Open access

Mon, November 20 – 10 Stories of The Day!

20Nov
2017

 

1 – News release: New global commitment to end tuberculosis – World Health Organization (free)

Commentary: Global health ministers commit to end TB – CIDRAP (free)

Related report: Global tuberculosis report 2017 – World Health Organization (free) AND News Release: WHO report signals urgent need for greater political commitment to end tuberculosis (free)

 

2 – Infection prevention and control measures and tools for the prevention of entry of carbapenem-resistant Enterobacteriaceae into healthcare settings: guidance from the European Centre for Disease Prevention and Control – Antimicrobial Resistance & Infection Control (free)

Related document: Guidelines for the prevention and control of carbapenem-resistant Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosain health care facilities – World Health Organization (free)

 

3 – The association between paternal and adolescent depressive symptoms: evidence from two population-based cohorts – The Lancet (free)

Editorial: The effect of paternal depression on depressive symptoms in adolescent offspring (free)

Commentaries: Dads’ Depression Tied to Increased Depression Risk in Teenage Children – Physician’s First Watch (free) AND Teenage depression linked to father’s depression – University College London, via ScienceDaily (free)

 

4 – The High Costs of Unnecessary Care – JAMA (free)

 

5 – “Maybe I Will Just Send a Quick Text…” – An Examination of Drivers’ Distractions, Causes, and Potential Interventions – Frontiers in Psycology (free)

Commentaries: Young Men, Frequent Drivers Most Likely To Get Distracted While Driving – NPR (free) AND Risk of distracted driving predicted by age, gender, personality and driving frequency – MedicalXpress (free)

 

6 – Dog ownership and the risk of cardiovascular disease and death – a nationwide cohort study – Scientific Reports (free)

Commentaries: Dog ownership linked to lower mortality – Uppsala University, via ScienceDaily (free) AND Owning A Dog May Help Your Heart, Study Shows – Forbes (free)

 

7 – Bird Flu Is Spreading in Asia, Experts (Quietly) Warn – The New York Times (10 articles per month are free)

 

8 – Taking Care of the Physician – The New York Times (10 articles per month are free)

 

9 – Pearls and pitfalls in comprehensive critical care echocardiography – Critical Care (free)

 

10 – Validation of the Ottawa Subarachnoid Hemorrhage Rule in patients with acute headache – Canadian Medical Association Journal (free)

Commentaries: Thunderclap Headache: Ottawa Rule To Exclude Subarachnoid Bleeding – Medical Research (free) AND New tool identifies headache patients at risk of aneurysms in emergency department – CMAJ, via EurekAlert (free)

 

Fri, November 17 – 10 Stories of The Day!

17Nov
2017

 

1 – Exploring Attributes of High-Value Primary Care – Annals of Family Medicine (free)

Commentaries: Lower cost, higher quality primary care practices are distinguished by six attributes – American Academy of Family Physicians, via ScienceDaily (free) AND Identifying ‘high-value’ practices in primary care; a Stanford study pinpoints key attributes – Stanford Medicine (free)

 

2 – Critical Lessons From High-Value Oncology Practices – JAMA Oncology (free)

Editorial: Strategies to Achieve High-Value Oncology Care: A Beginning (free)

Audio interview: Critical Lessons From High-Value Oncology Practices (free)

Commentary: High-Value Cancer Care Keeps Costs Down? Yes, It’s Possible! – Medscape (free registration required) AND High-value oncology practices include “support for the patient journey” – Stanford Medicine (free)

 

3 – Changing Health Care Compensation by Rewarding Value-Based Outcomes – NEJM Catalyst (free)

 

4 – Speed of processing training results in lower risk of dementia – Alzheimer’s & Dementia: Translational Research & Clinical Interventions (free)

Commentaries: Can brain training reduce dementia risk? Despite new research, the jury is still out – The Guardian (free) AND Nonpharma Intervention Cuts Dementia Risk by a Third – Medscape (free registration required) AND Dementia breakthrough? Brain-training game ‘significantly reduces risk’ – Medical News Today (free)

“There are good reasons to be cautious about a new study claiming computer-based training can reduce the risk of dementia. But what does work?” (from The Guardian).

 

5 – Timing of Angiography and Outcomes in High-Risk Patients With Non–ST-Segment–Elevation Myocardial Infarction Managed Invasively – Circulation (free)

“High risk NSTEMI undergoing cath within 12 hours had lower risk of death and MI at 180 days” (RT @CircAHA see Tweet)

 

6 – Why we should care that many editors of top medical journals get healthcare industry payments – Health News Reviews (free)

Original article: Payments by US pharmaceutical and medical device manufacturers to US medical journal editors: retrospective observational study – The BMJ (free)

 

7 – Review: Undernutrition and severe acute malnutrition in children – The BMJ (free)

Infographic: Screening and referring children under 5 years old with acute undernutrition (free PDF)

 

8 – Review: Diabetic foot – The BMJ (free)

Infographic: A visual overview of the primary care assessment and monitoring of a diabetic foot (free PDF)

 

9 – Review of Strategies to Reduce Central Line-Associated Bloodstream Infection (CLABSI) and Catheter-Associated Urinary Tract Infection (CAUTI) in Adult ICUs – Journal of Hospital Medicine (free) (via @brhospitalist)

 

10 – Simple steps help prevent ICU delirium – ACP Hospitalist (free)

 

Thu, November 16 – 10 Stories of The Day!

16Nov
2017

 

1 – Periodic preventive health visits: a more appropriate approach to delivering preventive services – Canadian Task Force on Preventive Health Care (free)

Summary: Periodic preventive health visits: A more appropriate approach to delivering preventive services (free)

News release: Annual checkups do not result in better health outcomes, national task force reaffirms (free)

 

2 – Sudden Cardiac Arrest during Participation in Competitive Sports – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Sudden Cardiac Arrest Rare During Competitive Sports – Physician’s First Watch (free) AND Cardiac arrest study in young athletes raises heart screening questions – Reuters (free) AND Cardiac Arrest Rare in Young Athletes But Tough to Predict – Health (free) AND Screening programs unlikely to prevent sudden cardiac arrest in competitive athletes – St. Michael’s Hospital, via EurekAlert (free)

 

3 – Guidelines for the prevention and control of carbapenem-resistant Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosain health care facilities – World Health Organization (free)

Commentary: WHO offers guidance on carbapenem-resistant bacteria – CIDRAP (free)

 

4 – CheXNet: Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learning – Stanford ML Group (free)

We develop an algorithm that can detect pneumonia from chest X-rays at a level exceeding practicing radiologists

 

5 – The Patients vs. Paperwork Problem for Doctors – The New York Times (10 articles per month are free)

Related guideline: Putting Patients First by Reducing Administrative Tasks in Health Care: A Position Paper of the American College of Physicians (free)

 

6 – World Chronic Obstructive Pulmonary Disease Day, 15 November 2017: A round up of Cochrane evidence – Evidently Cochrane (free)

 

7 – Comparative clinical effectiveness and cost effectiveness of endovascular strategy vopen repair for ruptured abdominal aortic aneurysm: three year results of the IMPROVE randomised trial – The BMJ (free)

Editorial: Endovascular or open repair for ruptured abdominal aortic aneurysm? (free)

Commentary: Keyhole surgery more effective than open surgery for ruptured aneurysm – MedicalXpress (free)

 

8 – Health Effects and Public Health Concerns of Energy Drink Consumption in the United States: A Mini-Review – Frontiers in Public Health (free)

Commentaries: Serious health risks associated with energy drinks – ScienceDaily (free)

“To curb this growing public health issue, policy makers should regulate sales and marketing towards children and adolescents and set upper limits on caffeine” (from ScienceDaily)

 

9 – Effects of Bariatric Surgery in Obese Patients With Hypertension: The GATEWAY Randomized Trial (Gastric Bypass to Treat Obese Patients With Steady Hypertension) – Circulation (free)

Commentary: Bariatric Surgery Can Lead to HTN ‘Remission’ in Obese: GATEWAY – Medscape (free registration required) AND Gastric Bypass to Treat Obese Patients With Steady Hypertension – GATEWAY – American College of Cardiology, Latest in Cardiology (free)

 

10 – Effects of weight loss interventions for adults who are obese on mortality, cardiovascular disease, and cancer: systematic review and meta-analysis – The BMJ (free)

 

Wed, November 15 – 10 Stories of The Day!

15Nov
2017

 

1 – Association of Blood Pressure Lowering With Mortality and Cardiovascular Disease Across Blood Pressure Levels: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Treating modestly high blood pressure may not boost survival odds – Reuters (free) AND No cardiovascular disease reduction with intensive blood pressure lowering treatment – Umea University, via EurekAlert (free)

See also new AHA/ACC Hypertension Guidelines and related resources in our November 13th issue (see #1)

“”Primary preventive BP lowering is associated with reduced risk for death and CVD if baseline SBP is 140 mm Hg or higher.” published same day as @ACCinTouch guideline w/SBP goals <130 mm Hg. Cognitive dissonance?” (RT @kennylinafp see Tweet)

 

2 – Noninvasive Cardiac Testing vs Clinical Evaluation Alone in Acute Chest Pain: A Secondary Analysis of the ROMICAT-II Randomized Clinical Trial – JAMA Internal Medicine (free)

Editorial: Acute Chest Pain in the Emergency Department (free)

Commentaries: Does Clinical Evaluation Plus Noninvasive Cardiac Testing Improve Outcomes in Emergency Department Patients with Chest Pain? – The JAMA Network (free) AND Noninvasive Cardiac Testing No Better Than Clinical Eval for Low-Risk Acute Chest Pain – Physician’s First Watch (free)

“Non-invasive testing of chest pain patients in the ED – longer stay; more testing, radiation and cost; no benefit”. (RT @JAMA_current see Tweet)

 

3 – World Antibiotic Awareness Week, 13-19 November 2017: A round up of Cochrane evidence – Evidently Cochrane (free)

 

4 – Guidelines on the management of abnormal liver blood tests – Gut (free)

 

5 – Increases in Depressive Symptoms, Suicide-Related Outcomes, and Suicide Rates Among U.S. Adolescents After 2010 and Links to Increased New Media Screen Time – Clinical Psychological Science (free)

Commentaries: Increased Hours Online Correlate With An Uptick In Teen Depression, Suicidal Thoughts – NPR (free) AND Smartphones a likely culprit in the recent decline in teen mental health – STAT (free)

 

6 – Tinder and Grindr don’t want to talk about their role in rising STDs – VOX (free)

 

7 – Review: The Diagnosis of Chronic Coronary Heart Disease – Deutsches Ärzteblatt international (free)

 

8 – Aspirin in Patients With Previous Percutaneous Coronary Intervention Undergoing Noncardiac Surgery – Annals of Internal Medicine (free)

Commentaries: Perioperative aspirin may improve short-term outcomes after noncardiac surgery in patients with prior PCI – ACP Internist (free) AND Aspirin can prevent heart attacks after noncardiac surgery in patients with prior PCI – University of Alberta Faculty of Medicine & Dentistry, via ScienceDaily (free) AND Aspirin Protective Against Early Death/MI in Prior PCI Patients Undergoing Noncardiac Surgery – TCTMD (free)

 

9 – Perinatal mortality associated with induction of labour versus expectant management in nulliparous women aged 35 years or over: An English national cohort study – PLOS Medicine (free)

Commentaries: Labor induction at 40 weeks associated with lower risk of perinatal mortality – PLOS, via ScienceDaily (free) AND Induction at Term Cuts Rates of Infant Death in Older First-Time Moms – MedPage Today (free registration required) Inducing Older Moms at 40 Weeks May Lower Stillbirth Risk – Medscape (free registration required)

 

10 – Effect of an Intervention to Promote Breastfeeding on Asthma, Lung Function, and Atopic Eczema at Age 16 Years: Follow-up of the PROBIT Randomized Trial – JAMA Pediatrics (free)

Commentary: Prolonged breastfeeding linked to halving of later eczema risk – OnMedica (free)

 

Tue, November 14 – 10 Stories of The Day!

14Nov
2017

 

1 – 2017 ACC/AHA Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults (free PDF)

See also: High Blood Pressure Guidelines Hub / Executive Summary / ACC/AHA Slide Set / ACC Key Points to Remember (free resources)

 

2 – Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine – New England Journal of Medicine (free)

Commentaries: Neither Sodium Bicarbonate nor Oral Acetylcysteine Prevents Contrast-Induced Kidney Injury – Physician’s First Watch (free) AND PRESERVE: No Benefit from Sodium Bicarbonate, Acetylcysteine After Angiography – Medscape (free registration required)

 

3 – Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery – New England Journal of Medicine (free)

Commentaries: TRICS III: Restrictive Red-Cell Transfusion Noninferior to Liberal Use in Cardiac Surgery – TCTMD (free) AHA: Restrictive Blood Transfusion OK for Select Patients – MedPage Today (free registration required)

Related article: Transfusion Requirements After Cardiac Surgery: The TRACS Randomized Controlled Trial – JAMA (free)

 

4 – Sexual Activity as a Trigger for Sudden Cardiac Arrest – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Sex poses little risk of triggering sudden cardiac arrest – Cedars-Sinai Heart Institute, via EurekAlert (free) AND Instances of cardiac arrest after sex are low, but so are the survival rates – Cardiovascular Business (free)

 

5 – Comparison of Hospital Resource Use and Outcomes Among Hospitalists, Primary Care Physicians, and Other Generalists – JAMA Internal Medicine (free)

Editorial: The Costs and Benefits of Hospital Care by Primary Physicians: Continuity Counts (free)

Audio interview: Hospital Resource Use and Outcomes Among Generalist Physicians (free)

Commentaries: Study: For Inpatients, Primary Care Docs Outperform Hospitalists – MedPage Today (free registration required) AND Mortality Lower When Inpatients See Their Own PCP in Hospital – Medscape (free registration required)

 

6 – Review: Eosinophilic esophagitis: update on management and controversies – The BMJ (free for 2 weeks)

 

7 – Risks for blood clot in a vein may rise with increased TV viewing – Presented at American Heart Association’s (AHA) Scientific Sessions 2017 (free)

Commentary: More TV viewing linked to higher risk of blood clots in veins – Medical News Today (free)

 

8 – Nut Consumption and Risk of Cardiovascular Disease – Journal of The American College of Cardiology (free)

Commentary: Eating Regular Variety of Nuts Associated With Lower Risk of Heart Disease – American College of Cardiology (free) AND Variety of nuts tied to lower risk of heart disease – Reuters (free)

 

9 – Richard Lehman’s journal review, 13 November 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

10 – 20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: ‘Unrelenting': 20-Year Recurrence Risks in Breast Cancer – Medscape (free registration required) AND Breast cancer recurrence risk lingers years after treatment ends – MedicalXpress (free) AND Risk of breast cancer’s return continues long after treatment ends – Medical News Today (free)

 

Mon, November 13 – 10 Stories of The Day!

13Nov
2017

 

1 – World Antibiotic Awareness Week, 13-19 November 2017 – World Health Organization (free resources)

 

2 – Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct – New England Journal of Medicine (free)

Editorial: A New DAWN for Imaging-Based Selection in the Treatment of Acute Stroke (free)

Commentaries: Landmark study may impact standard stroke treatment guidelines – MedicalXpress (free) AND Thrombectomy Works While Infarct Core is Small – MedPage Today (free registration required)

“DAWN data: Consider a “tissue window” rather than a “time window”” (from MedPage Today)

 

3 – Mechanical or Biologic Prostheses for Aortic-Valve and Mitral-Valve Replacement – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Mechanical heart valve often the safest choice – Stanford Medicine (free) AND Mechanical or Biologic Prostheses for Aortic-Valve and Mitral-Valve Replacement? – NEJM 360 Resident (free) AND Mechanical or Tissue Valve for AVR and MVR – American College of Cardiology, Latest in Cardiology (free) AND Mechanical Valves Show Mortality Benefit Over Biologic Valves – Medscape (free registration required) AND Heart valve replacement success may depend on age, valve type – Reuters (free)

 

4 – NICE Guideline: Bipolar disorder: assessment and management (free)

 

5 – Choice of implant combinations in total hip replacement: systematic review and network meta-analysis – The BMJ (free)

Commentary: What is the most effective type of hip implant combination for patients undergoing a hip replacement? – University of Bristol (free)

“…there is no evidence that any of the newer hip implant combinations, such as ceramic or uncemented, are better than the widely used small head metal-on-plastic cemented hip combination, which has been commonly used since the 1960s”.

 

6 – White Smoke From the Vatican? Not From Cigarettes – The New York Times (10 articles per month are free)

Related: No more Holy Smokes – Vatican bans sale of cigarettes – Reuters (free) AND Holy smoke: Vatican bans duty-free cigarette sales – BBC (free)

“WHO welcomes the Vatican’s decision to ban the sale of cigarettes as of next year. Tobacco kills more than 7 million people every year” (RT @WHO see Tweet)

 

7 – Exercise for the Prevention of Low Back Pain: Systematic Review and Meta-Analysis of Controlled Trials – American Journal of Epidemiology (link to abstract – $ for full-text)

Commentary: Exercise may help prevent low back pain or make it less severe – Reuters (free)

Related meta-analysis: Prevention of Low Back Pain: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free)

 

8 – How to survive the medical misinformation mess – European Journal of Clinical Investigation (free) (RT @RasoiniR see Tweet)

 

9 – Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study – The BMJ (free)

Commentary: Vitamin D level not associated with cancer risk – Clinical Adviser (free)

“These results, in combination with previous literature, provide evidence that population-wide screening for vitamin D deficiency and subsequent widespread vitamin D supplementation should not currently be recommended as a strategy for primary cancer prevention”.

 

10 – Long-term Sustainability of Diabetes Prevention Approaches: A Systematic Review and Meta-analysis of Randomized Clinical Trials – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Lifestyle Modifications Slow Progression To Diabetes As Effectively As Medications – Medical Research (free) AND Lifestyle changes successfully reduce incidence of diabetes – MedicalXpress (free) AND Lifestyle changes—not medications—linked to sustained risk reduction for diabetes – Cardiovascular Business (free)

 

Fri, November 10 – 10 Stories of The Day!

10Nov
2017

 

1 – Book: Major Infectious Diseases: Disease Control Priorities, Third Edition (free)

Press Release: Disease Control Priorities, 3rd Edition Launches Major Infectious Diseases Volume (free)

Previous volumes: 1 – Essential Surgery / 2 – Reproductive, Maternal, Newborn, and Child Health / 3 – Cancer / 4 – Mental, Neurological, and Substance Use Disorders / 5 – Injury Prevention and Environmental Health (all free)

 

2 – Inflammatory Bowel Disease, 4th Edition – Australian Guidelines for General Practitioners and Physicians (free PDF)

Source: Gastroenterology Research Review Australia

 

3 – Symptomatic treatment of uncomplicated lower urinary tract infections in the ambulatory setting: randomised, double blind trial- The BMJ (free)

Editorial: Antibiotics or NSAIDs for uncomplicated urinary tract infection? (free)

Commentary: NSAID Compared to Antibiotic for Symptomatic Treatment of UTI – MPR (free)

 

4 – Regeneration of the entire human epidermis using transgenic stem cells – Nature (link to abstract – $ for full-text)

Commentaries: A Dying Boy Gets a New, Gene-Corrected Skin – The Atlantic (free) Gene Therapy Creates Replacement Skin to Save a Dying Boy – The New York Times (10 articles per month are free) AND ‘Extraordinary’ tale: Stem cells heal a young boy’s lethal skin disease – STAT (free) AND Scientists grow replacement skin for boy suffering devastating genetic disorder – The Guardian (free) Boy with rare disease gets brand new skin with gene therapy – Associated Press (free)

 

5 – International variations in primary care physician consultation time: a systematic review of 67 countries – BMJ Open (free)

Commentary: Primary care consultations last less than 5 minutes for half the world’s population – BMJ, via ScienceDaily (free)

“Global assessment of the length of doctor visits (primary care): range of 48 seconds to 22 minutes” (RT @EricTopol see Tweet)

 

6 – The case against hospital beds – Politico (free)

 

7 – Pre-exposure prophylaxis for HIV-negative persons with partners living with HIV: uptake, use, and effectiveness in an open-label demonstration project in East Africa – Gates Open Research (free)

 

8 – Medications That Cause Dry Mouth As an Adverse Effect in Older People: A Systematic Review and Metaanalysis – Journal of The American Geriatrics Society (free)

Commentaries: Dry mouth symptoms can be side effect of certain medications for older adults – American Geriatrics Society, via EurekAlert (free) AND Certain medication use associated with dry mouth in older adults – Clinical Advisor (free)

 

9 – Coronary Artery Calcium Score for Long-term Risk Classification in Individuals With Type 2 Diabetes and Metabolic Syndrome From the Multi-Ethnic Study of Atherosclerosis – JAMA (free)

Commentaries: Risk Classification by CAC Score in Diabetes and Metabolic Syndrome – American College of Cardiology, Latest in Cardiology (free) AND CAC Score Aids in CVD Risk Prediction in Diabetes – MedPage Today (free registration required)

 

10 – Viewpoint: Placebo Effect of the Heart – The Atlantic (free)

Related viewpoints: 12 Seconds of Placebo – An Outsider’s View of ORBITA – The HealthCare Blog (free) AND ORBITA Trial Puts Interventional Cardiologists On The Defensive – Cardiobrief (free) AND ORBITA: Another clinical trial demonstrating the need for sham controls in surgical trials – Science-Based Medicine (free) AND Coronary Stents Humbled Yet Again in Stable CAD – Medscape (free)

See original ORBITA trial and commentaries in our November 3rd issue (see #1)

  

Thu, November 9 – 10 Stories of The Day!

