Open access

Fri, September 22 – 10 Stories of The Day!

22Sep
2017

 

1 – Weight and Metabolic Outcomes 12 Years after Gastric Bypass – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Benefits of gastric bypass persist for 12 years – Reuters (free) AND Gastric bypass surgery benefits continue for 12 years – Diabetes.co.uk (free) AND Bariatric Surgery’s Benefits Last Over a Decade – Physician’s First Watch (free)

 

2 – Do interventions that reduce the cost of smoking cessation treatment increase quit rates, quit attempts or use of treatments? – Cochrane Library (free)

Original article: Healthcare financing systems for increasing the use of tobacco dependence treatment – Cochrane Library (link to abstract – $ for full-text)

Full financial interventions directed at smokers when compared to no financial interventions increase the proportion of smokers who attempt to quit, use smoking cessation treatments, and succeed in quitting”.

 

3 – Lung Cancer Mortality Associated With Smoking and Smoking Cessation Among People Living With HIV in the United States – JAMA Internal Medicine (free)

Editorial: If We Are Smart Enough to Stop HIV From Replicating, Why Can’t We Help People to Stop Smoking? (free)

Commentaries: People with HIV who smoke are more likely to die from lung cancer than from HIV itself – eCancer (free) AND Smoking cuts life expectancy in HIV more than AIDS does – OnMedica (free)

 

4 – Randomized clinical trial of antibiotic therapy for uncomplicated appendicitis – British Journal of Surgery (link to abstract – $ for full-text)

See also a  related meta-analysis suggesting the safety of nonoperative treatment for uncomplicated cases (free) and a recent guideline that incorporates the possibility of non-operative treatment for uncomplicated disease (free)

“1st RCT to show uncomplicated appendicitis resolve even without antibiotics (let alone surgery)” (RT @villesallinen see Tweet)

 

5 – All Hypertensive Disorders of Pregnancy Increase the Risk of Future Cardiovascular Disease – Hypertension (link to abstract – free PDF via @unpaywall)

Commentaries: Hypertensive disorders of pregnancy increase future risk of heart disease – Cardiovascular Business (free) AND A type of hypertension during pregnancy more dangerous than thought – AHA News (free)

See related articles and commentaries in our August 22nd issue (see #3)

 

6 – Association of Trial Registration With Reporting of Primary Outcomes in Protocols and Publications – JAMA (free)

Commentaries: Discrepancy between trial goals, results may mask treatment risks – Reuters (free) AND Clinical Trials Often Unregistered, Unpublished – The JAMA Network (free)

 

7 – The interstitial lung disease multidisciplinary meeting: A position statement from the Thoracic Society of Australia and New Zealand and the Lung Foundation Australia (free)

 

8 – Cancer patients need better care, not just more technology – Nature News (free)

 

9 – Juvenile Stroke: A Practice-Oriented Overview – Deutsches Ärzteblatt international (free)

Commentary: German study dissects etiology behind juvenile stroke – Cardiovascular Business (free)

 

10 – FDA Drug Safety Communication: FDA recommends separating dosing of potassium-lowering drug sodium polystyrene sulfonate (Kayexalate) from all other oral drugs (free)

Commentary: Don’t Give Kayexalate With Other Oral Drugs, FDA Warns – Medscape (free registration required)

“Patients should take orally administered prescription and over-the-counter (OTC) medicines at least 3 hours before or 3 hours after sodium polystyrene sulfonate”

 

Thu, September 21 – 10 Stories of The Day!

21Sep
2017

 

1 – The world is running out of antibiotics, WHO report confirms – World Health Organization (free)

See WHO Reports: Antibacterial Agents in Clinical Development (free) AND Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics (free)

See also WHO Resources on Antibiotic Resistance

Commentaries: WHO report paints dire picture of antibiotic development – CIDRAP (free) AND Too few antibiotics in pipeline to tackle global drug-resistance crisis, WHO warns – The Guardian (free) AND The world is running out of antibiotics, WHO says – CNN (free text and video)

 

2 – Rapid Recommendation: Corticosteroids for sore throat: a clinical practice guideline – The BMJ (free text and infographic)

See also other Rapid Recommendations from The BMJ (all free)

 

3 – Improving health systems in low-income countries – 3 New Cochrane Library Reviews

Article 1: Implementation strategies for health systems in low-income countries: an overview of systematic reviews (free) AND Summary: Implementation strategies for health systems in low-income countries (free)

Article 2: Governance arrangements for health systems in low-income countries: an overview of systematic reviews (free) AND Summary: Effects of governance arrangements for health systems in low-income countries (free)

Article 3: Delivery arrangements for health systems in low-income countries: an overview of systematic reviews (free) AND Summary: Effects of delivery arrangements for health systems in low-income countries (free)

 

4 – Comprehensive geriatric assessment for older adults admitted to hospital – Cochrane Library (free)

Original article: Comprehensive geriatric assessment for older adults admitted to hospital – Cochrane Library (link to abstract – $ for full-text)

Related: Comprehensive assessment may reduce risk of delirium after hip fracture – NIHR Signal (free)

“Older patients are more likely to be alive and in their own homes at follow-up if they received comprehensive geriatric assessment on admission to hospital”.

 

5 – Low alcohol consumption and pregnancy and childhood outcomes: time to change guidelines indicating apparently ‘safe’ levels of alcohol during pregnancy? A systematic review and meta-analyses – BMJ Open (free)

Commentaries: No change to alcohol guidelines for pregnancy – NHS Choices (free) Health risks of light drinking in pregnancy confirms that abstention is the safest approach – The Conversation (free)

 

6 – Association of spontaneous abortion with receipt of inactivated influenza vaccine containing H1N1pdm09 in 2010–11 and 2011–12 – Vaccine (link to abstract – $ for full-text)

Commentaries: Study signals association between flu vaccine, miscarriage – CIDRAP (free) AND New study finds link between flu vaccine and miscarriage. But is it real? – Science (free) AND Study shows miscarriage risk may have increased after flu shots, puzzling researchers – STAT (free) AND A new finding of a possible flu shot-miscarriage link shows science prioritizes vaccine safety – STAT (free)

“This study does not and cannot establish a causal relationship between repeated influenza vaccination and SAB, but further research is warranted”.

 

7 – Metabolically Healthy Obese and Incident Cardiovascular Disease Events Among 3.5 Million Men and Women – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: New evidence shows that healthy obesity is a myth – The Conversation (free) AND Study shows so-called ‘healthy obesity’ is harmful to cardiovascular health – Medical News Today (free) AND Obesity, even without other risk factors, leads to higher rate of cardiovascular disease – STAT (free) AND Another Study Challenges Notion of ‘Healthy Obese’ – TCTMD (free)

See related article and commentaries in our August 21st issue (see #1)

 

8 – Expert consensus document: A ‘diamond’ approach to personalized treatment of angina – Nature Reviews Cardiology (free)

 

9 – What Does the Future Hold for Scientific Journals? Visual Abstracts and Other Tools for Communicating Research – Clinics in Colon and Rectal Surgery (free)

 

10 – Effect of Axillary Dissection vs No Axillary Dissection on 10-Year Overall Survival Among Women With Invasive Breast Cancer and Sentinel Node Metastasis: The ACOSOG Z0011 (Alliance) Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Author interview: Breast Cancer Surgery: Less Is More (free audio)

Commentary: In Treating Breast Cancer, Less Can Be As Good As More – American Council on Science and Health (free)

 

Wed, September 20 – 10 Stories of The Day!

20Sep
2017

 

1 – Corticosteroids in patients hospitalized with community-acquired pneumonia: systematic review and individual patient data meta-analysis – Clinical Infectious Diseases (link to abstract – $ for full-text)

Related Meta-analysis: Efficacy and Safety of Adjunctive Corticosteroids Therapy for Severe Community-Acquired Pneumonia in Adults: An Updated Systematic Review and Meta-Analysis – PLOS One (free) AND Efficacy and Safety of Corticosteroids for Community-Acquired Pneumonia – Chest (free) AND Adjunctive Systemic Corticosteroids for Hospitalized Community-Acquired Pneumonia: Systematic Review and Meta-Analysis 2015 Update – Scientific Reports (free)

 

2 – Summaries with 10 key points to remember of the latest European Society of Cardiology Guidelines – Latest in Cardiology, American College of Cardiology

– 2017 ESC Guidelines for the Management of STEMI (free)

– 2017 ESC/EACTS Guidelines for Management of Valvular Heart Disease (free)

– 2017 ESC Guidelines for PAD Diagnosis and Treatment (free)

– 2017 ESC Focused Update on DAPT in CAD (free)

See also our selection of the most relevant articles and commentaries from the Meeting, #ESCCongress Part I, #ESCCongress Part II and #ESCCongress Part III

 

3 – Noncommunicable Diseases Progress Monitor 2017 – World Health Organization (free)

News release: WHO launches new NCDs Progress Monitor (free)

Related WHO resources: Noncommunicable diseases: the slow-motion disaster – World Health Organization (free) AND Preventing noncommunicable diseases (NCDs) by reducing environmental risk factors – World Health Organization (free) AND Other dimensions of the NCD crisis: from mental health, ageing, dementia and malnutrition to deaths on the roads, violence and disability (free) AND Tools for implementing WHO PEN (Package of essential noncommunicable disease interventions) (free) AND WHO’s work on NCDs (free)

 

4 – Ethics and the Legalization of Physician-Assisted Suicide: An American College of Physicians Position Paper (free)

Commentaries: ACP reaffirms opposition to physician-assisted suicide – ACP Internist (free) AND ACP Reaffirms Position Against Physician-Assisted Suicide – Physician’s First Watch (free)

 

5 – Association of Cigarette Price Differentials With Infant Mortality in 23 European Union Countries – JAMA Pediatrics (free)

Commentaries: Budget cigs linked to higher infant mortality: Stopping their sale could reduce deaths – Irish Health (free) AND The Fatal Toll of Cheap Cigarettes – The New York Times (10 articles per month are free)

 

6 – Impact of Electronic Cigarettes on the Cardiovascular System – Journal of The American Heart Association (free)

 

7 – Guideline: Contemporary Management of Cardiogenic Shock: A Scientific Statement From the American Heart Association – Circulation (free PDF)

Top Ten Things to Know: Contemporary Management of Cardiogenic Shock (free PDF)

 

8 – Cancer’s Invasion Equation – The New Yorker (free)

We can detect tumors earlier than ever before. Can we predict whether they’re going to be dangerous?

 

9 – Medical News & Perspectives: Going With the Flow: The Promise and Challenge of Liquid Biopsies – JAMA (free)

Related: Emerging concepts in liquid biopsies – BMC Medicine (free) AND Can a ‘liquid biopsy’ detect cancer and save lives? – STAT (free)

 

10 – Use of public defibrillators linked to out-of-hospital cardiac arrest survival – NIHR Signal (free)

Original article: The Effects of Public Access Defibrillation on Survival After Out-of-Hospital Cardiac Arrest: A Systematic Review of Observational Studies – Circulation (link to abstract – $ for full-text)

“Each minute of delay to defibrillation is estimated to reduce the probability of long-term survival by 10%” (RT @NIHR_DC see Tweet)

 

Tue, September 19 – 10 Stories of The Day!

19Sep
2017

 

1 – Report: Diet, Nutrition, Physical Activity and Colorectal Cancer – American Institute for Cancer Research (AICR) and the World Cancer Research Fund (WCRF) (Free PDF)

News release: New Report finds whole grains lower colorectal cancer risk, processed meat increases risk (free)

Infographic: Preventing Colorectal Cancer (free)

Almost half cases of colorectal cancer cases can be prevented by staying lean, eating healthy, and moving more.

