[Abstract Only] Meta-Analysis: Extending Thrombolysis to 4·5–9 h and Wake-up Stroke Using Perfusion Imaging

Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data – The Lancet (link to abstract – $ for full-text)

“Patients with ischemic stroke 4·5–9 h from stroke onset or wake-up stroke with salvageable brain tissue who were treated with alteplase achieved better functional outcomes than did patients given placebo. The rate of symptomatic intracerebral hemorrhage was higher with alteplase, but this increase did not negate the overall net benefit of thrombolysis.”

Related Commentary on Twitter

Presenting now at #ESOC2019 @ESOstroke—Extending #thrombolysis to 4·5–9 h and wake-up #stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data https://t.co/Ep0JDiGzoF pic.twitter.com/lHqiWc63ji

— The Lancet (@TheLancet) May 22, 2019