Or

Open access

 

1 – Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Hyperthermic intraperitoneal chemotherapy with surgery increases survival for epithelial ovarian cancer patients – 2 Minute Medicine (free) AND Add-On Hyperthermic Intraperitoneal Chemotherapy Assessed in Ovarian CA – MPR (free)

Patients treated with hyperthermic intraperitoneal chemotherapy associated with surgery had increased median overall survival compared to patients treated with surgery alone (45,7 months vs 33,9 months).

 

2 – Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Synopsis of the 2017 American College of Cardiology/American Heart Association Hypertension Guideline – Annals of Internal Medicine (free)

Related: Redefining Hypertension: Assessing the New Blood-Pressure Guidelines – New England Journal of Medicine (free) AND AAFP Decides to Not Endorse AHA/ACC Hypertension Guideline – American Academy of Family Physicians (free)

 

3 – Clinical guideline and recommendations on pre-operative exercise training in patients awaiting major non-cardiac surgery – Anaesthesia (free)

 

4 – Review: Treatment of anxiety disorders – Dialogues in Clinical Neuroscience (free)

 

5 – Review: Update on the management of venous thromboembolism – Cleveland Clinic Journal of Medicine (free)

 

6 – Tracheal intubation in critically ill patients: a comprehensive systematic review of randomized trials – Critical Care (free) (via @fpereirapa)

 

7 – Non-Inferiority Trials in Medicine: Practice Changing or a Self-Fulfilling Prophecy? – Journal of General Internal Medicine (free for a period)

Related: Challenges in the Design and Interpretation of Noninferiority Trials – New England Journal of Medicine (free) AND Users’ guide to the surgical literature: how to assess a noninferiority trial – Canadian Journal of Surgery (free)

 

8 – Richard Lehman’s journal review, 22 January 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – The Right Place at the Right Time: Medical Oncology Outpatients’ Perceptions of Location of End-of-Life Care – JNCCN (free)

Commentary: Let’s Talk About End-of-Life Care – National Comprehensive Cancer Network, via NewsWise (free)

“…majority of people with cancer would like their physicians to ask them where they would prefer to receive end-of-life care” (from NewsWise).

 

10 – Evidence-Based Guidelines for Fatigue Risk Management in Emergency Medical Services – Prehospital Emergency Care (free)

Commentaries in the same issue: Evidence-Based Guidelines for Fatigue Risk Management in Emergency Medical Services: A Significant Step Forward and a Model for Other High-Risk Industries (free) AND What an Evidence-based Guideline for Fatigue Risk Management Means for Us: Statements From Stakeholders (free) AND Proposed Performance Measures and Strategies for Implementation of the Fatigue Risk Management Guidelines for Emergency Medical Services (free) AND Evidence-Based Guidelines for Fatigue Risk Management in Emergency Medical Services: A Step in the Right Direction Toward Better Sleep Health (free)

 


 

1 – Adjunctive Glucocorticoid Therapy in Patients with Septic Shock – New England Journal of Medicine (free)

Commentaries: The Definitive Word on Steroids in Septic Shock – Emergency Medicine Literature of Note (free) AND Adrenal – The Bottom Line (free)

“For the primary outcome, there was no statistically significance difference in mortality at 90 days – 27.9% in the hydrocortisone cohort, and 28.8% with placebo. Looking at secondary outcomes, the results here tended to favor hydrocortisone – a slightly faster resolution of shock, shorter ICU stays, and, oddly, decreased transfusion requirements”. (from Emergency Medicine Literature of Note Blog)

 

2 – Critical Care Reviews Book 2018 (free PDF)

“The Critical Care Reviews Book summarizes, critiques and puts in context the biggest trials of the year”.

 

3 – Weekend Surgical Care and Postoperative Mortality: A Systematic Review and Meta-Analysis of Cohort Studies (free)

Commentary: Evidence Supports ‘Weekend Effect’ for Mortality after Surgery – Wolters Kluwer, via NewsWise (free)

“The odds of postoperative mortality were 27 percent higher for patients admitted to the hospital on Saturday or Sunday, compared to those hospitalized on a weekday” (from NewsWise).

  

4 – Women’s reproductive factors and incident cardiovascular disease in the UK Biobank – Heart (link to abstract – $ for full-text)

Commentaries: Starting periods before age of 12 linked to heightened risk of heart disease and stroke – The BMJ, via EurekAlert (free) AND Early periods linked to heightened cardiovascular risk – OnMedica (free) AND Starting periods early linked to health risks later in life – Medical News Today (free) AND Early menarche and menopause linked to cardiovascular disease risk – The Guardian (free)

 

5 – To improve global health, tax the things that are killing us – Financial Times (free)

Related: The Case for the Health Taxes – The New York Times (10 articles per month are free) AND Mexico and Hungary tried junk food taxes — and they seem to be working – VOX (free) AND Sugar tax: why health experts want it but politicians and industry are resisting – The Guardian (free)

Related Policies, Guidelines and Commentaries (all free): Beverage consumption taxes on sugar-sweetened beverages AND The potential impact of food taxes and subsidies on cardiovascular disease and diabetes burden and disparities AND Fiscal policies for the prevention of diseases AND Reducing cardiovascular disease burden through targeted dietary policies