 

2 – Guideline: Adolescent and Young Adult Tattooing, Piercing, and Scarification – Pediatrics (free)

Commentaries: Clinical Guidance on Body Modification Among Youth – Journal Watch (free) AND When Adolescents Want Tattoos or Piercings – The New York Times (10 articles per month are free)

 

3 – The cumulative burden of surviving childhood cancer: an initial report from the St Jude Lifetime Cohort Study (SJLIFE) – The Lancet (link to abstract – $ for full-text)

Commentaries: Survivors of Childhood Cancer Face Continuing Chronic Health Conditions – Physician’s First Watch (free) AND Severe Health Problems Plague Survivors of Childhood CA – Medscape (free registration required) AND Comprehensive Study of Chronic Disease Reveals Vulnerability of Childhood Cancer Survivors – NewsWise (free)

 

4 – Viewpoint: Nutrition Counseling in Clinical Practice: How Clinicians Can Do Better – JAMA (free)

 

5 – How alcohol industry organisations mislead the public about alcohol and cancer – Drug and Alcohol Review (free)

Commentaries: Alcohol increases cancer risk, but don’t trust the booze industry to give you the facts straight – The Conversation (free) AND Drinks industry distorts alcohol cancer risk: scientists – Reuters (free) AND Drinks industry downplaying alcohol-cancer link – The Guardian (free) AND Drinks industry accused of downplaying ‘alcohol-cancer risk’ – NHS Choices (free)

 

6 – Safety of Medical Abortion Provided Through Telemedicine Compared With in Person – Obstetrics & Gynecology (free PDF)

Commentaries: Abortion via telemedicine as safe as seeing doctor in person – Reuters (free) AND Abortion Via Telemedicine Is Totally Safe, Study Says – HuffPost (free) AND Medical Abortion Via Telemedicine Found Safe – MedPage Today (free registration required)

 

7 – The Weekend Effect in Hospitalized Patients: A Meta-Analysis – Journal of Hospital Medicine (link to abstract – free full-text PDF via @unpaywall)

Commentary: Review finds evidence for weekend effect on mortality in hospitalized patients – ACP Hospitalist (free)

Related article: Weekends affect mortality risk and chance of discharge in critically ill patients: a retrospective study in the Austrian registry for intensive care – Critical Care (free) AND Commentary: “Weekend effects” in intensive care units – On Medicine (free)

 

8 – Richard Lehman’s journal review, 18 September 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Trends in standardized mortality among individuals with schizophrenia, 1993–2012: a population-based, repeated cross-sectional study – Canadian Medical Association Journal (free)

Commentaries: Schizophrenia linked to threefold increase in death risk – Medical News Today (free) AND People with schizophrenia have threefold risk of dying – CMAJ, via EurekAlert (free)

 

10 – Strategies to reduce antibiotic prescribing for acute respiratory infections in primary care – Cochrane Library (free)

Original article: Clinician-targeted interventions to influence antibiotic prescribing behaviour for acute respiratory infections in primary care: an overview of systematic reviews – Cochrane Library (link to abstract – $ for full-text)

 

Mon, September 18 – 10 Stories of The Day!

18Sep
2017

 

1 – Life, death, and disability in 2016: latest estimates from The Global Burden of Disease Study – The Lancet

Editorial: Life, death, and disability in 2016 (free)

– Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016 (free)

– Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016 (free)

– Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016 (free)

– Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016 (free)

– Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2016 (free)

– Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries (free)

Commentaries: New global study finds countries saving more lives, despite a ‘triad of troubles’ in obesity, violence, and mental illness – Institute of Health Metrics and Evaluation (free) AND Smoking And Poor Diet Still Leading Killers Worldwide – Pursuit (free)

See also: GBD Compare Interactive Tool – Explore which causes & risk factors are causing the most death & disability in your country over time (free tool)

 

2 – Guideline: Type 2 diabetes: prevention in people at high risk – National Institute for Health and Care Excellence (NICE) (free)

 

3 – Guideline: Depression in children and young people: identification and management – National Institute for Health and Care Excellence (NICE) (free)

 

4 – Percutaneous Coronary Intervention vs Coronary Artery Bypass Grafting in Patients With Left Main Coronary Artery Stenosis: A Systematic Review and Meta-analysis – JAMA Cardiology (free)

Commentary: CABG, PCI show similar long-term outcomes – Cardiovascular Business (free)

 

5 – Meat, Dietary Heme Iron, and Risk of Type 2 Diabetes Mellitus: The Singapore Chinese Health Study – American Journal of Epidemiology (link to abstract – $ for full-text)

Commentary: Eating meat linked to higher risk of diabetes – DukeNUS Medical School, via EurekAlert (free)

Related articles: Meat Consumption as a Risk Factor for Type 2 Diabetes – Nutrients (free) AND Meat consumption and the risk of type 2 diabetes: a systematic review and meta-analysis of cohort studies – Diabetologia (free) AND Red meat consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis – American Journal of Clinical Nutrition (free)

“The Singapore Chinese Health Study reveals increased risk of diabetes with higher intake of red meat and poultry, partially attributed to the dietary iron content in these meats” (from EurekAlert)

 

6 – How Big Business Got Brazil Hooked on Junk Food – The New York times (10 articles per month are free) (RT @glassmanamanda see Tweet)

“As growth slows in wealthy countries, Western food companies are aggressively expanding in developing nations, contributing to obesity and health problems”.

 

7 – Evaluation of a Rapid Molecular Drug-Susceptibility Test for Tuberculosis – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Detecting Tuberculosis Resistance (free)

Commentary: New rapid molecular test for MDR-TB shows promise – CIDRAP (free)

 

8 – European guidelines on perioperative venous thromboembolism prophylaxis: Surgery in the elderly – European Journal of Anaesthesiology (free PDF)

 

9 – Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentary: Sulfonylureas, Pioglitazone Similarly Safe for Add-On Therapy in Type 2 Diabetes – Physician’s First Watch (free)

 

10 – Review: Drug-induced liver injury: recent advances in diagnosis and risk assessment – Gut (free)

 

Fri, September 15 – 10 Stories of The Day!

15Sep
2017

 

1 – 2017 HIVMA of IDSA Clinical Practice Guideline for the Management of Chronic Pain in Patients Living With HIV – Clinical Infectious Diseases (free)

 

2 – Education and coronary heart disease: mendelian randomisation study – The BMJ (free)

Commentary: Going to university may cut your risk of heart disease – NHS Choices (free)

 

3 – Association Between More Intensive vs Less Intensive Blood Pressure Lowering and Risk of Mortality in Chronic Kidney Disease Stages 3 to 5: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Intensive blood pressure lowering linked to decreased mortality in patients with chronic kidney disease – 2 Minute Medicine (free) AND Intensive BP Lowering in Chronic Kidney Disease Associated with Lower Mortality – Physician’s First Watch (free) AND Is Strict BP Control a Good Bet for CKD Patients? – MedPage Today (free registration required)

 

4 – Pathophysiology, diagnosis and treatment of tachycardiomyopathy – Heart (free)

Source: Critical Care Review Newsletter

 

5 – Corticosteroid or Nonsteroidal Antiinflammatory Drugs for the Treatment of Acute Gout: A Systematic Review of Randomized Controlled Trials – The Journal of Rheumatology (free)

Source: EvidenceAlerts

Corticosteroids and NSAIDs did not have different effects on pain scores, but there was a higher risk of indigestion, nausea and vomiting with NSAIDs.

 

6 – New Series: The World Bank and financing global health – The BMJ

– World Bank’s financing, priorities, and lending structures for global health (free)

– Universal health coverage, health systems strengthening, and the World Bank (free)

– World Bank and the Global Financing Facility (free)

– Earmarking for global health: benefits and perils of the World Bank’s trust fund model (free)

– Health as a “global public good”: creating a market for pandemic risk (free)

– Baines and Babar: Why medical practitioners should be interested in the World Bank (free)

 

7 – The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis – The Lancet (free)

Commentaries: Sleep improvement by internet-based cognitive behavioural therapy might help prevent mental health disorders – The Lancet (free) AND Lack of sleep could contribute to mental health problems, researchers reveal – The Guardian (free) AND Tackling insomnia may be key to easing mental health issues – OnMedica (free)

 

8 – Protocol for the management of psychiatric patients with psychomotor agitation – BMC Psychiatry (free)

 

9 – A range of anti-epilepsy drugs are effective as first-line treatment – NIHR Signal (free)

Original article: Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data – Cochrane Library (link to abstract – $ for full-text)

 

10 – Osteoporosis drug treatment: duration and management after discontinuation. A position statement from the SVGO/ASCO – Swiss Medical Weekly (free)

 

Thu, September 14 – 10 Stories of The Day!

14Sep
2017

 

1 – Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016 – The Lancet (free)

Commentary: IHME releases second annual report on the Sustainable Development Goal indicators – Institute for Health Metrics and Evaluation (free)

See also: Health-related Sustainable Development Goals visualization tool, which allows users to compare and contrast between countries and among indicators, and the United Nations Sustainable Development Goals Website.

 

2 – Guideline: Prevention of Early-onset Neonatal Group B Streptococcal Disease – Royal College of Obstetricians and Gynaecologists (free)

News release: Group B Streptococcal Disease, Early-onset (free)

Commentaries: Antibiotics for women in early labour to combat Group B Strep – OnMedica (free) AND More pregnant women to get Group B Strep treatment – BBC News (free)

 

3 – Review article: Randomized, Controlled Trials in Health Insurance Systems – New England Journal of Medicine (free)

See also other articles in The Changing Face of Clinical Trials Series (all free)

 

4 – Benefit of Patent Foramen Ovale Closure Seen in Selected Patients with Cryptogenic Stroke – Journal Watch (free)

Original articles from the New England Journal of Medicine: Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke (link to abstract – $ for full-text) AND Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke (link to abstract – $ for full-text) AND Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke (link to abstract – $ for full-text)

 

5 – The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Treatment of Colon Cancer (free)

 

6 – Prevention of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline (free)

 

7 – European Respiratory Society guidelines for the management of adult bronchiectasis (free)

 

8 – Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: systematic review and meta-analysis of relapse prevention trials – The BMJ (free)

Commentary: Researchers: Antidepressants for Anxiety Should Be Continued for at Least a Year After Treatment Response – Physician’s First Watch (free)

 

9 – Association Between Laparoscopic Antireflux Surgery and Recurrence of Gastroesophageal Reflux – JAMA (link to abstract – $ for full-text)

Commentaries: Laparoscopic Antireflux Surgery Associated With High Rate of Recurrence of GERD – The JAMA Network (free) AND GERD Recurrence Fairly Common Following Laparoscopic Antireflux Surgery – Physician’s First Watch (free) AND High recurrence of gastroesophageal reflux disease in patients treated with laparoscopic antireflux surgery – 2 Minute Medicine (free)

 

10 – Differential blood pressure effects of ibuprofen, naproxen, and celecoxib in patients with arthritis: the PRECISION-ABPM (Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen Ambulatory Blood Pressure Measurement) Trial – European Heart Journal (free)

Commentaries: Under Pressure: PRECISION Substudy Shows Adverse BP Effects of Ibuprofen – TCTMD (free) AND Increases in BP, Hypertension Incidence Linked to Certain NSAIDs – MPR (free) AND Ibuprofen Ups Systolic BP, New-Onset Hypertension Risk – Medscape (free registration required)

 

Wed, September 13 – 10 Stories of The Day!

13Sep
2017

 

1 – International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia (free) (RT @CritCareReviews see Tweet)

 

2 – Report: Preventing noncommunicable diseases (NCDs) by reducing environmental risk factors – World Health Organization (free)

We welcome new @WHO report, showing 23% of all deaths can be prevented through healthier environments” (RT @HealthandEnv see Tweet)

 

3 – Draft Recommendation Statement: Cervical Cancer: Screening – U.S. Preventive Services Task Force (free)

Commentaries: USPSTF Draft Recommendation Eliminates Cervical Cytology-HPV Cotesting for Women Over 30 – Physician’s First Watch (free) AND USPSTF: Pap Test or HPV Test, Not Both, For Most Cervical Ca Screening – MedPage Today (free registration required) AND USPSTF Has New Draft Guidance for Cervical Cancer Screening – Medscape (free registration required) AND Age matters when it comes to screening for cervical câncer – STAT (free)

 

4 – Research and Development Spending to Bring a Single Cancer Drug to Market and Revenues After Approval – JAMA Internal Medicine (free)

Author interview: Cost of Developing a Single Cancer Drug (free audio)

Invited commentary: A Much-Needed Corrective on Drug Development Costs (free)

Commentaries: R&D Costs For Cancer Drugs Are Likely Much Less Than Industry Claims, Study Finds – NPR (free) AND A new study undermines Big Pharma’s justification for charging high drug prices – Business Insider (free) AND What Does It Cost to Create a Cancer Drug? Less Than You’d Think – The New York Times (10 articles per month are free)

 

5 – Antiretroviral therapy in pregnant women living with HIV: a clinical practice guideline – The BMJ (free guideline and infographic)

 

6 – Menopausal Hormone Therapy and Long-term All-Cause and Cause-Specific Mortality: The Women’s Health Initiative Randomized Trials – JAMA (link to abstract – $ for full-text)

Commentaries: Taking Hormones for Menopause Doesn’t Raise Early Death Risk – The New York Times (free) AND Menopause hormone therapy not linked to premature death – Reuters (free) AND Menopause hormones don’t shorten lives, long follow-up says – STAT (free)

 

7 – Patient-Clinician Communication: American Society of Clinical Oncology Consensus Guideline (free)

News release: New Guideline Aims to Improve Clinician Communication With Patients (free)

 

8 – Laparoscopic and robotic-assisted versus open radical prostatectomy for the treatment of localised prostate cancer – Cochrane Library (free)

Original article: Laparoscopic and robotic-assisted versus open radical prostatectomy for the treatment of localised prostate cancer – Cochrane Library (link to abstract – $ for full-text)

“Urinary and sexual quality of life-related outcomes appear similar”.