9Nov
2017

 

1 – European guidelines on perioperative venous thromboembolism prophylaxis – European Journal of Anaesthesiology (free PDF articles):

– Editorial

– Executive Summary

– Intensive care

– Mechanical prophylaxis

– Patients with preexisting coagulation disorders and after severe perioperative bleeding

– Inferior vena cava filters

– Cardiovascular and thoracic surgery

– Neurosurgery

– Surgery in the elderly

– Surgery in the obese patient

– Surgery during pregnancy and the immediate postpartum period

– Day surgery and fast-track surgery

– Chronic treatments with antiplatelet agents

– Aspirin

 

2 – Vancomycin Plus Piperacillin-Tazobactam and Acute Kidney Injury in Adults: A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)

Commentary: Vancomycin plus piperacillin-tazobactam associated with higher AKI risk – ACP Hospitalist (free)

Related article: Association of Acute Kidney Injury With Concomitant Vancomycin and Piperacillin/Tazobactam Treatment Among Hospitalized Children – JAMA Pediatrics (link to abstract – $ for full-text)

 

3 – 2017 Comprehensive Update of the Canadian Cardiovascular Society Guidelines for the Management of Heart Failure (free)

 

4 – Clinical Practice Guideline of Korean Diabetes Association (free articles):

– Antihyperglycemic Agent Therapy for Adult Patients with Type 2 Diabetes Mellitus 2017

– Insulin Therapy for Adult Patients with Type 2 Diabetes Mellitus

– Monotherapy in Patients with Type 2 Diabetes Mellitus

– Combination Therapy of Oral Hypoglycemic Agents in Patients with Type 2 Diabetes Mellitus

 

5 – 2017 Multimodality Appropriate Use Criteria for Noninvasive Cardiac Imaging: Expert Consensus of the Asian Society of Cardiovascular Imaging – Korean Journal of Cardiology (free)

 

6 – Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research – The Lancet Neurology (free registration required)

 

7 – Being overweight or obese is linked with heart disease even without other metabolic risk factors – NIHR Signal (free)

Original article: Separate and combined associations of obesity and metabolic health with coronary heart disease: a pan-European case-cohort analysis – European Heart Journal (free)

 

8 – Receipt of Warnings Regarding Potentially Impairing Prescription Medications and Associated Risk Perceptions in a National Sample of U.S. Drivers – Journal of Studies on Alcohol and Drugs (free)

Commentaries: Drivers not always told about their prescriptions’ potentially impairing effects – ACP Internist (free) AND Many People Prescribed Drugs That Could Impair Driving Aren’t Warned About Risk – Physician’s First Watch (free)

 

9 – Cardiovascular Effects of Long‐Term Exposure to Air Pollution: A Population‐Based Study With 900 845 Person‐Years of Follow‐up – Journal of The American Heart Association (free)

Commentaries: Air pollution as great a risk as hypertension, obesity, diabetes for CVD – Cardiovascular Business (free)

 

10 – Pulse oximetry screening for critical congenital heart defects: a European consensus statement – The Lancet Child & Adolescent Health (free)

Commentaries: All babies in Europe should be screened for heart defects at birth – OnMedica (free) AND Call for Europe-wide screening of babies for heart defects – MedicalXpress (free)

 

Wed, November 8 – 10 Stories of The Day!

8Nov
2017

 

1 – News Release and Summary: More Cardiac Arrest Victims Could Survive with Dispatcher CPR Instruction, Rescue Breaths for Children (free)

See Guidelines: 2017 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations Summary (free PDF) AND 2017 American Heart Association Focused Update on Adult Basic Life Support and Cardiopulmonary Resuscitation Quality (free PDF) AND 2017 American Heart Association Focused Update on Pediatric Basic Life Support and Cardiopulmonary Resuscitation Quality (free PDF)

Top Ten Things to Know: AHA Focused Update on Adult and Pediatric Basic Life Support and CPR Quality (free PDF)

 

2 – WHO guidelines on use of medically important antimicrobials in food-producing animals – World Health Organization (free)

News release: Stop using antibiotics in healthy animals to prevent the spread of antibiotic resistance (free)

Related Article: Restricting the use of antibiotics in food-producing animals and its associations with antibiotic resistance in food-producing animals and human beings: a systematic review and meta-analysis – The Lancet Planetary Health (free) and Editorial: Antimicrobial use and resistance in animals and human beings (free)

Commentaries: WHO calls for restrictions on use of antibiotics in food animal production – STAT (free) AND WHO Moves to Contain Superbugs on the Farm – Scientific American (free) WHO calls for an end to antibiotic use in healthy animals – CIDRAP (free)

 

3 – Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients – The Lancet (free)

Commentaries: Tranexamic acid: is it about time? – The Lancet (free) Rapid use of blood drug could save thousands of lives, study finds – The Guardian (free) AND Severely bleeding patients must receive lifesaving drug within minutes, not hours – London School of Hygiene & Tropical Medicine, via EurekAlert (free)

 

4 – Draft Recommendation Statement: Osteoporosis to Prevent Fractures: Screening – U.S. Preventive Services Task Force (free)

Commentary: New USPSTF Draft Recommendations for Osteoporosis Screening – Medscape (free registration required)

 

5 – Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: No Significant Difference in Pain Relief for Opioids vs Non-Opioid Analgesics for Treating Arm or Leg Pain – The JAMA Network (free) AND Acetaminophen plus Ibuprofen Noninferior to Low-Dose Oral Opioids for Acute Extremity Pain – Journal Watch (free)

 

6 – Comparisons of Interventions for Preventing Falls in Older Adults: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)

Commentaries: Exercise, Vision Testing and Osteoporosis Evaluation Are Keys To Fall Prevention – Medical Research (free) AND Exercise may be best intervention to prevent falls among elderly, according to new study – MedicalXpress (free) AND Adding other therapy to exercise may be best for fall prevention – Reuters (free) AND How to Prevent Falls in Older Adults – Consumer Reports (free)

 

7 – Alcohol and Cancer: A Statement of the American Society of Clinical Oncology – Journal of Clinical Oncology (free)

Commentaries: Cancer Doctors Cite Risks of Drinking Alcohol – The New York Times (10 articles per month are free) AND Cutting back on alcohol can prevent cancers: experts – Reuters (free) ASCO links alcohol to cancer, calls for reduced consumption – eCancer News (free)

 

8 – The Growing Value of Digital Health: Evidence and Impact on Human Health and the Healthcare System – IQVIA Institute (free)

Commentary: Study Names Top Apps for Patients to Manage Illnesses – Medscape (free registration required)

“An impressive, in-depth report on digital health, shows how the field is taking hold” (RT @EricTopol see Tweet)

 

9 – Clinical Guidelines Synopsis: Screening for Chronic Obstructive Pulmonary Disease – JAMA (free)

Original Guideline: GOLD 2017  Global Strategy for the Diagnosis, Management and Prevention of COPD (free PDF)

Related Guidelines: Final Recommendation Statement: Chronic Obstructive Pulmonary Disease: Screening – U.S. Preventive Services Task Force (free) AND Diagnosis and Management of Stable Chronic Obstructive Pulmonary Disease: A Clinical Practice Guideline Update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society (free)

 

10 – Projecting the impact of a nationwide school plain water access intervention on childhood obesity: a cost–benefit analysis – Pediatric Obesity (link to abstract – $ for full-text)

Commentaries: Making water available to school chilren at lunch may save $13B in health costs – UPI (free) AND Serving water with school lunches could curb obesity, save billions – Cardiovascular Business (free) AND Serving water with school lunches could prevent child, adult obesity: study – MedicalXpress (free)

 

Tue, November 7 – 10 Stories of The Day!

7Nov
2017

 

1 – The Burden of Group B Streptococcus Worldwide for Pregnant Women, Stillbirths, and Children – Clinical Infectious Diseases Supplement (free articles)

Commentaries: Group B Streptococcus infection causes an estimated 150,000 preventable stillbirths and infant deaths every year – London School of Hygiene & Tropical Medicine (free) AND Streptococcus vaccine ‘could prevent over 100,000 baby deaths worldwide’ – The Guardian (free)

 

2 – Effectiveness of β-Lactam Monotherapy vs Macrolide Combination Therapy for Children Hospitalized With Pneumonia – JAMA Pediatrics (link to abstract – $ for full-text)

Commentaries: Study: Azithromycin overprescribed for kids’ pneumonia – CIDRAP (free) AND Vanderbilt study shows azithromycin overprescribed for childhood pneumonia – Vanderbilt University Medical Center, via EurekAlert (free)

 

3 – Position Paper: Patient Safety in the Office-Based Practice Setting – American College of Physicians (free PDF)

Commentaries: ACP says patient safety must be improved in office-based practice setting – American College of Physicians, via EurekAlert (free) AND ACP: Recommendations for Improving Patient Safety in Ambulatory Settings – MPR (free)

 

4 – Debate: the case for and against screening for breast cancer with mammography:

The case for mammography: Routine mammograms do save lives: The Science – The Conversation (free)

The case against mammography: Routine mammograms do not save lives: The research is clear – The Conversation (free)

Related: Make Screening Mammography Personal, Say the French – Medscape (free registration required)

“The debate over breast cancer screening continues, with disagreements about the start age, frequency, mortality effect, overdiagnosis, and overtreatment” (from Medscape)

 

5 – ORBITA: Another clinical trial demonstrating the need for sham controls in surgical trials – Science-Based Medicine (free) (via @gorskon)

 

6 – Viewpoint: Advance Directives for Dementia: Meeting a Unique Challenge – JAMA (free)

 

7 – Richard Lehman’s journal reviews, 6 November 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – Last Month in Oncology with Dr. Bishal Gyawali: October 2017 – eCancer News (free)

 

9 – Association of Warfarin Use With Lower Overall Cancer Incidence Among Patients Older Than 50 Years – JAMA Internal Medicine (free)

“In this population-based cohort study of 1.256.725 persons, there was a significantly lower age- and sex-adjusted incidence rate ratio of cancer among warfarin users vs nonusers”.

 

10 – The Value of Preoperative Assessment Before Noncardiac Surgery in the Era of Value-Based Care – Circulation (free)

Related guidelines: 2014 ACC/AHA Guideline on Perioperative Cardiovascular Evaluation and Management of Patients Undergoing Noncardiac Surgery (free) AND 2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management (free) AND Routine preoperative tests for elective surgery – NICE Guideline (free) AND Canadian Cardiovascular Society Guidelines on Perioperative Cardiac Risk Assessment and Management for Patients Who Undergo Noncardiac Surgery (free) AND 3rd Guideline for Perioperative Cardiovascular Evaluation of the Brazilian Society of Cardiology (free)

 

Mon, November 6 – 10 Stories of The Day!

6Nov
2017

 

1 – European Guidelines for treatment of HIV-positive adults – European AIDS Clinical Society (free)

Commentary: New EACS treatment guidelines – Aidsmap (free) AND EACS updates HIV guidelines for adults – Healio (free registration required)

 

2 – Effect of Sertraline on Depressive Symptoms in Patients With Chronic Kidney Disease Without Dialysis Dependence: The CAST Randomized Clinical Trial – JAMA (free)

Editorial: Treating Depression in Patients With Advanced CKD: Beyond the Generalizability Frontier (free)

Commentary: Standard Antidepressant May Not Help Patients with Chronic Kidney Disease – UT Southwestern Medical Center, via NewsWise (free)

“Not only doesn’t help treat moderate depression, sertraline causes worse nausea (NNH=8) & diarrhea (NNH=10)” (RT @AnilMakam see Tweet 1 and Tweet 2)

 

3 – Working with influenza-like illness: Presenteeism among US health care personnel during the 2014-2015 influenza season – American Journal of Infection Control (free)

Commentaries: 4 in 10 healthcare professionals work when they’re sick, risking patients – HealthCare Finance (free) AND Four in 10 Healthcare Personnel Work While Sick – Medscape (free registration required) AND Four in 10 HCPs Work While Experiencing Flu-Like Illness, Says Survey – MPR (free)

 

4 – Cardiovascular, respiratory, and related disorders: key messages from Disease Control Priorities, 3rd edition – The Lancet (free registration required)

 

5 – Testing for chronic hepatitis B and C: a global perspective – BMC Infectious Diseases (free)

 

6 – Frequent sugar-sweetened beverage consumption and the onset of cardiometabolic diseases: cause for concern? – Journal of the Endocrine Society (free)

Commentaries: Just two sugary drinks per week may raise type 2 diabetes risk – Medical News Today (free) AND Sugar-sweetened drinks raise risk of diabetes, metabolic syndrome – The Endocrine Society, via EurekAlert (free)

 

7 – Choosing Wisely: Twenty Things Physicians and Patients Should Question – American Society for Clinical Pathology (free)

Commentary: More Lab Tests Deemed Inappropriate – Medscape (free registration required)

See more on the Choosing Wisely initiative in our April 5 issue (see #6)

 

8 – What We Know About Tuberculosis Transmission: An Overview – The Journal of Infectious Diseases (free) (RT @greg_folkers see Tweet)

 

9 – Fiber Intake and Survival After Colorectal Cancer Diagnosis – JAMA Oncology (free)

Commentaries: Is Eating Fiber After Colorectal Cancer Diagnosis Associated with Lower Death Risk? – The JAMA Network (free) AND Higher Fiber Intake After Colorectal Cancer Diagnosis Tied to Improved Survival – Physician’s First Watch (free)

 

10 – Glucocorticosteroids for people with alcoholic hepatitis – Cochrane Library (free)

Original article: Glucocorticosteroids for people with alcoholic hepatitis – Cochrane Library (link to abstract – $ for full-text)

“We found no evidence of a difference between glucocorticosteroids and placebo or no intervention on all-cause mortality, health-related quality of life, and serious adverse events during treatment”.

 

Fri, November 3 – 10 Stories of The Day!

3Nov
2017

 

1 – Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Small Trial Raises Big Concerns That PCI In Stable Angina Is Just A Placebo – Cardiobrief (free) AND Diving Deep Into The ORBITA Trial – Cardiobrief (free) AND Unbelievable’: Heart Stents Fail to Ease Chest Pain – The New York Times (10 articles per month are free) AND ORBITA: PCI Offers No Symptom Improvement Over Sham Procedure – TCTMD (free)

 

2 – Balanced Crystalloids vs Saline for Critically Ill Adults – American College of Chest Physicians Annual Meeting (free abstract)

Related Study: Balanced Crystalloids vs Saline for Noncritically Ill Adults in the Emergency Department – American College of Chest Physicians Annual Meeting (free abstract)

Commentaries: Landmark Trials Deliver Evidence to Rethink Saline Use – Medscape (free registration required) AND Saline on the Ropes? Studies find balanced crystalloid fluids safer – MedPage Today (free registration required)

 

3 – Familial hypercholesterolaemia: identification and management – NICE Guideline (free)

News release: Inherited risk of high cholesterol should be identified and treated as early as possible, NICE says in updated guidance (free)

 

4 – Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in Acute Ischemic Stroke: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association (free PDF)

Commentary: Intracranial Hemorrhage After Stroke Thrombolysis: More Questions Than Answers (free)

Top Ten Things to Know: Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in Acute Ischemic Stroke (free PDF)

Slide Set: Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in AIS (free PDF)

Related AHA/ASA Guidelines: Guidelines for the Early Management of Patients With Acute Ischemic Stroke (free) AND Guidelines for the Management of Spontaneous Intracerebral Hemorrhage (free)

 

5 – Cancer incidence and mortality among young adults aged 20–39 years worldwide in 2012: a population-based study – The Lancet Oncology (free)

Commentaries: Reducing the global cancer burden among young adults – The Lancet Oncology (free) AND Global burden of cancer among young adults aged 20–39 years – eCancer News (free) AND Cancer in Young Adults Disproportionately Affects Women – Medical Research (free)

 

6 – A ‘smart’ approach to performance drugs – ACP Internist (free)

Related: Growing use of smart drugs by students could be a recipe for disaster – The Conversation (free) AND Brain Hackers Seeking Peak Performance Use Risky Chemical Cocktails: “Smart drugs” are not clinically proven and could be dangerous – Scientific American (free) AND Universities must do more to tackle use of smart drugs, say experts – The Guardian (free) AND Tweaking brains with ‘smart drugs’ to get ahead in Silicon Valley – The Washington Post (free) AND Professors take same ‘smart drugs’ as students to keep up with workloads, claims academic – Independent (free)

 

6 – Seeing is Believing: Using Visual Abstracts to Disseminate Scientific Research – The American Journal of Gastroenterology (free)

 

7 – Opinion: Drug company sales reps should be banned from hospitals – STAT (free)

 

8 – Australia ends insurance subsidies for naturopathy, homeopathy, and more – Science-Based Medicine (free)

 

9 – Untreatable Gonorrhea Is Rapidly Spreading. Here’s What You Need to Know – TIME Health (free)

 

10 – Adolescent Childbirth Is Associated With Greater Framingham Risk Scores for Cardiovascular Disease Among Participants of the IMIAS (International Mobility in Aging Study) – Journal of The American Heart Association (free)

News release: Teen childbirth linked to increased risk for heart disease (free)

Commentaries: Teen childbirth linked to increased cardiovascular risk decades later – Cardiovascular Business (free) AND Study finds link between increased cardiovascular diseases and teen childbirth – News Medical (free)

 

Thu, November 2 – 10 Stories of The Day!

2Nov
2017

 

1 – The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases – Hepatology (free)

 

2 – The Care of Children With Congenital Heart Disease in Their Primary Medical Home – Pediatrics (free)

 

3 – Glaucoma: diagnosis and management – NICE Guideline (free)

News release: People at a low risk of developing glaucoma can avoid unnecessary referral, says NICE (free)

 

4 – Overdiagnosis and disease labels: the case of polycystic ovary syndrome – STAT (free)

Related: Are expanding disease definitions unnecessarily labelling women with polycystic ovary syndrome? – The BMJ (link to summary – $ for full-text)

 

5 – Bacteria Can Evolve Resistance to Drugs Before Those Drugs Are Used – The Atlantic (free)

 

6 – What I’ve learned from 547 doctor suicides – Pamela Wible, via KevinMd.com (free)

 

7 – Mortality lower with prolonged vs. short-term IV infusion of antipseudomonal beta-lactams – ACP Hospitalist (free)

Original article: Prolonged versus short-term intravenous infusion of antipseudomonal β-lactams for patients with sepsis: a systematic review and meta-analysis of randomised trials – The Lancet Infectious Diseases (link to abstract – $ for full-text)

 

8 – Updated WHO recommendation on intravenous tranexamic acid for the treatment of post-partum haemorrhage – The Lancet Global Health (free)

 

9 – Aspirin reduces a woman’s chance of developing pre-eclampsia in pregnancy – NIHR Signal (free)

Original article: Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia – New England Journal of Medicine (link to abstract – $ for full-text)

 

10 – Vaginal cleansing before caesarean delivery reduces risk of infections – NIHR signal (free)

Original article: Vaginal Cleansing Before Cesarean Delivery: A Systematic Review and Meta-analysis – Obstetrics & Gynecology (link to abstract – $ for full-text)

 

Wed, November 1 – 10 Stories of The Day!

