Mon, January 22 – 10 Stories of The Day!

1 – Adjunctive Glucocorticoid Therapy in Patients with Septic Shock – New England Journal of Medicine (free)

Commentaries: The Definitive Word on Steroids in Septic Shock – Emergency Medicine Literature of Note (free) AND Adrenal – The Bottom Line (free)

“For the primary outcome, there was no statistically significance difference in mortality at 90 days – 27.9% in the hydrocortisone cohort, and 28.8% with placebo. Looking at secondary outcomes, the results here tended to favor hydrocortisone – a slightly faster resolution of shock, shorter ICU stays, and, oddly, decreased transfusion requirements”. (from Emergency Medicine Literature of Note Blog)

2 – Critical Care Reviews Book 2018 (free PDF)

“The Critical Care Reviews Book summarizes, critiques and puts in context the biggest trials of the year”.

3 – Weekend Surgical Care and Postoperative Mortality: A Systematic Review and Meta-Analysis of Cohort Studies (free)

Commentary: Evidence Supports ‘Weekend Effect’ for Mortality after Surgery – Wolters Kluwer, via NewsWise (free)

“The odds of postoperative mortality were 27 percent higher for patients admitted to the hospital on Saturday or Sunday, compared to those hospitalized on a weekday” (from NewsWise).

4 – Women’s reproductive factors and incident cardiovascular disease in the UK Biobank – Heart (link to abstract – $ for full-text)

Commentaries: Starting periods before age of 12 linked to heightened risk of heart disease and stroke – The BMJ, via EurekAlert (free) AND Early periods linked to heightened cardiovascular risk – OnMedica (free) AND Starting periods early linked to health risks later in life – Medical News Today (free) AND Early menarche and menopause linked to cardiovascular disease risk – The Guardian (free)

5 – To improve global health, tax the things that are killing us – Financial Times (free)

Related: The Case for the Health Taxes – The New York Times (10 articles per month are free) AND Mexico and Hungary tried junk food taxes — and they seem to be working – VOX (free) AND Sugar tax: why health experts want it but politicians and industry are resisting – The Guardian (free)

Related Policies, Guidelines and Commentaries (all free): Beverage consumption taxes on sugar-sweetened beverages AND The potential impact of food taxes and subsidies on cardiovascular disease and diabetes burden and disparities AND Fiscal policies for the prevention of diseases AND Reducing cardiovascular disease burden through targeted dietary policies

6 – Integrating new approaches to atrial fibrillation management: the 6th AFNET/EHRA Consensus Conference – EP Europace (free)

7 – Italian guidelines on the assessment and management of pediatric head injury in the emergency department – Italian Journal of Pediatrics (free)

8 – Postsurgical prescriptions for opioid naive patients and association with overdose and misuse: retrospective cohort study – The BMJ (free)

“The duration of treatment rather than dose is more strongly associated with opioid misuse after surgery, concludes this study” (via @bmj_latest see Tweet)

9 – Infectious virus in exhaled breath of symptomatic seasonal influenza cases from a college community – Proceedings of the National Academy of Sciences (free)

Commentaries: Study confirms flu spreads by aerosols, not just coughs, sneezes – CIDRAP (free) AND Flu may be spread just by breathing, new UMD-led study shows – University of Maryland, via EurekAlert (free)

10 – Staying on antidepressants may prevent a relapse of anxiety – NIHR Signals (free)

Original article: Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: systematic review and meta-analysis of relapse prevention trials – The BMJ (free)