 

9 – LDL-Cholesterol Lowering for the Primary Prevention of Cardiovascular Disease Among Men with Primary Elevations of LDL-Cholesterol Levels of 190 mg/dL or Above: Analyses from the WOSCOPS 5-year Randomised Trial and 20-year Observational Follow-Up – Circulation (free)

Commentary: Statins cut heart deaths in men by 28% finds study – NHS Choices (free)

 

10 – Role of Total, Red, Processed, and White Meat Consumption in Stroke Incidence and Mortality: A Systematic Review and Meta‐Analysis of Prospective Cohort Studies – Journal of The American Heart Association (free)

Increased consumption of red and processed meat may be associated with higher risk of stroke.

 

Tue, September 12 – 10 Stories of The Day!

12Sep
2017

 

1 – Treatment of Type 1 Diabetes: Synopsis of the 2017 American Diabetes Association Standards of Medical Care in Diabetes – Annals of Internal Medicine (free)

 

2 – Recommendations on screening for abdominal aortic aneurysm in primary care – Canadian Task Force on Preventive Health Care (free)

See also: Summary of recommendations for clinicians and policy-makers (free) AND Abdominal Aortic Aneurysm (AAA): 1000-Person Tool (free)

“The number of men >65 needed to screen to prevent one AAA related death is 796 (95% confidence interval 621–1242) @ 3-5 yr follow-up” (RT @cantaskforce see Tweet)

  

3 – Clinical Practice Guideline: Evaluation of the Neck Mass in Adults – American Academy of Otolaryngology—Head and Neck Surgery Foundation (free)

See also: Executive Summary (free) AND News Release (free)

Commentaries: Neck Mass in Adults: Guideline for Evaluation Provides Framework for Timely Diagnosis – NewsWise (free) AND Guidelines Issued on Evaluating Neck Masses – Physician’s First Watch (free)

 

4 – A Comparison of Alkaline Water and Mediterranean Diet vs Proton Pump Inhibition for Treatment of Laryngopharyngeal Reflux – JAMA Otolaryngology Head Neck Surgery (free)

Commentaries: Could a Mediterranean diet be as good as drugs for acid reflux? – NHS Choices (free) AND Dietary Approach Found as Effective as Medications for Treating Type of Reflux Disease – The JAMA Network (free) AND Treating Reflux With Diet – The New York Times (10 articles per month are free)

A small retrospective cohort study suggests a plant-based, Mediterranean-style diet may be as effective as medication.

 

5 – The Joint Associations of Sedentary Time and Physical Activity With Mobility Disability in Older People: The NIH-AARP Diet and Health Study – The Journals of Gerontology (free)

Commentaries: Get Off The Couch Baby Boomers, Or You May Not Be Able To Later – NPR (free) AND Prospective Study Shows Just How Bad TV Can Be – Medscape (free registration required) AND Prolonged sitting and TV watching ‘dangerous’ for seniors – Medical News Today (free) AND TV viewing ‘a potent risk factor’ for disability – OnMedica (free)

 

6 – Guideline: National Partnership for Maternal Safety: Consensus Bundle on Severe Hypertension During Pregnancy and the Postpartum Period – Obstetrics & Gynecology (free)

Commentary: Management of Severe Maternal Hypertension During Pregnancy and Postpartum – Journal Watch (free)

 

7 – Hormonal contraceptive eligibility for women at high risk of HIV: Guidance Statement – World Health Organization (free PDF)

News release: Can women who are at high risk of acquiring HIV, safely use hormonal contraception? (free)

Frequently asked questions: Hormonal contraceptive eligibility for women at high risk of HIV (free)

Guideline Summary: Hormonal contraceptive eligibility for women at high risk of HIV: guidance statement – National Guideline Clearinghouse (free)

 

8 – Cardiovascular disease risk and androgen deprivation therapy in patients with localised prostate cancer: a prospective cohort study – British Journal of Cancer (link to abstract – $ for full-text)

Commentaries: Prostate cancer treatment associated with higher risk of heart failure – Cardiovascular Business (free) AND Hormone Treatment for Prostate Cancer Tied to Heart Risks – The New York Times (10 articles per month are free)

 

9 – Richard Lehman’s journal review, 11 September 2017 (free)

Richard Lehman reviews the latest research in the top medical journals.

 

10 – Adverse effects of proton-pump inhibitor use in older adults: a review of the evidence – Therapeutic Advances in Drug Safety (free)

 

Mon, September 11 – 10 Stories of The Day!

11Sep
2017

 

1 – Coursera – Free Online Health & Medicine Courses Starting Today!

– Easing the burden of obesity, diabetes and cardiovascular disease – University of Sidney

– Leading Healthcare Quality and Safety – The George Washington University

– Introduction to the Biology of Cancer – Johns Hopkins University

– Understanding Clinical Research: Behind the Statistics – University of Cape Town

– Health Across the Gender Spectrum – Stanford University

– Public Health in Humanitarian Crises – Johns Hopkins University

– Major Depression in the Population: A Public Health Approach – Johns Hopkins University

– Genomics: Decoding the Universal Language of Life – University of Illinois at Urbana-Champaign

– Living with Dementia: Impact on Individuals, Caregivers, Communities and Societies – Johns Hopkins University

– Health Care IT: Challenges and Opportunities – Icahn School of Medicine at Mount Sinai

– The People, Power, and Pride of Public Health – Johns Hopkins University

– The Science of Health Care Delivery – Arizona State University

– PrEParing: PrEP for Providers and Patients – Johns Hopkins University

 

2 – Management of Cardiac Involvement Associated With Neuromuscular Diseases: A Scientific Statement From the American Heart Association (free PDF)

News release: Experts aim to improve treatment for heart complications in people with neuromuscular disorders (free)

Top Ten Things to Know: Management of Cardiac Involvement Associated With Neuromuscular Diseases (free PDF)

Commentary: Statement on the Management of Cardiac Involvement Associated With Neuromuscular Diseases – Practice Update (free registration required)

 

3 – Comprehensive primary prevention of cardiovascular disease in women – Clinical Cardiology (free)

 

4 – Opinion: Cardiology Is Dead. Long Live Public Health – Cardiobrief (free)

 

5 – 11 Drugs You Should Seriously Consider Deprescribing – Medscape Slideshow (free registration required)

Related: Canadian Deprescribing Network (CaDeN) (free) AND CaDeN Deprescribing Guidelines and Algorithms (free) AND Deprescribing guidelines for the elderly – Ontario Pharmacy Evidence Network (free) AND Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Too Many Meds? America’s Love Affair With Prescription Medication – Consumer Reports (free) AND Patient often prescribed potentially futile drugs in their final months of life – Science Daily AND The Challenge of Polypharmacy: From Rhetoric to Reality – Royal Pharmaceutical Society and Royal College of General Practitioners Partnership (free PDF) Current and future perspectives on the management of polypharmacy – BMC Family Practice (free)

 

6 – Educating Girls, Ending Child Marriage – World Bank (free)

Related infographic and report: Putting a Price Tag on Child Marriage

“By keeping girls in school, girls would have a better chance for safety and security, to health and education, and to make their own life choices and decisions”.

“Being born to a mother younger than 18 increases the risk dying by the age of 5” (RT @WBG_Health see Tweet)

 

7 – Guidance on Forgoing Life-Sustaining Medical Treatment – Pediatrics (free)

News Release: Balancing act: Weighing the decision to withhold life-sustaining medical treatment (free)

 

8 – Palliative Care in Heart Failure: The PAL-HF Randomized, Controlled Clinical Trial – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Palliative Care Intervention Improves Quality of Life in Advanced Heart Failure Patients – American College of Cardiology, Latest in Cardiology (free) AND Palliative Care & CHF: PAL-HF trial – Pallimed (free)

 

9 – Development and risk factors of type 2 diabetes in a nationwide population of women with polycystic ovary syndrome – The Journal of Clinical Endocrinology & Metabolism (link to abstract – $ for full-text)

Commentaries: Type 2 diabetes risk four times higher in women with PCOS – Medical News Today (free) AND Researchers reveal link between PCOS, type 2 diabetes – The Endocrine Society, via EurekAlert (free)

 

10 – Addressing the Social Needs of Hypertensive Patients: The Role of Patient–Provider Communication as a Predictor of Medication Adherence – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Hypertension Medication Adherence May Be Improved by Collaborate Communication – Cardiology Advisor (free) AND Better Provider Communication Might Improve Medication Adherence – Medscape (free registration required) AND Talk Why, Not What for Better Antihypertensive Adherence – MedPage Today (free)

“Odds of poor med adherence 6x greater when patient-provider interactions don’t address patients’ unmet social needs” (RT @CircOutcomes see Tweet)

 

Fri, September 8 – 10 Stories of The Day!

8Sep
2017

 

1 – Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association (free)

See also: Advisory Highlights: Seven steps to keep your brain healthy from childhood to old age (free) AND News release: As brain problems increase, experts offer advice to keep yours healthy (free) AND Commentary: Optimal Cardiovascular Health and a Healthy Brain (free) AND Top Ten Things to Know: Defining Optimal Brain Health in Adults (free PDF)

Commentary: Heart and Stroke Groups Issue Advisory on Optimal Brain Health – Physician’s First Watch (free)

  

2 – Everybody active, every day: an evidence-based approach to physical activity – Public Health England (free report and other documents)

See also: 10 minutes brisk walking each day in mid-life for health benefits and towards achieving physical activity recommendations: evidence summary (free PDF)

Press release: 6 million adults do not do a monthly brisk 10-minute walk (free)

Commentaries: 10-minute walk a day app to tackle ‘inactivity epidemic’ – NHS Choices (free) AND 6 million middle-aged people take no exercise – The Guardian (free)

 

3 – Report: Size matters: The impact of upselling on weight gain – Royal Society for Public Health; Slimming World (free PDF)

See also: Press release (free)

Commentaries: Supersize us: upselling is fuelling the obesity epidemic, warns report – The Guardian (free) AND Going Large – Is Upselling Making You Gain Weight? – Medscape (free registration required)

 

4 – Extreme high high-density lipoprotein cholesterol is paradoxically associated with high mortality in men and women: two prospective cohort studies – European Heart Journal (free)

Commentaries: High levels of ‘good’ cholesterol linked to excessive mortality – University of Copenhagen, via ScienceDaily (free) AND Does ‘good cholesterol’ really deserve its name? – The Conversation (free) AND Can Your “Good” Cholesteral Be To High? – The New York Times (10 articles per month are free)

 

5 – Antipsychotic Use With and Without Comorbid Psychiatric Diagnosis Among Adults with Intellectual and Developmental Disabilities – The Canadian Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Antipsychotics common for adults with intellectual and developmental disabilities – Centre for Addiction and Mental Health (free) AND Antipsychotics Overused in Intellectually Disabled Adults – Medscape (free registration required)

“Antipsychotics are used inappropriately particularly in vulnerable groups: Poor children; Intellectually challenged; Autistic; Nursing homes. (RT @AllenFrancesMD see Tweet)

 

6 – Safety and Feasibility of Antiretroviral Preexposure Prophylaxis for Adolescent Men Who Have Sex With Men Aged 15 to 17 Years in the United States – JAMA Pediatrics (free)

Editorial: Human Immunodeficiency Virus Preexposure Prophylaxis for Adolescent Men (free)

Commentaries: Safety, Feasibility of PrEP for Adolescent Men Who Have Sex With Men – The JAMA Network (free) AND PrEP safe and effective for young men who have sex with men – OnMedica (free) AND HIV PrEP for adolescent men found to be safe, effective – UPI (free)

 

7 – Potential Implications of NORSTENT (Norwegian Coronary Stent Trial) in Contemporary Practice – Circulation (free)

Original article: Drug-Eluting or Bare-Metal Stents for Coronary Artery Disease – New England Journal of Medicine (free)

In this large trial, differences in outcomes between bare metal stents (BMS) and drug eluding stents (DES) were small. During 6 years of follow-up there was a 3.3% absolute risk reduction in any repeat revascularization with DES, without differences in cardiovascular mortality or death.