1Nov
2017

 

1 – Lancet Countdown: Traking Progress on Health and Climate Change (free infographics, video and other resources)

Report: The Lancet Countdown on health and climate change: from 25 years of inaction to a global transformation for public health (free registration required)

Commentaries: Health impacts of climate change already felt today – Imperial College London (free) AND How Climate Change Is Already Affecting Health, Spreading Disease – NPR Goats and Soda (free) AND Climate change already bringing disease, air pollution and heatwaves – The Guardian (free) AND Climate change isn’t just hurting the planet – it’s a public health emergency – The Guardian (free)

 

2 – Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study – Gut (link to abstract – $ for full-text)

Commentaries: Acid reflux drug linked to more than doubled risk of stomach cancer – study – The Guardian (free) AND Gastric Cancer Risk Doubled With Long-term PPI Use – Medscape (free registration required) AND PPI Use After H. pylori Eradication Therapy Tied to Increased Risk for Gastric Cancer – Physician’s First Watch (free)

 

3 – Maintenance therapy with proton pump inhibitors and risk of gastric cancer: a nationwide population-based cohort study in Sweden – BMJ Open (free)

“Among 797 067 individuals on maintenance PPI therapy, the SIR of gastric cancer was over threefold increased (SIR=3.38, 95% CI 3.23 to 3.53)”.

 

4 – Review: Point of Care Ultrasound: An Overview – American College of Cardiology, Latest in Cardiology (free)

Related reviews: Ultrasonography in the emergency department – Critical Care (free) AND Clinically integrated multi-organ point-of-care ultrasound for undifferentiated respiratory difficulty, chest pain, or shock: a critical analytic review – Journal of Intensive Care (free) AND Common pitfalls in point-of-care ultrasound: a practical guide for emergency and critical care physicians – Critical Ultrasound Journal (free) AND Point-of-Care Ultrasonography by Pediatric Emergency Medicine Physicians – Pediatrics (free)

 

5 – 25th UEG (United European Gastroenterology) Week: Long-term aspirin use reduces the incidence of digestive cancers by up to 47% (free)

Commentaries: Long-Term Aspirin Use May Reduce Cancer Risk, Study Finds – Forbes (free) AND Aspirin slashes risk of gastrointestinal cancer – Medical News Today (free)

 

6 – Joint statement for the diagnosis, management, and prevention of chronic obstructive pulmonary disease for Gulf Cooperation Council countries and Middle East–North Africa region, 2017 – International Journal of Chronic Obstructive Pulmonary Disease (free)

 

7 – Mefloquine for preventing malaria during travel to endemic areas – Cochrane Library (free)

News release: Can mefloquine prevent malaria during travel to areas where the disease is widespread? (free)

Commentary: Cochrane review provides clarity about safety of mefloquine for preventing malaria in travelers – News Medical (free)

 

8 – Enjoyment of Spicy Flavor Enhances Central Salty-Taste Perception and Reduces Salt Intake and Blood Pressure – Hypertension (free)

Commentary: Can spicy foods curb salt cravings or lower blood pressure? – Reuters (free) AND Need to cut down on salt? Try something spicy instead – Medical News Today (free)

 

9 – Economic impact of palliative care among elderly cancer patients – presented at: 2017 Palliative and Supportive Care in Oncology Symposium (free abstract)

Commentaries: Palliative Care Associated With Decreased Costs For Patients With Advanced Cancer – Oncology Nurse Advisor (free) AND Early Palliative Care Is Key Driver in Reducing Costs – Medscape (free registration required)

Related study: Effect of Palliative Care on Aggressiveness of End-of-Life Care Among Patients With Advanced Cancer – Journal of Oncology Practice (link to abstract – $ for full-text) AND Commentaries: Palliative Care May Substantially Decrease Health-Care Utilization in Patients With Advanced Cancer – ASCO Post (free) AND End-of-Life Palliative Care Lowered Utilization for Patients With Cancer – AJMC (free)

Related guideline: Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

 

10 – Classification of Cough as a Symptom in Adults and Management Algorithms: CHEST Guideline and Expert Panel Report (free PDF)

See also other recent CHEST guidelines on the management of cough in specific populations: Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold – CHEST Expert Panel Report (free) AND Chronic Cough Due to Gastroesophageal Reflux in Adults (free) AND Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer (free) AND Cough in the athlete (free) AND Occupational and Environmental Contributions to Chronic Cough in Adults (free) AND Treatment of Unexplained Chronic Cough (free) AND Use of Management Pathways or Algorithms in Children With Chronic Cough: CHEST Guideline and Expert Panel Report (free) AND Management of Children With Chronic Wet Cough and Protracted Bacterial Bronchitis: CHEST Guideline and Expert Panel Report (free)

 

 

Tue, October 31 – 10 Stories of The Day!

31Oct
2017

 

1 – Global tuberculosis report 2017 – World Health Organization (free PDF)

News release: WHO report signals urgent need for greater political commitment to end tuberculosis (free)

Commentaries: Tuberculosis world’s top infectious killer; UN health agency calls for political action to stop spread – UN News Center (free) AND Pandemic alert: Tuberculosis is world’s No. 1 infectious killer – CNBC (free) Despite progress, WHO paints ‘grim’ picture of global TB – CIDRAP (free)

 

2 – 2017 AHA/ACC/HRS Guideline for Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death (free PDF)

News release: Societies Detail Treatment for Patients With Ventricular Arrhythmias (free)

See also: Executive summary (free PDF) AND Top Ten Things to Know (free PDF) AND Slide Set (free PDF)

 

3 – PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock – New England Journal of Medicine (free)

Editorial: Back to the Future in Cardiogenic Shock — Initial PCI of the Culprit Lesion Only (free)

Commentaries: CULPRIT-SHOCK Disputes Benefit of Immediate Multivessel PCI in Patients With Cardiogenic Shock – TCTMD (free) AND CULPRIT-SHOCK: Culprit Lesion Only PCI Vs. Immediate Multivessel PCI in Cardiogenic Shock – American College of Cardiology, Latest in Cardiology (free)

 

4 – Prenatal Exposure to Acetaminophen and Risk of ADHD – Pediatrics (free)

Commentaries: An Association Between Prenatal Acetaminophen Use and ADHD: The Benefits of Large Data Sets – Pediatrics (free) AND Long-term Acetaminophen Use in Pregnancy and ADHD – 2 Minute Medicine (free) AND Study links acetaminophen in pregnancy to ADHD, but experts question results – CNN (free)

 

5 – Policy Statement: Cord Blood Banking for Potential Future Transplantation – American Academy of Pediatrics (free)

News release: Updated policy reaffirms value of public over private cord blood banks (free)

Commentaries: Pediatrics Group Updates Recommendations on Cord Blood Banking – Physician’s First Watch (free)

 

6 – Duration of Breastfeeding and Risk of SIDS: An Individual Participant Data Meta-analysis – Pediatrics (link to abstract – $ for full-text)

Commentary: Breastfeeding for two months halves risk of SIDS – University of Virginia Health System, via ScienceDaily (free)

 

7 – Is there a conflict of interest behind your cancer diagnosis? – STAT (free)

 

8 – Richard Lehman’s journal reviews, 30 October 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Electronic cigarette use and smoking initiation among youth: a longitudinal cohort study – Canadian Medical Association Journal (free)

Commentary: E-cigarette use by high school students linked to cigarette smoking – ScienceDaily (free)

 

10 – Review: So you think it is sepsis: considerations beyond lung and urine in the sick patient without a source – emDocs (free)

 

Mon, October 30 – 10 Stories of The Day!

30Oct
2017

 

1 – Book: Injury Prevention and Environmental Health – Disease Control Priorities, Third Edition (free)

Press Release: Disease Control Priorities, 3rd Edition Launches Volume on Injury Prevention & Environmental Health (free)

Previous volumes: 1 – Essential Surgery / 2 – Reproductive, Maternal, Newborn, and Child Health / 3 – Cancer / 4 – Mental, Neurological, and Substance Use Disorders

 

2 – NICE Guideline: Sinusitis (acute): antimicrobial prescribing (free)

News release: Antibiotics should not be used to treat the majority of sinus infections, NICE says (free)

 

3 – NICE Guideline: Cystic fibrosis: diagnosis and management (free)

News release: People with cystic fibrosis could be monitored through phone or video messaging, says NICE (free)

 

4 – NICE Guideline: Cataracts in adults: management (free)

News release: Take a patient-centred approach to treating cataracts, says NICE (free)

 

5 – KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors – Transplantation (free)

See also: Summary of KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors (free)

News release: KDIGO Guidelines on Living Kidney Donors: A Call for A Paradigm Shift (free)

 

6 – Influence of pharmaceutical marketing on Medicare prescriptions in the District of Columbia – PLOS One (free)

Commentaries: The More Lavish the Gifts to Doctors, the Costlier the Drugs They Prescribe – The New York Times (10 articles per month are free) AND Study finds even small gifts from pharma companies change prescribing habits – FierceHealthcare (free) AND Pharma gifts to providers result in more branded, expensive prescriptions – Georgetown University Medical Center, via EurekAlert (free)

 

7 – Why we need better evidence – Centre for Evidence-Based Medicine, University of Oxford (free)

“20 fundamental problems with the production of evidence” (RT @CochraneUK see Tweet)

 

8 – Viewpoint: The Evolution of Patient Diagnosis: From Art to Digital Data-Driven Science – JAMA (free)

 

9 – Review: Acute Management of Pulmonary Embolism – American College of Cardiology, Latest in Cardiology (free)

 

10 – Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study – The Lancet (link to abstract – $ for full-text)

Commentaries: Why Heart Surgery May be Better in the Afternoon – Scientific American (free) AND Afternoon heart surgery has lower risk of complications, study suggests – The Guardian (free) AND Aortic Valve Replacement: Afternoon Surgery Linked to Fewer Adverse Events – Physician’s First Watch (free)

 

Fri, October 27 – 10 Stories of The Day!

27Oct
2017

 

1 – Screening for Lung Cancer: CHEST Guideline and Expert Panel Report – American College of Chest Physicians (free)

News release: American College of Chest Physicians unveils new lung cancer screening guidelines at CHEST 2017 (free)

 

2 – Guideline: Responding to children and adolescents who have been sexually abused – World Health Organization (free)

News release: Responding to children and adolescents who have been sexually abused (free)

 

3 – Payments by US pharmaceutical and medical device manufacturers to US medical journal editors: retrospective observational study – The BMJ (free)

“Industry payments to journal editors are common and often large, particularly for certain subspecialties. Journals should consider the potential impact of such payments on public trust in published research”.

 

4 – Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis – The BMJ (free)

“Women with antithrombin, protein C, or protein S deficiency or with homozygous factor V Leiden should be considered for antepartum or postpartum thrombosis prophylaxis, or both”.

 

5 – Regular antibiotics for preventing pneumococcal infection in young children with sickle cell disease – Cochrane Library (free)

Original article: Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease – Cochrane Library (link to abstract – $ for full-text)

Source: EvidenceAlerts

 

6 – World leaders rehearse for a pandemic that will come ‘sooner than we expect’ – The Washington Post (free)

 

7 – Perspective: HIV Drug Resistance: An Emerging Threat to Epidemic Control – New England Journal of Medicine (free)

 

8 – Terbinafine is probably first choice oral drug for fungal toenail infection – NIHR Signal (free)

Original article: Oral antifungal medication for toenail onychomycosis – Cochrane Library (free)

 

9 – Clinical guidelines for the prevention and treatment of osteoporosis: summary statements and recommendations from the Italian Society for Orthopaedics and Traumatology – Journal of Orthopaedics and Traumatology (free)

 

10 – Austrian consensus guidelines on the management and treatment of portal hypertension (Billroth III) – Wiener klinische Wochenschrift (free)

 

Thu, October 26 – 10 Stories of The Day!

26Oct
2017

 

1 – Modifiers of the effect of maternal multiple micronutrient supplementation on stillbirth, birth outcomes, and infant mortality: a meta-analysis of individual patient data from 17 randomised trials in low-income and middle-income countries – The Lancet Global Health (free)

Commentaries: Antenatal multiple micronutrient supplementation: benefits beyond iron-folic acid alone – The Lancet Global Health (free) AND Multiple micronutrient supplements to mothers improve survival for newborn girls – Harvard School of Public health (free)

Related systematic review: Multiple-micronutrient supplementation for women during pregnancy – Cochrane Library (free summary)

 

2 – Less dementia with oral anticoagulation in atrial fibrillation – European Heart Journal (free)

Commentaries: Blood-thinning drugs appear to protect against dementia in AF patients – OnMedica (free) AND Blood-thinning drugs ‘can reduce risk of dementia by up to 48%’ – The Guardian (free) AND Oral Anticoagulants Tied to Less Dementia in Patients with Atrial Fibrillation – Physician’s First Watch (free)

 

3 – Surgery for Drug-Resistant Epilepsy in Children – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: First test of anti-epilepsy surgeries in children shows dramatic benefit – Reuters (free) AND Surgery Cuts Seizures in Drug-Resistant Epilepsy – MedPage Today (free registration required)

 

4 – Guideline: Long-Acting Reversible Contraception: Implants and Intrauterine Devices – American College of Obstetricians and Gynecologists (free)

News release: LARC and Reproductive Choice (free)

Commentary: New Guidelines on LARC Released by ACOG – Medscape (free registration required)

 

5 – Review: The Practice and Implications of Finding Fluid During Point-of-Care Ultrasonography – JAMA Internal Medicine (free)

Related JAMA Video: Finding Fluid With Point-of-Care Ultrasonography (free)

 

6 – Depression and mortality in a longitudinal study: 1952–2011 – Canadian Medical Association Journal (free)

Commentaries: Depression strongly linked to higher long-term risk of early death for both women, men – ScienceDaily (free) AND Depression raises risk of early death – Medical News Today (free) AND Depression tied to shorter lifespan – Reuters (free)

 

7 – Is It Possible to Predict the Next Pandemic? – The Atlantic (free)

“Large initiatives are underway to pinpoint the next big viral threats—but some virologists believe the task is too hard”.

 

8 – Prognostic Effect and Longitudinal Hemodynamic Assessment of Borderline Pulmonary Hypertension – JAMA Internal Medicine (free)

Commentary: Borderline Pulmonary Hypertension Tied to Mortality Risk – MedPage Today (free registration required)

 

9 – Here’s Why Vaccines Are So Crucial – National Geographic Magazine (free) (via @filiamd)

 

10 – Aerosol delivery during invasive mechanical ventilation: a systematic review – Critical Care (free)

 

Wed, October 25 – 10 Stories of The Day!

25Oct
2017

 

1 – Statin use and risk of developing diabetes: results from the Diabetes Prevention Program – BMJ Open Diabetes Research & Care (free)

Commentaries: Statins increase the risk of developing diabetes in at-risk people – Medical News Today (free) AND Statin use link to heightened type 2 diabetes risk in some people – OnMedica (free)

 

2 – Synopsis of the 2017 U.S. Department of Veterans Affairs/U.S. Department of Defense Clinical Practice Guideline: Management of Type 2 Diabetes Mellitus – Annals of Internal Medicine (free)

Related 2017 Guidelines: Type 2 diabetes in adults: management – NICE Guideline (free) AND Pharmacologic Therapy for Type 2 Diabetes: Synopsis of the 2017 American Diabetes Association Standards of Medical Care in Diabetes (free) AND Oral Pharmacologic Treatment of Type 2 Diabetes Mellitus: A Clinical Practice Guideline Update From the American College of Physicians (free)

 

3 – Global prevalence of injecting drug use and sociodemographic characteristics and prevalence of HIV, HBV, and HCV in people who inject drugs: a multistage systematic review – The Lancet Global Health (free)

Related article: Global, regional, and country-level coverage of interventions to prevent and manage HIV and hepatitis C among people who inject drugs: a systematic review – The Lancet Global Health (free)

Commentary: New research highlights worldwide risk of HIV, Hepatitis C epidemics – University of New South Wales, via ScienceDaily (free)

 

4 – Effect of Robotic-Assisted vs Conventional Laparoscopic Surgery on Risk of Conversion to Open Laparotomy Among Patients Undergoing Resection for Rectal Cancer: The ROLARR Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Related Study: Association of Robotic-Assisted vs Laparoscopic Radical Nephrectomy With Perioperative Outcomes and Health Care Costs, 2003 to 2015 – JAMA (free)

Commentaries: Comparison of Outcomes for Robotic-Assisted vs Laparoscopic Surgical Procedures – The JAMA Network (free) AND Robotic docs can boost surgery time and cost – Science News (free) AND Robot-assisted surgery for kidney removal associated with longer operating times, higher cost – Stanford Medicine (free) AND Robotic-assisted surgery: more expensive, but not always more effective – Reuters (free)

 

5 – Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms – Scientific Reports (free)

Recommended Commentary: Magic mushrooms: Some reporters buy magical notion of ‘reset’ button for depression – Health News Review (free)

Other Commentaries: Magic mushrooms ‘reboot’ brain in depressed people – study – The Guardian (free) AND Magic mushrooms can ‘reset’ depressed brain – BBC News (free)

 

6 – Cardiovascular Health in African Americans: A Scientific Statement From the American Heart Association – Circulation (free PDF)

News releases: African Americans live shorter lives due to heart disease and stroke – AHA / ASA Newsroom (free) AND New report raises concerns about the cardiovascular health of African-Americans – AHA News (free)

Commentaries: Blacks Face Higher Mortality from Heart Disease, Stroke – Cardiobrief (free) AND Heart health disparities take toll on African-Americans – Reuters (free)

 

7 – A baby with a disease gene or no baby at all: Genetic testing of embryos creates an ethical morass – STAT (free)

 

8 – Richard Lehman’s journal review, 23 October 2017 – The BMJ Opinion (free)

Richard Lehman’s weekly review of medical journals.

 

9 – Protection of the house against Chagas disease, dengue, leishmaniasis, and lymphatic filariasis: a systematic review – The Lancet Infectious Diseases (free registration required)

 

10 – Head position after acute stroke does not affect disability outcomes – NIHR Signal (free)

Original article: Cluster-Randomized, Crossover Trial of Head Positioning in Acute Stroke – The New England Journal of Medicine (link to abstract – $ for full-text)

 

Tue, October 24 – 10 Stories of The Day!

24Oct
2017

 

1 – Guideline: Hepatitis B (chronic): diagnosis and management – National Institute for Health and Care Excellence (free)

 

2 – British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD) – Thorax (free)

 

3 – A toolkit for reducing repetitive routine blood draws in hospitals – Choosing Wisely Canada (free PDF)

News release: Toolkit: Pause the Draws (free)

 

4 – Policy Statement: Infection Prevention and Control in Pediatric Ambulatory Settings – American Academy of Pediatrics (free)

News release: Updated policy offers guidance on infection prevention, control in ambulatory settings (free)

Commentaries: Pediatrician’s New Germ-Control Advice: Bring Your Own Toys (10 articles per month are free) AND AAP: Hygiene, isolation protocols critical for infection control in pediatric office – Healio (free registration required)

 

5 – Clinical Report: Sexual and Reproductive Health Care Services in the Pediatric Setting – American Academy of Pediatrics (free)

News release: Pediatricians have key role in providing sexual, reproductive health care services (free)

 

6 – Incidence, Demographics, and Clinical Characteristics of Diabetes of the Exocrine Pancreas (Type 3c): A Retrospective Cohort Study – Diabetes Care (link to abstract – $ for full-text)

Commentary: Newly-identified third type of diabetes is being wrongly diagnosed as type 2 – The Conversation (free)

“Diabetes of the exocrine pancreas is frequently labeled type 2 diabetes but has worse glycemic control and a markedly greater requirement for insulin”.

 

7 – Concussion in adolescence and risk of multiple sclerosis – Annals of Neurology (link to abstract – $ for full-text)

Commentaries: Concussions in Teenagers Tied to Multiple Sclerosis Risk – The New York Times (10 articles per month are free) AND Teenage concussion linked to later risk of MS – Medical News Today (free)

 

8 – Multidisciplinary consensus on screening for, diagnosis and management of fetal growth restriction in the Netherlands – BMC Pregnancy and Childbirth (free)

 

9 – Clinical Management of Insomnia Disorder – JAMA (free)

“Cognitive Behavior Therapy for insomnia is recommended as 1st-line Tx; pharmacotherapy, if used, should be on a short-term basis” (RT @JAMAInternalMed see Tweet)

 

10 – Review: The challenge of Takotsubo syndrome: heterogeneity of clinical features – Swiss Medical Weekly (free)

 

Mon, October 23 – 10 Stories of The Day!

