Daily Archives: May 6, 2017
The Paternal Epigenome Makes Its Mark
6 May, 2017 | 20:38h | UTCMedical News & Perspectives: The Paternal Epigenome Makes Its Mark – JAMA (free)
Related: Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype – American Journal of Stem Cells (free)
“Epigenetic changes may be the underlying mechanism by which paternal factors such as age, diet, weight, stress, and alcohol consumption contribute to a range of health outcomes in offspring including birth defects, behavioral problems, developmental disorders, obesity, diabetes, cardiovascular disease, and cancer”.
Reducing inappropriate prescribing easier said than done
6 May, 2017 | 20:37h | UTCReducing inappropriate prescribing easier said than done – CMAJ News (free)
Related: Canadian Deprescribing Network (CaDeN) (free)
AND CaDeN Deprescribing Guidelines and Algorithms (free) AND Deprescribing guidelines for the elderly – Ontario Pharmacy Evidence Network(free)
Series: Acute Kidney Injury in the Intensive Care Unit
6 May, 2017 | 20:32h | UTCSeries: Acute Kidney Injury in the Intensive Care Unit
Fluid management in acute kidney injury – Intensive Care Medicine (free PDF)
Renal recovery after acute kidney injury – Intensive Care Medicine (free)
Diagnostic work-up and specific causes of acute kidney injury – Intensive Care Medicine (free PDF)
Source: Critical Care Reviews Newsletter
CDC updates Zika test guidance for pregnant women
6 May, 2017 | 20:33h | UTCCDC updates Zika test guidance for pregnant women – CIDRAP (free)
Centers for Disease Control and Prevention (CDC) related resources: CDC Zika Interim Response Plan (free) (RT @greg_folkers) AND CDC updates guidance on interpretation of Zika testing results for pregnant women AND Outcomes of Pregnancies with Laboratory Evidence of Possible Zika Virus Infection in the United States AND Prolonged IgM Antibody Response in People Infected with Zika Virus: Implications for Interpreting Serologic Testing Results for Pregnant Women (free)
Guidelines for Management of Incidental Pulmonary Nodules Detected on CT Images
6 May, 2017 | 20:34h | UTCSource: Management of Pulmonary Nodules Found Incidentally on Computed Tomography Scans – Journal Watch (free)
Incidental pulmonary nodules discovered outside the context of screening or cancer follow-up are increasingly common in clinical practice. The purpose of these updated recommendations is to reduce the number of unnecessary follow-up examinations while providing practical guidance on follow-up intervals for selected larger nodules.
Cardiac Patients in Trials Don’t Reflect Real-World Populations – MedPage Today
6 May, 2017 | 20:39h | UTCResearch letter: Applicability of the IMPROVE-IT Trial to Current Patients With Acute Coronary Syndrome – JAMA Internal Medicine (link to abstract – $ for full text)
Source: Cardiac Patients in Trials Don’t Reflect Real-World Populations – MedPage Today (free registration required)
Related: Exclusion of patients with concomitant chronic conditions in ongoing randomised controlled trials targeting 10 common chronic conditions and registered at ClinicalTrials.gov: a systematic review of registration details – BMJ Open (free) AND Do cancer clinical trials exaggerate the real-world benefits of drugs? – STAT News (free)
Patients in clinical trials are often younger, healthier (with less comorbidities), better plugged in to the health care system, better educated and wealthier, indicating that the external validity or generalizability of much of the current evidence to real-world settings may be relatively weak.
USPSTF recommendations: A 2017 roundup
6 May, 2017 | 20:36h | UTCUSPSTF recommendations: A 2017 roundup – Journal of Family Practice
Management of severe perioperative bleeding
6 May, 2017 | 20:31h | UTCManagement of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology (free)
Source: Critical Care Reviews Newsletter