 

6 – Integrating new approaches to atrial fibrillation management: the 6th AFNET/EHRA Consensus Conference – EP Europace (free)

 

7 – Italian guidelines on the assessment and management of pediatric head injury in the emergency department – Italian Journal of Pediatrics (free)

 

8 – Postsurgical prescriptions for opioid naive patients and association with overdose and misuse: retrospective cohort study – The BMJ (free)

“The duration of treatment rather than dose is more strongly associated with opioid misuse after surgery, concludes this study” (via @bmj_latest see Tweet)

 

9 – Infectious virus in exhaled breath of symptomatic seasonal influenza cases from a college community – Proceedings of the National Academy of Sciences (free)

Commentaries: Study confirms flu spreads by aerosols, not just coughs, sneezes – CIDRAP (free) AND Flu may be spread just by breathing, new UMD-led study shows – University of Maryland, via EurekAlert (free)

 

10 – Staying on antidepressants may prevent a relapse of anxiety – NIHR Signals (free)

Original article: Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: systematic review and meta-analysis of relapse prevention trials – The BMJ (free)

 


Catalogue of Bias – Centre for Evidence-Based Medicine, University of Oxford (free)

“25 biases affecting evidence on health kick off the new @CebmOxford Catalog of Bias” (via @hildabast see Tweet)

 


Identifying older adults at risk of harm following elective surgery: a systematic review and meta-analysis – BMC Medicine (free)

Commentary : Age itself is not a risk factor for complications after surgery among older patients – OnMedica (free)

“Q: What predicts poor outcome after elective surgery in older people?

A: Frailty, cognitive impairment, depression, smoking but NOT age per se”. (via @trishgreenhalgh see Tweet)

 


Richard Smith: The corruption of medical language – The BMJ Opinion (free)

Related: It’s not just you: science papers are getting harder to read – Nature (free) ‘It’s time to make sure research is understandable to all’ – The Telegraph (free) AND Scientific language is becoming more informal – Nature (free)

“Too often, academic journals are filled with complex language and turgid prose, which is intended not to inform the reader but to ennoble the writer”. (via @bmj_latest see Tweet)

 


USPSTF Not Backing Ankle-Brachial Index, CRP, or Coronary Calcium – MedPage Today (free registration required) AND No Change in USPSTF’s Stance on Using Nontraditional Risk Factors to Assess CV Risk – Physician’s First Watch (free)

Draft Recommendation Statement 1: Cardiovascular Disease: Risk Assessment With Nontraditional Risk Factors – USPSTF (free)

Draft Recommendation Statement 2: Peripheral Artery Disease and Cardiovascular Disease: Screening and Risk Assessment With the Ankle-Brachial Index (free)

“The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of adding the ankle-brachial index (ABI), high-sensitivity C-reactive protein (hsCRP), or coronary artery calcification (CAC) score to traditional risk assessment for cardiovascular disease (CVD) in asymptomatic adults to prevent CVD events”.

 



 

1 – The 2017 Update of the German Clinical Guideline on Epidemiology, Diagnostics, Therapy, Prevention, and Management of Uncomplicated Urinary Tract Infections in Adult Patients: Part 1 – Karger, Urologia Internationalis (free) (via @CIDRAP_ASP see Tweet)

 

2 – Detection and localization of surgically resectable cancers with a multi-analyte blood test – Science (link to abstract – $ for full-text)

Commentaries: Simple blood test detects eight different kinds of cancer – Nature News (free) A new blood test can detect eight different cancers in their early stages – The Conversation (free) AND CancerSEEK: Blood Test That Detects Eight Common Cancers – Medscape (free registration required) AND Scientists Edge Closer To A Blood Test To Detect Cancers – NPR (free) And Blood test could use DNA to spot early-stage cancers, study shows – The Guardian (free)

 

3 – Perspective: Redefining Hypertension: Assessing the New Blood-Pressure Guidelines – New England Journal of Medicine (free)

Related: AAFP Decides to Not Endorse AHA/ACC Hypertension Guideline – American Academy of Family Physicians (free)

 

4 – Video: Pandemics – a worrying global public health threat (free) (via @RSTMH see Tweet)

Related: The World Is Completely Unprepared for a Global Pandemic – Harvard Business Review (free) AND Is It Possible to Predict the Next Pandemic? – The Atlantic (free) AND Stopping Pandemics Before They Start – The New York Times (10 articles per month are free)

 

5 – Single dose moxidectin versus ivermectin for Onchocerca volvulus infection in Ghana, Liberia, and the Democratic Republic of the Congo: a randomised, controlled, double-blind phase 3 trial – The Lancet (free)

Editorial: A new powerful drug to combat river blindness (free)

 

6 – Association of Dietary Inflammatory Potential With Colorectal Cancer Risk in Men and Women – JAMA Oncology (free)

Author interview: Dietary Inflammatory Potential and Risk of Colorectal Cancer in Men and Women (free)

Commentary: Why certain diets may increase your cancer risk – VOX (free)

 