 

8 – Chronic Health Conditions and Key Health Indicators Among Lesbian, Gay, and Bisexual Older US Adults, 2013–2014 – American Journal of Public Health (link to abstract – $ for full-text)

Commentaries: Lesbian, Gay and Bisexual Older Adults Suffer More Chronic Health Conditions Than Heterosexuals, Study Finds – The University of Washington, via NewsWise (free) AND LGB Older Adults Suffer More Chronic Health Conditions Than Heterosexuals, Study Finds – Science Magazine (free)

 

9 – IBM pitched its Watson supercomputer as a revolution in cancer care. It’s nowhere close – STAT (free)

 

10 – Intravenous Versus Nonintravenous Benzodiazepines for the Cessation of Seizures: A Systematic Review and Meta-analysis of Randomized Controlled Trials – Academic Emergency Medicine (link to abstract – $ for full-text)

Source: Hospital Medicine Virtual Journal Club

 “Should you give your preferred benzo by the fastest means possible? Or establish an IV and administer via that route? The short answer provided by this study, is to give your benzo IM or IN. While seizures stopped sooner after IV administration, the additional time needed to establish an IV resulted in overall longer seizure time when administered via that method” (by Jeremy Fried in Research and Reviews in the Fastlane 182).

 

Thu, September 7 – 10 Stories of The Day!

7Sep
2017

 

1 – Guideline: Endometriosis: diagnosis and management – National Institute for Health and Care Excellence (NICE) (free)

News release: Suspect endometriosis in women with chronic pelvic pain, says NICE (free)

 

2 – Vision Screening in Children Aged 6 Months to 5 Years: US Preventive Services Task Force Recommendation Statement – JAMA (free)

USPSTF Recommendation Summary: Vision in Children Ages 6 Months to 5 Years: Screening (free)

Editorials: The 2017 US Preventive Services Task Force Report on Preschool Vision Screening – JAMA Ophthalmology (free) AND Vision Screening in Very Young Children—Making Sense of an Inexorable Diagnostic Process – JAMA Pediatrics (free)

Author interview: USPSTF Recommendation: Vision Screening in Children (free audio)

 

3 – Antidepressant use during pregnancy and psychiatric disorders in offspring: Danish nationwide register based cohort study – The BMJ (free)

Editorial: Prenatal exposure to antidepressants and increased risk of psychiatric disorders (free)

Commentary: Antidepressant Use During Pregnancy Linked to Psychiatric Disorders in Offspring – Physician’s First Watch (free)

 

4 – Treatment of idiopathic pulmonary fibrosis in Australia and New Zealand: A position statement from the Thoracic Society of Australia and New Zealand and the Lung Foundation Australia (free)

 

5 – European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis – endorsed by the European Academy of Neurology (free)

 

6 – Effectiveness of a Third Dose of MMR Vaccine for Mumps Outbreak Control – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Third Dose of MMR Vaccine to Reduce Risk of Mumps during Outbreaks? (free)

Commentary: Third dose of mumps vaccine could help stop outbreaks, researchers say – STAT (free)

 

7 – State of The Art Review: Perioperative tobacco use treatments: putting them into practice – The BMJ (free for 2 weeks)

 

8 – Review: The Diagnosis and Management of Bipolar I and II Disorders – Mayo Clinic Proceedings (free)

 

9 – Global Prevalence of Fetal Alcohol Spectrum Disorder Among Children and Youth: A Systematic Review and Meta-analysis – JAMA Pediatrics (link to abstract – $ for full-text)

Commentary: What Is the Global Prevalence of Fetal Alcohol Spectrum Disorder? – The JAMA Network (free)

 

10 – 2017 Focused Update of the 2016 ACC Expert Consensus Decision Pathway on the Role of Non-Statin Therapies for LDL-Cholesterol Lowering in the Management of Atherosclerotic Cardiovascular Disease Risk (free)

Commentary: Updated Decision Pathway For Non-Statin Therapies Published – American College of Cardiology, Latest in Cardiology (free)

 

Tue, September 5 – 10 Stories of The Day!

5Sep
2017

 

1 – Estimated economic impact of vaccinations in 73 low- and middle-income countries, 2001–2020 – Bulletin of the World Health Organization (free) (RT @Onisillos see Tweet)

Commentaries: Vaccines Save 20 Million Lives, $350 billion in Poor Countries since 2001 – Eshelman School of Pharmacy (free) AND Global vaccine program will save 20 million lives and $820 billion by 2020, research finds – International Business Times (free)

 

2 – Ranking 93 health interventions for low- and middle-income countries by cost-effectiveness – PLOS One (free) (RT @equitylist see Tweet)

 

3 – Effect of Palliative Care on Aggressiveness of End-of-Life Care Among Patients With Advanced Cancer – Journal of Oncology Practice (link to abstract – $ for full-text)

Commentaries: Palliative Care May Substantially Decrease Health-Care Utilization in Patients With Advanced Cancer – ASCO Post (free) AND End-of-Life Palliative Care Lowered Utilization for Patients With Cancer – AJMC (free) AND Palliative Care Cut Healthcare Use in Advanced Cancer – MedPage Today (free registration required)

Related guideline: Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

 

4 – Doctors want to give their cancer patients every chance. But are they pushing off hard talks too long? – STAT (free)

 

5 – Committee Opinion: Obesity in Adolescents – American College of Obstetricians and Gynecologists (free)

Commentary: ACOG Offers Tips for Managing Obesity in Adolescents – Physician’s First Watch (free)

 

6 – Can low doses of chemicals affect your health? A new report weighs the evidence – The Conversation (free)

Original report: Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals – The National Academies Press (free PDF)

Related Scientific Statement: EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals (free) AND Executive Summary (free)

Source: Global Health NOW Newsletter

 

7 – Richard Lehman’s journal review / 4 September 2017 (free)

Richard Lehman’s weekly review of medical journals.

 

8 – Zika virus: still no clear answers – The Globe and Mail (free) (RT @Onisillos  see Tweet)

 

9 – Self‐Care for the Prevention and Management of Cardiovascular Disease and Stroke: A Scientific Statement for Healthcare Professionals From the American Heart Association (free)

 

10 – Comparative Effectiveness and Safety of Cognitive Behavioral Therapy and Pharmacotherapy for Childhood Anxiety Disorders: A Systematic Review and Meta-analysis – JAMA Pediatrics (free)

Editorial: Medication and Cognitive Behavioral Therapy for Pediatric Anxiety Disorders: No Need for Anxiety in Treating Anxiety (free)

Commentary: SSRIs, Cognitive-Behavioral Therapy Effective for Childhood Anxiety – Physician’s First Watch (free) AND SSRIs, SNRIs Provide Modest Benefit to Kids with Mental Disorders – MedPage Today (free registration required)

 

Wed, September 6 – 10 Stories of The Day!

6Sep
2017

 

1 – Designing a High-Performing Health Care System for Patients with Complex Needs: Ten Recommendations for Policymakers – The Commonwealth fund (free)

Related: Redesigning Care for High-Cost, High-Risk Patients – Harvard Business Review (a few articles per month are free) AND Caring for High-Need, High-Cost Patients — An Urgent Priority – New England Journal of Medicine (free) AND Multimorbidity: clinical assessment and management – NICE Guideline (free) AND Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology (free) AND Focusing on High-Cost Patients — The Key to Addressing High Costs? – NEJM Catalyst (free) AND Richard Smith: The challenge of high need, high cost patients – The BMJ Blogs (free) AND Playbook: Better Care for People with Complex Needs – Institute for Healthcare Improvement (free)

 

2 – Reconciling the Effects of Screening on Prostate Cancer Mortality in the ERSPC and PLCO Trials – Annals of Internal Medicine (free)

Editorial: Prostate Cancer Screening: Time to Question How to Optimize the Ratio of Benefits and Harms (free)

Commentaries: A new study claims prostate cancer screenings significantly reduce deaths. Not everyone agrees – STAT (free) AND New Study Offers Support for Prostate Testing – The New York Times (10 articles per month are free)

 

3 – Scanning The Future, Radiologists See Their Jobs At Risk – NPR (free)

See more on the impact of artificial intelligence in healthcare in our June 14th issue (see #2), in our April 28th issue (see #1) and in our April 10th issue (see #8).

 

4 – Identifying incipient dementia individuals using machine learning and amyloid imaging – Neurobiology of Aging (free)

Commentaries: A.I., Big Data Project Predicts Dementia 2 Years Before Symptoms Onset, Researchers Show – Alzheimer’s News Today (free) AND Artificial intelligence predicts dementia before onset of symptoms – Science Daily (free)

See also related article and commentaries on Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons.

 

5 – Management of Atherosclerotic Carotid and Vertebral Artery Disease: 2017 Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS) (free)

Commentary with highlights from the document: European Society for Vascular Surgery Guidelines on the Management of Atherosclerotic Carotid and Vertebral Artery Disease (free)

 

6 – Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO) (free)

Related Guidelines: Management of febrile neutropaenia: ESMO Clinical Practice Guidelines (free) AND Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update (free)

 

7 – Headache and migraine: interventions for preventing or treating headache and migraine – Cochrane Library (free) (RT @CochraneUK see Tweet)

Migraine awareness week (3-9 September). Latest Cochrane Evidence on interventions for preventing or treating headache and migraine.

 

8 – Comprehensive assessment may reduce risk of delirium after hip fracture – NIHR Signal (free)

Original article: Comprehensive Geriatric Assessment for Prevention of Delirium After Hip Fracture: A Systematic Review of Randomized Controlled Trials – Journal of The American Geriatrics society (link to abstract – $ for full-text)

“Comprehensive geriatric assessment reduced the risk of delirium by 20% in patients having hip fracture surgery” (RT @NIHR_DC see Tweet)

 

9 – Physical Activity Frequency and the Risk of Stroke: A Nationwide Cohort Study in Korea – Journal of The American Heart Association (free)

“Even 1 to 2 times a week of moderate to vigorousintensity physical activity might be beneficial to prevent a firstever stroke in the general population… from a public health perspective, we need to encourage inactive people to start exercising with moreachievable goals”.

 

10 – Association between sedentary time and mortality across levels of frailty – Canadian Medical Association Journal (free)

Commentary: Prolonged sitting and frailty a deadly combination – Medical News Today (free) AND Inactivity Toll Worst for Frailest Elders – Medscape (free registration required)

 

Mon, September 4 – 10 Stories of The Day!