23Oct
2017

 

1 – Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis – The Lancet Global Health (free)

Invited commentary: Global causes of vision loss in 2015: are we on track to achieve the Vision 2020 target? (free)

Related study: Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis – The Lancet Global Health (free) AND Invited Commentary: Universal eye health: are we getting closer? (free)

 

2 – Upright versus lying down position in second stage of labour in nulliparous women with low dose epidural: BUMPES randomised controlled trial – The BMJ (free)

Commentaries: During Labor, Lie Down – The New York Times (10 articles per month are free) AND Normal birth more likely when lying down in late stages, post epidural – OnMedica (free)

 

3 – Summary with 10 key points to remember: Thrombophilia Testing and Venous Thrombosis – American College of Cardiology, Latest in Cardiology (free)

See also: Thrombophilia Testing and Venous Thrombosis – NEJM Resident 360 (free)

Original article: Thrombophilia Testing and Venous Thrombosis – New England Journal of Medicine (link to abstract – $ for full-text)

 

4 – Is gene editing ethical? – Medical News Today (free)

Related: Embryo Gene-Editing Experiment Reignites Ethical Debate – Scientific American (free) AND U.S. scientists edit genome of human embryo, but cast doubt on possibility of ‘designer babies’ – STAT (free)

Related Position Statement: Human Germline Genome Editing – American Society of Human Genetics (free) AND Commentary: 11 Organizations Urge Cautious but Proactive Approach to Gene Editing (free)

 

5 – Trial Evaluating Ambulatory Therapy of Travelers’ Diarrhea (TrEAT TD) Study: A Randomized Controlled Trial Comparing 3 Single-Dose Antibiotic Regimens With Loperamide – Clinical Infectious Diseases (link to abstract – $ for full-text)

Commentary: Azithromycin, levofloxacin, rifaximin all effective for travelers diarrhea – Healio (free registration required)

 

6 – Literature review: the economic costs of lung disease and the cost effectiveness of policy and service interventions – British Lung Foundation and British Thoracic Society (free PDF)

News release: New report identifies the most cost effective NHS activities and programmes to improve lung health – British Thoracic Society (free)

Source: Most cost effective treatments for lung disease identified – The BMJ News ($)

“The most cost effective treatments are: patient education and self management for asthma; stop smoking support for chronic obstructive pulmonary disease (COPD); vaccination programmes for pneumonia; and awareness campaigns for lung cancer” (from The BMJ).

 

7 – Walking in Relation to Mortality in a Large Prospective Cohort of Older U.S. Adults – American Journal of Preventive Medicine (free)

Commentaries: Regular Walking, Even if Minimal, Tied to Lower Death Risk – Medscape (free registration required) AND Study finds even regular walking can lower mortality risk – UPI (free)

 

8 – Weight Gain in Women at Midlife: A Concise Review of the Pathophysiology and Strategies for Management – Mayo Clinic Proceedings (free)

Commentary: Docs Call Attention to Women Piling on Pounds in Midlife – Medscape (free registration required)

 

9 – Carefully managed antibiotic use could halve antibiotic-resistant infections – NIHR Signal (free)

Original article: Effect of antibiotic stewardship on the incidence of infection and colonisation with antibiotic-resistant bacteria and Clostridium difficile infection: a systematic review and meta-analysis – The Lancet Infectious Diseases (link to abstract – $ for full-text)

 

10 – Placing wet gauze on babies’ tummies speeds up urine collection – NIHR Signal (free)

Original article: Faster clean catch urine collection (Quick-Wee method) from infants: randomised controlled trial – The BMJ (free)

 

Fri, October 20 – 10 Stories of The Day!

20Oct
2017

 

1 – Levels & Trends in Child Mortality – UNICEF (free PDF)

News release: Levels and Trends in Child Mortality (free)

Commentaries: 7,000 newborns die every day, despite steady decrease in under-five mortality, new report says – The World Bank (free) AND New child mortality estimates show that 15,000 children died every day in 2016 – The World Bank (free) AND Unconscionable': 7,000 babies die daily despite record low for child mortality – The Guardian (free)

 

2 – Report: The Lancet Commission on pollution and health (Report, Executive Summary, Video, Audio and Comments – free registration required)

Commentaries: Report: Pollution Kills 3 Times More than AIDS, TB And Malaria Combined – NPR (free) AND Pollution linked to one in six deaths – BBC (free)

 

3 – 2017 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea (free)

Commentary: New diarrhea guidelines stress implications of molecular tests – CIDRAP (free)

 

4 – Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology (free)

 

5 – Elevated blood pressure and risk of mitral regurgitation: A longitudinal cohort study of 5.5 million United Kingdom adults – PLOS Medicine (free)

Commentaries: High Blood Pressure Is a Risk Factor For Mitral Regurgitation – Medical Research (free) AND High Blood Pressure May Raise Mitral Regurgitation Risk – TCTMD (free) AND Inevitable or preventable? High blood pressure linked to mitral regurgitation – Cardiovascular Business (free)

 

6 – High-flow oxygen via nasal cannulae in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis – Systematic Reviews (free)

“In patients with acute hypoxemic respiratory failure HFNC was not associated with a difference in mortality compared to Noninvasive ventilation or standard oxygen”

 

7 – Imaging Studies Offer New Insights Into Inflammation In CV Disease – Cardiobrief (free)

Original article: Colchicine Therapy and Plaque Stabilization in Patients With Acute Coronary Syndrome – Journal of The American College of Cardiology (link to abstract – $ for full-text)

“Preliminary evidence that colchicine may reduce coronary plaque”.

 

8 – Evidence-based guidelines for supportive care of patients with Ebola virus disease – The Lancet (free)

Commentaries: New Ebola guidelines address immediate supportive care – CIDRAP (free)

 

9 – Update: Interim Guidance for the Diagnosis, Evaluation, and Management of Infants with Possible Congenital Zika Virus Infection – MMWR / CDC (free)

Commentaries: CDC Offers New Guidance on Diagnosing and Managing Zika in Infants – Physician’s First Watch (free)

 

10 – A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets – Cell Host Microbe (free)

Commentaries: H7N9 study finds virus poised to become more lethal, resistant to treatment – CIDRAP (free) AND H7N9 influenza is both lethal and transmissible in animal model for flu – University of Wisconsin–Madison (free) AND Will the World’s Most Worrying Flu Virus Go Pandemic? – The Atlantic (free)

 

Thu, October 19 – 10 Stories of The Day!

19Oct
2017

 

1 – 2017 ACC Expert Consensus Decision Pathway on the Management of Mitral Regurgitation – Journal of The American College of Cardiology (free)

Commentaries: Expert Consensus Decision Pathway for Management of Mitral Regurgitation – American College of Cardiology, Latest in Cardiology (free) AND ACC Recommends ‘Structured Approach’ to Mitral Regurgitation – MedPage Today (free registration required)

 

2 – Update to Practice Standards for Electrocardiographic Monitoring in Hospital Settings: A Scientific Statement From the American Heart Association – Circulation (free PDF)

Commentaries: 12 key points to remember: Standards for Inpatient Electrocardiographic Monitoring – American College of Cardiology, Latest in Cardiology (free) AND AHA updates practice standards for electrocardiographic monitoring – ACP Hospitalist (free)

 

3 – Dark chocolate is now a health food. Here’s how that happened – VOX (free)

Related: Chocolate health: advice by Thomas Lüscher and peer review by Jonas Malmstedt – For Better Science (by @schneiderleonid)

“Big Chocolate’s investment in health science was a marketing masterstroke…” Interesting tale by @juliaoftoronto (RT @hildabast see Tweet)

 

4 – Long-term antibiotics likely to reduce risk of recurrent cellulitis – NIHR Signal (free)

Original article: Interventions for the prevention of recurrent erysipelas and cellulitis – Cochrane Library (link to abstract – $ for full-text)

 

5 – Comparing the Outcomes of Adults With Enterobacteriaceae Bacteremia Receiving Short-Course Versus Prolonged-Course Antibiotic Therapy in a Multicenter, Propensity Score–Matched Cohort – Clinical Infectious Diseases (link to abstract – $ for full-text)

Commentary: Short course of antibiotics worked as well as long for Enterobacteriaceae bacteremia – ACP Hospitalist (free)

 

6 – Report: Opportunities for Organ Donor Intervention Research: Saving Lives by Improving the Quality and Quantity of Organs for Transplantation (2017) – National Academies Press (free PDF)

Related Viewpoint: Organ Donor Research: Overcoming Challenges, Increasing Opportunities – JAMA (free)

 

7 – Short and Long Term Complications of In Utero Exposure to Lamotrigine – British Journal of Clinical Pharmacology (free PDF)

News release: Study Finds Epilepsy Drug to Be Safe During Pregnancy – Wiley (free)

Source: Study finds lamotrigine to be safe during pregnancy – The BMJ Research News ($)

 

8 – Richard Lehman’s journal review, 17 October 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Association of Patient Frailty With Increased Morbidity After Common Ambulatory General Surgery Operations – JAMA Surgery (link to abstract – $ for full-text)

Commentaries: Frailty Associated With Increased Risk of Complications Following Common, Outpatient Operations – The JAMA Network (free) AND Frailty tied to higher risk of complications with common surgeries – Reuters (free) AND Frailty linked to higher rate of perioperative morbidity – OnMedica (free)

 

10 – 25-Year Physical Activity Trajectories and Development of Subclinical Coronary Artery Disease as Measured by Coronary Artery Calcium – Mayo Clinic Proceedings (free)

Commentaries: Excessive Exercise May Harm The Heart, Study Suggests – Forbes (free) AND Physically active white men at high risk for plaque buildup in arteries – ScienceDaily (free)

 

Wed, October 18 – 10 Stories of The Day!

18Oct
2017

 

1 – Guideline: 2017 Appropriate Use Criteria for the Treatment of Patients With Severe Aortic Stenosis (free)

Commentaries: 2017 AUC for Management of Severe Aortic Stenosis – American College of Cardiology, Latest in Cardiology (free) AND First Appropriate Use Criteria Issued for Severe Aortic Stenosis – Medpage Today (free registration required)

 

2 – Association of Blood Transfusion From Female Donors With and Without a History of Pregnancy With Mortality Among Male and Female Transfusion Recipients – JAMA (link to abstract – $ for full-text)

Commentaries: Blood Boundaries: Should Transfusions Be Matched by Sex? – Scientific American (free) AND Are transfusions harmful to men if the blood comes from women who have been pregnant? – STAT (free) AND Receipt of Blood Transfusion From Previously Pregnant Donor Associated with Increased Risk of Death Among Male Recipients – The JAMA Network (free)

 

3 – Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients—A Systematic Review and Meta-Analysis – Antibiotics (free)

Antibiotic-associated diarrhea ocurred in 8.0% of the probiotic group compared to 17.7% in the control group. The number needed to treat (NNT) to prevent one case of diarrhea was 11 (95% CI 6 to 13).

 

4 – Approach to recurrent fever in childhood – Canadian medical Association Journal (free)

 

5 – Comparative safety of direct oral anticoagulants and warfarin in venous thromboembolism: multicentre, population based, observational study – The BMJ (free)

Commentary: New Anticoagulants Not Linked To Excess Bleeding Rates – Cardiobrief (free)

 

6 – How Low to Go With Glucose, Cholesterol, and Blood Pressure in Primary Prevention of CVD – Journal of The American College of Cardiology (free)

Summary with 12 key points to remember: Glucose, Cholesterol, BP Targets for CVD Risk Factors – American College of Cardiology, Latest in Cardiology (free)

 

7 – Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentaries: Omega-6 fats may help prevent type 2 diabetes – George Institute for Global Health (free) AND Eating More Nuts Could Protect Against Type 2 Diabetes – Medscape (free registration required) AND Omega-6 could lower type 2 diabetes risk by 35 percent – Medical News Today (free)

 

8 – The oncologic burden of hepatitis C virus infection: A clinical perspective – CA: A Cancer Journal for Clinicians (free)

 

9 – Recommendations for Prevention and Control of Influenza in Children, 2017 – 2018 – American Academy of Pediatrics (free)

Commentary: 2017-2018 recommendations for pediatric influenza vaccination – Clinical Advisor (free) AND Fall Weather Headed Your Way? Time For Flu Shots – NPR (free)

 

10 – Individual support of nurses using electronic medicine monitors can improve HIV treatment – NIHR Signal (free)

Original article: Effectiveness and cost-effectiveness of a nurse-delivered intervention to improve adherence to treatment for HIV: a pragmatic, multicentre, open-label, randomised clinical trial – The Lancet Infectious Diseases (free)

 

Tue, October 17 – 10 Stories of The Day!

17Oct
2017

 

1 – Association of History of Gestational Diabetes With Long-term Cardiovascular Disease Risk in a Large Prospective Cohort of US Women – JAMA Internal Medicine (free)

Commentaries: CVD Risk for Women Rises After Gestational Diabetes – TCTMD (free) AND Does Gestational Diabetes Per Se Up Long-Term Cardiovascular Risk? – Medscape (free registration required) AND Gestational Diabetes Raises Heart Attack, Stroke Risk, NIH Study Finds – AJMC (free)

 

2 – Association of Antidepressant Medications With Incident Type 2 Diabetes Among Medicaid-Insured Youths – JAMA Pediatrics (link to abstract – $ for full-text)

Commentaries: Antidepressant Use in Youth Tied to Increased Diabetes Risk – Physician’s First Watch (free)

Related article: The risk of new-onset diabetes in antidepressant users – A systematic review and meta-analysis – PLOS One (free) AND Commentary: Type 2 Diabetes and Antidepressant Drug Use: Is There a Causal Link? – Endocrinology Advisor (free)

 

3 – State of The Art Review: Why and how to step down chronic asthma drugs – The BMJ (free)

 

4 – Clinical Use of a Home Sleep Apnea Test: An American Academy of Sleep Medicine Position Statement (free)

News release: AASM releases position statement on home sleep apnea testing (free)

Commentaries: AASM: Position Statement on Home Sleep Apnea Testing – MPR (free) AND Sleep Medicine Academy Releases Statements on Home Apnea Testing – Physician’s First Watch (free)

 

5 – Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) – Circulation (link to abstract – $ for full-text)

Commentaries: A-fib strikes men a decade earlier than women – Medical News Today (free) And AHA: Men develop AFib a decade before women do; BMI linked to increased risk – Cardiovascular Business (free)

 

6 – Modelled Cost-Effectiveness of a Package Size Cap and a Kilojoule Reduction Intervention to Reduce Energy Intake from Sugar-Sweetened Beverages in Australia – Nutrients (free)

Commentaries: Cutting sugar in soft drinks would save 155,000 lives and $8 billion: experts – The Age (free) AND Study spells out huge health benefits by cutting back sugar in sugary drinks – University of New South Wales, Sidney (free)

 

7 – We may soon have our first $1 million drug. Who will pay for it? And how? – STAT (free)

 

8 – Long-term Outcomes of Multiple Arterial Coronary Artery Bypass Grafting: A Population-Based Study of Patients in British Columbia, Canada – JAMA Cardiology (free)

Commentaries: Study: Triple-Vessel CABG Strategy Matters in the Long Run – MedPage Today (free registration required)

In patients with multivessel disease who are undergoing coronary artery bypass grafting, multiple arterial grafting (MAG) is associated with reduced mortality, repeated revascularization, myocardial infarction, and heart failure when compared with left internal thoracic artery (LITA) supplemented by saphenous vein grafts (LITA+SVG).

 

9 – 2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery (free)

 

10 – Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus – Nature Communications (free)

Commentaries: Proton pump inhibitors linked to liver disease, researchers find – The Pharmaceutical Journal (free) AND Liver disease risk may be heightened by gastric acid drugs – Medical News Today (free) AND Common acid reflux medications promote chronic liver disease – EurekAlert (free)

 

Mon, October 16 – 10 Stories of The Day!

16Oct
2017

 

1 – The Revised Declaration of Geneva: A Modern-Day Physician’s Pledge – JAMA (free)

 

2 – Alleviating the access abyss in palliative care and pain relief—an imperative of universal health coverage: the Lancet Commission report (free registration required)

Commentaries: A milestone for palliative care and pain relief – The Lancet (free registration required) AND Millions die suffering amid global opioid gap, report says – STAT (free) AND More than 25 million people dying in agony without morphine every year – The Guardian (free)

 

3 – Guideline: Assessing and managing children at primary health-care facilities to prevent overweight and obesity in the context of the double burden of malnutrition – World Health Organization (free) (RT @equitylist see Tweet)

News release: WHO releases guidelines to address overweight and obesity in children (free)

Related report: Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults – The Lancet (free) AND Commentaries: Tenfold increase in childhood and adolescent obesity in four decades: new study by Imperial College London and WHO – World Health Organization (free) Double-duty solutions for the double burden of malnutrition (free)

 

4 – Long Sleeves on Doctors’ White Coats May Spread Germs – Scientific American (free)

Related guideline: Healthcare Personnel Attire in Non-Operating-Room Settings – Infection Control and Hospital Epidemiology (free) AND Commentaries: Goodbye to the Doctor’s White Coat? – The New York Times (10 articles per month are free) AND New infection control recommendations could make white coats obsolete – ScienceDaily (free) AND Should Doctors Still Be Allowed to Wear White Coats? You Decide – HIV and ID Observations (free)

 

5 – Draft Recommendation Statement: Skin Cancer Prevention: Behavioral Counseling – U.S. Preventive Services Task Force (free)

Commentary: USPSTF Draft Statement Recommends Sun-Safe Behavioral Counseling for More Fair-Skinned Youth – Physician’s First Watch (free)

 

6 – Blood pressure targets in people with cardiovascular disease – Cochrane Library (free)

 

7 – Testing blood procalcitonin levels to decide when to start and stop antibiotics in adults with acute respiratory tract infections – Cochrane Library (free)

Original Article: Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections – Cochrane Library (link to abstract – $ for full-text)

“the use of procalcitonin to guide initiation and duration of antibiotic treatment results in lower risks of mortality, lower antibiotic consumption, and lower risk for antibiotic-related side effects”.

 

8 – 2017 EACTS Guidelines on perioperative medication in adult cardiac surgery – European Journal of Cardio-Thoracic Surgery (free)

Source: Critical Care Reviews Newsletter (free)

 

9 – Antibiotic susceptibility testing in less than 30 min using direct single-cell imaging – Proceedings of the National Academy of Sciences (free)

Commentary: Rapid Test for Antibiotic Susceptibility – JAMA (free)

 

10 – Older people with acute coronary syndromes may benefit from routine invasive therapy – NIHR Signal (free)

Original article: Revascularisation compared with initial medical therapy for non-ST-elevation acute coronary syndromes in the elderly: a meta-analysis – Heart (link to abstract – $ for full-text)

 

Fri, October 13 – 10 Stories of The Day!

13Oct
2017

 

1 – Phase 2 Placebo-Controlled Trial of Two Vaccines to Prevent Ebola in Liberia – New England Journal of Medicine (free)

Editorial: Handle Survivors with Care (free)

Commentaries: Experimental Ebola vaccines elicit year-long immune response – NIH New Releases (free) AND Ebola Vaccines Elicit Immune Responses in Liberian Adults – Physician’s First Watch (free) AND Liberia trial finds Ebola vaccines yield year-long immune response – CIDRAP (free)

 

2 – Roadmap for zoonotic tuberculosis – Worl Health Organization (free)

WHO News release: TB partners launch first roadmap to jointly stop the transmission of bovine and zoonotic tuberculosis (free)

 

3 – Increasing prevalence of vascular risk factors in patients with stroke – Neurology (link to abstract – $ for full-text)

Commentary: Health Conditions That Increase Stroke Risk Rise Across All Ages, Races – NPR (free)

“An estimated 80% of all 1st strokes are due to risk factors that can be changed,” says new study (RT @ACCmediacenter see Tweet)

 

4 – Review: Management of cardiovascular diseases in patients with obesity – Nature Reviews Cardiology (free)

 

5 – Clinical Practice Guidelines for the Treatment of Rectal Prolapse – Diseases of the Colon & Rectum (free)

 

6 – Management of a Diabetic Foot – JAMA Clinical Guidelines Synopsis (free) (RT @adamcifu)

Original guideline: The management of diabetic foot: A clinical practice guideline by the Society for Vascular Surgery in collaboration with the American Podiatric Medical Association and the Society for Vascular Medicine (free)

 

7 – We Need to Talk About Kids and Smartphones – TIME (free)

Related: Have Smartphones Destroyed a Generation? – The Atlantic (free)

“Just how dangerous are smartphones for kids? Here’s why health experts are worried”

 

8 – Last Month in Oncology with Dr. Bishal Gyawali: September 2017 – eCancer News (free)

 

9 – Diagnostic and therapeutic treatment modalities for acute lower gastrointestinal bleeding: a systematic review – Endoscopy International Open (free)

 

10 – Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials – The Lancet Haematology (free)

Commentaries: Treatment of iron deficiency is getting trendy – The Lancet Haematology (free) AND Taking Iron Every Other Day Linked to Better Absorption in Iron-Deficient Women – Physician’s First Watch (free)

 

Thu, October 12 – 10 Stories of The Day!