7 – The Best Response to Medical Errors? Transparency – AAMC News (free)

Related: The Michigan Model: Medical Malpractice and Patient Safety at UMHS (free)

 

8 – Patient reminder and recall interventions to improve immunization rates – Cochrane Library (link to abstract – $ for full-text)

Commentaries: Boosting vaccination rates with reminders: new Cochrane evidence – Evidently Cochrane (free) AND Sending out reminders/recalls can drive up immunisation rates – OnMedica (free) AND Patient Reminders Improve Vaccination Rates in Primary Care – Physician’s First Watch (free)

 

9 – Video: Early Palliative Care: a video for health and care professionals – University of Edinburgh (free) (via @OUPMedicine see Tweet)

Related: Early palliative care for adults with advanced cancer – Cochrane Library (free summary and original article) AND How Early Palliative Care May Benefit Patients With Incurable Cancer – ASCO Post (free)

Related guideline: Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

 

10 – Prescribing Cascade in a Cardiology Practice – American College of Cardiology, Latest in Cardiology (free)

“Before starting a medication to treat a new medical condition, consider whether this condition could be a drug-related adverse event. Specifically, consider whether this could represent a prescribing cascade”.

 


 

1 – Household-Contact Investigation for Detection of Tuberculosis in Vietnam – The New England Journal of Medicine (free)

Quick Take Video Summary: Contact Investigation for Tuberculosis (free)

 

2 – Interventions to increase tuberculosis case detection at primary healthcare or community-level services – Cochrane Library (free)

Summary: Interventions to increase the number of tuberculosis cases being diagnosed – Evidently Cochrane (free)

Commentary: Cochrane review of effectiveness of strategies to improve access to treatment for TB – Liverpool School of Tropical Medicine, via EurekAlert (free)

 

3 – Long-Term Follow-up of Monoclonal Gammopathy of Undetermined Significance – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Monoclonal Gammopathy of Undetermined Significance: Risk for Progression to Cancer, Other Disorders Examined – Physician’s First Watch (free) AND Patients with blood cancer precursor at risk of developing cancer even after 30 years – Mayo Clinic, via EurekAlert (free)

 

4 – Catalogue of Bias – Centre for Evidence-Based Medicine, University of Oxford (free)

“25 biases affecting evidence on health kick off the new @CebmOxford Catalog of Bias” (via @hildabast see Tweet)

 

5 – Identifying older adults at risk of harm following elective surgery: a systematic review and meta-analysis – BMC Medicine (free)

Commentary: Age itself is not a risk factor for complications after surgery among older patients – OnMedica (free)

“Q: What predicts poor outcome after elective surgery in older people?

A: Frailty, cognitive impairment, depression, smoking but NOT age per se”. (via @trishgreenhalgh see Tweet)

 

6 – Richard Smith: The corruption of medical language – The BMJ Opinion (free)

Related: It’s not just you: science papers are getting harder to read – Nature (free) ‘It’s time to make sure research is understandable to all’ – The Telegraph (free) AND Scientific language is becoming more informal – Nature (free)

“Too often, academic journals are filled with complex language and turgid prose, which is intended not to inform the reader but to ennoble the writer”. (via @bmj_latest see Tweet)

 

7 – Red and processed meat consumption and breast cancer: UK Biobank cohort study and meta-analysis – European Journal of Cancer (link to abstract – $ for full-text)

Commentaries: Processed meat ‘cancer risk’ in older women – OnMedica (free) AND Consumption of processed meat may increase the risk of breast cancer, according to a new study – MedicalXpress (free)

 

8 – Review: What works in inclusion health: overview of effective interventions for marginalised and excluded populations – The Lancet (free registration required)

Related Article: Morbidity and mortality in homeless individuals, prisoners, sex workers, and individuals with substance use disorders in high-income countries: a systematic review and meta-analysis – The Lancet (free) AND Commentary: Inclusion health: addressing the causes of the causes (free)

 

9 – Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial – The Lancet (free)

Commentaries: Learning from TARDIS: time for more focused trials in stroke prevention – The Lancet (free) AND Triple Antiplatelets for Reducing Dependency After Ischaemic Stroke – TARDIS – American College of Cardiology, Latest in Cardiology (free)

“Among patients with recent cerebral ischaemia, intensive antiplatelet therapy did not reduce the incidence and severity of recurrent stroke or TIA, but did significantly increase the risk of major bleeding. Triple antiplatelet therapy should not be used in routine clinical practice”.

 

10 – Early Recurrence and Major Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation Treated With Non–Vitamin‐K Oral Anticoagulants (RAF‐NOACs) Study – Journal of the American Heart Association (free)

“Composite rates of recurrence and major bleeding were 12.4% in patients who initiated NOACs within 2 days after acute stroke, 2.1% in those who initiated NOACs between 3 and 14 days, and 9.1% in patients who initiated NOACs >14 days after acute stroke. Future randomized studies to assess timing of initiation and choice of agent in patients with acute stroke and AF are warranted”.