4Sep
2017

 

1 – Reducing the Global Burden of Cardiovascular Disease, Part 1: The Epidemiology and Risk Factors – Circulation Research (free)

 

2 – Reducing the Global Burden of Cardiovascular Disease, Part 2: Prevention and Treatment of Cardiovascular Disease – Circulation Research (free)

 

3 – Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure (free)

Source: Hospital Medicine Virtual Journal Club

 

4 – Review: Mechanical Ventilation: State of the Art – Mayo Clinic Proceedings (free)

 

5 – Guideline: Psoriasis: assessment and management – National Institute for Health and Care Excellence (NICE) (free)

 

6 – FDA News Release: FDA approval brings first gene therapy to the United States (free)

Commentaries: A $475,000 cancer drug: Wall Street sees ‘bargain’; patients see ‘completely broken’ system – HealthNewsReview (free) FDA Approves First CAR-T Cell Therapy for Pediatric Acute Lymphoblastic Leukemia – National Institutes of Health (free) AND FDA Approves First Gene-Altering Leukemia Treatment, Costing $475.000 – New York Times (10 articles per month are free) AND The FDA Approves a Landmark Cancer Drug – The Atlantic (free)

“…is a cancer therapy that represents several things at once: a game-changing way to treat cancer through genetic engineering, a novel paradigm for the biotech business, and the latest turn in the debate over just how astronomically expensive a life-saving therapy can be”. (from The Atlantic)

 

7 – ACC/AATS/AHA/ASE/ASNC/HRS/SCAI/SCCT/SCMR/STS 2017 Appropriate Use Criteria for Multimodality Imaging in Valvular Heart Disease (free)

Commentary with highlights from the document: Appropriate Use Criteria Published for Valvular Heart Disease Imaging Tests – American College of Cardiology, Latest in Cardiology (free)

 

8 – Accelerometer-assessed sedentary work, leisure time and cardio-metabolic biomarkers during one year: Effectiveness of a cluster randomized controlled trial in parents with a sedentary occupation and young children – PLOS One (free)

Commentaries: Sitting for 20 minutes less a day won’t make you ‘more muscly’ – NHS Choices (free) AND Just 21 minutes less sitting improves health – Medical News Today (free)

 

9 – New Nutrition Study Changes Nothing – The Atlantic (free) (RT @drjohnm see Tweet)

See original article and commentaries in our August 30 issue (see #1 and #2)

“Why the science of healthy eating appears confusing – but isn’t”

 

10 – Molluscum contagiosum is best left to clear by itself – NIHR Signal (free)

Original article: Interventions for cutaneous molluscum contagiosum – Cochrane Library (link to abstract – $ for full-text)

“Clinicians should advise people with a healthy immune system to leave molluscum contagiosum to clear by itself” (RT @NIHR_DC  see Tweet)

 

Fri, September 1 – 10 Stories of The Day!

1Sep
2017

 

1 – Public Health Guideline: Vitamin D: supplement use in specific population groups – National Institute for Health and Care Excellence (NICE) (free)

“Only test vitamin D status if someone has symptoms of deficiency or is at very high risk”

 

2 – Drug treatment effects on outcomes in heart failure with preserved ejection fraction: a systematic review and meta-analysis – Heart (free)

Commentary: Heart Failure with Preserved Ejection Fraction: Treatments Compared – MPR (free)

Source: ACP Journal Wise ($)

This study suggests a reduction in all-cause mortality with beta-blocker therapy in patients with heart failure with preserved ejection fraction. The authors recommend further trials to confirm the benefits of beta-blockers in this patient group.

 

3 – Drug-Free Interventions to Reduce Pain or Opioid Consumption After Total Knee Arthroplasty: A Systematic Review and Meta-analysis – JAMA Surgery (free)

Commentaries: Acupuncture, Electrotherapy after Knee Replacement Associated with Reduced and Delayed Opioid Use – The JAMA Network (free) AND Electrotherapy, Acupuncture Tied to Less Opioid Use After Knee Arthroscopy – Medscape (free registration required) AND Meta-Analysis: Electrotherapy, Acupuncture May Help Reduce Opioid Use After Knee Arthroplasty – Physician’s First Watch (free)

 

4 – Original articles: Cost-Effectiveness of Intensive versus Standard Blood-Pressure Control – New England Journal of Medicine (link to abstract – $ for full-text) AND Effect of Intensive Blood-Pressure Treatment on Patient-Reported Outcomes – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Analyses from SPRINT examine cost-effectiveness, patient-reported outcomes with intensive BP control – ACP Internist (free) AND Intensive BP Management Well Tolerated, Cost-effective: SPRINT – Medscape (free registration required) AND Can SPRINT Be Used To Inform Hypertension Treatment? – Cardiobrief (free)

Be sure to measure the patient’s blood pressure in the same way it was done in the SPRINT trial before adopting this study results in clinical practice (see Cardiobrief commentary)

 

5 – Natural History and Tumor Volume Kinetics of Papillary Thyroid Cancers During Active Surveillance – JAMA Otolaryngology Head & Neck Surgery (free for a week)

Author interview: Natural History and Tumor Volume Kinetics of Papillary Thyroid Cancers (free audio)

Commentaries: Findings Support Use of Active Surveillance for Low-Risk Papillary Thyroid Cancer – The JAMA Network (free) AND Many People Can Delay Treatment For Thyroid Cancer, Study Finds – NPR (free)

 

6 – How should we deal with non-culprit lesions during a STEMI? A mid-night conundrum – Evidently Cochrane (free)

Original article: Complete versus culprit-only revascularisation in ST elevation myocardial infarction with multi-vessel disease – Cochrane Library (link to abstract – $ for full-text)

 

7 – Preventing Teen Suicide: What Does the Evidence Shows – The New York Times (10 articles per month are free)

Related Guideline: Preventing Suicide: A Technical Package of Policy, Programs, and Practices – Centers for Disease Control and Prevention (free PDF)

 

8 – Low molecular weight heparin for prevention of venous thromboembolism in patients with lower-limb immobilization – Cochrane Library (link to abstract – $ for full-text)

“Moderate-quality evidence showed that the use of LMWH in outpatients reduced DVT when immobilization of the lower limb was required, when compared with no prophylaxis or placebo”. 

 

9 – Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006) – The Lancet (link to abstract – $ for full-text)

Commentary: Pembrolizumab Prolongs Overall Survival Compared With Ipilimumab in Melanoma – Cancer Therapy Advisor (free)

Source: Richard Lehman’s journal review (free)

 

10 – Impact of Obesity on Intensive Care Unit Resource Utilization After Cardiac Operations – The Annals of Thoracic Surgery (link to abstract – $ for full-text)

Commentaries: Obese cardiac patients a drain on ICU resources – Cardiovascular Business (free) AND Obese Cardiac Surgery Patients a Burden on ICU Resources – TCTMD (free) AND Post–Cardiac Surgery ICU Usage Rises With Increasing Obesity – Medscape (free registration required)

 

Thu, August 31 – 10 Stories of The Day!

31Aug
2017

 

1 – Comparison of recommendations for screening mammography using CISNET models – Cancer (link to abstract – $ for full-text)

Commentaries: Three questions to ask about calls to widen breast cancer screening – The Conversation (free) AND Comparison of Screening Recommendations for Mammography – ASCO Post (free)

Canadian Task Force on Preventive Health Care: Risks & Benefits, Age 40–49 (free) AND Risks & Benefits, Age 50–69 (free) AND Risks & Benefits, Age 70–74 (free) AND Full Guideline and Resources (free)

This article had a lot of attention from the media and suggests an annual screening starting at age 40 would prevent more breast cancer deaths. But screening has potential harms. For a clearer picture of the benefits and harms of screening in this context have a look at The Conversation commentary above and the infographics from the Canadian Task Force.

 

2 – History of breast feeding and risk of incident endometriosis: prospective cohort study – The BMJ (free)

Commentaries: Breast-Feeding Associated with Reduced Endometriosis Risk – Physician’s First Watch (free) AND Breast-Feeding May Lower Risk of Endometriosis – The New York Times (10 articles per month are free)

 

3 – Sleep architecture and the risk of incident dementia in the community – Neurology (link to abstract – $ for full-text)

Commentaries: Lack of REM sleep may lead to higher risk for dementia – Boston University School of Medicine, via EurekAlert (free) AND Less REM Sleep May Significantly Boost Dementia Risk – Medscape (free registration required) AND Dreaming may keep dementia at bay – Medical News Today (free) AND Lack of REM sleep tied to increased risk of dementia – Reuters (free)

 

4 – Association of Sleep-Disordered Breathing With Cognitive Function and Risk of Cognitive Impairment: A Systematic Review Meta-analysis – JAMA Neurology (link to abstract – $ for full-text)

Commentaries: Breathing Disorders During Sleep Tied to Cognitive Issues – MedPage Today (free registration required) AND Sleep-Disordered Breathing Raises Risk for Cognitive Decline – Medscape (free registration required)

This meta-analysis of observational studies suggests a possible association. Further studies are needed to examine whether the treatment of this condition can help in the prevention of dementia and in improvement of cognition.

 

5 – Chest CT Signs in Pulmonary Disease: A Pictorial Review – Chest (free)

Source: Critical Care Review Newsletter (free)

 

6 – Viewpoint: Management of Parkinson Disease in 2017: Personalized Approaches for Patient-Specific Needs – JAMA (free)

 

7 – Chronic cough postacute respiratory illness in children: a cohort study – Archives of Disease in Childhood (link to abstract – $ for full-text)

Commentary: Kids often have a chronic cough after respiratory illness – Reuters (free)

 

8 – Medical News & Perspectives: Medical Students Fall Short on Blood Pressure Check Challenge – JAMA (free)

Original Article: Medical students and measuring blood pressure: Results from the American Medical Association Blood Pressure Check Challenge – The Journal of Clinical Hypertension (free)

“Only 1 out of 159 medical students correctly performed all 11 elements in a BP check challenge w simulated patients” (RT @JAMA_current see Tweet)

 

9 – #ESCCongress – Clopidogrel or ticagrelor in acute coronary syndrome patients treated with newer-generation drug-eluting stents: CHANGE DAPT – EuroIntervention (link to abstract – $ for full-text)

Commentaries: Rethinking dual antiplatelet guidelines in acute coronary syndrome? (CHANGE-DAPT) – ESC Press Releases (free) AND Ticagrelor for DAPT Again Questioned in Current Era of PCI for ACS: CHANGE DAPT – Medscape (free registration required) AND CHANGE DAPT: Study Contests Benefit of Ticagrelor Over Clopidogrel After PCI in ACS – TCTMD (free)

 

10 – Resistance training may prevent obese older people becoming frail when losing weight – NIHR Signal (free)

Original article: Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults – New England Journal of Medicine (link to abstract – $ for full-text) AND Video Summary: Exercise and Dieting in Obese Older Adults (free)

 

Wed, August 30 – 10 Stories of The Day!

30Aug
2017

 

#ESCCongress – Highlights from the European Society of Cardiology Congress 2017 – Part III

 

1 – #ESCCongress – Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study – The Lancet (link to abstract – $ for full-text)

Commentaries: Revisiting dietary fat guidelines? (PURE) – ESC Press Release (free) AND PURE Investigators: Rethink Diet Guidance to Plug More Fats, Fewer Carbs – TCTMD (free) AND International study shows moderate consumption of fats and carbohydrates best for health – McMaster University, via EurekAlert (free) AND PURE: Findings Could Have Implications For Global Dietary Guidelines – ACC News Story (free) AND Huge Diet Study Questions Conventional Wisdom About Carbs And Fats – Cardiobrief (free)

 

2 – #ESCCongress – Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study – The Lancet (link to abstract – $ for full-text)

Commentaries: Reassessing the benefits of plant-based eating (PURE) – ESC Press Release (free) Fruit, Vegetable, Legume Intake and CVD Events – American College of Cardiology, Latest in Cardiology (free) AND Life-saving fruit and vegetable diet need only be three portions – study – The Guardian (free) AND Less Is More? Health Benefits of Fruits, Vegetables, and Legumes Seen at Lower Intake Levels – TCTMD (free)

 

3 – #ESCCongress – Study confirms safety of rapid algorithm to rule-out and rule-in myocardial infarction – ESC Press Release (free) (the results have not been published yet)

Commentary: ESC Rapid Rule-In, Rule-Out Algorithm for NSTEMI Safe, Accurate – Medscape (free registration required)

Related guideline: 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation (free) AND Other Resources (free)

 

4 – #ESCCongress – Underweight associated with highest mortality and costs after cardiac catheterization (free) (the results have not been published yet)

Commentaries: Underweight and Overlooked: Low BMI Patients May Be Highest-Risk Post-PCI – TCTMD (free) AND Underweight Patients Fare Worse After Heart Catheterization – Medscape (free registration required) AND ESC 2017: Underweight Is Associated With Highest Mortality and Costs After Cardiac Catheterization – PracticeUpdate (free registration required)

 

5 – #ESCCongress – Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease – New England Journal of Medicine (free)

Commentaries: Anacetrapib REVEALs ‘Modest’ Effect on Cardiovascular Outcomes – Medscape (free registration required) AND Anacetrapib Finds (Modest) Success Where All Other CETP Inhibitors Failed – TCTMD (free) AND REVEAL Revealed: A Slightly Positive CETP Inhibitor Trial – Cardiobrief (free)

Interesting new drug, but with modest benefits. During the median follow-up period of 4.1 years, the primary outcome occurred in fewer patients in the anacetrapib group than in the placebo group (10.8% vs. 11.8% / absolute risk difference = 1%, meaning 100 patients would have to be treated for 4.1 years to benefit 1 patient)

 

6 – #ESCCongress – Automatic external defibrillators save lives in amateur sports and fitness centres (free) (the results have not been published yet)

“Neurologically intact survival was 93% for patients treated with an onsite Automatic external defibrillator (AED) compared to 9% without an AED”

 

7 – Richard Lehman’s journal review, 29 August 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – The role of nutritional support in the physical and functional recovery of critically ill patients: a narrative review – Critical Care (free)

 

9 – Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017 – European Urology (free)

Commentary: International Consensus (or Not) on Management of Advanced Prostate Cancer – ASCO Post (free)

 

10 – Clinical Report: Pediatric Integrative Medicine – American Academy of Pediatrics (free)

AAP News: From acupuncture to yoga, report updates integrative medicine therapies (free)

Commentaries: AAP Recommendations Address Complementary Therapies – Medscape (free registration required) AND AAP: Counsel on Complementary Medicine: Natural doesn’t always mean safe – MedPage Today (free registration required)

 

Tue, August 29 – 10 Stories of The Day!