12Oct
2017

 

1 – The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults (free)

See also: Executive Summary (free)

 

2 – Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association (free)

News release: Looking beyond the heart in adults with congenital heart disease (free)

Commentary: Think Outside the Heart: Noncardiac Complications and Considerations in the Adult Congenital Patient (free)

Top Ten Things to Know: Diagnosis and Management of Noncardiac Complications in Adults with Congenital Heart Disease (free PDF)

 

3 – Social Determinants of Health 101 for Health Care: Five Plus Five – National Academy of Medicine (free)

See also: About social determinants of health – World Health Organization (free) AND WHO’s work on SDoH (free resources)

 

4 – Relative age within the school year and diagnosis of attention-deficit hyperactivity disorder: a nationwide population-based study – The Lancet Psychiatry (free)

Commentaries: The role of schools in the diagnosis of ADHD – The Lancet Psychiatry (free) AND ‘Relative’ school age biases ADHD diagnosis – OnMedica (free) AND Youngest children in school year ‘more likely’ to get ADHD diagnosis – NHS Choices (free)

 

5 – Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age – JAMA (free)

Commentaries: Ovarian reserve tests aren’t a good predictor of fertility, study finds – STAT (free) AND Tests Thought To Predict Future Fertility May Be Overused – Forbes (free) AND Fertility MOT tests ‘a waste of money’ – BBC News (free) AND Biomarkers Indicating Diminished Reserve of Eggs not Associated with Reduced Fertility – The JAMA Network (free)

 

6 – Meet the nocebo effect, the placebo effect’s evil twin that makes you feel pain – VOX (free)

 

7 – Comparison of postoperative outcomes among patients treated by male and female surgeons: a population based matched cohort study – The BMJ (free)

Editorial: Improving patient outcomes after surgery (free)

Commentaries: Female Surgeons Hold Slight Edge Over Male Peers in Terms of Patients’ 30-Day Mortality – TCTMD (free) AND Do Patients Have Better Survival with Female Surgeons? – MedPage Today (free registration required)

 

8 – Is child vaccination boosted by educating mothers? – BBC News (free)

 

9 – Contribution of dietary intake to relapse rate in early paediatric multiple sclerosis – Journal of Neurology, Neurosurgery & Psychiatry article (link to abstract – $ for full-text)

Commentaries: Fatty diets may boost relapse risk in MS children – OnMedica (free) AND High Fat Intake Linked to Risk for MS Relapse in Kids – Physician’s First Watch (free)

 

10 – Association of Insulin Pump Therapy vs Insulin Injection Therapy With Severe Hypoglycemia, Ketoacidosis, and Glycemic Control Among Children, Adolescents, and Young Adults With Type 1 Diabetes – JAMA (link to abstract – $ for full-text)

Commentaries: Insulin Pumps Associated With Lower Risk of Serious Complications among Young Patients with Type 1 Diabetes – The JAMA Network (free) AND Insulin-Pump Use Benefits Young People With Type 1 Diabetes – Medscape (free registration required) AND Can insulin pumps work better than injections for kids with diabetes? – Reuters (free)

 

Wed, October 11 – 10 Stories of The Day!

11Oct
2017

 

1 – Today is #WorldObesityDay: Tenfold increase in childhood and adolescent obesity in four decades: new study by Imperial College London and WHO – World Health Organization (free)

Original article: Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults – The Lancet (free) AND Invited Commentary: Double-duty solutions for the double burden of malnutrition (free)

Related report: Ending Childhood Obesity Implementation Plan: executive summary – World Health Organization (free PDF)

 

2 – #WorldObesityDay – Global cost of obesity-related illness to hit $1.2tn a year from 2025 – The Guardian (free)

See related Global Burden of Disease Study: Health Effects of Overweight and Obesity in 195 Countries over 25 Years – New England Journal of Medicine (free), Editorial: Global Health Effects of Overweight and Obesity (free) AND Commentary: New study finds more than 2 billion people overweight or obese – Institute for Health Metrics and Evaluation (free) 

 

3 – #WorldObesityDay – Meta-analysis on shift work and risks of specific obesity types – Obesity Reviews (link to abstract – $ for full-text)

Commentaries: Meta-Analysis Links Night Shift to Obesity Risk, Especially “Belly Fat” – AJMC (free) AND Night Shift Work Linked To Increased Risk of Obesity – Medical Research (free) AND Shift Work Increases Risk of Apple-Shaped Overweight/Obesity – Medscape (free registration required) AND Night shift work linked to an increased risk of obesity – Wiley, via EurekAlert (free)

 

4 – Guidelines: The do’s, don’ts and don’t knows of direct observation of clinical skills in medical education – Perspectives on Medical Education (free) (RT @brhospitalist and @CvanderVleuten see Tweet)

 

5 – Opinion: Updating Wikipedia should be part of all doctors’ jobs – STAT (free) (RT @Onisillos)

 

6 – Candida auris Clinical Update – September 2017 – Centers for Disease Control and Prevention (free)

Commentary: CDC Updates Guidance as Candida auris Cases Grow – Medscape (free registration required)

Related: Candida auris: A rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally – PLOS Pathogens (free) AND A ‘perfect storm’ superbug: How an invasive fungus got health officials’ attention – STAT (free) AND CDC keeping a watchful eye on Candida auris – CIDRAP (free) AND CDC reports uptick in Candida auris cases – CIDRAP (free)

 

7 – Review: The Treatment of Illnesses Arising in Pregnancy – Deutsches Ärzteblatt international (free)

 

8 – Changes in marital quality over 6 years and its association with cardiovascular disease risk factors in men: findings from the ALSPAC prospective cohort study – Journal of Epidemiology & Community Health (free)

Commentaries: Marital ups and downs affect heart health – OnMedica (free) AND Marital ups and downs may impact men’s heart health – Medical News Today (free) AND Cardiovascular risk factors for married men linked to changes in relationship quality over time – News Medical (free)

 

9 – Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case–control study – PLOS Medicine (free)

Commentaries: Gabapentin, Opioid Combo May Up the Risk of Opioid-Related Death – MPR (free) AND Gabapentin Plus Opioids a Deadly Combination? – MPR (free)

 

10 – Oral morphine versus ibuprofen administered at home for postoperative orthopedic pain in children: a randomized controlled trial – Canadian Medical Association Journal (free)

Commentaries: Ibuprofen Better Than Morphine After Minor Surgery in Kids – Medscape (free registration required) AND Ibuprofen better choice over oral morphine for pain relief in children after minor surgery – MedicalXpress (free)

 

Tue, October 10 – 10 Stories of The Day!

10Oct
2017

 

1 – Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold – CHEST Expert Panel Report (free)

See also other recent CHEST guidelines on the management of cough in specific populationsChronic Cough Due to Gastroesophageal Reflux in Adults (free) AND Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer (free) AND Cough in the athlete (free) AND Occupational and Environmental Contributions to Chronic Cough in Adults (free) AND Treatment of Unexplained Chronic Cough (free) AND Use of Management Pathways or Algorithms in Children With Chronic Cough: CHEST Guideline and Expert Panel Report (free) AND Management of Children With Chronic Wet Cough and Protracted Bacterial Bronchitis: CHEST Guideline and Expert Panel Report (free)

 

2 – New NICE Guidelines on Guild Abuse, Neglect and Maltreatment

– Child abuse and neglect – National Institute for Health and Care Excellence (free)

– Child maltreatment: when to suspect maltreatment in under 18s – National Institute for Health and Care Excellence (free)

News release: Responding to child abuse and neglect – a view from NICE (free)

 

3 – Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data – The Lancet Respiratory Medicine (free)

Commentaries: Vitamin D and asthma: a case to answer – The Lancet Respiratory Medicine (free) AND Vitamin D may prevent asthma worsening for some – NHS Choices (free)

 

4 – Upstream watershed condition predicts rural children’s health across 35 developing countries – Nature Communications (free)

Commentaries: Healthy watersheds help stem deadly childhood diseases downstream – WWF Global (free) AND Global kids study: More trees, less disease – University of Vermont (free) AND More trees help water sanitation, reduce child deaths: study – Reuters (free)

 

5 – Adjunctive Bright Light Therapy for Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Trial – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Midday Light Therapy May Improve Depressive Symptoms in Patients With Bipolar Disorder – Psychiatric News Allert (free) AND Bright Light Therapy Improves Bipolar Depression – Medscape (free registration required)

 

6 – Predicting 30-Day Mortality for Patients With Acute Heart Failure in the Emergency Department: A Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Tool may help accurately predict 30-day mortality for emergency department patients with acute heart failure – 2 Minute Medicine (free) AND Simple tool accurately predicts 30-day mortality for patients with acute heart failure in the ER – MedicalXpress (free)

See Calculator: MEESSI-AHF RISK MODEL

 

7 – The Painful Side Of Positive Health Care Marketing – NPR (free)

Related: I have cancer. This comic shows how much pressure I feel to be a hero – VOX (free) AND Why cancer is not a war, fight, or battle – CNN (free) AND He’s a Fighter – The Atlantic (free)

 

8 – Richard Lehman’s journal review, 9 October 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Interventions to reduce harm in people who use tobacco. The latest Cochrane Evidence – Cochrane Tobbaco Edition (free summaries) (RT @CochraneUK see Tweet)

Comprehensive resource on evidence-based interventions to reduce tobacco related harm.

 

10 – Female sex, early-onset hypertension, and risk of dementia – Neurology (link to abstract – $ for full-text)

Commentaries: For women, high blood pressure in your 40s may be tied to increased risk of Dementia – American Academy of Neurology, via ScienceDaily (free) AND Women’s dementia risk increased by midlife hypertension – Medical News Today (free) AND Mid-adulthood hypertension linked to dementia risk in women – Clinical Advisor (free)

Related Study: Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort – JAMA Neurology (link to abstract – $ for full-text) AND Commentaries: Midlife cardiovascular risk factors may increase chances of dementia – NIH News Releases (free) AND Midlife smoking, diabetes, and hypertension associated with late life dementia – 2 Minute Medicine (free) AND Heart disease risk in middle age tied to dementia later – Reuters (free)

 

Mon, October 9 – 10 Stories of The Day!

9Oct
2017

 

1 – Study links dental antibiotics to C diff cases – CIDRAP (free) AND Antibiotics for dental procedures linked to superbug infection – Infectious Diseases Society of America, via ScienceDaily (free)

Study Presented at #IDWeek2017

 

2 – Women who get frequent UTIs may reduce risk by drinking plenty of water – Infectious Diseases Society of America, via ScienceDaily (free) AND Recurrent Cystitis? Drink More Water – MedPage Today (free registration required) AND Drinking More Water Really Does Ward Off UTIs – LiveScience (free)

Study Presented at #IDWeek2017

 

3 – Efficacy and safety of switching from boosted protease inhibitors plus emtricitabine and tenofovir disoproxil fumarate regimens to single-tablet darunavir, cobicistat, emtricitabine, and tenofovir alafenamide at 48 weeks in adults with virologically suppressed HIV-1 (EMERALD): a phase 3, randomised, non-inferiority trial – The Lancet HIV (free)

Commentaries: Towards a universal second-line fixed-dose combination ART – The Lancet HIV (free) AND Single-Tablet ART: New Hope in HIV Therapy? All-in-one fixed dose combo proves safe, effective in EMERALD trial – MedPage Today (free registration required) AND EMERALD Trial: Week 48 Results Demonstrate Efficacy in Single-Tablet HIV Therapy – Infectious Diseases Advisor (free)

Study Presented at #IDWeek2017

 

4 – How Smartphones Hijack Our Minds – The Wall Street Journal (free) (RT @EricTopol see Tweet)

“Research suggests that as the brain grows dependent on phone technology, the intellect weakens”

 

5 – Impact of the Commercialization of Three Generic Angiotensin II Receptor Blockers on Adverse Events in Quebec, Canada: A Population-Based Time Series Analysis – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Generic Blood Pressure Drugs May Be Tied to Increase in Adverse Events – Physician’s First Watch (free) AND Generic ARBs Linked to Increased Adverse Events – TCTMD (free)

As in any observational study, association does not necessarily imply causation.

 

6 – Anticoagulant Use and Risk of Ischemic Stroke and Bleeding in Patients With Secondary Atrial Fibrillation Associated With Acute Coronary Syndromes, Acute Pulmonary Disease, or Sepsis – JACC: Clinical Electrophysiology (link to abstract – $ for full-text)

Commentaries: Anticoagulation didn’t benefit patients with afib secondary to ACS, pulmonary disease, or sepsis – ACP Hospitalist (free) AND No Anticoagulation Benefit, High Bleeding Risk Seen in Patients With Secondary A-fib – TCTMD (free)

 

7 – Serum Calcium and Risk of Sudden Cardiac Arrest in the General Population – Mayo Clinic Proceedings (link to abstract – $ for full-text)

Commentaries: Low serum calcium may increase risk of sudden cardiac arrest – EurekAlert (free) AND Low calcium may raise cardiac arrest risk by twofold – Medical News Today (free)

 

8 – Impact of the US Maternal Tetanus, Diphtheria, and Acellular Pertussis Vaccination Program on Preventing Pertussis in Infants <2 Months of Age: A Case-Control Evaluation – Clinical Infectious Diseases (link to abstract – $ for full-text)

Commentaries: Study: Tdap vaccine in pregnancy protects infants – CIDRAP (free) AND Fewer newborns get whooping cough when moms get vaccinated – Reuters (free)

 

9 – Pharmacologically controlled drinking in the treatment of alcohol dependence or alcohol use disorders: a systematic review with direct and network meta-analyses on nalmefene, naltrexone, acamprosate, baclofen and topiramate – Addiction (link to abstract – $ for full-text) checar acesso

Commentary: Pills prescribed for alcoholism might not work, study finds – The Guardian (free)

 

10 – ‘Antibiotic apocalypse’: doctors sound alarm over drug resistance – The Guardian (free)

Related WHO Reports: Antibacterial Agents in Clinical Development (free) AND Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics (free) AND Commentary: WHO report paints dire picture of antibiotic development – CIDRAP (free)

 

Fri, October 6 – 10 Stories of The Day!

6Oct
2017

 

1 – Availability of evidence of benefits on overall survival and quality of life of cancer drugs approved by European Medicines Agency: retrospective cohort study of drug approvals 2009-13 – The BMJ (free)

Editorials: Do cancer drugs improve survival or quality of life? (free) AND Cancer drugs: high price, uncertain value (free)

Commentaries: Over half of new cancer drugs ‘show no benefits’ for survival or wellbeing – The Guardian (free) AND Only half of new cancer drugs extend or improve life – OnMedica (free) AND Some cancer drugs approved in Europe might not have sufficient evidence of survival benefits, says study – Cancer Research UK (free)

 

2 – Antenatal nutritional supplementation and autism spectrum disorders in the Stockholm youth cohort: population based cohort study – The BMJ (free)

Commentaries: Multivitamins in pregnancy may be linked to lower autism risk in children – ScienceDaily (free) AND Could multivitamin use in pregnancy protect children from autism? – Medical News Today (free) AND Multivitamin Use in Pregnancy Might Be Tied to Lower Autism Risk in Offspring – Physician’s First Watch (free)

 

3 – Simple preventive actions by parents linked to fewer child injuries – NIHR Signal (free)

Original article: Keeping Children Safe: a multicentre programme of research to increase the evidence base for preventing unintentional injuries in the home in the under-fives – Programme Grants for Applied Research (free)

“Children more than twice as likely to attend hospital for stair falls if safety gate not used. Home hazards studied” (RT @NIHR_DC see Tweet)

 

4 – Review: Current Practice of State-of-the-Art Surgical Coronary Revascularization – Circulation (free)

 

5 – Vital Signs: Trends in Incidence of Cancers Associated with Overweight and Obesity — United States, 2005–2014 – Centers for Disease Control and Prevention (CDC) (free)

News Release: Cancers Associated with Overweight and Obesity Make up 40 percent of Cancers Diagnosed in the United States (free)

Commentaries: Excessive Weight Gain, Obesity, and Cancer Opportunities for Clinical Intervention – JAMA Viewpoint (free) AND Cancer: 40 percent of all cases related to obesity, overweight – Medical News Today (free)

 

6 – 2017 Update on Medical Overuse: A Systematic Review – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Study highlights 10 most unnecessary and overused medical tests and treatments – University of Maryland School of Medicine, via EurekAlert (free)

 

7 – The Burden of Primary Liver Cancer and Underlying Etiologies From 1990 to 2015 at the Global, Regional, and National Level: Results From the Global Burden of Disease Study 2015 – JAMA Oncology (free)

Commentary: Global burden of disease study focuses on liver cancer – eCancer News (free)

 

8 – Association Between Use of Non–Vitamin K Oral Anticoagulants With and Without Concurrent Medications and Risk of Major Bleeding in Nonvalvular Atrial Fibrillation – JAMA (link to abstract – $ for full-text)

Commentaries: Use of Non-Vitamin K Blood-Thinners with Certain Medications Associated With Increased Risk of Major Bleeding – The JAMA Network (free) AND Drug reactions with NOACs in AFib patients could result in major bleeding problems – Cardiovascular Business (free)

 

9 – Association Between Use of Antithrombotic Medication and Hematuria-Related Complications – JAMA (link to abstract – $ for full-text)

Commentaries: Haematuria more common in people taking antithrombotics – OnMedica (free) AND Blood-Thinning Medications Associated With Increased Risk of Complications from Having Blood in Urine – The JAMA Network (free)

 

10 – Association of trauma and posttraumatic stress disorder with incident systemic lupus erythematosus (SLE) in a longitudinal cohort of women – Arthritis & Rheumatology (link to abstract – $ for full-text)

Commentaries: A Stress Link to Lupus – The New York Times (10 articles per month are free) AND PTSD linked with increased lupus risk – Willey, via EurekAlert (free) AND Lupus risk almost three times higher after trauma – Medical News Today (free)

 

Wed, October 4 – 10 Stories of The Day!

4Oct
2017

 

1 – Report: Ending Cholera: A Global Roadmap to 2030 – World Health Organization (free) (RT @Onisillos)

News release: Partners commit to reduce cholera deaths by 90% by 2030 (free)

See also: WHO’s work on cholera (free resources)

 

2 – Potential deaths averted in USA by replacing cigarettes with e-cigarettes – Tobacco Control (free)

Commentaries: Switch to vaping could prevent millions of premature deaths – OnMedica (free) AND Tobacco smokers could gain 86 million years of life if they switch to vaping, study finds – eCancer News (free) AND Switching to e-cigarettes could save 6.6 million American smokers: researchers – Reuters (free)

Related review: Key issues surrounding the health impacts of electronic nicotine delivery systems (ENDS) and other sources of nicotine – CA: A Cancer Journal for Clinicians (free)

 

3 – Coronary Computed Tomography Angiography vs Functional Stress Testing for Patients With Suspected Coronary Artery Disease: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free)

Invited commentary: Coronary Computed Tomographic Angiography—The First Test for Evaluating Patients With Chest Pain? (free)

Commentary: Coronary CT Angiography vs. Stress Testing: Meta-Analysis Offers Mixed Results – Physician’s First Watch (free)

Coronary Computed Tomografic Angiography (CCTA) was associated with a very small reduction in the incidence of myocardial infarction (0.7% vs 1.1% = 0.4% absolute risk reduction), but without differences in death or cardiac hospitalization. Patients undergoing CCTA were significantly more likely to undergo invasive coronary angiography (11.7% vs 9.1%), revascularization (7.2% vs 4.5%) and were also more likely to receive a diagnosis of new CAD and to have initiated aspirin or statin therapy.