 


 

1 – Association of Bariatric Surgery Using Laparoscopic Banding, Roux-en-Y Gastric Bypass, or Laparoscopic Sleeve Gastrectomy vs Usual Care Obesity Management With All-Cause Mortality – JAMA (link to abstract – $ for full-text)

Commentaries: Bariatric Surgery Prolongs Lifespan in Obese – Northwestern University, via NewsWise (free) AND Obesity surgery ‘halves risk of death’ compared with lifestyle changes – The Guardian (free) AND Bariatric Tx Bests Usual Care for Long-Term Health – MedPage Today (free registration required)

 

2 – Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss at 5 Years Among Patients With Morbid Obesity: The SLEEVEPASS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Related article: Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss in Patients With Morbid ObesityThe SM-BOSS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Laparoscopic Gastric Sleeve Compared to Bypass Bariatric Surgery – RheumNow (free) AND No Clinical Significance in Weight Loss Among Sleeve Gastrectomy and Gastric Bypass Patients – AJMC (free) AND Weight-Loss Surgery Approaches Offer Similar Results – MedPage Today (free registration required) AND Rise of Sleeve Gastrectomy Is No Therapeutic Misadventure – Medscape (free registration required) AND Newer weight-reduction surgery effective, but may worsen acid reflux – Reuters (free)

 

3 – Association of Bariatric Surgery vs Medical Obesity Treatment With Long-term Medical Complications and Obesity-Related Comorbidities – JAMA (link to abstract – $ for full-text)

Commentaries: Bariatric Surgery for Obesity Reduces Some Risks, Raises Others – Medscape (free registration required)

 

4 – USPSTF Not Backing Ankle-Brachial Index, CRP, or Coronary Calcium – MedPage Today (free registration required) AND No Change in USPSTF’s Stance on Using Nontraditional Risk Factors to Assess CV Risk – Physician’s First Watch (free)

Draft Recommendation Statement 1: Cardiovascular Disease: Risk Assessment With Nontraditional Risk Factors – USPSTF (free)

Draft Recommendation Statement 2: Peripheral Artery Disease and Cardiovascular Disease: Screening and Risk Assessment With the Ankle-Brachial Index (free)

The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of adding the ankle-brachial index (ABI), high-sensitivity C-reactive protein (hsCRP), or coronary artery calcification (CAC) score to traditional risk assessment for cardiovascular disease (CVD) in asymptomatic adults to prevent CVD events”.

 

5 – Adverse effects of caffeinated energy drinks among youth and young adults in Canada: a Web-based survey – CMAJ Open (free)

Commentaries: Over half of 12-24 year olds have side effects from energy drinks, survey reports – NHS Choices (free) AND Energy drinks can negatively impact health of youth – University of Waterloo, via ScienceDaily (free)

Related Position Statement: Energy and sports drinks in children and adolescents – Canadian Pediatric Society (free)

 

6 – Medical News & Perspectives: Interest in the Ketogenic Diet Grows for Weight Loss and Type 2 Diabetes – JAMA (free)

 

7 – Case Report: Snap, crackle and pop: when sneezing leads to crackling in the neck – BMJ Case Reports (free)

Commentaries: Man Ruptures His Throat By Stifling A Big Sneeze, Prompting Doctors’ Warning – NPR (free) AND Here Is What Can Happen If You Hold In A Sneeze – Forbes (free)

 

8 – Trial of Contralateral Seventh Cervical Nerve Transfer for Spastic Arm Paralysis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Swapping cervical nerves – Richard Lehman’s journal reviews (free) AND Nerve Transfer May Restore Function in Stroke Victims – MedPage Today (free registration required)

 

9 – FDA News Release: FDA acts to protect kids from serious risks of opioid ingredients contained in some prescription cough and cold products by revising labeling to limit pediatric use (free)

Commentaries: FDA strengthens warning on opioid cold medicine – CNN (free) AND FDA: Children should not take cough medicine with codeine – AAP News (free) AND FDA Updates Labeling for Opioid-Containing Medications to Limit Use in Children – Pharmacy Times (free) AND No Opioid Cough Meds in Children Under 18, FDA Says – Medscape (free registration required)

 

10 – Prevention of Hepatitis B Virus Infection in the United States: Recommendations of the Advisory Committee on Immunization Practices – Morbidity and Mortality Weekly Report (MMWR), CDC (free)

Commentary: ACIP: Updated Recommendations for Hepatitis B Virus Infection Prevention – MPR (free)

Related guideline and commentaries: Hepatitis B Vaccination, Screening, and Linkage to Care: Best Practice Advice From the American College of Physicians and the Centers for Disease Control and Prevention

 


Can Your Hip Replacement Kill You? – The New York Times (10 articles per month are free)

“Lawsuits are pulling back the curtain on what some doctors call the Wild West of medicine: the untested and largely unregulated medical device industry” (via @NYTHealth see Tweet)

 


Richard Lehman’s journal review, 15 January 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Editorial: Children and social media – The Lancet (free)

Original report: Life in ‘likes’ – Children’s Commissioner (free)

See also a recent Pediatrics supplement: Children, Adolescents and Screens: What We Know and What We Need To Learn (series of free articles) and related articles on Social Media and Mental Health

 


Supporting Patients Through Serious Illness and the End of Life: Sutter Health’s AIM Model – The Commonwealth Fund (free)

“By proactively managing care for the terminally ill, the Advanced Illness Management program has produced savings of $8,000–$9,000 per patient” (via @commonwealthfnd see Tweet)

 


Which stent is best for heart attacks? – Evidently Cochrane (free)

Original article: Drug-eluting stents versus bare-metal stents for acute coronary syndrome – Cochrane Library (free)

“The current review suggests that using DES rather than BMS may reduce the need for future coronary procedures but there is no evidence that it saves lives or reduces major cardiovascular events”.

