Daily Archives: August 3, 2017 | LinksMedicus Free Medical News & Perspectives

Mechanical clot removal for stroke reduces disability at two years

3 Aug, 2017 | 22:07h | UTC

Mechanical clot removal for stroke reduces disability at two years – NIHR Signal (free)

“Mechanical thrombectomy within six hours of stroke onset provides a sustained reduction of disability for patients” (RT @NIHR_DC see Tweet)

Bevacizumab for advanced cervical cancer

3 Aug, 2017 | 21:56h | UTC

Bevacizumab for advanced cervical cancer: final overall survival and adverse event analysis of a randomised, controlled, open-label, phase 3 trial – The Lancet (link to abstract – $ for full-text)

“Benefit of adding bevacizumab to CT for cervical cancer is sustained: OS curves remain separated with ext. follow-up” and “Unfortunately though bevacizumab is out of reach of many patients living in #LMICs” (RT @oncology_bg see Tweets)

Evidence for Health Decision Making: Beyond Randomized, Controlled Trials

3 Aug, 2017 | 22:21h | UTC

Evidence for Health Decision Making: Beyond Randomized, Controlled Trials – New England Journal of Medicine (free)

Commentary: Why the ‘gold standard’ of medical research is no longer enough – STAT (free)

See also other articles in The Changing Face of Clinical Trials Series (all free)

Trial of Tocilizumab in Giant-Cell Arteritis

3 Aug, 2017 | 21:39h | UTC

Trial of Tocilizumab in Giant-Cell Arteritis – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: The GiACTA Trial (free)

Commentaries: Tocilizumab improves remission rates in giant-cell arteritis: The GiACTA trial – 2 Minute Medicine (free) AND Phase 3 trial confirms superiority of tocilizumab to steroids for giant cell arteritis – Massachusetts General Hospital, via EurekAlert (free) AND Tocilizumab With Steroid Taper Superior in GCA – Medscape (free registration required)

Are high heels bad for your health?

3 Aug, 2017 | 21:17h | UTC

The 2016 HIGh Heels: Health effects And psychosexual BenefITS (HIGH HABITS) study: systematic review of reviews and additional primary studies – BMC Public Health (free)

Commentary: Are high heels bad for your health? Two experts review the evidence – The Conversation (free)

Mortality Risk After Roux-en-Y Gastric Bypass in Patients With and Without Diabetes

3 Aug, 2017 | 21:14h | UTC

All-Cause and Specific-Cause Mortality Risk After Roux-en-Y Gastric Bypass in Patients With and Without Diabetes (link to abstract – $ for full-text)

Commentary: Gastric Bypass Sharply Lowers Death Risk for People With Diabetes, Study Finds – AJMC (free)

Case-control study suggests the procedure may reduce the risk of death in patients with diabetes.

Prescribing regular drugs to prevent febrile convulsions risks more harm than benefit

3 Aug, 2017 | 21:25h | UTC

Prescribing regular drugs to prevent febrile convulsions risks more harm than benefit – NIHR Signal (free)

Original article: Prophylactic drug management for febrile seizures in children – Cochrane Library (link to summary – $ for full-text)

“Benefits of anti-epileptic medication for children who’ve had a convulsion while feverish, do not outweigh harms” (RT @NIHR_DC see Tweet)

Atypical fracture with long-term bisphosphonate therapy is associated with altered cortical composition and reduced fracture resistance

3 Aug, 2017 | 20:55h | UTC

Atypical fracture with long-term bisphosphonate therapy is associated with altered cortical composition and reduced fracture resistance – Proceedings of the National Academy of Sciences (free)

Commentaries: Long-Term Bisphosphonate Use Degrades Cortical Bone – Medscape (free registration required) AND How Do Bisphosphonates Cause Atypical Femoral Fractures? – MedPage Today (free registration required) AND Study highlights underlying mechanisms of fractures associated with osteoporosis drug – Cornell University, via EurekAlert (free)

Discover and defeat your diagnostic errors

3 Aug, 2017 | 20:33h | UTC

Discover and defeat your diagnostic errors – ACP Internist (free) (RT @acpinternist see Tweet)

“Experts explain the causes and solutions for common mistakes in diagnosis”.

What is a pilot study?

3 Aug, 2017 | 20:00h | UTC

What is a pilot study? – Students 4 Best Evidence (free) (RT @iainchalmersTTi see Tweet)

A soft robotic exosuit improves walking in patients after stroke

3 Aug, 2017 | 20:40h | UTC

A soft robotic exosuit improves walking in patients after stroke – Science Translational Medicine (free)

Commentaries: Robotic Exosuit Improves Walking After Stroke – Medscape (free registration required) AND Watch a robotic exoskeleton help a stroke patient walk – Science (free text and video)

Oral fluoroquinolones and risk of secondary pseudotumor cerebri syndrome

3 Aug, 2017 | 20:21h | UTC

Oral fluoroquinolones and risk of secondary pseudotumor cerebri syndrome – Neurology (link to abstract – $ for full-text)

Commentary: Fluoroquinolones May Up Risk of PTCS, a Rare But Serious Condition – MPR (free) (RT @AmeshAA see Tweet)

Effect of Oral Methylprednisolone on Clinical Outcomes in Patients With IgA Nephropathy:

3 Aug, 2017 | 19:57h | UTC

Effect of Oral Methylprednisolone on Clinical Outcomes in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Steroid treatment for type of kidney disease associated with increased risk for serious infections – The JAMA Network (free)

Renal outcomes seemed to be less frequent in the group using methylprednisolone (5,9% vs 15,9%), but the trial was stopped early due to a significantly increased risk of serious adverse events with oral methylprednisolone vs placebo (14.7% vs 3.2%, primarily excess infections)