Daily Archives: March 2, 2018
Fri, March 2 – 10 Stories of The Day!
2 Mar, 2018 | 02:16h | UTC
1 – Hydrocortisone plus Fludrocortisone for Adults with Septic Shock – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Hydrocortisone-fludrocortisone cuts deaths in septic shock – The Hospitalist (free)
See related research and commentaries on adjunctive glucocorticoid therapy in patients with septic shock
2 – Policy Statement: Pediatric Medication Safety in the Emergency Department – American Academy of Pediatrics (free)
Commentaries: Recommendations Issued on Reducing Pediatric Medication Errors in the ED – NEJM Physician’s First Watch (free) AND Policy statement outlines ways to improve pediatric medication safety – 2 Minute Medicine (free)
3 – Mortality after coronary artery bypass grafting versus percutaneous coronary intervention with stenting for coronary artery disease: a pooled analysis of individual patient data – The Lancet (link to abstract – $ for full-text)
This meta-analysis of randomized trials showed CABG had a mortality benefit over PCI in patients with multivessel disease, particularly those with diabetes and higher coronary complexity. There was no mortality benefit in patients with left main disease.
4 – Meta-analysis: Long-Term Outcomes of On- Versus Off-Pump Coronary Artery Bypass Grafting – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Long-Term Outcomes of On- vs. Off-Pump CABG – American College of Cardiology, Latest in Cardiology (free) AND Long-term survival benefit seen in on-pump vs off-pump CABG – Cardiovascular Business (free)
“Off pump CABG. probably best used in a limited set of patients…” (via @keaglemd see Tweet)
5 – Public Health: Tackling multiple unhealthy risk factors: Emerging lessons from practice – The King’s Fund (free PDF)
Commentary: Multiple unhealthy risk factors: why they matter and how practice is changing (free)
See also: Summary (free PDF) AND Overview (free)
Commentaries: Turn it off: Binge watching TV can cause venous thromboembolism—even if you’re fit – Cardiovascular Business (free) AND How too much TV could kill you – MedicalNewsToday (free)
Related article: Watching Television and Risk of Mortality From Pulmonary Embolism Among Japanese Men and Women – Circulation (free)
Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)
“Despite higher operative cost, robot-assisted laparoscopic surgery does not result in statistically better treatment outcomes, with the exception of lower estimated blood loss. Operative time and total complication rate are significantly more favorable with conventional laparoscopic surgery”.
Source: Medscape (free registration required)
“Cognitive enhancers in general have minimal effects on cognition according to minimal clinically important difference and global ratings. The drugs appear safe, but this must be interpreted cautiously because trial participants may have less comorbidity and fewer adverse effects than those treated with these drugs in clinical practice”.
Commentary: EHR Time Exceeds Patient Face Time in Family Practice Visits – Medscape (free registration required)
Related: Care-Centered Clinical Documentation in the Digital Environment: Solutions to Alleviate Burnout – National Academy of Medicine (free) AND Date Night with the EHR – NEJM Catalyst (free) AND Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free) AND Putting Patients First by Reducing Administrative Tasks in Health Care: A Position Paper of the American College of Physicians(free)
Practical recommendations for managing in-flight medical emergencies
2 Mar, 2018 | 02:08h | UTCNews release: Responding to inflight medical emergencies can be stressful for doctors – CMAJ News (free)
Related video: Managing medical emergencies at 36,000 ft: A guide to Air Canada’s in-flight emergency medical kit (free)
Balanced Crystalloids vs Saline in Hospitalized Patients
2 Mar, 2018 | 02:10h | UTCBalanced Crystalloids versus Saline in Critically Ill Adults – New England Journal of Medicine (free)
Related article: Balanced Crystalloids versus Saline in Noncritically Ill Adults – New England Journal of Medicine (free)
