Daily Archives: August 17, 2017
Global burden of chronic obstructive pulmonary disease and asthma
17 Aug, 2017 | 21:39h | UTCInvited commentary: COPD and asthma: the emergency is clear, now is the time for action (free)
Saying Goodbye to Lectures in Medical School: Paradigm Shift or Passing Fad?
17 Aug, 2017 | 21:38h | UTCPerspective: Saying Goodbye to Lectures in Medical School: Paradigm Shift or Passing Fad? – New England Journal of Medicine (free)
Related: Vermont Medical School Says Goodbye To Lectures – NPR (free)
The global burden of tuberculosis mortality in children
17 Aug, 2017 | 18:33h | UTCCommentaries: Tuberculosis in children: under-counted and under-treate – The Lancet Global Health (free) AND TB killed an estimated 239,000 children in 2015, nearly all of them untreated, study finds – Science Speaks Blog (free)
Study: probiotics can prevent sepsis in newborns
17 Aug, 2017 | 21:41h | UTCA randomized synbiotic trial to prevent sepsis among infants in rural India – Nature (free PDF)
Commentaries: At Last, a Big, Successful Trial of Probiotics – The Atlantic (free) AND Probiotic Bacteria Could Protect Newborns From Deadly Infection – NPR Goats and Soda (free) AND Seeding the Gut Microbiome Prevents Sepsis in Infants – The Scientist (free)
Too much medicine: Mapping the drivers of overdiagnosis to potential solutions
17 Aug, 2017 | 21:37h | UTCAnalysis – Too much medicine: Mapping the drivers of overdiagnosis to potential solutions – The BMJ (free)
Related: Overdiagnosis, ethics, and trolley problems: why factors other than outcomes matter – The BMJ (free) AND The overdiagnosis community targets solutions – The BMJ (free) AND Are expanding disease definitions unnecessarily labelling women with polycystic ovary syndrome? – The BMJ (free) AND When technology creates uncertainty: pulse oximetry and Overdiagnosis of hypoxaemia in bronchiolitis – The BMJ (free)
Standard of Care in Critically Ill Adult Patients With Atypical Hemolytic Uremic Syndrome
17 Aug, 2017 | 18:22h | UTCSource: Critical Care Reviews Newsletter
Coma After Acute Head Injury
17 Aug, 2017 | 18:39h | UTCReview: Coma After Acute Head Injury – Deutsches Ärzteblatt international (free)
Source: Critical Care Reviews Newsletter
Comparison of early versus late initiation of renal replacement therapy for acute kidney injury in critically ill patients
17 Aug, 2017 | 17:55h | UTCSource: Critical Care Reviews Newsletter
Early initiation of RRT in critically ill patients did not result in reduced mortality, change in renal function recovery, dependence, duration of RRT, renal recovery time, mechanical ventilation time or complications.
Decompensated Heart Failure
17 Aug, 2017 | 18:11h | UTCSpecial issue: Topical Collection on Decompensated Heart Failure – Current Heart Failure Reports
Source: Critical Care Reviews Newsletter
– Inpatient Monitoring of Decompensated Heart Failure: What Is Needed? (free)
– Acute Heart Failure: Definition, Classification and Epidemiology (free)
– Mechanical Circulatory Support for Decompensated Heart Failure (free)
– Pharmacological and Non-pharmacological Treatment for Decompensated Heart Failure: What Is New? (free)
– Current Approach to Decongestive Therapy in Acute Heart Failure (free)
Anesthesia for ambulatory surgery
17 Aug, 2017 | 18:19h | UTCReview: Anesthesia for ambulatory surgery – Korean Journal of Anesthesiology (free)
Source: Critical Care Reviews Newsletter
Stop Treating 70- and 90-Year-Olds the Same
17 Aug, 2017 | 16:31h | UTCOpinion: Stop Treating 70- and 90-Year-Olds the Same – New York Times (free)
Too Many Drug Trials, Too Few Patients
17 Aug, 2017 | 17:37h | UTCA Cancer Conundrum: Too Many Drug Trials, Too Few Patients – The New York Times (10 articles per month are free)
The role of bariatric surgery to treat diabetes
17 Aug, 2017 | 15:45h | UTCReview: The role of bariatric surgery to treat diabetes: current challenges and perspectives – BMC Endocrine Disorders (free)
Recommendations for HIV Screening of Gay, Bisexual, and Other Men Who Have Sex with Men
17 Aug, 2017 | 16:25h | UTC“@CDC_HIVAIDS recommends men who have sex with men be tested for HIV at least annually”. (RT @CDCMMWR see Tweet)
A National Implementation Project to Prevent Catheter-Associated Urinary Tract Infection in Nursing Home Residents
17 Aug, 2017 | 15:57h | UTCA National Implementation Project to Prevent Catheter-Associated Urinary Tract Infection in Nursing Home Residents – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Study Shows 54 Percent Drop in CAUTIs Among Nursing Home Residents – Infection Control Today (free) AND AHRQ safety program helps cut catheter infections by more than 50% among nursing home patients, JAMA study shows – Healthcare Finance (free) AND Implementing technical and socioadaptive bundles may decrease catheter-associated urinary tract infections in nursing homes – 2 Minute Medicine (free) AND Nursing homes cut urinary tract infections in half through focused effort on catheter care – Michigan University, via EurekAlert (free)
Related: Toolkit for Reducing Catheter-Associated Urinary Tract Infections (CAUTI) – Agency for Healthcare Research and Quality (free resources)
Should Potential Risk of Chronic Traumatic Encephalopathy Be Discussed with Young Athletes?
