Digoxin Use and Subsequent Clinical Outcomes in Patients With Atrial Fibrillation With or Without Heart Failure

Digoxin Use and Subsequent Clinical Outcomes in Patients With Atrial Fibrillation With or Without Heart Failure in the ENGAGE AF‐TIMI 48 Trial – Journal of The American Heart Association (free)

Source: Hospital Medicine Virtual Journal Club

In this observational analysis, patients with atrial fibrillation without heart failure had increased risk of sudden cardiac death with digoxin use. Among patients with heart failure, digoxin use was associated with an increase in all‐cause death, cardiovascular death, sudden cardiac death, and death caused by HF/cardiogenic shock.