Daily Archives: January 30, 2019 | LinksMedicus Free Medical News & Perspectives

Randomized Trial: Oral versus Intravenous Antibiotics for Bone and Joint Infection

30 Jan, 2019 | 23:56h | UTC

Oral versus Intravenous Antibiotics for Bone and Joint Infection – New England Journal of Medicine (link to abstract – $ for full-text)

Related Trial: Partial Oral vs. Intravenous Antibiotic Treatment of Endocarditis (link to abstract and commentaries)

Commentary: Oral antibiotics may work for some ortho, heart infections – CIDRAP (free)

Related Commentary on Twitter

In this trial, 1054 participants with complex orthopedic infections were assigned to receive either oral or intravenous antibiotics for the first 6 weeks of treatment. At 1 year, oral therapy was noninferior to intravenous therapy.

— NEJM (@NEJM) January 30, 2019

10 Myths About Frusemide

30 Jan, 2019 | 23:31h | UTC

10 myths about frusemide – Intensive Care Medicine (free)

Note: if the above link is paywalled, try this one

Randomized Trial: E-Cigarettes vs. Nicotine-Replacement Therapy

30 Jan, 2019 | 23:35h | UTC

A Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy – New England Journal of Medicine (link to abstract – $ for full-text)

Editorial: The Dangerous Flavors of E-Cigarettes (free)

Commentaries: E-cigarettes more effective than nicotine replacement therapies, finds major trial – Queen Mary University of London (free) AND UK study shows e-cigarettes help adult smokers quit, but US experts urge caution – CNN (free) AND E-Cigarettes Are Effective at Helping Smokers Quit, a Study Says – The New York times (10 articles per month are free) AND E-cigarettes ‘much better for quitting smoking’ – BBC (free) AND Study Found Vaping Beat Traditional Smoking-Cessation Options – NPR (free)

Related Commentary on Twitter

Trial finds e-cigarettes more effective than nicotine-replacement therapy with respect to the 1-year abstinence rate (18% vs. 10%). Throat or mouth irritation was more common with e-cigarettes, and nausea was more common with nicotine-replacement. https://t.co/cyEnDP630v pic.twitter.com/1je5vN87ru

— NEJM (@NEJM) January 30, 2019

Perspective: Are Probiotics Money Down the Toilet? Or Worse?

30 Jan, 2019 | 23:34h | UTC

Are Probiotics Money Down the Toilet? Or Worse? – JAMA (free for a limited period)

Related: Randomized Trials: Probiotics Ineffective Against Gastroenteritis (link to abstract and commentaries) AND Perspective: The Problem with Probiotics (free commentaries) AND Probiotics: Does the Evidence Match the Hype? (link to abstract and commentaries) AND Systematic Review: Harms Reporting in Trials with Probiotics (link to abstract and commentaries)

Meta-Analysis: Effect of Breakfast on Weight and Energy Intake

30 Jan, 2019 | 23:33h | UTC

Effect of breakfast on weight and energy intake: systematic review and meta-analysis of randomised controlled trials – The BMJ (free)

Commentary: Breakfast—the most important meal of the day? – The BMJ Opinion (free)

State of the Art Review: Peripartum cardiomyopathy

30 Jan, 2019 | 23:32h | UTC

State of the Art Review: Peripartum cardiomyopathy – The BMJ (free for a limited period)

Perspective: Debates in Sepsis

30 Jan, 2019 | 23:20h | UTC

Debates in sepsis – ACP Hospitalist (free)

Why Are So Many People Still Dying from Snake Bites?

30 Jan, 2019 | 23:15h | UTC

Why are so many people still dying from snake bites? – BBC (free)

ESC Position Statement: Depression and Coronary Heart Disease

30 Jan, 2019 | 23:30h | UTC

Depression and coronary heart disease: 2018 ESC position paper of the working group of coronary pathophysiology and microcirculation developed under the auspices of the ESC Committee for Practice Guidelines – European Heart Journal (free)

Wed, January 30 – 10 Stories of The Day!

30 Jan, 2019 | 01:33h | UTC

1 – β-Blocker Therapy and Risk of Chronic Obstructive Pulmonary Disease – A Danish Nationwide Study of 1·3 Million Individuals – EClinicalMedicine (free)

Commentary: Beta-Blocker Use Linked to Lower Risk for COPD Hospitalization – NEJM Journal Watch (free)

2 – Implementation of a Health Plan Program for Switching From Analogue to Human Insulin and Glycemic Control Among Medicare Beneficiaries With Type 2 Diabetes – JAMA (link to abstract – $ for full-text)

Commentary: Medicare Patients with Type 2 Diabetes Safely Switched From Analog to Human Insulin, JAMA Study Finds – AJMC (free)

Related: Meta-Analysis: Comparative Benefits and Harms of Basal Insulin Analogues for Type 2 Diabetes (link to abstract and commentaries) AND Retrospective Observational Study: Basal Insulin Analogs vs NPH Insulin for Type 2 Diabetes (link to abstract and commentaries)

“Patients with type 2 diabetes (T2D) enrolled in a CareMore Health Medicare Part D plan switched from analog to human insulin without significant loss of glycemic control while saving millions for themselves and for the health plan.” (from AJMC)

3 – Prevalence of Cannabis Use Among Medical Students: A Systematic Review and Meta-analysis – Substance Abuse: Research and Treatment (free)

