Daily Archives: February 22, 2018
Research: Human Neonatal Rotavirus Vaccine (RV3-BB) to Target Rotavirus from Birth
22 Feb, 2018 | 23:38h | UTCCommentaries: New rotavirus vaccine to curb child deaths in developing countries – New Zealand Doctor (free) AND Researchers successfully develop a rotavirus vaccine which could benefit millions of children – MedicalXpress (free)
Guideline: Diagnosis and Treatment of Neurocysticercosis
22 Feb, 2018 | 23:39h | UTC
Guideline: Spontaneous Coronary Artery Dissection
22 Feb, 2018 | 23:39h | UTCSee also: Commentary: Spontaneous Coronary Artery Dissection: Making strides, long journey ahead! (free) AND Top Ten Things to Know (free PDF)
Research: Robot-assisted radical prostatectomy vs laparoscopic and open retropubic radical prostatectomy
22 Feb, 2018 | 23:36h | UTCCommentary: After-effects not necessarily reduced with robotic prostate surgery – Reuters (free)
Related Cochrane Review with similar results: Laparoscopic and robotic-assisted versus open radical prostatectomy for the treatment of localised prostate cancer – Cochrane Library (free)
Research: Association of Cigarette, Cigar, and Pipe Use With Mortality Risk
22 Feb, 2018 | 23:34h | UTCAssociation of Cigarette, Cigar, and Pipe Use With Mortality Risk in the US Population – JAMA Internal Medicine (free for a limited period)
Commentaries: Cigars and pipes tied to same risks as cigarettes – Reuters (free) AND Cigars and pipes raise mortality risk independent of cigarettes – OnMedica (free)
Benzodiazepines: Our Other Prescription Drug Epidemic
22 Feb, 2018 | 23:37h | UTCPerspective: Our Other Prescription Drug Problem – New England Journal of Medicine (free)
Related opinion: Benzodiazepines: our other prescription drug epidemic – STAT (free)
Research: Maternal thyroid function and child educational attainment
22 Feb, 2018 | 23:32h | UTCMaternal thyroid function and child educational attainment: prospective cohort study – The BMJ (free)
Related study and commentary: Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy – New England Journal of Medicine (free) AND Treating subclinical thyroid dysfunction in pregnancy probably has no benefit – NIHR Signal (free)
Maternal thyroid dysfunction in the first trimester had no impact on child performance at school or educational achievement.
Research: Ischaemic stroke, haemorrhage, and mortality in older patients with chronic kidney disease newly started on anticoagulation for atrial fibrillation
22 Feb, 2018 | 23:35h | UTCCommentaries: Anticoagulants Tied With Stroke, Hemorrhage in CKD – Renal & Urology News (free) AND Could a Blood Thinner Actually Raise Stroke Risk for Some? – HealthDay (free) AND Anticoagulants for Patients with Afib and Kidney Disease? Study Yields Mixed Findings – Physician’s First Watch (free) AND Blood-thinning drugs designed to cut stroke risk may actually increase it – The Guardian (free)
“Given the lack of guidelines, the decision to start anticoagulant treatment in patients with chronic kidney disease and new onset atrial fibrillation should be made on an individual basis, concludes research” (via @bmj_latest see Tweet)
Meta-analysis: Outcomes of non-invasive diagnostic modalities for the detection of coronary artery disease
22 Feb, 2018 | 23:33h | UTCAmong patients with low risk acute coronary syndrome, stress echocardiography, cardiovascular magnetic resonance, and exercise electrocardiograms resulted in fewer invasive referrals for coronary angiography than coronary computed tomographic angiography, without apparent impact on the future risk of myocardial infarction. Similarly, for outpatients with suspected stable angina, an initial strategy based on functional testing might be preferable, resulting in fewer referrals for invasive coronary angiography and revascularization, without a statistically significant difference in the future risk of MI.
Avoid common mistakes when treating hyponatremia
22 Feb, 2018 | 23:30h | UTCAvoid common mistakes when treating hyponatremia – ACP Hospitalist (free)
Research: Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium
22 Feb, 2018 | 23:31h | UTCProphylactic haloperidol in this population with elevated risk of delirium did not reduce mortality or any of the 15 prespecified secondary outcomes, including delirium incidence, 28-day delirium-free and coma-free days, duration of mechanical ventilation, and ICU and hospital length of stay.
Research: Continuous Glucose Monitoring in Adults with Type 1 Diabetes
22 Feb, 2018 | 23:29h | UTCReal-time continuous glucose monitoring in adults with type 1 diabetes and impaired hypoglycaemia awareness or severe hypoglycaemia treated with multiple daily insulin injections (HypoDE): a multicentre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
The mean number of hypoglycemic events per 28 days was reduced from 10.8 to 3.5 among patients in the continuous glucose monitoring group and from 14.4 to 13.7 among control group participants.