Commentary: Balanced Crystalloids May Be Better Than Saline for Critically Ill Patients – NEJM Physician’s First Watch (free)
“Balanced crystalloids may be superior to saline in critically ill patients — but not in patients hospitalized outside an ICU” (from Physician’s First Watch)
Hydrocortisone plus Fludrocortisone Reduces Deaths in Septic Shock
2 Mar, 2018 | 02:08h | UTCHydrocortisone plus Fludrocortisone for Adults with Septic Shock – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Hydrocortisone-fludrocortisone cuts deaths in septic shock – The Hospitalist (free)
ACG Clinical Guideline: Alcoholic Liver Disease
2 Mar, 2018 | 02:05h | UTCACG Clinical Guideline: Alcoholic Liver Disease – The American Journal of Gastroenterology (free)
Commentary and summary: New Guideline for Management of Alcoholic Liver Disease – NEJM Journal Watch (free for a limited period)
Clinical Practice Guidelines for the Management of Hemorrhoids
2 Mar, 2018 | 02:07h | UTCRelated guideline: ACG Clinical Guideline: Management of Benign Anorectal Disorders – The American Journal of Gastroenterology (free)
Research: Impact of treatment delay on mortality in ST-segment elevation myocardial infarction (STEMI)
2 Mar, 2018 | 02:06h | UTCCommentaries: 3% rise in deaths for every 10 min delay in restoring blood flow after heart attack – OnMedica (free) AND Treatment Delay and Mortality in STEMI With Shock – American College of Cardiology, Latest in Cardiology (free)
Report: Tackling Multiple Unhealthy Risk Factors
2 Mar, 2018 | 02:02h | UTCPublic Health: Tackling multiple unhealthy risk factors: Emerging lessons from practice – The King’s Fund (free PDF)
Commentary: Multiple unhealthy risk factors: why they matter and how practice is changing (free)
See also: Summary (free PDF) AND Overview (free)
Guideline: Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy
2 Mar, 2018 | 02:04h | UTCRelated guidelines: Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO) (free) AND Management of febrile neutropaenia: ESMO Clinical Practice Guidelines (free) AND Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update (free)
Opinion: Doctors, Revolt!
2 Mar, 2018 | 02:04h | UTCOpinion: Doctors, Revolt! – The New York Times (free)
“Healing is replaced with treating, caring is supplanted by managing, and the art of listening is taken over by technological procedures. Bernard Lown” (via @lucadf see Tweet)
Scientists Aim to Pull Peer Review Out Of The 17th Century
2 Mar, 2018 | 02:03h | UTCScientists Aim to Pull Peer Review Out Of The 17th Century – NPR (free)
Related: The Future of Peer Review – Scientific American (free) AND Peer review is a black box. Let’s open it up – STAT News (free) AND Exposing peer review – Research Information (free) AND Researchers debate whether journals should publish signed peer reviews – Science (free) AND The peer-review system for academic papers is badly in need of repair – The Conversation (free)
Policy Statement: Pediatric Medication Safety in the Emergency Department
2 Mar, 2018 | 02:00h | UTCPolicy Statement: Pediatric Medication Safety in the Emergency Department – American Academy of Pediatrics (free)
Commentaries: Recommendations Issued on Reducing Pediatric Medication Errors in the ED – NEJM Physician’s First Watch (free) AND Policy statement outlines ways to improve pediatric medication safety – 2 Minute Medicine (free)
WHO Guideline: Latent TB Infection
2 Mar, 2018 | 01:59h | UTCNews release: WHO issues new recommendations calling for accelerated uptake of testing and treatment for TB prevention (free)
Guidelines for Burn Care Under Austere Conditions
2 Mar, 2018 | 01:57h | UTCSee also: Guideline for Burn Care Under Austere Conditions: Special Care Topics (free)
Source: Critical Care Reviews Newsletter
Guidelines for Adolescent Depression in Primary Care
2 Mar, 2018 | 01:56h | UTCGuidelines for Adolescent Depression in Primary Care – American Academy of Pediatrics
Part I. Practice Preparation, Identification, Assessment, and Initial Management (free)
Part II. Treatment and Ongoing Management (free)
Commentary: Pediatricians Call For Universal Depression Screening For Teens – NPR (free)