“1 in 3 medical students has used cannabis, whereas 8.8% were current users”

4 – Ann Robinson’s research reviews, 29 January 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

5 – Point-of-Care Ultrasound in General Practice: A Systematic Review – Annals of Family Medicine (free)

6 – Perspective: Promises, promises, and precision medicine – JCI The Journal of Clinical Investigation (free)

“Hype vs. reality. Vast disconnect between actual achievements of “precision medicine” and how portrayed in popular culture” (via @CaulfieldTim see Tweet)

“Nearly two decades after the first predictions of dramatic success, we find no impact of the human genome project on the population’s life expectancy or any other public health measure.” (via @MuinJKhoury see Tweet)

7 – British Association for Sexual Health and HIV national guideline for the management of infection with Neisseria gonorrhoeae (2019) (free PDF)

Commentary: UK Gonorrhea Guideline Guards Against Antibiotic Resistance – MD Magazine (free)

8 – FSRH Clinical Guidance: Combined Hormonal Contraception – January 2019 – Faculty of Sexual and Reproductive Healthcare (free PDF)

Commentaries: No benefit to contraception pill intervals — according to guidance – OnMedica (free) AND Is it OK to take the pill every day without a break? – BBC News (free)

9 – Call to Action: Urgent Challenges in Cardiovascular Disease: A Presidential Advisory From the American Heart Association – Circulation (free PDF)

News Release: Lagging drug innovation, variations in quality of care and rising health care costs remain major barriers in fight against cardiovascular disease (free)

Commentaries: AHA issues ‘urgent’ call to action: 5 things to know – Cardiovascular Business (free) AND AHA Warns of Stagnating CVD Gains, Barriers to Access, and Dismal Drug Pipeline – TCTMD (free)

10 – Association Between Screen Time and Children’s Performance on a Developmental Screening Test – JAMA Pediatrics (free for a limited period)

Commentaries: Expert reaction to study on use of screen time and child development – Science Media Centre (free) AND Too much toddler screen time tied to worse social, motor skills by kindergarten – Reuters (free) AND More screen time for toddlers is tied to poorer development a few years later, study says – CNN (free) AND Screen time ‘may harm toddlers’ – BBC (free) AND Screen time predicts delays in child development, says new research – The Conversation (free)

See also: Children, Adolescents and Screens: What We Know and What We Need To Learn (Pediatrics Supplement with free articles)

Research: This Is Your Brain Off Facebook

30 Jan, 2019 | 18:46h | UTC

This Is Your Brain Off Facebook – The New York Times (10 articles per month are free)

Original randomized trial, involving nearly 3000 individuals: The Welfare Effects of Social Media (free PDF)

“Expect the consequences to be fairly immediate: More in-person time with friends and family. Less political knowledge, but also less partisan fever. A small bump in one’s daily moods and life satisfaction. And, for the average Facebook user, an extra hour a day of downtime.”

Observational Study: β-Blocker Therapy Reduces the Risk for COPD Hospitalization

30 Jan, 2019 | 01:22h | UTC

β-Blocker Therapy and Risk of Chronic Obstructive Pulmonary Disease – A Danish Nationwide Study of 1·3 Million Individuals – EClinicalMedicine (free)

Commentary: Beta-Blocker Use Linked to Lower Risk for COPD Hospitalization – NEJM Journal Watch (free)

Meta-Analysis: Prevalence of Cannabis Use Among Medical Students

30 Jan, 2019 | 01:10h | UTC

Prevalence of Cannabis Use Among Medical Students: A Systematic Review and Meta-analysis – Substance Abuse: Research and Treatment (free)

“1 in 3 medical students has used cannabis, whereas 8.8% were current users”

Study: Patients with Type 2 Diabetes Safely Switched from Analog to Less Costly Human Insulin

30 Jan, 2019 | 01:13h | UTC

Implementation of a Health Plan Program for Switching From Analogue to Human Insulin and Glycemic Control Among Medicare Beneficiaries With Type 2 Diabetes – JAMA (link to abstract – $ for full-text)

Commentary: Medicare Patients with Type 2 Diabetes Safely Switched From Analog to Human Insulin, JAMA Study Finds – AJMC (free)

Related: Meta-Analysis: Comparative Benefits and Harms of Basal Insulin Analogues for Type 2 Diabetes (link to abstract and commentaries) AND Retrospective Observational Study: Basal Insulin Analogs vs NPH Insulin for Type 2 Diabetes (link to abstract and commentaries)

Ann Robinson’s Research Reviews, 29 January 2019

30 Jan, 2019 | 01:05h | UTC

Ann Robinson’s research reviews, 29 January 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

Perspective: Promises, Promises, and Precision Medicine

30 Jan, 2019 | 00:56h | UTC

Promises, promises, and precision medicine – JCI: The Journal of Clinical Investigation (free)

“Hype vs. reality. Vast disconnect between actual achievements of “precision medicine” and how portrayed in popular culture” (via @CaulfieldTim see Tweet)

Related Commentary on Twitter

“Nearly two decades after the first predictions of dramatic success, we find no impact of the human genome project on the population’s life expectancy or any other public health measure.” @DrMJoyner & Paneth write a scathing piece on genomic medicine. https://t.co/MzCcM7vQWu pic.twitter.com/h04jaIstlX

— Dr Muin J. Khoury (@MuinJKhoury) January 29, 2019