 


Deep learning sharpens views of cells and genes – Nature (free)

Neural networks are making biological images easier to process.

 


Satellites Predict a Cholera Outbreak Weeks in Advance – Scientific American (free)

“A test in Yemen showed satellite data could foresee an outbreak four weeks before it exploded”.

 


What physicians can do about ransomware – ACP Hospitalist (free)

“Protecting a practice doesn’t always require a large investment of money, just time and employee training”.

 


How to get the best out of exercise – The Guardian (free)

“Conflicting theories on how to maximise exercise would stretch anyone to the limit. As New Year fitness plans begin in earnest, here’s a scientific response to some frequently asked questions”.

 


Meta-analysis of Interventions to Reduce Adverse Drug Reactions in Older Adults – Journal of the American Geriatrics Society (link to abstract – $ for full-text)

“Interventions designed to optimize medication use reduced the risk of any and serious ADRs in older adults. Implementation of these successful interventions in healthcare systems may improve medication safety in older adults”.

 


Chemical venous thromboembolism prophylaxis in neurosurgical patients: an updated systematic review and meta-analysis – Journal of Neurosurgery (link to abstract – $ for full-text)

Chemical venous thromboembolism prophylaxis seems to be effective and safe in neurosurgical patients.

Source: EvidenceAlerts

 


Risk of Stroke in Patients With Short-Run Atrial Tachyarrhythmia – Stroke (free)

Source: EvidenceAlerts

Short-run AT seems to increase the risk of stroke. Randomized controlled trials to find out which group of patients would benefit from anticoagulation are warranted.

 


The role of selective serotonin reuptake inhibitors in preventing relapse of major depressive disorder – Therapeutic Advances in Psychotherapy (free PDF)

“Review: The relapse risk during 1 year in adults with MDD was lower when SSRIs were combined with psychotherapy. Results comparing SSRIs and SNRIs were inconclusive. TCAs may be equally as effective as SSRIs” (via @psychopharmacol see Tweet)

 


Effect of an Indwelling Pleural Catheter vs Talc Pleurodesis on Hospitalization Days in Patients With Malignant Pleural Effusion: The AMPLE Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Treatment with pleural catheter resulted in fewer hospitalization days from treatment to death (median, 10 vs 12 days).

 


Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial – The Lancet (free)

Commentaries: Learning from TARDIS: time for more focused trials in stroke prevention – The Lancet (free) AND Triple Antiplatelets for Reducing Dependency After Ischaemic Stroke – TARDIS – American College of Cardiology, Latest in Cardiology (free)

“Among patients with recent cerebral ischaemia, intensive antiplatelet therapy did not reduce the incidence and severity of recurrent stroke or TIA, but did significantly increase the risk of major bleeding. Triple antiplatelet therapy should not be used in routine clinical practice”.

 


 

1 – European Resuscitation Council Guidelines for Resuscitation: 2017 update (free)

Source: Critical Care Reviews Newsletter

Related guidelines: 2017 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations Summary – Resuscitation (free) 2017 American Heart Association Focused Update on Adult Basic Life Support and Cardiopulmonary Resuscitation Quality (free PDF) AND 2017 American Heart Association Focused Update on Pediatric Basic Life Support and Cardiopulmonary Resuscitation Quality (free PDF)

 

2 – Editorial: The natural environment and emergence of antibiotic resistance – The Lancet Planetary Health (free)

Related reports: Combating Antimicrobial Resistance: A One Health Approach to a Global Threat – The National Academies Press (free PDF) AND Antimicrobial Resistance: Investigating the Environmental Dimension (free PDF) AND Tackling Drug-Resistant Infections Globally: final report and recommendations (free PDF)

 

3 – Effect of Changing Work Stressors and Coping Resources on the Risk of Type 2 Diabetes: The OHSPIW Cohort Study – Diabetes Care (link to abstract – $ for full-text)

Commentary: Increased stress at work linked to higher risk of diabetes – Reuters (free)

 

4 – Transfer of Fresh versus Frozen Embryos in Ovulatory Women – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Frozen vs. fresh embryos for IVF? Study finds little impact on fertility – Yale News (free) AND Frozen just as good as fresh embryo when it comes to success in IVF, study shows – The Sydney Morning Herald (free) AND Live-birth rates similar among ovulating women undergoing fresh- or frozen-embryo transfer – 2 Minute Medicine (free) AND Fresh Embryos as Good as Frozen Ones for In Vitro Fertilization – The New York Times (10 articles per month are free)

 

5 – Childhood trajectories of peer victimization and prediction of mental health outcomes in midadolescence: a longitudinal population-based study – Canadian Medical Association Journal (free)