 

4 – Korean Guidelines for Diagnosis and Management of Chronic Heart Failure – The Korean Society of Cardiology (free)

Source: Critical Care Review Newsletter

 

5 – No Calm After the Storm: A Systematic Review of Human Health Following Flood and Storm Disasters – Prehospital and Disaster Medicine (free)

Commentary: After a disaster, contaminated floodwater can pose a threat for months to come – The Conversation (free)

Related guideline: Hurricane Season Public Health Preparedness, Response, and Recovery Guidance for Health Care Providers, Response and Recovery Workers, and Affected Communities — CDC, 2017 (free) AND Commentary: CDC issues guidance on storm recovery – Reuters (free)

 

6 – Olfactory Dysfunction Predicts Subsequent Dementia in Older U.S. Adults – Journal of the American Geriatrics Society (link to abstract – $ for full-text)

Commentaries: Elderly Who Have Trouble Identifying Odors Face Risk of Dementia – NewsWise (free) AND Poor Sense of Smell May Signal Impending Dementia – The New York Times (10 articles per month are free) AND Sniffing out dementia with a simple smell test – Medical News Today (free)

 

7 – Gestational Age and Cardiorespiratory Fitness in Individuals Born At Term: A Life Course Study – Journal of The American Heart Association (free)

Commentaries: Early babies could face lifelong fitness risks – The University of Queensland (free) AND Early-Term Birth Tied to Poor Cardiorespiratory Fitness Later – Medscape (free registration required) AND Early ‘full-term’ babies have poorer fitness into young adulthood – Cardiovascular Business (free)

 

8 – The risk of new-onset diabetes in antidepressant users – A systematic review and meta-analysis – PLOS One (free)

Commentary: Type 2 Diabetes and Antidepressant Drug Use: Is There a Causal Link? – Endocrinology Advisor (free)

 

9 – Carbohydrate-last meal pattern lowers postprandial glucose and insulin excursions in type 2 diabetes – BMJ Open Diabetes Research & Care (free)

Commentary: People with type 2 diabetes should ‘save carbs for last’, study claims – NHS Choices (free)

 

10 – Review: Palliative Care in Neurology – Mayo Clinic Proceedings (free)

 

Thu, October 5 – 10 Stories of The Day!

5Oct
2017

 

1 – Safety and Immunogenicity of an Anti–Zika Virus DNA Vaccine — Preliminary Report – New England Journal of Medicine (free)

Commentaries: First human trial of DNA-based Zika vaccine shows promise – CIDRAP (free) AND DNA-based Zika vaccine candidate found safe and effective at inducing immune response – University of Pennsylvania School of Medicine, via EurekAlert (free) AND Zika vaccine shows promise in early human trial – Reuters (free)

 

2 – Challenges in the Design and Interpretation of Noninferiority Trials – New England Journal of Medicine (free)

See also other articles in The Changing Face of Clinical Trials Series (all free)

“All too often non-inferiority clinical trials are a means of asserting false equivalence” (RT @EricTopol see Tweet)

 

3 – Guidelines for the Management of Congenital Heart Diseases in Childhood and Adolescence – The German Society of Paediatric Cardiology (free PDF)

 

4 – New Choosing Wisely Recommendations

Choosing Wisely US: Five Things Physicians and Patients Should Question: American Academy of Pediatrics – Section on Endocrinology (free) AND Commentary: Choosing Wisely: 5 Pediatric Endocrinology Tests to Avoid – Physician’s First Watch (free)

Choosing Wisely Canada: Nine Things Nurse Practitioners and Patients Should Question – Nurse Practitioner Association of Canada (free)

See more on the Choosing Wisely initiative in our April 5 issue (see #6)

 

5 – Outcomes In Two Massachusetts Hospital Systems Give Reason For Optimism About Communication-And-Resolution Programs – Health Affairs (link to abstract – $ for full-text)

Commentaries: After medical error, apology goes a long way – Stanford University Medical Center, via ScienceDaily (free) AND Conflict Resolution Program: ‘Cause for Optimism’ – MedPage Today (free registration required)

Explaining and apologizing to patients after a medical error does not increase lawsuits, large US study finds” (RT @bmj_latest see Tweet)

 

6 – Exercise and the Prevention of Depression: Results of the HUNT Cohort Study – American Journal o Psychiatry (free)

Commentary: Just One Hour of Exercise a Week May Help Prevent Depression – TIME Magazine (free) AND One hour of exercise a week can prevent depression – EurekAlert (free) AND What’s the ultimate way to defy depression, disease and early death? Exercise – The Guardian (free)

 

7 – The high price of anticancer drugs: origins, implications, barriers, solutions – Nature Reviews: Clinical Oncology (free PDF)

Related: Cancer drugs are getting better and dearer – The Economist (a few articles per month are free) Financial toxicity: 1 in 3 cancer patients have to turn to friends or family to pay for care – STAT News (free) AND Not Just Nausea And Vomiting: Cancer Docs Now Worry About ‘Financial Toxicity’ – WBUR (free) AND Financial Toxicity and Cancer Treatment (PDQ®) – National Institute of Cancer (free) AND Financial Toxicity: Cancer Supportive Care Professionals Consider the Side Effects of Soaring Costs – ASCO Post (free)

 

8 – Meta-Analysis of the Antidepressant Effects of Acute Sleep Deprivation – The Journal of Clinical Psychiatry (link to abstract – $ for full-text)

Commentaries: Summary of studies on sleep deprivation didn’t caution that depression benefits are short lived – HealthNewsReview (free) AND Sleep Deprivation May Treat Depression. But Would It Ever Be Prescribed? – Forbes (free) AND Sleep Deprivation a Rapid, Effective Depression Treatment – Medscape (free registration required) AND Sleep deprivation rapidly reduces depression symptoms in nearly half of depressed patients – News Medical (free)

 

9 – Respiratory support in patients with acute respiratory distress syndrome: an expert opinion – Critical Care (free)

Related article published recently: Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial – JAMA (free) AND Editorial: Lung Recruitment and Titrated PEEP in Moderate to Severe ARDS: Is the Door Closing on the Open Lung? (free)

 

10 – Association Between Use of Antithrombotic Medication and Hematuria-Related Complications – JAMA (link to abstract – $ for full-text)

Commentaries: Antithrombotics Associated with Gross Hematuria – Physician’s First Watch (free) AND Haematuria more common in people taking antithrombotics – OnMedica (free)

 

Tue, October 3 – 10 Stories of The Day!

3Oct
2017

 

1 – The Importance of Breakfast in Atherosclerosis Disease: Insights From the PESA Study – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Skipping Breakfast May Be Bad For The Heart – But There Are Caveats – Forbes (free) AND Most important meal of the day? Skipping breakfast may be linked to poor heart health – The Guardian (free) AND Cardiologists, moms agree: Breakfast the most important meal of the day – Cardiovascular Business (free) Skipping breakfast associated with hardening of the arteries – American College of Cardiology, via ScienceDaily (free)

 

2 – Development and validation of QMortality risk prediction algorithm to estimate short term risk of death and assess frailty: cohort study – The BMJ (free)

Editorial: Identifying frailty in primary care (free)

Commentary: Frailty calculator to support GPs in targeting patients for better care – MyScience (free)

See calculators: QMortality®-2017 risk calculator (free) AND QFrailty®-2017 risk calculator (free)

“the tool can reliably estimate risk of dying within 12 months and risk of unplanned admissions among patients aged between 65 and 100 years old” (from MyScience).

 

3 – Efficiency and safety of varying the frequency of whole blood donation (INTERVAL): a randomised trial of 45 000 donors – The Lancet (free)

Commentaries: The price of blood is measured in iron – The Lancet (free) AND Increasing frequency of blood donation has no major side effects – ScienceDaily (free)

 

4 – Managing Head Trauma in Children – The New York Times (10 articles per month are free)

Related Articles: Reducing Head CT Use for Children With Head Injuries in a Community Emergency Department – Pediatrics (link to abstract – $ for full-text) AND Development and Internal Validation of a Clinical Risk Score for Treating Children With Mild Head Trauma and Intracranial Injury – JAMA Pediatrics (free PDF) AND Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort stud – The Lancet (free PDF)

 

5 – How well do flu shots work? Here’s what the science says – VOX (free)

  

6 – Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017 (free)

 

7 – Richard Lehman’s journal review, 2 October 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – Guidelines for Diagnostic Imaging During Pregnancy and Lactation – American College of Obstetricians and Gynecologists (free)

See also: Guideline Summary (free)

 

9 – The British Society for Rheumatology guideline for the management of adults with primary Sjögren’s Syndrome – Rheumatology (free)

See also: Guideline Summary (free)

Commentary: Guidelines for treatment of primary Sjögren’s syndrome: a first useful stone but still much to do – Rheumatology (free)

 

10 – Review: Acute Coronary Syndromes: The Way Forward From Mechanisms to Precision Treatment – Circulation (free)

 

Mon, October 2 – 10 Stories of The Day!

2Oct
2017

 

1 – International Day of Older Persons – 1st October 2017: Health services must stop leaving older people behind – World Health Organization (free)

Related Guideline: WHO Guidelines on Integrated Care for Older People (ICOPE) – World Health Organization (free)

See also: WHO’s work on ageing

 

2 – Guideline: Preventive chemotherapy to control soil-transmitted helminth infections in at-risk population groups – World Health Organization (free)

News release: WHO recommends large-scale deworming to improve children’s health and nutrition (free)

Infographic: WHO publishes recommendations for large-scale deworming to improve children’s health and nutrition (free)

See also: WHO intestinal worms website (free resources) AND Fact sheet: Soil-transmitted helminth infections (free)

 

3 – Evaluation of telephone first approach to demand management in English general practice: observational study – The BMJ (free)

Editorial: Telephone first consultations in primary care (free)

Commentaries: Phone-first GP consults ‘no panacea for reducing workload’ – OnMedica (free) AND No evidence to support claims that telephone consultations reduce GP workload or hospital referrals – University of Cambridge (free)

Related study: Direct-To-Consumer Telehealth May Increase Access To Care But Does Not Decrease Spending – Health Affairs (link to abstract – $ for full-text) AND Commentaries: Telehealth Doctor Visits May Be Handy, But Aren’t Cheaper Overall – NPR (free) AND Are Virtual Doctor Visits Really Cost-Effective? Not So Much, Study Says – Health News Florida (free)

 

4 – Medical News & Perspectives: Study Questions Use of Acid Suppressors To Curb Mild Infant Reflux – JAMA (free) (RT @DeeMangin see Tweet)

See study abstract presented at the Pediatric Academic Societies meeting: Infants prescribed antacids for reflux have increased risk of bone fractures (free)

 

5 – Perspectives: Lost in Thought: The Limits of the Human Mind and the Future of Medicine – New England Journal of Medicine (free)

 

6 – A single mutation in the prM protein of Zika virus contributes to fetal microcephaly – Science (link to abstract – $ for full-text)

Commentaries: A Single Mutation Helps Modern Zika Cause Birth Defects – Scientific American (free) AND The Zika Virus Grew Deadlier With a Small Mutation, Study Suggests – The New York Times (10 articles per month are free) AND Zika was a mild bug. A new discovery shows how it turned monstrous – The Washington Post (free) AND How Zika Became So Dangerous For Babies – NPR (free)

 

7 – Association of Vision Loss With Cognition in Older Adults – JAMA Ophthalmology (link to abstract – $ for full-text)

Commentaries: Vision and Hearing Loss Are Tied to Cognitive Decline – The New York Times (10 articles per month are free) AND Visual impairment among older adults associated with poor cognitive function – Medical News Today (free)

 

8 – Relationship of Sleep Duration With All‐Cause Mortality and Cardiovascular Events: A Systematic Review and Dose‐Response Meta‐Analysis of Prospective Cohort Studies – Journal of The American Heart Association (free)

Our findings indicate that both short and long sleep duration is associated with an increased risk of allcause mortality and cardiovascular events”.

 

9 – Effect of a Community Health Worker–Led Multicomponent Intervention on Blood Pressure Control in Low-Income Patients in Argentina: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: Community Intervention among Low-Income Patients Results in Improved Blood Pressure Control – The JAMA Network (free)

“The proportion of patients with controlled hypertension (BP <140/90 mm Hg) increased from 17 percent at baseline to 73 percent in the intervention group and from 18 percent to 52 percent in the usual care group”.

 

10 – Self-monitoring of blood pressure in hypertension: A systematic review and individual patient data meta-analysis – PLOS Medicine (free)

Commentary: Home blood pressure monitoring works best with extra support – Reuters (free)

 

Fri, September 29 – 10 Stories of The Day!

29Sep
2017

 

1 – Meditation and Cardiovascular Risk Reduction: A Scientific Statement From the American Heart Association (free)

News releases: Meditation may decrease the risk of heart disease – AHA News (free) AND Meditation might be useful addition to heart-healthy lifestyle and medical treatment – AHA / ASA Newsroom (free)

Commentary: AHA: Meditation Might Lower Cardiovascular Risk – Physician’s First Watch (free)

 

2 – NICE Guideline: Urinary tract infection in under 16s: diagnosis and management (free)

News Release: Test children’s urine before prescribing antibiotics for UTIs, says NICE (free)

 

3 – NICE Guideline: Faltering growth: recognition and management of faltering growth in children (free)

News Release: Allow underweight children to be ‘messy’ with their food, says NICE (free)

See also: Faltering growth in children: summary of NICE guidance – The BMJ (free infographic and key points – $ for full-text)

 

4 – Effect of Routine Low-Dose Oxygen Supplementation on Death and Disability in Adults With Acute Stroke: The Stroke Oxygen Study Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Low-dose oxygen no benefit in adults with acute stroke – MedicalXpress (free) AND UK study ‘settles debate’ over whether to give routine oxygen to stroke patients – Nursing Times (free)

Routine oxygen was also of no benefit in a recent trial in patients with acute myocardial infarction, see Original Article (link to abstract – $ for full-text) and Quick Take Video Summary (free)

 

5 – State of the Art Review: Asthma-COPD overlap syndrome: pathogenesis, clinical features, and therapeutic targets – The BMJ (free)

 

6 – Risk factors for admission to hospital with laboratory-confirmed influenza in young children: birth cohort study – European Respiratory Journal (link to abstract – $ for full-text)

Commentaries: Protect babies from flu by getting older siblings vaccinated, parents advised – The Guardian (free) AND Older Siblings a Risk Factor for Serious Flu Infections in Infants – The New York Times (10 articles per month are free)

 

7 – Methods to improve healthcare worker hand hygiene to decrease infection in patient care – Cochrane Library (free)

Original article: Interventions to improve hand hygiene compliance in patient care – Cochrane Library (link to abstract – $ for full-text)

 

8 – World Rabies Day (28 September) – World Health Organization (free news release and infographics)

Updated Fact Sheet: Rabies – World Health Organization (free)

Related Website: Global Alliance for Rabies Control

See also: How to end human deaths from rabies: lessons from Kenya – The Conversation (free) (RT @Onisillos see Tweet)

 

9 – Position Statement: Energy and sports drinks in children and adolescents – Canadian Paediatric Society (free)

Commentaries: Energy, sports drinks should be avoided by children and teens, Canadian Paediatric Society warns – The Globe and Mail (free) AND Sports drinks and energy drinks unhealthy for kids and teens, Canadian pediatricians say – CBCNews (free)

 

10 – Local nerve blocks can improve outcomes for people with hip fracture – NIHR Signal (free)

Original article: Peripheral nerve blocks for hip fractures – Cochrane Library (link to abstract – $ for full-text)

One case of pneumonia prevented for every 7 hip fracture patients given pain relief with nerve block” (RT @NIHR_DC see Tweet)

 

Thu, September 28 – 10 Stories of The Day!

28Sep
2017

 

#LIVES2017 – Highlights from 30th European Society of Intensive Care Medicine Annual Congress

 

1 – #LIVES2017 – Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension: A Randomized Clinical Trial – JAMA (free)

Editorial: Trying to Improve Sepsis Care in Low-Resource Settings (free)

An early resuscitation protocol for adults w sepsis in Zambia increased mortality” (RT @JAMA_current see Tweet)

 

2 – #LIVES2017 – Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial – JAMA (free)

Editorial: Lung Recruitment and Titrated PEEP in Moderate to Severe ARDS: Is the Door Closing on the Open Lung? (free)

Commentary: Open Lung Ventilation May Worsen ARDS Mortality – MedPage Today (free registration required)

“A strategy using a lung recruitment maneuver and titrated PEEP, in association with volume-assist control ventilation, increased mortality of patients with moderate to severe ARDS”.

 

3 – #LIVES2017 – Effect of Individualized vs Standard Blood Pressure Management Strategies on Postoperative Organ Dysfunction Among High-Risk Patients Undergoing Major Surgery: A Randomized Clinical Trial – JAMA (free)

Editorial: Perioperative Management of High-Risk Patients: Going Beyond “Avoid Hypoxia and Hypotension” (free)

Commentary: Individualized SBP tx cuts risk for post-op organ dysfunction – MedicalXpress (free)

 

4 – #LIVES2017 – Effect of Systematic Intensive Care Unit Triage on Long-term Mortality Among Critically Ill Elderly Patients in France: A Randomized Clinical Trial – JAMA (free)

Editorial: Admitting Elderly Patients to the Intensive Care Unit—Is it the Right Decision? (free)

 

5 – #LIVES2017 – Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults – New England Journal of Medicine (free)

Commentaries: Red blood cells for transfusion like a good red: A little older, a little better – Monash University, via ScienceDaily (free) AND Is Older Blood OK to Use in a Transfusion? – WebMD (free)

 

6 – Global, regional, and subregional classification of abortions by safety, 2010–14: estimates from a Bayesian hierarchical model – The Lancet (free)

Commentaries: Worldwide, an estimated 25 million unsafe abortions occur each year – World Health Organization (free) AND Estimating abortion safety: advancements and challenges – The Lancet (free) AND More than 25 million unsafe abortions performed worldwide each year – STAT (free)

 

7 – Treating tobacco dependence: guidance for primary care on life-saving interventions. Position statement of the IPCRG – Primary Care Respiratory Medicine (free)

 

8 – A Treatment Algorithm for Emergent Invasive Cardiac Procedures in the Resuscitated Comatose Patient – Journal of The American College of Cardiology (free)

Commentary: Cardiac Arrest: A Treatment Algorithm for Emergent Invasive Cardiac Procedures in the Resuscitated Comatose Patient – American College of Cardiology, Latest in Cardiology (free)

 

9 – New Approaches to Prevent Healthcare-Associated Infection – Clinical Infectious Diseases (free)

 

10 – Guidelines for the prevention of travel-associated illness in older adults – Tropical Diseases, Travel Medicine and Vaccines (free)

 

Wed, September 27 – 10 Stories of The Day!

27Sep
2017

 

1 – Draft Recommendation Statement: Falls Prevention in Community-Dwelling Older Adults: Interventions – U.S. Preventive Services Task Force (free)

Commentaries: USPSTF Draft Recommendations for Falls and Fracture Prevention – Medscape (free registration required) AND USPSTF Draft Statement: Vitamin D Supplements No Longer Recommended to Prevent Falls in Seniors – Physician’s First Watch (free)

Related guidelines: Falls in older people: assessing risk and prevention – NICE (free) AND Evidence-based guidelines for fall prevention in Korea (free) AND Summary of the Updated American Geriatrics Society/British Geriatrics Society Clinical Practice Guideline for Prevention of Falls in Older Persons (free PDF) AND Management of Falls in Community-Dwelling Older Adults: Clinical Guidance Statement From the Academy of Geriatric Physical Therapy of the American Physical Therapy Association (free) AND Prevention of fall-related injuries in the elderly: An Eastern Association for the Surgery of Trauma practice management guideline (free)

 

2 – Review: A Test in Context: Lipid Profile, Fasting Versus Nonfasting – Journal of The American College of Cardiology (link to abstract and free infographic – $ for full-text)

Commentary: Is fasting before a lipid panel necessary? – Cardiovascular Business (free)

Related guideline: Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points—a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine (free) AND Commentary: New guidelines simplify cholesterol tests: no fasting needed – STAT (free)

  

3 – The effects of a rise in cigarette price on cigarette consumption, tobacco taxation revenues, and of smoking-related deaths in 28 EU countries– applying threshold regression modelling – BMC Public Health (free)

See also: Smoking prevalence and attributable disease burden in 195 countries and territories in our April 7th issue (see #1) AND WHO report on the global tobacco epidemic 2017 in our July 20th issue (see #1) AND  “Tobacco Endgame” policies in our May 12th issue (see #3).