17 Aug, 2017 | 17:46h | UTCSee also a recent article on the high incidence of Chronic Traumatic Encephalopathy in Players of American Football in our July 26th issue (see #3)
Cardiac Toxicity Of Cancer Chemotherapy
17 Aug, 2017 | 16:40h | UTCReview: Cardiac Toxicity Of Cancer Chemotherapy – US Cardiology Review (free)
Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free) AND Radiation Associated Cardiac Disease – American College of Cardiology, Latest in Cardiology (free)
New 8-Week Treatment Approved for All Hepatitis C Genotypes
17 Aug, 2017 | 15:42h | UTCNew 8-Week Treatment Approved for All Hepatitis C Genotypes – Physician’s First Watch (free)
See also: FDA News Release
Standard treatment length was previously 12 weeks or more.
Assessing the impact of healthcare research
17 Aug, 2017 | 15:38h | UTCAssessing the impact of healthcare research: A systematic review of methodological frameworks – PLOS One (free) (RT @trishgreenhalgh see Tweet)
Thu, August 17 – 10 Stories of The Day!
17 Aug, 2017 | 00:18h | UTC
1 – Special issue: 60 years of metformin use – Diabetologia (Source: ACP Diabetes Monthly)
– Editorial: 60 years of metformin use: a glance at the past and a look to the future (free)
– Metformin: historical overview (free)
– The mechanisms of action of metformin (free)
– Metformin: clinical use in type 2 diabetes (free)
– A new perspective on metformin therapy in type 1 diabetes (free)
– Metformin use in pregnancy: promises and uncertainties (free)
– Metformin and ageing: improving ageing outcomes beyond glycaemic control (free)
– Repurposing metformin for the prevention of cancer and cancer recurrence (free)
– The pharmacogenetics of metformin (free)
– Metformin therapy for the reproductive and metabolic consequences of polycystic ovary syndrome (free)
– The effects of metformin on gut microbiota and the immune system as research frontiers (free)
2 – Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9 – Science (link to abstract – $ for full-text)
Commentaries: Birth of CRISPR’d pigs advances hopes for turning swine into organ donos – STAT (free) AND Gene editing to remove viruses brings transplant organs from pigs a step closer – The Guardian (free) AND Gene Editing Spurs Hope for Transplanting Pig Organs Into Humans – New York Times (10 articles per month are free) AND Gene editing brings pig organ transplant closer – NHS Choices (free) AND Scientists edit pig genome with goal of human organ transplants – CNN (free text and video)
3 – Five-Year Outcomes after On-Pump and Off-Pump Coronary-Artery Bypass – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Off-Pump CABG Raises Long-Term Mortality Risk – Cardiobrief (free) AND Newer method of open-heart surgery carries more risks, study finds – STAT (free)
Commentaries: Gabapentinoids Seem to Offer Little Benefit, Substantial Risks in Low Back Pain – Physician’s First Watch (free) AND Evidence does not support the use of gabapentinoids for chronic low back pain – PLOS, via Science Daily (free) AND Gabapentinoids for Chronic Low Back Pain? Not So Fast – Practical Pain Management (free)
Pregabalin and gabapentin have significant risk of adverse effects without any demonstrated benefit in chronic low back pain.
5 – Bored reading science? Let’s change how scientists write – The Conversation (free) (RT @Onisillos see Tweet)
“Science communicators, journalists, entrepreneurs, policymakers and interested members of the general public are all motivated to follow the latest scientific research. And yet, strangely enough, science papers are a communication tool but they are not that effective at communication”.
6 – The Fight Against Antibiotic-Resistant Bacteria Might Start With Vaccines – Allice Callahan, via FiveThirtyEight (free) (RT @greg_folkers see Tweet with infographic)
7 – Cardiovascular mortality and morbidity in patients with type 2 diabetes following initiation of sodium-glucose co-transporter-2 inhibitors versus other glucose-lowering drugs (CVD-REAL Nordic): a multinational observational analysis – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentaries: SGLT2 Agents Cut CV Events in ‘Real-World’ Analysis – MedPage Today (free registration required) AND Cardiovascular disease and mortality appear lower in patients on SGLT2 inhibitors – ACP Diabetes (free)
Related article: Lower Risk of Heart Failure and Death in Patients Initiated on SGLT-2 Inhibitors Versus Other Glucose-Lowering Drugs: The CVD-REAL Study – Circulation (free PDF)
Another observational study suggests this class of drugs may reduce cardiovascular mortality and morbidity.
Source: Journal Watch ($)
“we found that the risk associated with nonobstetric surgery was relatively low, confirming that surgical procedures during pregnancy are generally safe”
9 – Study: diet soda can really mess with your metabolism – VOX (free)
Original article: Integration of Sweet Taste and Metabolism Determines Carbohydrate Reward – Current Biology (link to abstract – $ for full-text)
See also a related meta-analysis showing little evidence of benefit from the consumption of artificial sweeteners for weight loss in our July 18th issue (see #2)
“New research helps explain why artificial sweeteners are linked to obesity and metabolic disease”.
10 – Talking therapy given by parents shows promise for childhood anxiety disorders – NIHR Signal (free)
Original article: Clinical outcomes and cost-effectiveness of brief guided parent-delivered cognitive behavioural therapy and solution-focused brief therapy for treatment of childhood anxiety disorders: a randomised controlled trial – The Lancet Psychiatry (free) AND Commentary: Low-intensity interventions for anxiety disorders (free)
“70% of children receiving guided parent-delivered CBT had recovered from anxiety six months after treatment” (RT @NIHR_DC see Tweet)