Commentary: Teens who were severely bullied as children at higher risk of suicidal thoughts, mental health issue – CMAJ, via EurekAlert (free)

 

6 – Effect of the School-Based Telemedicine Enhanced Asthma Management (SB-TEAM) Program on Asthma Morbidity: A Randomized Clinical Trial – JAMA Pediatrics (free)

Commentaries: School-based telemedicine enhances asthma management in children – 2 Minute Medicine (free) AND For City Kids with Asthma, Telemedicine and In-School Care Cut ER Visits in Half – University of Rochester (free)

 

7 – Can Your Hip Replacement Kill You? – The New York Times (10 articles per month are free)

“Lawsuits are pulling back the curtain on what some doctors call the Wild West of medicine: the untested and largely unregulated medical device industry” (via @NYTHealth see Tweet)

 

8 – Amyotrophic lateral sclerosis – Nature Reviews Disease Primers (free)

 

9 – Richard Lehman’s journal review, 15 January 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

10 – Primary prophylaxis of invasive fungal infections in patients with haematological malignancies: 2017 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO) (free)

 


 

1 – International guidelines for groin hernia management – HerniaSurge Group (free)

 

2 – Excerpt from the Canadian Ophthalmological Society evidence-based clinical practice guidelines for the management of diabetic retinopathy – Canadian Journal of Ophthalmology (free)

Commentary in: Clinical Practice Guidelines, December 2017 – Medscape (free registration required)

 

3 – Breast Implants and the Risk of Anaplastic Large-Cell Lymphoma in the Breast – JAMA Oncology (link to abstract – $ for full-text)

Commentaries: Breast Implants Associated With Increased Risk of Breast Anaplastic Large-cell Lymphoma – Oncology Nurse Advisor (free) AND Dutch Study Links Implants to Increased Breast-ALCL Risk – MedPage Today (free registration required)

 

4 – Editorial: Children and social media – The Lancet (free)

Original report: Life in ‘likes’ – Children’s Commissioner (free)

See also a recent Pediatrics supplement on Children, Adolescents and Screens (free articles) and other commentaries on Social Media and Mental Health (free articles)

 

5 – Reversing the Cardiac Effects of Sedentary Aging in Middle Age—A Randomized Controlled Trial: Implications For Heart Failure Prevention – Circulation (free PDF)

Commentaries: Exercise Study Hints at Volume, Intensity Levels Needed to Improve Cardiac Fitness in Middle Age – TCTMD (free) AND Exercise in middle age can reverse heart effects of sedentary lifestyle – Cardiovascular Business (free) AND Exercise May Reverse Negative Cardiac Effects of Sedentary Life – Medscape (free registration required) AND Exercise is good for you, but did this study actually show it can ‘reverse damage from heart aging’? – HealthNewsReview (free)

 

6 – How to Counter the Circus of Pseudoscience – The New York Times (10 articles per month are free)

Related: In 2018 we need less nonsense and more science – The Globe and Mail (free)

 

7 – What I’ve learned from my tally of 757 doctor suicides – The Washington Post (free)

Related: Why are doctors killing themselves? – MJA InSight (free) AND Why are doctors plagued by depression and suicide? A crisis comes into focus – STAT (free) AND Protecting interns and other physicians from depression and suicide – STAT (free)

 

8 – Supporting Patients Through Serious Illness and the End of Life: Sutter Health’s AIM Model – The Commonwealth Fund (free)

“By proactively managing care for the terminally ill, the Advanced Illness Management program has produced savings of $8,000–$9,000 per patient” (via @commonwealthfnd see Tweet)

 

9 – Supported employment helps people with severe mental illness to obtain work – NIHR Signal (free)

Original article: Interventions for obtaining and maintaining employment in adults with severe mental illness, a network meta-analysis – Cochrane Library (link to abstract – $ for full-text)

 

10 – Antipsychotics and the Risk of Aspiration Pneumonia in Individuals Hospitalized for Nonpsychiatric Conditions – Journal of the American Geriatrics Society, via Medscape (free registration required)

Commentary: Antipsychotics May Increase Risk of Aspiration Pneumonia in Older Adults – Psychiatric News Alert (free)

Related: Antipsychotic use in elderly patients and the risk of pneumonia – Expert Opinion on Drug Safety (free) AND Antipsychotic drug exposure and risk of pneumonia: a systematic review and meta-analysis of observational studies – Pharmacoepidemiology & Drug Safety (free)

 


One smart upstream investment – Politico (free)

“14 public health all-stars offer their top ideas for reshaping America’s long-term health”.