29Aug
2017

 

#ESCCongress – Highlights from the European Society of Cardiology Congress 2017 – Part II

 

1 – #ESCCongress – Oxygen Therapy in Suspected Acute Myocardial Infarction – New England Journal of Medicine (free)

Editorial: Is Oxygen Therapy Beneficial in Acute Myocardial Infarction? Simple Question, Complicated Mechanism, Simple Answer (free)

Commentaries: Oxygen therapy does not improve survival in patients with heart attack symptoms (DETO2X-AMI) – ESC Press Releases (free) AND Supplemental Oxygen Provides No Benefit to Patients With Suspected MI: DETO2X-AMI – TCTMD (free) AND Suspected MI and Normal Oxygen Saturation? Don’t Bother with Supplemental Oxygen – Physician’s First Watch (free)

 

2 – #ESCCongress – Population screening and intervention for vascular disease in Danish men (VIVA): a randomised controlled trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Screening for vascular disease saves one life for every 169 patients assessed (VIVA) – ESC Press Releases (free) AND VIVA: Could Population-Wide Screening Trial for AAA, PAD, and Hypertension Save Lives at Low Cost? – TCTMD (free) AND VIVA: Overall Mortality Significantly Reduced Among Older Men Receiving Triple Vascular Screening – American College of Cardiology, Latest in Cardiology (free)

 

3 – #ESCCongress – PATHWAY-2 uncovers main cause of drug-resistant hypertension, finds old drugs work best – ESC Press Releases (free) (the results have not been published yet)

Commentary: Prevention And Treatment of Hypertension With Algorithm based therapY-2 – PATHWAY-2 – American College of Cardiology, Latest in Cardiology (free)

 

4 – #ESCCongress – Bag-mask ventilation fails to improve on endotracheal intubation in cardiac arrest (CAAM) – ESC Press Releases (free) (the results have not been published yet)

Commentary: CAAM: Is Bag-Mask Ventilation Superior to ETI During CPR? – American College of Cardiology, Latest in Cardiology (free)

 

5 – #ESCCongress – Closure of left atrial appendage during heart surgery protects the brain (LAACS) – ESC Press Releases (free) (the results have not been published yet)

Commentary: LAACS: LAA Closure May Protect Against Long-Term Cerebral Ischemic Events – American College of Cardiology, Latest in Cardiology (free)

 

6 – #ESCCongress – Risk factor driven upstream atrial fibrillation therapy improves sinus rhythm maintenance (RACE 3) – ESC Press Releases (free) (the results have not been published yet)

Commentaries: Broad, Early AF Risk-Factor Intervention Preserves Sinus Rhythm: RACE-3 – Medscape (free registration required) AND Routine vs. Aggressive upstream rhythm Control for prevention of Early persistent atrial fibrillation in heart failure study – RACE 3 – American College of Cardiology, Latest in Cardiology (free)

 

7 – #ESCCongress – The Prognostic Value of Coronary Artery Calcium in the PROMISE Study – Circulation (free PDF)

Editorial: Computed Tomography or Functional Stress Testing for the Prediction of Risk: Can I Have My Cake and Eat It? (free PDF)

Commentary: Prospective Multicenter Imaging Study for Evaluation of Chest Pain – PROMISE – American College of Cardiology, Latest in Cardiology (free)

 

8 – Why developing countries must improve primary care – The Economist (free) (RT @AnjaNitzscheB see Tweet)

“The changing burden of disease requires a better approach to keeping people healthy”

 

9 – Necrotizing pancreatitis: Diagnose, treat, consult – Cleveland Clinic Journal of Medicine (free)

Source: Hospital Medicine Virtual Journal Club (free resource to find articles of interest)

 

10 – Using mesh does not improve results in vaginal prolapse surgery – NIHR Signal (free)

Original article: Mesh, graft, or standard repair for women having primary transvaginal anterior or posterior compartment prolapse surgery: two parallel-group, multicentre, randomised, controlled trials (PROSPECT) – The Lancet (free) AND Commentary: Mesh, graft, or standard repair for prolapse surgery? – The Lancet (free)

“About 12% of vaginal prolapse patients had complications from surgery using mesh” (RT @NIHR_DC see Tweet)

 

Mon, August 28 – 10 Stories of The Day!

28Aug
2017

 

#ESCCongress – Highlights from the European Society of Cardiology Congress 2017

 

1 – 2017 ESC/EACTS Guidelines for the management of valvular heart disease (free) (RT @rafavidalperez see Tweet)

Commentary: European Societies Issue New Valvular Heart Disease Guidelines, With Important Shifts – TCTMD (free)

See also: #ESCCongress Slides (free PPT file)

 

2 – 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC) (free) (RT @rafavidalperez see Tweet)

Commentary: ESC Updates Guidelines for Treating STEMI Patients – TCTMD (free)

See also: #ESCCongress Slides (free PPT file)

 

3 – 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS): Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries (free) (RT @rafavidalperez see Tweet)

See also: #ESCCongress Slides (free PPT file)

 

4 – 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS (free) (RT @rafavidalperez see Tweet)

See also: #ESCCongress Slides (free PPT file)

 

5 – Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease – New England Journal of Medicine (free)

Editorial by Dr. Eugene Braunwald: An Important Step for Thrombocardiology (free)

Commentaries: Cardiovascular Outcomes for People Using Anticoagulation Strategies – COMPASS – American College of Cardiology, Latest in Cardiology (free) AND COMPASS: Does Rivaroxaban Plus Aspirin Improve CV Outcomes in Patients With Stable Atherosclerotic Vascular Disease or PAD? – ACC News Story (free) AND Rivaroxaban, Aspirin, or Both in Stable Coronary Disease – Physician’s First Watch (free)

The primary outcome (composite of cardiovascular death, stroke, or myocardial infarction) occurred in fewer patients in the rivaroxaban-plus-aspirin group than in the aspirin-alone group (4.1% vs. 5.4% / Absolute risk difference = 1.3% / NNT = 76), but major bleeding events occurred in more patients in the rivaroxaban-plus-aspirin group (3.1% vs. 1.9% / Absolute risk difference = 1.2 / NNH = 83).

 

6 – Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation – New England Journal of Medicine (free)

Commentaries: Randomized Evaluation of Dual Antithrombotic Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With Nonvalvular Atrial Fibrillation Undergoing Percutaneous Coronary Intervention – RE-DUAL PCI – American College of Cardiology, Latest in Cardiology (free) Dual Antithrombotic Therapy Is Safe for Patients with AF and a New Stent – Physician’s First Watch (free) AND When two is better than three: Dual antithrombotic therapy cuts bleeding risk – Brigham and Women’s Hospital, via ScienceDaily (free)

“In summary, several lines of evidence now suggest that it is safe to treat atrial fibrillation patients who undergo coronary revascularization with anticoagulation (warfarin studied in WOEST, rivaroxaban studied in PIONEER AF-PCI, dabigatran studied in RE-DUAL PCI) and clopidogrel monotherapy” (from American College of Cardiology, Latest in Cardiology).

 

7 – Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease – New England Journal of Medicine (free)

Editorial: Targeting Inflammation in Coronary Artery Disease (free)

Commentaries: Anti-Inflammatory Therapy for Atherosclerotic Disease: A Step Closer? – Physician’s First Watch (free) AND CANTOS: Anti-inflammatory Agent Canakinumab Modestly Reduces Major CVD Events – TCTMD (free) AND CANTOS Validates Role Of Inflammation In Heart Disease – Cardiobrief (free)

“This widely anticipated study delivered some modestly positive results (fewer nonfatal MIs), some worrisome results (increased fatal infections), and some unexpected results (fewer cancer deaths)” (from Physician’s First Watch). 

 

8 – Catheter ablation improves outcomes in patients with heart failure and atrial fibrillation (CASTLE-AF) (free)

Commentary: CASTLE-AF: Catheter Ablation vs. Conventional Therapy For Patients With AFib and LV Dysfunction – American College of Cardiology, Latest in Cardiology (free)

The study has not been published yet, but the results suggest that patients with symptomatic paroxysmal or persistent AF and heart failure with ejection fraction less than 35% may have a better outcome with catheter ablation.

 

9 – Incidence of Previously Undiagnosed Atrial Fibrillation Using Insertable Cardiac Monitors in a High-Risk Population: The REVEAL AF Study (free)

Commentaries: What Do Implanted Cardiac Monitors Reveal About Atrial Fibrillation? – JAMA Cardiology (free) AND REVEAL AF: Incidence of AFib Could Be Substantial in Older Patients With Stroke Risk Factors – American College of Cardiology, Latest in Cardiology (free) AND Detection of Undiagnosed AF Using Insertable Cardiac Monitors – American College of Cardiology, Latest in Cardiology (free)

Implanted Cardiac Monitors showed the incidence of intermittent atrial fibrillation is extremely common among older individuals with stroke risk factors, but the clinical significance of these findings (do they need to be anticoagulated??) remains to be determined by further trials.

“Previous long-term monitoring studies have suggested that patients with short episodes of subclinical AF have a lower risk of stroke compared with traditional clinical AF, which raises important questions about the risk-benefit ratio of anticoagulation in this setting” (from Latest in Cardiology).

 

10 – CI Versus CABG in Patients With Type 1 Diabetes and Multivessel Disease – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Patients With Type 1 Diabetes and Multivessel Disease Have Greater Benefit From CABG Than PCI – American College of Cardiology, Latest in Cardiology (free) AND Revascularization in Patients With Type 1 Diabetes – American College of Cardiology, Latest in Cardiology (free) AND CABG Appears Superior to PCI for Patients With Type 1 Diabetes, Multivessel Disease – TCTMD (free)

“The observational findings support existing recommendations favoring surgical revascularization in patients with diabetes” (from TCTMD).

 

Fri, August 25 – 10 Stories of The Day!

