Evidence Synthesis: Should Antidepressants be Used for Major Depressive Disorder?

Should antidepressants be used for major depressive disorder? – BMJ Evidence-Based Medicine (free)

Related Meta-analysis: Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis – The Lancet (free)

Related Commentary: Do Antidepressants Work? – The New York Times (10 articles per month are free)

“Generally, all the previous reviews show that antidepressants seem to have statistically significant effects on depressive symptoms, but the size of the effect has questionable importance to most patients.”