 


 

1 – Bioethics: 200th anniversary of Mary Shelley’s Frankenstein (selected free texts)

‘Frankenstein’ Reflects The Hopes And Fears Of Every Scientific Era – The Atlantic (Free) AND The Horror Story That Haunts Science: Two Hundred Years Later, Frankenstein still Shocks And Inspires – Science (free) AND Infographic: Creating a modern monster – Science (free) AND Taming the Monsters of Tomorrow – Science (free) AND Dr Frankenstein’s Bioethical Experiment – The Lancet (Free Registration Required)

 

2 – Subclinical device-detected atrial fibrillation and stroke risk: a systematic review and meta-analysis – European Heart Journal (free)

See related opinion and commentaries in Get Ready For A Tsunami Of ECGs

 

3 – Which stent is best for heart attacks? – Evidently Cochrane (free)

Original article: Drug-eluting stents versus bare-metal stents for acute coronary syndrome – Cochrane Library (free)

“The current review suggests that using DES rather than BMS may reduce the need for future coronary procedures but there is no evidence that it saves lives or reduces major cardiovascular events”.

 

4 – Attention-Deficit/Hyperactivity Disorder and Very Preterm/Very Low Birth Weight: A Meta-analysis – Pediatrics (free)

Commentaries: Premature Infants Particularly Vulnerable to ADHD – Psychiatric Times (free) AND ADHD and Early Experience: Revisiting the Case of Low Birth Weight – Pediatrics (free)

 

5 – Acid-Suppressive Drug Use During Pregnancy and the Risk of Childhood Asthma: A Meta-analysis – Pediatrics (link to abstract – $ for full-text)

Commentaries: Antacids During Pregnancy Tied to Asthma in Children – The New York Times (10 articles per month are free) AND Is antacid use during pregnancy tied to childhood asthma? – Reuters (free)

 

6 – Prenatal exposure to acetaminophen and children’s language development at 30 months – European Psychiatry (link to abstract – $ for full-text)

Commentaries: Is acetaminophen really safe in pregnancy? – Medical News Today (free) AND Acetaminophen Use During Pregnancy Associated With Elevated Rate of Language Delay in Girls, Mount Sinai Researchers Find – Mount Sinai Health System, via NewsWise (free)

 

7 – Adherence to Mediterranean Diet Reduces Incident Frailty Risk: Systematic Review and Meta-Analysis – Journal of the American Geriatrics Society (link to abstract – $ for full-text)

Commentaries: Mediterranean diet may help protect older adults from becoming frail – Wiley, via ScienceDaily (free) AND Mediterranean Diet May Lessen Frailty Risk in Older Adults – Medscape (free registration required)

 

8 – A Mediterranean-style dietary intervention supplemented with fish oil improves diet quality and mental health in people with depression: A randomized controlled trial (HELFIMED) – Nutritional Neuroscience (free)

Commentaries: Mediterranean Diet Improves Mental Health, Study Finds – Mad in America (free) AND Mediterranean Diet Improves Depression – Mescape (free registration required)

 

9 – Cardiovascular Risk Factors After Adolescent Bariatric Surgery – Pediatrics (free)

Commentary: Bariatric Surgery Helps Teens With Severe Obesity Reduce Heart Disease Risk – NPR (free) AND Teens show decreased risk for heart disease later in life after bariatric surgery – Nationwide Children’s Hospital, via ScienceDaily (free)

 

10 – Risk of suicide and non-fatal self-harm after bariatric surgery: results from two matched cohort studies – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentary: Bariatric Surgery Associated with Higher Suicide Risk – Physician’s First Watch (free)

 


 

1 – The American Psychiatric Association Practice Guideline for the Pharmacological Treatment of Patients With Alcohol Use Disorder (free)

News release: APA Releases New Practice Guideline on Treatment of Alcohol Use Disorder – American Psychiatry Association (free)

Commentary: New Alcohol Use Disorder Guideline Emphasizes Medication – Medscape (free registration required)

 

2 – News Release: AAOS approves diagnostic and treatment criteria for osteoarthritis of the hip – American Academy of Orthopedic Surgeons (free)

See Apropriate Use Criteria: Management of Osteoarthritis of the Hip (free)

Related AAOS Guideline: Management of Osteoarthritis of the Hip (free PDF)

Commentary: AAOS: Non-Surgical Tx Best for Hip OA – MedPage Today (free registration required)

 

3 – Too much screening has misled us about real cancer risk factors, experts say – STAT (free) AND Overscreening for Cancer Yields Misleading Results – MedPage Today (free) AND Could finding more cancer lead us to understand risk factors less? – HealthNewsReview (free)

Original article: Scrutiny-Dependent Cancer and Self-fulfilling Risk Factors – Annals of Internal Medicine (link to abstract – $ for full-text)

 

4 – Opinion: The Less-Is-More Crusade — Are We Overmedicalizing or Oversimplifying? (free)

Commentaries rebutting the opinion: In Defense of Less-Is-More – Medscape (free registration required) AND Has “Less is More” gone too far? The New England Journal says it has – Lown Institute (free) AND Ms. Inappropriate Defends The Status Quo – Cardiobrief (free) AND Nuance And The Healthcare Apocalypse – Cardiobrief (free)

 

5 – Pharmacotherapy for obesity: What you need to know – Cleveland Clinic Journal of Medicine (free)

 

6 – How Big Tech is Going After Your Health Care – The New York Times (10 articles per month are free)

 

7 – Perspective: Evidence-Based Health Policy – New England Journal of Medicine (free)

 

8 – Sugar tax: why health experts want it but politicians and industry are resisting – The Guardian (free)