25Aug
2017

 

1 – Diabetes and Hypertension: A Position Statement by the American Diabetes Association (free) (RT @Abraham_RMI and @ADA_Journals see Tweet)

Commentary: ADA Offers Position Statement on Diabetes and Hypertension – AJMC (free)

“the guideline continues the advice that most patients with diabetes should be treated to a blood pressure goal of <140/90 mm Hg; a goal of <130/80 can be considered for patients who have other cardiovascular risk factors” (from AJMC)

 

2 – Global, Regional, and National Burden of Rheumatic Heart Disease, 1990–2015 – New England Journal of Medicine (free)

Editorial: Rheumatic Heart Disease — An Iceberg in Tropical Waters (free) (RT @NEJM see Tweet with interesting table)

Quick Take Video Summary: What is the Global Burden of Rheumatic Heart Disease? (free)

Commentary: Death rates from rheumatic heart disease falling since 1990 – Institute for Health Metrics and Evaluation (free)

 

3 – Long-Term, Supplemental, One-Carbon Metabolism–Related Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) Cohort – Journal of Clinical Oncology (link to abstract – $ for full-text)

Commentaries: Vitamin B supplements linked to lung cancer – here’s why you probably don’t need to worry – The Conversation (free) AND High Doses of Vitamin B Linked to Lung Cancer Increase – Medscape (free registration required) AND High Dose Vitamin B Supplements Should Not Be Taken for Lung Cancer Prevention – Cancer Therapy Advisor (free) AND High doses of vitamin B tied to lung cancer risk, study says – CNN (free)

 

4 – Association of Lithium in Drinking Water With the Incidence of Dementia – JAMA Internal Medicine (free)

Editorial: Could Lithium in Drinking Water Reduce the Incidence of Dementia? (free)

Commentaries: Lithium in drinking water may affect Alzheimer’s risk – Reuters (free) AND Dementia Rates Fall with Rising Lithium Levels in Water – MedPage Today (free registration required) AND Lithium in Drinking Water Linked to Lower Dementia Risk? – Physician’s First Watch (free) AND Lithium in tap water may cut dementia – BBC Health (free)

 

5 – The Case for a Breakfast Feast – The New York Times (free)

Related article: Meal Frequency and Timing Are Associated with Changes in Body Mass Index in Adventist Health Study 2 – The Journal of Nutrition (link to abstract – $ for full-text)

 

6 – EULAR recommendations for the use of imaging in the clinical management of peripheral joint osteoarthritis – Annals of Rheumatic Diseases (free)

 

7 – British Society of Gastroenterology position statement on serrated polyps in the colon and rectum – Gut (free)

 

8 – Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory tract infections in 195 countries: a systematic analysis for the Global Burden of Disease Study 2015 – Lancet Infectious Diseases (free) (RT @simonihay and @IHME_UW see Tweet)

Invited commentary: Measuring progress on preventing pneumonia deaths: are we there yet? (free)

 

9 – A bold open-access push in Germany could change the future of academic publishing – Science (free) (RT @hildabast and @RickyPo see Tweet)

Related commentary: Sci-Hub’s cache of pirated papers is so big, subscription journals are doomed, data analyst suggests – Science (free)

 

10 – Drug reduces deaths from bleeding after childbirth – NIHR Signal (free)

Original article: Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial – The Lancet (free) and Editorial: WOMAN: reducing maternal deaths with tranexamic acid (free)

“Tranexamic acid reduces risk of death from bleeding after childbirth by 31% when given within three hours”. (RT @NIHR_DC see Tweet)

 

Thu, August 24 – 10 Stories of The Day!

24Aug
2017

 

1 – Effect of Oral Prednisolone on Symptom Duration and Severity in Nonasthmatic Adults With Acute Lower Respiratory Tract Infection: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Oral Steroid Does Not Reduce Lower Respiratory Tract Infection Symptoms in Nonasthmatic Adults – JAMA Network (free) AND No Benefit for Oral Steroids in Lower Respiratory Tract Infection – Medscape (free registration required) AND Don’t use steroids for chest infections, GPs advised – Pulse (free)

In patients with acute respiratory infection without evidence of pneumonia or asthma, the addition of corticosteroids did not reduce symptom duration or severity.

 

2 – Screening for Occult Cancer in Patients With Unprovoked Venous Thromboembolism: A Systematic Review and Meta-analysis of Individual Patient Data – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Outcomes of limited cancer screening after unprovoked VTE similar to extensive screening – ACP Hospitalist (free) AND Cancer Screening Not Recommended in Patients With VTEs – Medscape (free registration required) AND Extensive cancer screening may not improve outcomes for patients with unprovoked venous thromboembolism – 2 Minute Medicine (free) AND Screening for Occult Cancer in Patients With Unprovoked Venous Thromboembolism – ASCO Post (free)

 

3 – Splenic trauma: WSES classification and guidelines for adult and pediatric patients – World Journal of Emergency Surgery (free)

 

4 – Longer sleep is associated with lower BMI and favorable metabolic profiles in UK adults: Findings from the National Diet and Nutrition Survey – PLOS One (free)

Commentaries: Short sleep linked to body mass, waist size – Reuters (free) AND Insufficient sleep may be adding to your waistline – University of Leeds, via Science Daily (free)

 

5 – ESO-ESMO 3rd international consensus guidelines for breast cancer in young women (BCY3) – The Breast (free)

 

6 – Update of EULAR recommendations for the treatment of systemic sclerosis – Annals of Rheumatic Diseases (free)

 

7 – Effect of Natriuretic Peptide–Guided Therapy on Hospitalization or Cardiovascular Mortality in High-Risk Patients With Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Natriuretic Peptide-Guided Therapy No Better Than Usual Care in Heart Failure Patients – Physician’s First Watch (free) AND NT-proBNP Tx Disappoints for HF Drug Titration – MedPage Today (free registration required)

 

8 – Global Burden of Sugar-Related Dental Diseases in 168 Countries and Corresponding Health Care Costs – Journal of Dental Research (link to abstract – $ for full-text)

Commentaries: High sugar consumption gives rise to dental treatment costs in the billions – Science Daily (free)

Worldwide, people are eating far too much sugar. This has negative consequences for their teeth and for their purses: seen at the global level, the costs of dental treatment are currently running at around $172 billion”

 

9 – Benefits and Harms of Osteoporosis Medications in Patients With Chronic Kidney Disease: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Benefits and harms of osteoporosis medications unclear for patients with CKD – Medical News Today (free) AND Benefits and harms of osteoporosis medications unclear for patients with CKD – 2 Minute Medicine (free)

Source: ACP Journal Club ($)

 

10 – National Estimates of Reductions in Acute Gastroenteritis–Related Hospitalizations and Associated Costs in US Children After Implementation of Rotavirus Vaccines – Journal of the Pediatric Infectious Diseases Society (free)

Commentary: Rotavirus vaccines continue to reduce diarrhea hospitalizations, medical costs in US kids – Medical News Today (free) AND Study: Rotavirus vaccine cuts healthcare costs in US children – CIDRAP (free)

 

Wed, August 23 – 10 Stories of The Day!

23Aug
2017

 

1 – Risk of Arterial Thromboembolism in Patients With Cancer – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Cancer Patients at Heightened Risk for Arterial Thromboembolism – American College of Cardiology, Latest in Cardiology (free) AND Thromboembolism Risk Doubled in Cancer Patients – Medscape (free registration required) AND Cancer patients carry double the short-term risk of arterial thromboembolism – Cardiovascular Business (free) AND Short-Term Risk of Arterial Thromboembolism in Newly Diagnosed Patients With Cancer – ASCO Post (free)

 

2 – Effect of Oral Dexamethasone Without Immediate Antibiotics vs Placebo on Acute Sore Throat in Adults: A Randomized Clinical Trial – JAMA (free)

Multimedia: Author Interview (free) AND JAMA Report Video (free)

Commentaries: Study Examines Effectiveness of Steroid Medication for Sore Throat – The JAMA Network (free) AND Corticosteroids for sore throat: a mixed bag of results – Clinical Advisor (free)

Source: ACP Journal Club ($)

Dexamethasone increased complete symptom resolution at 48 hours (35.4% vs 27.1%), but not at 24 hours. Trade-offs between the benefits and risks of dexamethasone in this situation are uncertain.

 

3 – Prevention of acute kidney injury and protection of renal function in the intensive care unit: update 2017 – Intensive Care Medicine (free)

Expert opinion of the Working Group on Prevention, AKI section, European Society of Intensive Care Medicine

 

4 – Guideline: Antenatal Corticosteroid Therapy for Fetal Maturation – American College of Obstetricians and Gynecologists (free)

See also: Summary

Related: Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth – Cochrane Library (link to abstract – $ for full-text) AND A dose of corticosteroids benefit most women anticipating a preterm delivery – NIHR Signals (free)

 

5 – Guideline: Opioid Use and Opioid Use Disorder in Pregnancy – American College of Obstetricians and Gynecologists (free)

See also: Summary

Related: Opioid Use in Pregnancy, Neonatal Abstinence Syndrome, and Childhood Outcomes: Executive Summary of a Joint Workshop by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, American College of Obstetricians and Gynecologists, American Academy of Pediatrics, Society for Maternal-Fetal Medicine, Centers for Disease Control and Prevention, and the March of Dimes Foundation (free)

 

6 – Is Weight Loss Associated with Less Progression of Changes in Knee Articular Cartilage among Obese and Overweight Patients as Assessed with MR Imaging over 48 Months? Data from the Osteoarthritis Initiative – Radiology (link to abstract – $ for full-text)

Commentaries: Weight Loss Can Slow Down Knee Joint Degeneration – RSNA Press Release (free) AND Osteoarthritis: Knee joint degeneration slowed with weight loss, study confirms – Medical News Today (free)

 

7 – Particulate Matter Exposure and Stress Hormone Levels: A Randomized, Double-Blind, Crossover Trial of Air Purification – Circulation (free)

Commentaries: Air pollution ups stress hormones, alters metabolismo – Reuters (free) AND AND Novel Study Shows How Air Pollution Increases CVD Risk – MedPage Today (free registration required) AND Air pollution linked to cardiovascular disease; air purifiers may lessen impact – American Heart Association, via Science Daily (free)

Related: The cost of a polluted environment: 1.7 million child deaths a year, says WHO – World Health Organization (free) AND Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015 – The Lancet (free) AND Death in the Air: Air Pollution Costs Money and Lives – World Bank (free infographic and report)

 

8 – Systemic Therapy for Stage IV Non–Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

Commentary: ASCO Guideline on Stage IV NSCLC Therapy Updated – ASCO Post (free)

 

9 – The Saudi Thoracic Society guidelines for diagnosis and management of noncystic fibrosis bronchiectasis – Annals of Thoracic Medicine (free)

 

10 – Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets – Cancer Cell (free)

Commentaries: Liquid Biopsy Reads RNA Collected by Platelets to Diagnose Cancer – Genetic Engineering & Biotechnology News (free) AND Blood biopsy test reads platelets to detect human lung cancer – Cell Press, via EurekAlert (free)

Related: Analysis of Plasma Epstein–Barr Virus DNA to Screen for Nasopharyngeal Cancer – New England Journal of Medicine (link to abstract – $ for full-text) AND Video – EBV DNA Screening for Nasopharyngeal Carcinoma (free) AND Can a ‘liquid biopsy’ detect cancer and save lives? – STAT (free) AND Plasma Epstein–Barr virus DNA useful for nasopharyngeal carcinoma screening – 2 Minute Medicine (free)

 

Tue, August 22 – 10 Stories of The Day!

22Aug
2017

 

1 – Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents – American Academy of Pediatrics (free)

News release: AAP issues new pediatric hypertension clinical practice guideline – AAP News (free)

 

2 – Factors Associated With Choice of Infant Sleep Position – Pediatrics (free)

Commentaries: Less than half of mothers place sleeping infants supine – 2 Minute Medicine (free) AND Most moms aren’t putting babies to sleep safely, study says – CNN (free) AND Less Than Half of Mothers Report Always Putting Babies to Sleep in Supine Position – Physician’s First Watch (free) AND Parents still failing to put babies to sleep on their backs – Reuters (free)

Placing infants in the supine position for sleep reduces the risk of sudden unexpected infant death and has been recommended by the American Academy of Pediatrics since 2005. Nevertheless, in this survey only 43,7% of mothers placed their infants exclusively in supine position for sleep.

 

3 – Hypertensive Disorders in Pregnancy and the Risk of Subsequent Cardiovascular Disease – Perinatal and Paediatric Epidemiology (free)

Commentaries: Study: Hypertension in pregnancy may affect long-term heart health – UPI (free) AND Hypertension during pregnancy may affect women’s long-term cardiovascular health – Wiley, via EurekAlert (free)

Related: Women with High-Risk Pregnancies Are More Likely To Develop Heart Disease – NPR (free) AND Adverse Pregnancy Conditions, Infertility, and Future Cardiovascular Risk: Implications for Mother and Child – Cardiovascular Drugs and Therapy (free)

 

4 – Medical News & Perspectives: Chess Study Revives Debate Over Cognition-Enhancing Drugs – JAMA (free)

Related: Growing use of smart drugs by students could be a recipe for disaster – The Conversation (free) AND Brain Hackers Seeking Peak Performance Use Risky Chemical Cocktails: “Smart drugs” are not clinically proven and could be dangerous – Scientific American (free) AND Universities must do more to tackle use of smart drugs, say experts – The Guardian (free) AND Tweaking brains with ‘smart drugs’ to get ahead in Silicon Valley – The Washington Post (free) AND Professors take same ‘smart drugs’ as students to keep up with workloads, claims academic – Independent (free)

 

5 – When surgery is just a stitch-up – The Guardian (RT @Onisillos  see Tweet)

Related article: Use of placebo controls in the evaluation of surgery: systematic review – The BMJ (free)

“With evidence mounting that many minor operations owe their success to the placebo effect, is it time to call a halt to some routine procedures?”

