Daily Archives: September 12, 2018

Wed, September 12 – 10 Stories of The Day!

12 Sep, 2018 | 01:52h | UTC

 

1 – Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Video Summary: Effect of Piperacillin-Tazobactam vs Meropenem on Mortality in Gram-Negative Bloodstream Infection – JAMA (free)

Commentaries: Combo antibiotic found inferior for MDR bloodstream infections – CIDRAP (free) AND Drug Combo No Better for Hard-to-Treat Bloodstream Infections – Medscape (free registration required)

“The results do not support the use of Pip/Tazo as 30 d mortality was 12.3% in Pip/Tazo vs 3.7% in Mero arms” (via @CarlosdelRio7 see Tweet)

 

2 – Antibiotics for acute rhinosinusitis in adults – Cochrane Library (free for a limited period)

Summary: Antibiotics for sinus infection of short duration in adults – Cochrane Library (free)

“Considering antibiotic resistance, and the very low incidence of serious complications, we conclude there is no place for antibiotics for people with uncomplicated acute rhinosinusitis.”

 

3 – Opinion: Are We Being Misled About Precision Medicine? – The New York Times (10 articles per month are free)

“Doctors and hospitals love to talk about the cancer patients they’ve saved, and reporters love to write about them. But deaths still vastly outnumber the rare successes.”

 

4 – Comparisons of Guidelines and Recommendations on Managing Antineutrophil Cytoplasmic Antibody–Associated Vasculitis – Kidney International Reports (free)

 

5 – Screening: How overdiagnosis and other harms can undermine the benefits – Health News Review (free)

“All screening programs do harm, some do good as well.”

 

6 – Last Month in Oncology with Dr. Bishal Gyawali: August 2018 – eCancer News (free)

 

7 – Alex Nowbar’s research reviews, 10 September 2018 – The BMJ (free)

 

8 – How well do you know your anticholinergic (antimuscarinic) drugs? – Therapeutics Initiative (free)

 

9 – Long-term Outcomes of the Effects of Home Blood Pressure Telemonitoring and Pharmacist Management on Blood Pressure Among Adults With Uncontrolled Hypertension: Follow-up of a Cluster Randomized Clinical Trial – JAMA Network Open (free)

Commentary: Pharmacist-Led BP Telemonitoring Intervention Works Up to 1 Year After Program Stops – TCTMD (free)

 

10 – Association of dairy intake with cardiovascular disease and mortality in 21 countries from five continents (PURE): a prospective cohort study – The Lancet (link to abstract – $ for full-text)

Commentaries: The Lancet: Dairy consumption linked to lower rates of cardiovascular disease and mortality – EurekAlert (free) AND Dairy food in moderation ‘may protect the heart’ – The Guardian (free) AND Is Whole-Fat Dairy Good for the Heart? – New York Times (free)

Related: Meta-Analysis: Cheese consumption and risk of cardiovascular disease (link to abstract and commentaries) AND Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality (free study and commentaries)

“It is not the ultimate seal of approval for recommending whole-fat dairy over its low-fat or skimmed counterparts. Readers should be cautious, and treat this study only as yet another piece of the evidence (albeit a large one) in the literature.”

 

---