 

4 – Efficacy of recommended drugs against soil transmitted helminths: systematic review and network meta-analysis – The BMJ (free)

Commentary: Reduced Efficacy of Anthelmintic Drugs – MyScience (free)

 

5 – Childhood onset inflammatory bowel disease and risk of cancer: a Swedish nationwide cohort study 1964-2014 – The BMJ (free)

Editorial: Increased risk of cancer in children with inflammatory bowel disease (free)

Commentaries: Inflammatory Bowel Disease in Childhood Tied to Higher Cancer Risk Later – Physician’s First Watch (free) AND IBD in Childhood Raises Cancer Risk – Medscape (free registration required)

 

6 – Effect of Genotype-Guided Warfarin Dosing on Clinical Events and Anticoagulation Control Among Patients Undergoing Hip or Knee Arthroplasty: The GIFT Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Genotyping Reduces Adverse Events with Warfarin – Cardiobrief (free) AND Genotype-Guided Warfarin Dosing Reduces Adverse Events After Hip, Knee Arthroplasty – Physician’s First Watch (free)

 

7 – Clinical Report: Infectious Diseases Associated With Organized Sports and Outbreak Control – American Academy of Pediatrics (free)

News release: AAP Offers New Guidance on Preventing Spread of Infectious Diseases Associated with Organized Sports (free)

Commentary: When Athletes Share Infections – The New York Times (10 articles per month are free)

 

8 – Mapping under-5 and neonatal mortality in Africa, 2000–15: a baseline analysis for the Sustainable Development Goals – The Lancet (free)

Commentaries: Precision public health: mapping child mortality in Africa – The Lancet (free) AND ‘Precision public health:’ 5 x 5 kilometer mapping identifies significant differences in child deaths throughout Africa – Institute for Health Metrics and Evaluation (free)

 

9 – Pregnant Women Should Still Get The Flu Vaccine, Doctors Advise – NPR (free)

Statement: It is Safe to Receive Flu Shot During Pregnancy – American College of Obstetricians and Gynecologists (free)

See original study showing a possible association between flu vaccine and miscarriage in our September 21st issue (see #6)

 

10 – Diagnostic Accuracy of Novel and Traditional Rapid Tests for Influenza Infection Compared With Reverse Transcriptase Polymerase Chain Reaction: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Newer influenza diagnostic tests more accurate than traditional tests – Clinical Advisor (free) AND Rapid tests linked to quicker and more accurate results for influenza diagnosis than traditional tests – 2 Minute Medicine (free)

 

Tue, September 26 – 10 Stories of The Day!

26Sep
2017

 

1 – News release: Draft Guideline: Most common ear infections should not be treated with antibiotics, says NICE (free)

Commentaries: Common ear infections don’t need antibiotics, health watchdog says – The Guardian (free) AND Antibiotics not recommended for acute otitis, says NICE (free)

 

2 – Low-Dose Aspirin Discontinuation and Risk of Cardiovascular Events: A Swedish Nationwide, Population-Based Cohort Study – Circulation (link to abstract – $ for full-text)

Commentaries: Stopping Aspirin Hikes CV risk – Cardiobrief (free) AND Aspirin Discontinuation Tied to Increased Risk for CV Events – Physician’s First Watch (free)

 

3 – This map shows how many years could be added to you life – if the air you breathe was less polluted – World Economic Forum (free)

Related: The cost of a polluted environment: 1.7 million child deaths a year, says WHO – World Health Organization (free) AND Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015 – The Lancet (free) AND Death in the Air: Air Pollution Costs Money and Lives – World Bank (free infographic and report)

 

4 – Olfaction and incident Parkinson disease in US white and black older adults – Neurology (link to abstract – $ for full-text)

Commentaries: Parkinson’s: Sniff test could predict risk up to a decade earlier – Medical News Today (free) AND Can a Smell Test Predict Parkinson’s? – MedPage Today (free registration required) AND Scratch-and-sniff test could predict Parkinson’s even earlier – Michigan State University, via EurekAlert (free) AND Parkinson’s Disease May Be Diagnosed With Smell Test 10 Years Before Symptoms – Medical Daily (free)

 

5 – Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6–12 Years of Age in Mexico – Environmental Health Perspectives (free)

Commentaries: Four questions to ask when reading or writing about water fluoridation and IQ – HealthNewsReview (free) AND High fluoride levels in pregnancy may lower offspring IQ – Medical News Today (free) AND Fluoride exposure in utero linked to lower IQ in kids, study says – CNN (free)

 

6 – Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicentre international randomised controlled trial – The Lancet (link to abstract – $ for full-text)

Commentaries: In Pregnant Women with Type 1 Diabetes, Continuous Glucose Monitoring Linked to Better Outcomes – Physician’s First Watch (free) AND All pregnant women with type 1 diabetes should be offered continuous glucose monitoring – OnMedica (free)

 

7 – Richard Lehman’s journal review, 25 September 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – The path to longer and healthier lives for all Africans by 2030: the Lancet Commission on the future of health in sub-Saharan Africa – The Lancet (free registration required)

Invited commentaries: Africa and health: a Commission to accelerate success (free registration required) AND Longer and healthier lives for all Africans by 2030: perspectives and action of WHO AFRO (free registration required)

 

9 – Modeling the Cost-Effectiveness of Interventions to Reduce Suicide Risk Among Hospital Emergency Department Patients – Psychiatric Services (link to abstract – $ for full-text)

Commentary: Life-Saving Post-ER Suicide Prevention Strategies are Cost Effective – National Institute of Mental Health (free)

See also related meta-analysis and studies on strategies to prevent suicide in our August 11th issue (see #6 and #7)

 

10 – Addiction Potential of Cigarettes With Reduced Nicotine Content in Populations With Psychiatric Disorders and Other Vulnerabilities to Tobacco Addiction – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Lowering Nicotine in Cigarettes Could Help Most Vulnerable – MedPage Today (free registration required) AND Could Nicotine Reduction Help Curb Addiction? – Science Newsline (free)

 

Mon, September 25 – 10 Stories of The Day!

25Sep
2017

 

1 – The effect of physical activity on mortality and cardiovascular disease in 130 000 people from 17 high-income, middle-income, and low-income countries: the PURE study – The Lancet (link to abstract – $ for full-text)

Commentaries: Any type of physical exercise is good for the heart – NHS Choices (free) AND Physical Activity of Any Ilk Cuts CVD, Deaths in Global Study: PURE – TCTMD (free) AND Being active saves lives whether a gym workout, walking to work or washing the floor – McMaster University, via ScienceDaily (free) AND Don’t overthink your exercise: just 2.5 hours per week of any kind could help you live longer – VOX (free) AND A daily half hour’s exercise could prevent 1 in 12 early deaths, study shows – Reuters (free)

 

2 – The Mortality and Myocardial Effects of Antidepressants Are Moderated by Preexisting Cardiovascular Disease: A Meta-Analysis – Psychotherapy and Psychosomatics (link to abstract – $ for full-text)

Commentaries: Antidepressant use associated with higher risk of death – OnMedica (free) AND Antidepressants may raise death risk by a third – Medical News Today (free) AND Antidepressants Tied to a Significantly Increased Risk for Death – Medscape (free registration required) AND Antidepressants Associated with Significantly Elevated Risk of Death, Researchers Find – McMaster University, via NewsWise (free)

 

3 – Adherence Tradeoff to Multiple Preventive Therapies and All-Cause Mortality After Acute Myocardial Infarction – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Study Questions Incremental Benefit of Beta-Blockers After Acute MI – TCTMD (free) AND Beta blockers not needed after heart attack if other medications taken – University of North Carolina at Chapel Hill, via Eurekalert (free) AND Adherence to medications post-MI is below 50%; beta-blockers offer little incremental benefit – Cardiovascular Business (free)

Related study published recently: β-Blockers and Mortality After Acute Myocardial Infarction in Patients Without Heart Failure or Ventricular Dysfunction – Journal of The American College of Cardiology (free)

 

4 – 2017 AHA/ACC Clinical Performance and Quality Measures for Adults With ST-Elevation and Non–ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures (free)

 

5 – Homepage: Cardiomyopathy Compendium – Circulation Research

– Cardiomyopathies: An Overview, by Eugene Brawnwald (free)

– Classification, Epidemiology, and Global Burden of Cardiomyopathies (free)

– Dilated Cardiomyopathy: Genetic Determinants and Mechanisms (free)

– Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy (free)

– Hypertrophic Obstructive Cardiomyopathy: Surgical Myectomy and Septal Ablation (free)

– Arrhythmogenic Cardiomyopathy (free)

– Inflammatory Cardiomyopathic Syndromes (free)

– Restrictive Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy (free)

– Cardiomyopathies Due to Left Ventricular Noncompaction, Mitochondrial and Storage Diseases, and Inborn Errors of Metabolism (free)

– Pediatric Cardiomyopathies (free)

– Modern Imaging Techniques in Cardiomyopathies (free)

Source: Critical Care Reviews Newsletter

 

6 – Adverse drug reactions of montelukast in children and adults – Pharmacology Research & Perspectives (free)

Commentaries: Montelukast Tied to Psychiatric Adverse Events in Kids, Adults – Medscape (free registration required) AND Asthma Drug, Montelukast, Tied to Nightmares, Depression – Drugs.com (free)

 

7 – Effect of Post–Cesarean Delivery Oral Cephalexin and Metronidazole on Surgical Site Infection Among Obese Women: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Post-Cesarean Antibiotics Reduce Risk for Surgical Site Infections in Obese Women – Physician’s First Watch (free) AND Antibiotics After C-Section Cut Infections in Obese Women – MedPage Today (free registration required) AND Antibiotics cut infection risk in obese women after caesarean – OnMedica (free)

 

8 – Interventions for treating tuberculous pericarditis – Cochrane Library (free)

News release: Treatment for tuberculosis infection of the membrane around the heart (free)

For HIV-negative patients, corticosteroids may reduce death. For HIV-positive patients not on antiretroviral drugs, corticosteroids may reduce constriction. For HIV-positive patients with good antiretroviral drug viral suppression, clinicians may consider the results from HIV-negative patients more relevant”.

 

9 – Mechanical Thrombectomy Outcomes With and Without Intravenous Thrombolysis in Stroke Patients: A Meta-Analysis – Stroke (link to abstract – $ for full-text)

Commentary: Better outcomes seen in patients who received IV thrombolysis before thrombectomy – ACP Hospitalist (free)

The results support current guideline recommendations to give intravenous thrombolysis to eligible patients even if they are being considered for mechanical thrombectomy, according to the meta-analysis authors” (from ACP)

 

10 – Blood test and ECG may safely rule out heart attack – NIHR Signal (free)

Original article: Rapid Rule-out of Acute Myocardial Infarction With a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection: A Collaborative Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text) and Commentary: High-sensitivity troponin T result may help rule out of myocardial infarction – 2 Minute Medicine (free)

 

Fri, September 22 – 10 Stories of The Day!

22Sep
2017

 

1 – Weight and Metabolic Outcomes 12 Years after Gastric Bypass – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Benefits of gastric bypass persist for 12 years – Reuters (free) AND Gastric bypass surgery benefits continue for 12 years – Diabetes.co.uk (free) AND Bariatric Surgery’s Benefits Last Over a Decade – Physician’s First Watch (free)

 

2 – Do interventions that reduce the cost of smoking cessation treatment increase quit rates, quit attempts or use of treatments? – Cochrane Library (free)

Original article: Healthcare financing systems for increasing the use of tobacco dependence treatment – Cochrane Library (link to abstract – $ for full-text)

Full financial interventions directed at smokers when compared to no financial interventions increase the proportion of smokers who attempt to quit, use smoking cessation treatments, and succeed in quitting”.

 

3 – Lung Cancer Mortality Associated With Smoking and Smoking Cessation Among People Living With HIV in the United States – JAMA Internal Medicine (free)

Editorial: If We Are Smart Enough to Stop HIV From Replicating, Why Can’t We Help People to Stop Smoking? (free)

Commentaries: People with HIV who smoke are more likely to die from lung cancer than from HIV itself – eCancer (free) AND Smoking cuts life expectancy in HIV more than AIDS does – OnMedica (free)

 

4 – Randomized clinical trial of antibiotic therapy for uncomplicated appendicitis – British Journal of Surgery (link to abstract – $ for full-text)

See also a  related meta-analysis suggesting the safety of nonoperative treatment for uncomplicated cases (free) and a recent guideline that incorporates the possibility of non-operative treatment for uncomplicated disease (free)

“1st RCT to show uncomplicated appendicitis resolve even without antibiotics (let alone surgery)” (RT @villesallinen see Tweet)

 

5 – All Hypertensive Disorders of Pregnancy Increase the Risk of Future Cardiovascular Disease – Hypertension (link to abstract – free PDF via @unpaywall)

Commentaries: Hypertensive disorders of pregnancy increase future risk of heart disease – Cardiovascular Business (free) AND A type of hypertension during pregnancy more dangerous than thought – AHA News (free)

See related articles and commentaries in our August 22nd issue (see #3)

 

6 – Association of Trial Registration With Reporting of Primary Outcomes in Protocols and Publications – JAMA (free)

Commentaries: Discrepancy between trial goals, results may mask treatment risks – Reuters (free) AND Clinical Trials Often Unregistered, Unpublished – The JAMA Network (free)

 

7 – The interstitial lung disease multidisciplinary meeting: A position statement from the Thoracic Society of Australia and New Zealand and the Lung Foundation Australia (free)

 

8 – Cancer patients need better care, not just more technology – Nature News (free)

 

9 – Juvenile Stroke: A Practice-Oriented Overview – Deutsches Ärzteblatt international (free)

Commentary: German study dissects etiology behind juvenile stroke – Cardiovascular Business (free)

 

10 – FDA Drug Safety Communication: FDA recommends separating dosing of potassium-lowering drug sodium polystyrene sulfonate (Kayexalate) from all other oral drugs (free)

Commentary: Don’t Give Kayexalate With Other Oral Drugs, FDA Warns – Medscape (free registration required)

“Patients should take orally administered prescription and over-the-counter (OTC) medicines at least 3 hours before or 3 hours after sodium polystyrene sulfonate”

 

Thu, September 21 – 10 Stories of The Day!

21Sep
2017

 

1 – The world is running out of antibiotics, WHO report confirms – World Health Organization (free)

See WHO Reports: Antibacterial Agents in Clinical Development (free) AND Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics (free)

See also WHO Resources on Antibiotic Resistance

Commentaries: WHO report paints dire picture of antibiotic development – CIDRAP (free) AND Too few antibiotics in pipeline to tackle global drug-resistance crisis, WHO warns – The Guardian (free) AND The world is running out of antibiotics, WHO says – CNN (free text and video)

 

2 – Rapid Recommendation: Corticosteroids for sore throat: a clinical practice guideline – The BMJ (free text and infographic)

See also other Rapid Recommendations from The BMJ (all free)

 

3 – Improving health systems in low-income countries – 3 New Cochrane Library Reviews

Article 1: Implementation strategies for health systems in low-income countries: an overview of systematic reviews (free) AND Summary: Implementation strategies for health systems in low-income countries (free)

Article 2: Governance arrangements for health systems in low-income countries: an overview of systematic reviews (free) AND Summary: Effects of governance arrangements for health systems in low-income countries (free)

Article 3: Delivery arrangements for health systems in low-income countries: an overview of systematic reviews (free) AND Summary: Effects of delivery arrangements for health systems in low-income countries (free)

 

4 – Comprehensive geriatric assessment for older adults admitted to hospital – Cochrane Library (free)

Original article: Comprehensive geriatric assessment for older adults admitted to hospital – Cochrane Library (link to abstract – $ for full-text)

Related: Comprehensive assessment may reduce risk of delirium after hip fracture – NIHR Signal (free)

“Older patients are more likely to be alive and in their own homes at follow-up if they received comprehensive geriatric assessment on admission to hospital”.

 

5 – Low alcohol consumption and pregnancy and childhood outcomes: time to change guidelines indicating apparently ‘safe’ levels of alcohol during pregnancy? A systematic review and meta-analyses – BMJ Open (free)

Commentaries: No change to alcohol guidelines for pregnancy – NHS Choices (free) Health risks of light drinking in pregnancy confirms that abstention is the safest approach – The Conversation (free)

 

6 – Association of spontaneous abortion with receipt of inactivated influenza vaccine containing H1N1pdm09 in 2010–11 and 2011–12 – Vaccine (link to abstract – $ for full-text)

Commentaries: Study signals association between flu vaccine, miscarriage – CIDRAP (free) AND New study finds link between flu vaccine and miscarriage. But is it real? – Science (free) AND Study shows miscarriage risk may have increased after flu shots, puzzling researchers – STAT (free) AND A new finding of a possible flu shot-miscarriage link shows science prioritizes vaccine safety – STAT (free)

“This study does not and cannot establish a causal relationship between repeated influenza vaccination and SAB, but further research is warranted”.

 

7 – Metabolically Healthy Obese and Incident Cardiovascular Disease Events Among 3.5 Million Men and Women – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: New evidence shows that healthy obesity is a myth – The Conversation (free) AND Study shows so-called ‘healthy obesity’ is harmful to cardiovascular health – Medical News Today (free) AND Obesity, even without other risk factors, leads to higher rate of cardiovascular disease – STAT (free) AND Another Study Challenges Notion of ‘Healthy Obese’ – TCTMD (free)

See related article and commentaries in our August 21st issue (see #1)

 

8 – Expert consensus document: A ‘diamond’ approach to personalized treatment of angina – Nature Reviews Cardiology (free)

 

9 – What Does the Future Hold for Scientific Journals? Visual Abstracts and Other Tools for Communicating Research – Clinics in Colon and Rectal Surgery (free)

 

10 – Effect of Axillary Dissection vs No Axillary Dissection on 10-Year Overall Survival Among Women With Invasive Breast Cancer and Sentinel Node Metastasis: The ACOSOG Z0011 (Alliance) Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Author interview: Breast Cancer Surgery: Less Is More (free audio)

Commentary: In Treating Breast Cancer, Less Can Be As Good As More – American Council on Science and Health (free)

 

Wed, September 20 – 10 Stories of The Day!

20Sep
2017

 

1 – Corticosteroids in patients hospitalized with community-acquired pneumonia: systematic review and individual patient data meta-analysis – Clinical Infectious Diseases (link to abstract – $ for full-text)

Related Meta-analysis: Efficacy and Safety of Adjunctive Corticosteroids Therapy for Severe Community-Acquired Pneumonia in Adults: An Updated Systematic Review and Meta-Analysis – PLOS One (free) AND Efficacy and Safety of Corticosteroids for Community-Acquired Pneumonia – Chest (free) AND Adjunctive Systemic Corticosteroids for Hospitalized Community-Acquired Pneumonia: Systematic Review and Meta-Analysis 2015 Update – Scientific Reports (free)

 

2 – Summaries with 10 key points to remember of the latest European Society of Cardiology Guidelines – Latest in Cardiology, American College of Cardiology

– 2017 ESC Guidelines for the Management of STEMI (free)

– 2017 ESC/EACTS Guidelines for Management of Valvular Heart Disease (free)

– 2017 ESC Guidelines for PAD Diagnosis and Treatment (free)

– 2017 ESC Focused Update on DAPT in CAD (free)

See also our selection of the most relevant articles and commentaries from the Meeting, #ESCCongress Part I, #ESCCongress Part II and #ESCCongress Part III

 

3 – Noncommunicable Diseases Progress Monitor 2017 – World Health Organization (free)

News release: WHO launches new NCDs Progress Monitor (free)

Related WHO resources: Noncommunicable diseases: the slow-motion disaster – World Health Organization (free) AND Preventing noncommunicable diseases (NCDs) by reducing environmental risk factors – World Health Organization (free) AND Other dimensions of the NCD crisis: from mental health, ageing, dementia and malnutrition to deaths on the roads, violence and disability (free) AND Tools for implementing WHO PEN (Package of essential noncommunicable disease interventions) (free) AND WHO’s work on NCDs (free)

 

4 – Ethics and the Legalization of Physician-Assisted Suicide: An American College of Physicians Position Paper (free)

Commentaries: ACP reaffirms opposition to physician-assisted suicide – ACP Internist (free) AND ACP Reaffirms Position Against Physician-Assisted Suicide – Physician’s First Watch (free)

 

5 – Association of Cigarette Price Differentials With Infant Mortality in 23 European Union Countries – JAMA Pediatrics (free)

Commentaries: Budget cigs linked to higher infant mortality: Stopping their sale could reduce deaths – Irish Health (free) AND The Fatal Toll of Cheap Cigarettes – The New York Times (10 articles per month are free)

 

6 – Impact of Electronic Cigarettes on the Cardiovascular System – Journal of The American Heart Association (free)

 

7 – Guideline: Contemporary Management of Cardiogenic Shock: A Scientific Statement From the American Heart Association – Circulation (free PDF)

Top Ten Things to Know: Contemporary Management of Cardiogenic Shock (free PDF)

 

8 – Cancer’s Invasion Equation – The New Yorker (free)

We can detect tumors earlier than ever before. Can we predict whether they’re going to be dangerous?

