Daily Archives: October 5, 2018
Study: Acceleration of BMI in Early Childhood and Risk of Sustained Obesity
5 Oct, 2018 | 02:45h | UTCAcceleration of BMI in Early Childhood and Risk of Sustained Obesity – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: Childhood BMI Acceleration and Sustained Obesity (free)
Commentary: BMI in Early Childhood and Sustained Obesity – American College of Cardiology (free)
Perspective: Given Their Potential for Harm, It’s Time to Focus on the Safety of Supplements
5 Oct, 2018 | 02:41h | UTCGiven Their Potential for Harm, It’s Time to Focus on the Safety of Supplements – JAMA (free for a limited period) (via @NUNESDOC)
“About 23 000 visits to emergency departments each year can be attributed to adverse events from dietary supplements.”
Meta-Analysis: Effects of Vitamin D Supplementation on Musculoskeletal Health
5 Oct, 2018 | 02:44h | UTCEffects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, and trial sequential analysis – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentaries: The Lancet Diabetes & Endocrinology: Vitamin D supplementation in adults does not prevent fractures, falls or improve bone mineral density – The Lancet (free) AND Vitamin D supplements don’t help bone health, major study concludes – The Guardian (free) AND Millions of Americans take vitamin D. Most should just stop – VOX (free)
Related: Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It (free commentaries and NICE Guideline) AND Vitamin D Not Linked to Fracture Risk (free study and commentaries)
Study: Effect of Lorcaserin on Prevention and Remission of Type 2 Diabetes in Overweight and Obese Patients
5 Oct, 2018 | 02:38h | UTCEffect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Weight loss drug shows positive effect on diabetes – Brigham and Women’s Hospital (free) AND Weight Loss Drug Helped Prevent Diabetes in Overweight People – MedPage Today (free registration required)
Related Article: Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients (link to abstract and commentaries)
Clinical Update: Immune Checkpoint Inhibitor Toxicity in 2018
5 Oct, 2018 | 02:42h | UTCImmune Checkpoint Inhibitor Toxicity in 2018 – JAMA (free for a limited period)
Related Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)
Related Review: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)
Report: The Future of Healthcare
5 Oct, 2018 | 02:39h | UTCThe future of healthcare – The Economist (free PDF)
Perspective: When Conventional Wisdom Is Put on Trial
5 Oct, 2018 | 02:40h | UTCWhen Conventional Wisdom Is Put on Trial – UNDark (free) (via @EricTopol)
“The author of “Randomistas” shows how randomized trials have overturned many popular findings, from hormone therapy to the benefits of multivitamins.”
Perspective: New Tools in the Ebola Arsenal
5 Oct, 2018 | 02:37h | UTCNew Tools in the Ebola Arsenal – New England Journal of Medicine (free)
Related: DRC Ebola cases rise as security concerns continue – CIDRAP (free) AND Officials fear Ebola epidemic may be spinning beyond their control, threatening regional spread – STAT (free) AND Ebola Likely to Spread From Congo to Uganda, W.H.O. Says – The New York Times (10 articles per month are free)
Study: Collaboration Between Academics and Industry in Clinical Trials
5 Oct, 2018 | 02:37h | UTCCommentaries: Shining a light on industry collaboration – The BMJ Opinion (free) AND Industry funders involved in most aspects of funded trials – OnMedica (free)
Meta-Analysis: Prescribed Exercise with Compression vs Compression Alone in Treating Patients With Venous Leg Ulcers
5 Oct, 2018 | 02:36h | UTCPrescribed Exercise With Compression vs Compression Alone in Treating Patients With Venous Leg Ulcers: A Systematic Review and Meta-analysis – JAMA Dermatology (link to abstract – $ for full-text)
Commentaries: Adding Exercise to Compression Improves Outcomes in Venous Leg Ulcers – Physcian’s First Watch (free) AND Compressions May Remedy Venous Leg Ulcers – MedPage Today (free)
Study: The Projected Timeframe Until Cervical Cancer Elimination in Australia
5 Oct, 2018 | 02:31h | UTCCommentaries: Modelling cervical cancer elimination – The Lancet Public Health (free) AND Australia on track to wipe out cervical cancer within 20 years – The Guardian (free) AND In Australia, Cervical Cancer Could Soon Be Eliminated – The New York Times (10 articles per month are free)
NICE Guideline: Renal Replacement Therapy
5 Oct, 2018 | 02:31h | UTC
Global, Regional, and National Burden of Parkinson’s Disease
5 Oct, 2018 | 02:30h | UTCInvited Commentary: The burden of Parkinson’s disease: a worldwide perspective (free)
“In 2016, 6·1 million people worldwide had Parkinson’s disease, 2·9 million (48%) women & 3·2 million (52%) men; the increase in burden since 1990 was not exclusively explained by an increasing number of older people” (via @TheLancet see Tweet)