Systematic Review: Nutritional labelling for healthier food or non-alcoholic drink purchasing and consumption
2 Mar, 2018 | 01:53h | UTCNews release: New Cochrane Review evidence suggests that nutritional labelling on menus in restaurants and cafes may reduce our calorie intake (free)
Video: Nutritional labelling for healthier food or non alcoholic purchasing and consumption (free)
Commentary: Expert reaction to Cochrane review on nutrition labelling and calorie intake – Science Media Centre (free)
“For a typical lunch with an intake of 600 calories, such as a slice of pizza and a soft drink, labelling may reduce the energy content of food purchased by about 8% (48 calories)”
Guidelines for the Use of Antiplatelet Therapy
2 Mar, 2018 | 01:57h | UTCRelated guidelines: 2017 European Society of Cardiology focused update on dual antiplatelet therapy in coronary artery disease (free) AND 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease (free)
Research: Efficacy of self-monitored blood pressure for titration of antihypertensive medication
2 Mar, 2018 | 01:53h | UTCCommentaries: Hypertension: time for doctors to switch the driver’s seat? (free) AND Should home-based blood pressure monitoring be commonplace in NHS? – University of Oxford News & Events (free)
“Self-monitoring, with or without telemonitoring, when used by general practitioners to titrate antihypertensive medication in individuals with poorly controlled blood pressure, leads to significantly lower blood pressure than titration guided by clinic readings”.
Guideline: pharmacological management of patients with type 2 diabetes and cardiovascular diseases
2 Mar, 2018 | 01:55h | UTCRelated guideline: Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes, 2018 – American Diabetes Association (free)
Meta-Analysis: Mortality after coronary artery bypass grafting versus percutaneous coronary intervention with stenting for coronary artery disease
2 Mar, 2018 | 01:49h | UTCThis meta-analysis of randomized trials showed CABG had a mortality benefit over PCI in patients with multivessel disease, particularly those with diabetes and higher coronary complexity. There was no mortality benefit in patients with left main disease.
Meta-Analysis: Clinical course of untreated cervical intraepithelial neoplasia grade 2 under active surveillance
2 Mar, 2018 | 01:51h | UTCEditorial: Treatment or surveillance for CIN2? (free)
Commentaries: Treatment or surveillance for CIN2: when less is more – The BMJ Opinion (free) AND Some irregular cervical lesions could be monitored rather that treated immediately – OnMedica (free) AND Regular monitoring rather than immediate treatment justified for some cervical lesions – EurekAlert (free)
Research: Infant Hospitalizations and Mortality After Maternal Vaccination
2 Mar, 2018 | 01:45h | UTCInfant Hospitalizations and Mortality After Maternal Vaccination – Pediatrics (free)
Commentaries: Maternal vaccination during pregnancy not associated with infant hospitalization, mortality – 2 Minute Medicine (free) AND Getting Recommended Vaccines During Pregnancy Doesn’t Lead to Harm in Infants – Physician’s First Watch (free)
Meta-analysis: Long-Term Outcomes of On- Versus Off-Pump Coronary Artery Bypass Grafting
2 Mar, 2018 | 01:50h | UTCMeta-analysis: Long-Term Outcomes of On- Versus Off-Pump Coronary Artery Bypass Grafting – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentary: Long-Term Outcomes of On- vs. Off-Pump CABG – American College of Cardiology, Latest in Cardiology (free)
“Off pump CABG. probably best used in a limited set of patients…” (via @keaglemd see Tweet)
Systematic Review: Antifibrinolytic drugs for treating primary postpartum haemorrhage
2 Mar, 2018 | 01:46h | UTCAntifibrinolytic drugs for treating primary postpartum haemorrhage – Cochrane Library (free)
Related: Updated WHO Recommendation on Tranexamic Acid for the Treatment of Postpartum Haemorrhage (free PDF) AND Early use of tranexamic acid reduces bleeding more effectively – NIHR Signal (free) AND Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients – The Lancet (free)
WAO/EAACI guideline for the management of hereditary angioedema
2 Mar, 2018 | 01:34h | UTC