Research: Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis
22 Feb, 2018 | 23:28h | UTCHydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis: A Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Hydroxychloroquine no more effective than placebo for relieving osteoarthritis hand pain – American College of Physicians, via EurekAlert (free)
Assessing 2030 sustainable development goal trajectories for maternal and child health
22 Feb, 2018 | 23:30h | UTCAnalysis: How many lives are at stake? Assessing 2030 sustainable development goal trajectories for maternal and child health – The BMJ (free)
Related review: Countdown to 2030: tracking progress towards universal coverage for reproductive, maternal, newborn, and child health – The Lancet (free registration required)
Meta-Analysis: Short-Term Versus Long-Term Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation in Elderly Patients
22 Feb, 2018 | 23:27h | UTCShort-Term Versus Long-Term Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation in Elderly Patients: A Meta-Analysis of Individual Participant Data From 6 Randomized Trials – JACC: Cardiovascular Interventions (link to abstract – $ for full-text)
Commentary: Dual Antiplatelet Therapy Duration in Elderly Patients – American College of Cardiology, Latest in Cardiology (free)
Short-term Dual Antiplatelet Therapy was not associated with increased risk of ischemic events in elderly patients and was associated with a significant reduction in major bleeding.
Research: Risk of Recurrent Disease and Surgery Following an Admission for Acute Diverticulitis
22 Feb, 2018 | 23:25h | UTCRisk of Recurrent Disease and Surgery Following an Admission for Acute Diverticulitis – Diseases of the Colon and Rectum (link to abstract – $ for full-text)
Commentary: Which Patients with Diverticulitis Require Surgery? – Diseases of the Colon & Rectum, via NewsWise (free)
In this large cohort of 65,162 patients identified with a first episode of acute diverticulitis, younger patients, women, smokers, obese individuals, and those who had diverticulitis with perforation and/or abscess were more likely to develop recurrent diverticulitis.
BTS Guideline for the Investigation and Management of Malignant Pleural Mesothelioma
22 Feb, 2018 | 23:26h | UTCRelated guideline: Treatment of Malignant Pleural Mesothelioma: American Society of Clinical Oncology Clinical Practice Guideline – Journal of Clinical Oncology (free)
Review: Anaphylaxis
22 Feb, 2018 | 23:24h | UTCReview: Anaphylaxis – Chest (free)
Source: Critical Care Reviews Newsletter
Opinion: Stories about tragic flu deaths wrongly portray Tamiflu as a panacea
22 Feb, 2018 | 23:25h | UTCOpinion: Stories about tragic flu deaths wrongly portray Tamiflu as a panacea – HealthNewsReview (free)
Related: Tamiflu and Relenza: getting the full evidence picture – Cochrane Library (free)
“The review confirms small benefits on symptom relief, namely shortening duration of symptoms by half a day on average. However, there is little evidence to support any belief that use of NIs reduces hospital admission or the risk of developing confirmed pneumonia”. (from Cochrane)
Richard Lehman’s journal reviews – 19 February 2018
22 Feb, 2018 | 23:24h | UTCRichard Lehman’s journal reviews, 19 February 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
Guideline for Prescribing Medical Cannabinoids in Primary Care
22 Feb, 2018 | 23:22h | UTCCommentary: New guideline warns pain benefits of medical cannabis overstated – University of Alberta Faculty of Medicine & Dentistry, via ScienceDaily (free)
Research: Incidence, Etiology, and Outcomes of Community-Acquired Pneumonia
22 Feb, 2018 | 23:23h | UTC“Aside from the rare extra-pulmonary manifestations of mycoplasma (e.g., rashes, hemolysis, neurologic complications), do any of the many causes of pneumonia have distinctive clinical presentations? Probably not”. (via @PaulSaxMD see Tweet)
Interim Estimates of 2017–18 Seasonal Influenza Vaccine Effectiveness
22 Feb, 2018 | 23:20h | UTCCommentaries: US study finds 36% flu vaccine protection, 25% against H3N2 – CIDRAP (free) AND Three-quarters of people who got flu shot this year weren’t protected against most common strain – STAT (free)
Research: Systolic Blood Pressure and Outcomes in Patients With Heart Failure With Preserved Ejection Fraction
22 Feb, 2018 | 23:21h | UTCSystolic Blood Pressure and Outcomes in Patients With Heart Failure With Preserved Ejection Fraction – JAMA Cardiology (link to abstract – $ for full-text)
Commentaries: Aggressive Systolic Blood Pressure Control In Older Patients With HFpEF Should Be Avoided – MedicalResearch.com (free) AND Low blood pressure linked to worse outcomes in HFpEF patients – Cardiovascular Business (free)
“A systolic blood pressure level of less than 120 mm Hg identifies patients with heart failure with preserved ejection fraction at higher risk for short- and long-term mortality and emphasizes the need for future prospective studies to evaluate optimal systolic blood pressure treatment goals in this patient population”.
Editorial: Vitamin D Screening and Supplementation in Primary Care
22 Feb, 2018 | 23:21h | UTCRelated: Your vitamin D tests and supplements are probably a waste of money – VOX (free) AND Why Are So Many People Popping Vitamin D? – The New York Times (free)