Recommendations for the use of Electrophysiological Study
5 Oct, 2018 | 02:28h | UTC
Enhanced Recovery After Surgery Guidelines for Perioperative Care in Esophagectomy
5 Oct, 2018 | 02:29h | UTCGuidelines for Perioperative Care in Esophagectomy: Enhanced Recovery After Surgery (ERAS®) Society Recommendations – World Journal of Surgery (free for a limited period)
Study: Evaluating Progression-Free Survival as a Surrogate Outcome for Health-Related Quality of Life in Oncology
5 Oct, 2018 | 02:26h | UTCEvaluating Progression-Free Survival as a Surrogate Outcome for Health-Related Quality of Life in Oncology: A Systematic Review and Quantitative Analysis – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Health-related quality of life overlooked in cancer drug studies – McMaster University (free) AND Investigators Question the Use of PFS as a Surrogate End Point – Cancer Therapy Advisor (free) AND Preventing tumor spread may not improve quality of life – Reuters (free) AND Research: Consider quality of life when evaluating cancer drug studies – UPI (free)
Guideline: Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency
5 Oct, 2018 | 02:27h | UTCNews Release: Managing congenital adrenal hyperplasia requires shared decisions among patients, families, and heal – The Endocrine Society (free)
ACOG Committee Opinion: Well-Woman Visit
5 Oct, 2018 | 02:25h | UTCWell-Woman Visit – American College of Obstetrics and Gynecology (free)
News Release: ACOG and WPSI Release Materials to Support Women’s Preventive Care at Every Life Stage (free)
Commentary: ACOG Stresses Role of Ob/Gyns in Preventive Care For Women – Medscape (free registration required)
Study: Teen Cannabis Use and Cognitive Development
5 Oct, 2018 | 02:23h | UTCA Population-Based Analysis of the Relationship Between Substance Use and Adolescent Cognitive Development – American Journal of Psychiatry (link to abstract – $ for full-text)
Commentaries: Teen cannabis use is not without risk to cognitive development – Université de Montréal (free) AND Cannabis ‘more harmful than alcohol’ for teen brains – BBC (free)
Two Antiplatelet Drugs may Prevent Further Strokes but Increase Major Bleeds
5 Oct, 2018 | 02:24h | UTCTwo antiplatelet drugs may prevent further strokes but increase major bleeds – NIHR Signal (free)
Original Article: Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA – New England Journal of Medicine (link to abstract – $ for full-text)
Randomized Trial: Early Surgery vs Physical Therapy on Knee Function Among Patients With Nonobstructive Meniscal Tears
5 Oct, 2018 | 02:21h | UTCEffect of Early Surgery vs Physical Therapy on Knee Function Among Patients With Nonobstructive Meniscal Tears: The ESCAPE Randomized Clinical Trial – JAMA (free for a limited period)
Commentary: PT an Alternative to Surgery for Some Meniscal Tears – Physician’s First Watch (free)
Related: Adverse Outcomes After Arthroscopic Partial Meniscectomy (free study, commentary and guideline on the subject)
“Our Dutch multi center RCT demonstrates noninferiority of physical therapy compared with early surgery with arthroscopic partial meniscectomy for improving self-reported knee function in patients with nonobstructive meniscal tears.” (via @RudolfPoolman see Tweet)
Ten Principles for More Conservative, Care-Full Diagnosis
5 Oct, 2018 | 02:22h | UTCTen Principles for More Conservative, Care-Full Diagnosis – Annals of Internal Medicine (free) (via @EricTopol)
Guideline: Management of Malignant Pleural Effusions
5 Oct, 2018 | 02:21h | UTCRelated Guideline: ERS/EACTS statement on the management of malignant pleural effusions – European Respiratory Journal (free)
Sytematic Review: Antidepressant Withdrawal Effects
5 Oct, 2018 | 02:06h | UTCA systematic review into the incidence, severity and duration of antidepressant withdrawal effects: Are guidelines evidence-based? – Addictive Behaviours (free PDF)
Commentaries: Antidepressant withdrawal ‘hits millions’ – BBC (free) AND Antidepressant withdrawal symptoms severe, says new report – The Guardian (free)
Related: Antidepressant Withdrawal Syndrome (free review and NYT article)
Meta-Analysis: Treating Subclinical Hypothyroidism is Not Associated with Quality of Life and Thyroid-Related Symptoms
5 Oct, 2018 | 02:18h | UTCAssociation of Thyroid Hormone Therapy With Quality of Life and Thyroid-Related Symptoms in Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)
Commentaries: Most Patients With Subclinical Hypothyroidism May Not Require Thyroid Medication – MedicalResearch.com (free) AND Hormone Tx May Not Benefit Subclinical Hypothyroidism – MedPage Today (free registration required) AND Treating Subclinical Hypothyroidism Is of Little Benefit – Medscape (free registration required)