randomized Trial: Oral versus Intravenous Antibiotics for Bone and Joint Infection

Oral versus Intravenous Antibiotics for Bone and Joint Infection – New England Journal of Medicine (link to abstract – $ for full-text)

Related Trial: Partial Oral vs. Intravenous Antibiotic Treatment of Endocarditis (link to abstract and commentaries)

Commentary: Oral antibiotics may work for some ortho, heart infections – CIDRAP (free)

Related Commentary on Twitter

In this trial, 1054 participants with complex orthopedic infections were assigned to receive either oral or intravenous antibiotics for the first 6 weeks of treatment. At 1 year, oral therapy was noninferior to intravenous therapy.

— NEJM (@NEJM) January 30, 2019