 

9 – Medical News & Perspectives: Going With the Flow: The Promise and Challenge of Liquid Biopsies – JAMA (free)

Related: Emerging concepts in liquid biopsies – BMC Medicine (free) AND Can a ‘liquid biopsy’ detect cancer and save lives? – STAT (free)

 

10 – Use of public defibrillators linked to out-of-hospital cardiac arrest survival – NIHR Signal (free)

Original article: The Effects of Public Access Defibrillation on Survival After Out-of-Hospital Cardiac Arrest: A Systematic Review of Observational Studies – Circulation (link to abstract – $ for full-text)

“Each minute of delay to defibrillation is estimated to reduce the probability of long-term survival by 10%” (RT @NIHR_DC see Tweet)

 

Tue, September 19 – 10 Stories of The Day!

19Sep
2017

 

1 – Report: Diet, Nutrition, Physical Activity and Colorectal Cancer – American Institute for Cancer Research (AICR) and the World Cancer Research Fund (WCRF) (Free PDF)

News release: New Report finds whole grains lower colorectal cancer risk, processed meat increases risk (free)

Infographic: Preventing Colorectal Cancer (free)

Almost half cases of colorectal cancer cases can be prevented by staying lean, eating healthy, and moving more.

 

2 – Guideline: Adolescent and Young Adult Tattooing, Piercing, and Scarification – Pediatrics (free)

Commentaries: Clinical Guidance on Body Modification Among Youth – Journal Watch (free) AND When Adolescents Want Tattoos or Piercings – The New York Times (10 articles per month are free)

 

3 – The cumulative burden of surviving childhood cancer: an initial report from the St Jude Lifetime Cohort Study (SJLIFE) – The Lancet (link to abstract – $ for full-text)

Commentaries: Survivors of Childhood Cancer Face Continuing Chronic Health Conditions – Physician’s First Watch (free) AND Severe Health Problems Plague Survivors of Childhood CA – Medscape (free registration required) AND Comprehensive Study of Chronic Disease Reveals Vulnerability of Childhood Cancer Survivors – NewsWise (free)

 

4 – Viewpoint: Nutrition Counseling in Clinical Practice: How Clinicians Can Do Better – JAMA (free)

 

5 – How alcohol industry organisations mislead the public about alcohol and cancer – Drug and Alcohol Review (free)

Commentaries: Alcohol increases cancer risk, but don’t trust the booze industry to give you the facts straight – The Conversation (free) AND Drinks industry distorts alcohol cancer risk: scientists – Reuters (free) AND Drinks industry downplaying alcohol-cancer link – The Guardian (free) AND Drinks industry accused of downplaying ‘alcohol-cancer risk’ – NHS Choices (free)

 

6 – Safety of Medical Abortion Provided Through Telemedicine Compared With in Person – Obstetrics & Gynecology (free PDF)

Commentaries: Abortion via telemedicine as safe as seeing doctor in person – Reuters (free) AND Abortion Via Telemedicine Is Totally Safe, Study Says – HuffPost (free) AND Medical Abortion Via Telemedicine Found Safe – MedPage Today (free registration required)

 

7 – The Weekend Effect in Hospitalized Patients: A Meta-Analysis – Journal of Hospital Medicine (link to abstract – free full-text PDF via @unpaywall)

Commentary: Review finds evidence for weekend effect on mortality in hospitalized patients – ACP Hospitalist (free)

Related article: Weekends affect mortality risk and chance of discharge in critically ill patients: a retrospective study in the Austrian registry for intensive care – Critical Care (free) AND Commentary: “Weekend effects” in intensive care units – On Medicine (free)

 

8 – Richard Lehman’s journal review, 18 September 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Trends in standardized mortality among individuals with schizophrenia, 1993–2012: a population-based, repeated cross-sectional study – Canadian Medical Association Journal (free)

Commentaries: Schizophrenia linked to threefold increase in death risk – Medical News Today (free) AND People with schizophrenia have threefold risk of dying – CMAJ, via EurekAlert (free)

 

10 – Strategies to reduce antibiotic prescribing for acute respiratory infections in primary care – Cochrane Library (free)

Original article: Clinician-targeted interventions to influence antibiotic prescribing behaviour for acute respiratory infections in primary care: an overview of systematic reviews – Cochrane Library (link to abstract – $ for full-text)

 

Mon, September 18 – 10 Stories of The Day!

18Sep
2017

 

1 – Life, death, and disability in 2016: latest estimates from The Global Burden of Disease Study – The Lancet

Editorial: Life, death, and disability in 2016 (free)

– Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016 (free)

– Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016 (free)

– Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016 (free)

– Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016 (free)

– Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2016 (free)

– Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries (free)

Commentaries: New global study finds countries saving more lives, despite a ‘triad of troubles’ in obesity, violence, and mental illness – Institute of Health Metrics and Evaluation (free) AND Smoking And Poor Diet Still Leading Killers Worldwide – Pursuit (free)

See also: GBD Compare Interactive Tool – Explore which causes & risk factors are causing the most death & disability in your country over time (free tool)

 

2 – Guideline: Type 2 diabetes: prevention in people at high risk – National Institute for Health and Care Excellence (NICE) (free)

 

3 – Guideline: Depression in children and young people: identification and management – National Institute for Health and Care Excellence (NICE) (free)

 

4 – Percutaneous Coronary Intervention vs Coronary Artery Bypass Grafting in Patients With Left Main Coronary Artery Stenosis: A Systematic Review and Meta-analysis – JAMA Cardiology (free)

Commentary: CABG, PCI show similar long-term outcomes – Cardiovascular Business (free)

 

5 – Meat, Dietary Heme Iron, and Risk of Type 2 Diabetes Mellitus: The Singapore Chinese Health Study – American Journal of Epidemiology (link to abstract – $ for full-text)

Commentary: Eating meat linked to higher risk of diabetes – DukeNUS Medical School, via EurekAlert (free)

Related articles: Meat Consumption as a Risk Factor for Type 2 Diabetes – Nutrients (free) AND Meat consumption and the risk of type 2 diabetes: a systematic review and meta-analysis of cohort studies – Diabetologia (free) AND Red meat consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis – American Journal of Clinical Nutrition (free)

“The Singapore Chinese Health Study reveals increased risk of diabetes with higher intake of red meat and poultry, partially attributed to the dietary iron content in these meats” (from EurekAlert)

 

6 – How Big Business Got Brazil Hooked on Junk Food – The New York times (10 articles per month are free) (RT @glassmanamanda see Tweet)

“As growth slows in wealthy countries, Western food companies are aggressively expanding in developing nations, contributing to obesity and health problems”.

 

7 – Evaluation of a Rapid Molecular Drug-Susceptibility Test for Tuberculosis – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Detecting Tuberculosis Resistance (free)

Commentary: New rapid molecular test for MDR-TB shows promise – CIDRAP (free)

 

8 – European guidelines on perioperative venous thromboembolism prophylaxis: Surgery in the elderly – European Journal of Anaesthesiology (free PDF)

 

9 – Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentary: Sulfonylureas, Pioglitazone Similarly Safe for Add-On Therapy in Type 2 Diabetes – Physician’s First Watch (free)

 

10 – Review: Drug-induced liver injury: recent advances in diagnosis and risk assessment – Gut (free)

 

Fri, September 15 – 10 Stories of The Day!

15Sep
2017

 

1 – 2017 HIVMA of IDSA Clinical Practice Guideline for the Management of Chronic Pain in Patients Living With HIV – Clinical Infectious Diseases (free)

 

2 – Education and coronary heart disease: mendelian randomisation study – The BMJ (free)

Commentary: Going to university may cut your risk of heart disease – NHS Choices (free)

 

3 – Association Between More Intensive vs Less Intensive Blood Pressure Lowering and Risk of Mortality in Chronic Kidney Disease Stages 3 to 5: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Intensive blood pressure lowering linked to decreased mortality in patients with chronic kidney disease – 2 Minute Medicine (free) AND Intensive BP Lowering in Chronic Kidney Disease Associated with Lower Mortality – Physician’s First Watch (free) AND Is Strict BP Control a Good Bet for CKD Patients? – MedPage Today (free registration required)

 

4 – Pathophysiology, diagnosis and treatment of tachycardiomyopathy – Heart (free)

Source: Critical Care Review Newsletter

 

5 – Corticosteroid or Nonsteroidal Antiinflammatory Drugs for the Treatment of Acute Gout: A Systematic Review of Randomized Controlled Trials – The Journal of Rheumatology (free)

Source: EvidenceAlerts

Corticosteroids and NSAIDs did not have different effects on pain scores, but there was a higher risk of indigestion, nausea and vomiting with NSAIDs.

 

6 – New Series: The World Bank and financing global health – The BMJ

– World Bank’s financing, priorities, and lending structures for global health (free)

– Universal health coverage, health systems strengthening, and the World Bank (free)

– World Bank and the Global Financing Facility (free)

– Earmarking for global health: benefits and perils of the World Bank’s trust fund model (free)

– Health as a “global public good”: creating a market for pandemic risk (free)

– Baines and Babar: Why medical practitioners should be interested in the World Bank (free)

 

7 – The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis – The Lancet (free)

Commentaries: Sleep improvement by internet-based cognitive behavioural therapy might help prevent mental health disorders – The Lancet (free) AND Lack of sleep could contribute to mental health problems, researchers reveal – The Guardian (free) AND Tackling insomnia may be key to easing mental health issues – OnMedica (free)

 

8 – Protocol for the management of psychiatric patients with psychomotor agitation – BMC Psychiatry (free)

 

9 – A range of anti-epilepsy drugs are effective as first-line treatment – NIHR Signal (free)

Original article: Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data – Cochrane Library (link to abstract – $ for full-text)

 

10 – Osteoporosis drug treatment: duration and management after discontinuation. A position statement from the SVGO/ASCO – Swiss Medical Weekly (free)

 

Thu, September 14 – 10 Stories of The Day!

14Sep
2017

 

1 – Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016 – The Lancet (free)

Commentary: IHME releases second annual report on the Sustainable Development Goal indicators – Institute for Health Metrics and Evaluation (free)

See also: Health-related Sustainable Development Goals visualization tool, which allows users to compare and contrast between countries and among indicators, and the United Nations Sustainable Development Goals Website.

 

2 – Guideline: Prevention of Early-onset Neonatal Group B Streptococcal Disease – Royal College of Obstetricians and Gynaecologists (free)

News release: Group B Streptococcal Disease, Early-onset (free)

Commentaries: Antibiotics for women in early labour to combat Group B Strep – OnMedica (free) AND More pregnant women to get Group B Strep treatment – BBC News (free)

 

3 – Review article: Randomized, Controlled Trials in Health Insurance Systems – New England Journal of Medicine (free)

See also other articles in The Changing Face of Clinical Trials Series (all free)

 

4 – Benefit of Patent Foramen Ovale Closure Seen in Selected Patients with Cryptogenic Stroke – Journal Watch (free)

Original articles from the New England Journal of Medicine: Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke (link to abstract – $ for full-text) AND Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke (link to abstract – $ for full-text) AND Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke (link to abstract – $ for full-text)

 

5 – The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Treatment of Colon Cancer (free)

 

6 – Prevention of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline (free)

 

7 – European Respiratory Society guidelines for the management of adult bronchiectasis (free)

 

8 – Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: systematic review and meta-analysis of relapse prevention trials – The BMJ (free)

Commentary: Researchers: Antidepressants for Anxiety Should Be Continued for at Least a Year After Treatment Response – Physician’s First Watch (free)

 

9 – Association Between Laparoscopic Antireflux Surgery and Recurrence of Gastroesophageal Reflux – JAMA (link to abstract – $ for full-text)

Commentaries: Laparoscopic Antireflux Surgery Associated With High Rate of Recurrence of GERD – The JAMA Network (free) AND GERD Recurrence Fairly Common Following Laparoscopic Antireflux Surgery – Physician’s First Watch (free) AND High recurrence of gastroesophageal reflux disease in patients treated with laparoscopic antireflux surgery – 2 Minute Medicine (free)

 

10 – Differential blood pressure effects of ibuprofen, naproxen, and celecoxib in patients with arthritis: the PRECISION-ABPM (Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen Ambulatory Blood Pressure Measurement) Trial – European Heart Journal (free)

Commentaries: Under Pressure: PRECISION Substudy Shows Adverse BP Effects of Ibuprofen – TCTMD (free) AND Increases in BP, Hypertension Incidence Linked to Certain NSAIDs – MPR (free) AND Ibuprofen Ups Systolic BP, New-Onset Hypertension Risk – Medscape (free registration required)

 

Wed, September 13 – 10 Stories of The Day!

13Sep
2017

 

1 – International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia (free) (RT @CritCareReviews see Tweet)

 

2 – Report: Preventing noncommunicable diseases (NCDs) by reducing environmental risk factors – World Health Organization (free)

We welcome new @WHO report, showing 23% of all deaths can be prevented through healthier environments” (RT @HealthandEnv see Tweet)

 

3 – Draft Recommendation Statement: Cervical Cancer: Screening – U.S. Preventive Services Task Force (free)

Commentaries: USPSTF Draft Recommendation Eliminates Cervical Cytology-HPV Cotesting for Women Over 30 – Physician’s First Watch (free) AND USPSTF: Pap Test or HPV Test, Not Both, For Most Cervical Ca Screening – MedPage Today (free registration required) AND USPSTF Has New Draft Guidance for Cervical Cancer Screening – Medscape (free registration required) AND Age matters when it comes to screening for cervical câncer – STAT (free)

 

4 – Research and Development Spending to Bring a Single Cancer Drug to Market and Revenues After Approval – JAMA Internal Medicine (free)

Author interview: Cost of Developing a Single Cancer Drug (free audio)

Invited commentary: A Much-Needed Corrective on Drug Development Costs (free)

Commentaries: R&D Costs For Cancer Drugs Are Likely Much Less Than Industry Claims, Study Finds – NPR (free) AND A new study undermines Big Pharma’s justification for charging high drug prices – Business Insider (free) AND What Does It Cost to Create a Cancer Drug? Less Than You’d Think – The New York Times (10 articles per month are free)

 

5 – Antiretroviral therapy in pregnant women living with HIV: a clinical practice guideline – The BMJ (free guideline and infographic)

 

6 – Menopausal Hormone Therapy and Long-term All-Cause and Cause-Specific Mortality: The Women’s Health Initiative Randomized Trials – JAMA (link to abstract – $ for full-text)

Commentaries: Taking Hormones for Menopause Doesn’t Raise Early Death Risk – The New York Times (free) AND Menopause hormone therapy not linked to premature death – Reuters (free) AND Menopause hormones don’t shorten lives, long follow-up says – STAT (free)

 

7 – Patient-Clinician Communication: American Society of Clinical Oncology Consensus Guideline (free)

News release: New Guideline Aims to Improve Clinician Communication With Patients (free)

 

8 – Laparoscopic and robotic-assisted versus open radical prostatectomy for the treatment of localised prostate cancer – Cochrane Library (free)

Original article: Laparoscopic and robotic-assisted versus open radical prostatectomy for the treatment of localised prostate cancer – Cochrane Library (link to abstract – $ for full-text)

“Urinary and sexual quality of life-related outcomes appear similar”.

 

9 – LDL-Cholesterol Lowering for the Primary Prevention of Cardiovascular Disease Among Men with Primary Elevations of LDL-Cholesterol Levels of 190 mg/dL or Above: Analyses from the WOSCOPS 5-year Randomised Trial and 20-year Observational Follow-Up – Circulation (free)

Commentary: Statins cut heart deaths in men by 28% finds study – NHS Choices (free)

 

10 – Role of Total, Red, Processed, and White Meat Consumption in Stroke Incidence and Mortality: A Systematic Review and Meta‐Analysis of Prospective Cohort Studies – Journal of The American Heart Association (free)

Increased consumption of red and processed meat may be associated with higher risk of stroke.

 

Tue, September 12 – 10 Stories of The Day!

12Sep
2017

 

1 – Treatment of Type 1 Diabetes: Synopsis of the 2017 American Diabetes Association Standards of Medical Care in Diabetes – Annals of Internal Medicine (free)

 

2 – Recommendations on screening for abdominal aortic aneurysm in primary care – Canadian Task Force on Preventive Health Care (free)

See also: Summary of recommendations for clinicians and policy-makers (free) AND Abdominal Aortic Aneurysm (AAA): 1000-Person Tool (free)

“The number of men >65 needed to screen to prevent one AAA related death is 796 (95% confidence interval 621–1242) @ 3-5 yr follow-up” (RT @cantaskforce see Tweet)

  

3 – Clinical Practice Guideline: Evaluation of the Neck Mass in Adults – American Academy of Otolaryngology—Head and Neck Surgery Foundation (free)

See also: Executive Summary (free) AND News Release (free)

Commentaries: Neck Mass in Adults: Guideline for Evaluation Provides Framework for Timely Diagnosis – NewsWise (free) AND Guidelines Issued on Evaluating Neck Masses – Physician’s First Watch (free)

 

4 – A Comparison of Alkaline Water and Mediterranean Diet vs Proton Pump Inhibition for Treatment of Laryngopharyngeal Reflux – JAMA Otolaryngology Head Neck Surgery (free)

Commentaries: Could a Mediterranean diet be as good as drugs for acid reflux? – NHS Choices (free) AND Dietary Approach Found as Effective as Medications for Treating Type of Reflux Disease – The JAMA Network (free) AND Treating Reflux With Diet – The New York Times (10 articles per month are free)

A small retrospective cohort study suggests a plant-based, Mediterranean-style diet may be as effective as medication.

 

5 – The Joint Associations of Sedentary Time and Physical Activity With Mobility Disability in Older People: The NIH-AARP Diet and Health Study – The Journals of Gerontology (free)

Commentaries: Get Off The Couch Baby Boomers, Or You May Not Be Able To Later – NPR (free) AND Prospective Study Shows Just How Bad TV Can Be – Medscape (free registration required) AND Prolonged sitting and TV watching ‘dangerous’ for seniors – Medical News Today (free) AND TV viewing ‘a potent risk factor’ for disability – OnMedica (free)

 

6 – Guideline: National Partnership for Maternal Safety: Consensus Bundle on Severe Hypertension During Pregnancy and the Postpartum Period – Obstetrics & Gynecology (free)

Commentary: Management of Severe Maternal Hypertension During Pregnancy and Postpartum – Journal Watch (free)

 

7 – Hormonal contraceptive eligibility for women at high risk of HIV: Guidance Statement – World Health Organization (free PDF)

News release: Can women who are at high risk of acquiring HIV, safely use hormonal contraception? (free)

Frequently asked questions: Hormonal contraceptive eligibility for women at high risk of HIV (free)

Guideline Summary: Hormonal contraceptive eligibility for women at high risk of HIV: guidance statement – National Guideline Clearinghouse (free)

 

8 – Cardiovascular disease risk and androgen deprivation therapy in patients with localised prostate cancer: a prospective cohort study – British Journal of Cancer (link to abstract – $ for full-text)

Commentaries: Prostate cancer treatment associated with higher risk of heart failure – Cardiovascular Business (free) AND Hormone Treatment for Prostate Cancer Tied to Heart Risks – The New York Times (10 articles per month are free)

 

9 – Richard Lehman’s journal review, 11 September 2017 (free)

Richard Lehman reviews the latest research in the top medical journals.

 

10 – Adverse effects of proton-pump inhibitor use in older adults: a review of the evidence – Therapeutic Advances in Drug Safety (free)

 

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