Related: Beverage consumption taxes on sugar-sweetened beverages AND The potential impact of food taxes and subsidies on cardiovascular disease and diabetes burden and disparities AND Fiscal policies for the prevention of diseases AND Reducing cardiovascular disease burden through targeted dietary policies

 

9 – Association of Maternal Use of Folic Acid and Multivitamin Supplements in the Periods Before and During Pregnancy With the Risk of Autism Spectrum Disorder in Offspring – JAMA Psychiatry (free)

Commentaries: Use of Folic Acid and Multivitamins During Pregnancy May Lower Autism Risk – Psychiatry News Alert (free) AND Folic Acid, Multivitamins During Pregnancy May Cut ASD Risk – MedPage Today (free registration required) AND Are Vitamin Supplements Used Before or During Pregnancy Associated with Risk of Autism Spectrum Disorder? – The JAMA Network (free)

 

10 – Association of Folic Acid Supplementation During Pregnancy With the Risk of Autistic Traits in Children Exposed to Antiepileptic Drugs In Utero – JAMA Neurology (link to abstract – $ for full-text)

Commentaries: Lack of Folic Acid Supplements During Pregnancy Linked With Increased Autism Risk in Children Exposed to Seizure Drugs In Utero – Medical Research (free) AND Folic Acid in Pregnant Women on Antiepileptic Drugs Linked to Lower Autism Risk – Medscape (free registration required) AND Folic Acid May Limit Autism Traits in Children of Epileptic Women – MedPage Today (free registration required) AND Folic acid lessens autism risk for fetal anti-epileptic exposure – MedicalXpress (free)

 


Treatment of Non-neurogenic Male LUTS – European Urology Association (free, but not accessible via mobile devices) (via @KariTikkinen)

 


 

1 – Report: The High Toll of Traffic Injuries : Unacceptable and Preventable – The World Bank (free PDF) (via @equitylist)

Press release: Road Deaths and Injuries Hold Back Economic Growth in Developing Countries (free)

Key Findings: The High Toll of Traffic Injuries : Unacceptable and Preventable – The World Bank (free)

 

2 – Screening for Adolescent Idiopathic Scoliosis: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: Evolving Recommendations for Scoliosis Screening: A Compelling Need for Further Research (free) AND Early Detection of Scoliosis—What the USPSTF “I” Means for Us (free)

Author interview: USPSTF Recommendation: Screening for Adolescent Idiopathic Scoliosis (free)

Commentaries: Not Enough Evidence on Benefits, Harms of Routine Scoliosis Screening for Children and Adolescents – The JAMA Network (free) AND U.S. doctors not certain all kids need scoliosis screening – Reuters (free)

 

3 – Guideline: Treatment of Non-neurogenic Male LUTS – European Urology Association (free, but not accessible via mobile devices) (via @KariTikkinen)

 

4 – We’re Not Ready for a Flu Pandemic – The New York Times (10 articles per month are free)

 

5 – Non-alcoholic Fatty Liver Disease: A Clinical Update – Journal of Clinical and Translational Hepatology (free)

 

6 – Open Access 2017: A Year of Stand-Offs, Showdowns, & Funders’ Own Journals – Absolutely Maybe, in PLOS Blogs (free)

 

7 – Effect of Physical Activity on Frailty: Secondary Analysis of a Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Structured exercise may offer mobility benefits to all older patients, regardless of frailty – ACP Internist (free) AND Exercise may reduce disability even in frail elders – Reuters (free) AND Effect of Physical Activity on Frailty – Summary for Patients, Annals of Internal Medicine (free)

 

8 – Percutaneous PFO Closure Tied to Lower Risk for Recurrent Stroke – Physician’s First Watch (free) AND Meta-Analyses Support Stroke Prevention With PFO Closure – MedPage Today (free registration required)

Original article 1: Device Closure Versus Medical Therapy Alone for Patent Foramen Ovale in Patients With Cryptogenic Stroke: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Original article 2: Percutaneous Closure Versus Medical Treatment in Stroke Patients With Patent Foramen Ovale: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

 

9 – Ambient carbon monoxide and cardiovascular mortality: a nationwide time-series analysis in 272 cities in China – The Lancet Planetary Health (free)

See 2 other recent studies showing the association of air pollution and mortality: Association of Short-term Exposure to Air Pollution With Mortality in Older Adults AND Air Pollution and Mortality in the Medicare Population

Related: The cost of a polluted environment: 1.7 million child deaths a year, says WHO – World Health Organization (free) AND Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015 – The Lancet (free) AND Death in the Air: Air Pollution Costs Money and Lives – World Bank (free infographic and report)

 

10 – Silent Myocardial Infarction and Long-Term Risk of Heart Failure: The ARIC Study – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Silent MI and the Risk of Heart Failure – American College of Cardiology, Latest in Cardiology (free) AND Silent MI associated with downstream heart failure risk – Cardiovascular Business (free) AND Heart Failure Risk Following ‘Silent’ MI Warrants Scrutiny: ARIC Analysis – TCTMD (free) AND Silent MI Predicts Heart Failure, Deserves More Respect as CHD Risk Factor – Medscape (free registration required)

 


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