 

6 – Smoking Cessation Pharmacotherapy Among Smokers Hospitalized for Coronary Heart Disease – JAMA Internal Medicine (free)

Commentaries: Smokers hospitalized for heart attacks often don’t get cessation drugs – Reuters (free) AND Smokers Hospitalized for CHD Rarely Receive Cessation Pharmacotherapy During Hospitalization – American College of Cardiology, Latest in Cardiology (free)

 

7 – Re-analysis of All-Cause Mortality in the U.S. Preventive Services Task Force 2016 Evidence Report on Colorectal Cancer Screening – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Flexible Sigmoidoscopy Tied to Lower Mortality Risk – Physician’s First Watch (free) AND Flexible Sigmoidoscopy Reduces All-Cause Mortality – Medscape (free registration required)

 

8 – The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Inherited Polyposis Syndromes – Diseases of the Colon & Rectum (free)

 

9 – Oncological patients in the intensive care unit: prognosis, decision-making, therapies and end-of-life care – Swiss Medical Weekly (free)

Source: Critical Care Review Newsletter

 

10 – Uric acid and incident dementia over 12 years of follow-up: a population-based cohort study – Annals of Rheumatic Diseases (link to abstract – $ for full-text)

Commentaries: Elevated Uric Acid Linked to Dementia in the Elderly – MedPage Today (free registration required) AND Dementia risk may be higher in elderly patients with high serum uric acid levels – ACP Internist (free)

 

Fri, August 18 – 10 Stories of The Day!

18Aug
2017

 

1 – A randomized synbiotic trial to prevent sepsis among infants in rural India – Nature (free PDF)

Commentaries: At Last, a Big, Successful Trial of Probiotics – The Atlantic (free) AND Probiotic Bacteria Could Protect Newborns From Deadly Infection – NPR Goats and Soda (free) AND Seeding the Gut Microbiome Prevents Sepsis in Infants – The Scientist (free)

 

2 – Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015 – Lancet Respiratory Medicine (free)

Invited commentary: COPD and asthma: the emergency is clear, now is the time for action (free)

 

3 – Perspective: Saying Goodbye to Lectures in Medical School: Paradigm Shift or Passing Fad? – New England Journal of Medicine (free)

Related: Vermont Medical School Says Goodbye To Lectures – NPR (free)

 

4 – Analysis – Too much medicine: Mapping the drivers of overdiagnosis to potential solutions – The BMJ (free)

Related: Overdiagnosis, ethics, and trolley problems: why factors other than outcomes matter – The BMJ (free) AND The overdiagnosis community targets solutions – The BMJ (free) AND Are expanding disease definitions unnecessarily labelling women with polycystic ovary syndrome? – The BMJ (free) AND When technology creates uncertainty: pulse oximetry and Overdiagnosis of hypoxaemia in bronchiolitis – The BMJ (free)

 

5 – The global burden of tuberculosis mortality in children: a mathematical modelling study – The Lancet Global Health (free)

Commentaries: Tuberculosis in children: under-counted and under-treate – The Lancet Global Health (free) AND TB killed an estimated 239,000 children in 2015, nearly all of them untreated, study finds – Science Speaks Blog (free)

 

6 – A comparison of early versus late initiation of renal replacement therapy for acute kidney injury in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials – BMC Nephrology (free)

Source: Critical Care Reviews Newsletter

Early initiation of RRT in critically ill patients did not result in reduced mortality, change in renal function recovery, duration of RRT, renal recovery time, mechanical ventilation time or complications.

 

7 – Recommendations for HIV Screening of Gay, Bisexual, and Other Men Who Have Sex with Men — United States, 2017 – CDC, MMWR (free)

@CDC_HIVAIDS recommends men who have sex with men be tested for HIV at least annually”. (RT @CDCMMWR see Tweet)

 

8 – Special issue: Topical Collection on Decompensated Heart Failure – Current Heart Failure Reports

Source: Critical Care Reviews Newsletter

– Inpatient Monitoring of Decompensated Heart Failure: What Is Needed? (free)

– Acute Heart Failure: Definition, Classification and Epidemiology (free)

– Mechanical Circulatory Support for Decompensated Heart Failure (free)

– Pharmacological and Non-pharmacological Treatment for Decompensated Heart Failure: What Is New? (free)

– Venous Congestion, Endothelial and Neurohormonal Activation in Acute Decompensated Heart Failure: Cause or Effect? (free)

– Current Approach to Decongestive Therapy in Acute Heart Failure (free)

 

9 – A National Implementation Project to Prevent Catheter-Associated Urinary Tract Infection in Nursing Home Residents – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Study Shows 54 Percent Drop in CAUTIs Among Nursing Home Residents – Infection Control Today (free) AND AHRQ safety program helps cut catheter infections by more than 50% among nursing home patients, JAMA study shows – Healthcare Finance (free) AND Implementing technical and socioadaptive bundles may decrease catheter-associated urinary tract infections in nursing homes – 2 Minute Medicine (free) AND Nursing homes cut urinary tract infections in half through focused effort on catheter care – Michigan University, via EurekAlert (free)

Related: Toolkit for Reducing Catheter-Associated Urinary Tract Infections (CAUTI) – Agency for Healthcare Research and Quality (free resources)

 

10 – Review: The role of bariatric surgery to treat diabetes: current challenges and perspectives – BMC Endocrine Disorders (free)

 

Mon, August 21 – 10 Stories of The Day!

21Aug
2017

 

1 – Separate and combined associations of obesity and metabolic health with coronary heart disease: a pan-European case-cohort analysis – European Heart Journal (link to abstract – $ for full-text)

Commentaries: ‘Fat but fit’ people may still be at risk of heart disease – NHS Choices (free) AND ‘Fat but fit’ still has higher risk of heart disease, study confirms – CNN (free) AND ‘Fat but Fit’ is Myth; New UK Study Finds BMI>25 Ups MI Risk – Medscape (free registration required) AND ‘Fat but fit’ still risk heart disease – BBC (free)

 

2 – Clinical Practice Guideline: Safe Medication Use in the ICU – Critical Care Medicine (free)

See also: Executive Summary (free)

 

3 – Free Online Courses Starting Today

– Introduction to Health Technology Assessment – University of Glasgow and FutureLearn

– Science of Exercise – University of Colorado Boulder and Coursera

– Psychological First Aid – Johns Hopkins University and Coursera

– Epidemiology in Public Health Practice – Johns Hopkins University and Coursera

– Tropical Parasitology: Protozoans, Worms, Vectors and Human Diseases – Duke University, Kilimanjaro Christian Medical University College and Coursera

– Essentials of Global Health – Yale University and Coursera

– Understanding Cancer Metastasis – Johns Hopkins University and Coursera

– Advanced Neurobiology I – Peking University and Coursera

– Anatomy of the Abdomen and Pelvis; a journey from basis to clinic – Leiden University Medical Center and Coursera

– Systems Thinking In Public Health – Jonhs Hopkins University and Coursera

– Bacteria and Chronic Infections – University of Copenhagen and Coursera

– Introduction to Breast Cancer – Yale University and Coursera

– Healthcare Innovation and Entrepreneurship – Duke University and Coursera

– Foundations for Assisting in Home Care – The State University of New York and Coursera

 

4 – Acute Kidney Injury After Computed Tomography: A Meta-analysis – Annals of Emergency Medicine (link to abstract – $ for full-text)

Commentary: When kidneys are injured, CT contrast isn’t the culprit – Health Imaging (free)

Related article: Risk of Acute Kidney Injury After Intravenous Contrast Media Administration – Annals of Emergency Medicine (free)

Source: Hospital Medicine Virtual Journal Club

Compared with noncontrast CT, contrast-enhanced CT was not significantly associated with either acute kidney injury, need for renal replacement therapy, or all-cause mortality.

 

5 – Trajectories of energy drink consumption and subsequent drug use during young adulthood – Drug & Alcohol Dependence (link to abstract – $ for full-text)

Commentaries: Study suggests energy drinks can lead to cocaine use – News.com.au (free text and video) AND Energy Drinks May Trigger Future Substance Use – Medscape (free registration required)

 

6 – Sleep Duration and Risk of Type 2 Diabetes – Pediatrics (link to abstract – $ for full-text)

Commentaries: Lack of sleep tied to higher risk of diabetes in kids – Reuters (free) AND Sleep in Children Linked to Later Risk of Type 2 Diabetes – AJMC (free) AND Insufficient sleep raises type 2 diabetes risk in children – Medical News Today (free) AND Sleep duration inversely related to childhood type 2 diabetes risk makers – 2 Minute Medicine (free)

 

7 – Review: Postoperative pulmonary complications – British Journal of Anaesthesia (free)

Source: Critical Care Reviews Topic of The Week

 

8 – When Sports Injuries Lead to Arthritis in Joints – The New York Times (10 articles per month are free)

Related guideline: The Role of Athletic Trainers in Preventing and Managing Posttraumatic Osteoarthritis in Physically Active Populations: a Consensus Statement of the Athletic Trainers’ Osteoarthritis Consortium (free)

 

9 – NCCN Guidelines Insights: Palliative Care, Version 2.2017 – JNCCN (free)

Related guidelineIntegration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

 

10 – Neurodevelopmental outcome at 2 years for preterm children born at 22 to 34 weeks’ gestation in France in 2011: EPIPAGE-2 cohort study – The BMJ (free)

Commentaries: Ahead of their time – The BMJ (free) AND Preemies do better now than years ago, but still at risk – Reuters (free) AND Premature baby survival rates are improving – OnMedica (free)

 

Thu, August 17 – 10 Stories of The Day!

17Aug
2017

 

1 – Special issue: 60 years of metformin use – Diabetologia (Source: ACP Diabetes Monthly)

– Editorial: 60 years of metformin use: a glance at the past and a look to the future (free)

– Metformin: historical overview (free)

– The mechanisms of action of metformin (free)

– Metformin: clinical use in type 2 diabetes (free)

– A new perspective on metformin therapy in type 1 diabetes (free)

– Metformin for diabetes prevention: insights gained from the Diabetes Prevention Program/Diabetes Prevention Program Outcomes Study (free)

– Metformin use in pregnancy: promises and uncertainties (free)

– Impact of metformin on cardiovascular disease: a meta-analysis of randomised trials among people with type 2 diabetes (free)

– Metformin and ageing: improving ageing outcomes beyond glycaemic control (free)

– Repurposing metformin for the prevention of cancer and cancer recurrence (free)

– The pharmacogenetics of metformin (free)

– Metformin therapy for the reproductive and metabolic consequences of polycystic ovary syndrome (free)

– The effects of metformin on gut microbiota and the immune system as research frontiers (free)

 

2 – Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9 – Science (link to abstract – $ for full-text)

Commentaries: Birth of CRISPR’d pigs advances hopes for turning swine into organ donos – STAT (free) AND Gene editing to remove viruses brings transplant organs from pigs a step closer – The Guardian (free) AND Gene Editing Spurs Hope for Transplanting Pig Organs Into Humans – New York Times (10 articles per month are free) AND Gene editing brings pig organ transplant closer – NHS Choices (free) AND Scientists edit pig genome with goal of human organ transplants – CNN (free text and video)

 

3 – Five-Year Outcomes after On-Pump and Off-Pump Coronary-Artery Bypass – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Off-Pump CABG Raises Long-Term Mortality Risk – Cardiobrief (free) AND Newer method of open-heart surgery carries more risks, study finds – STAT (free)

 

4 – Benefits and safety of gabapentinoids in chronic low back pain: A systematic review and meta-analysis of randomized controlled trials – PLOS Medicine (free)

Commentaries: Gabapentinoids Seem to Offer Little Benefit, Substantial Risks in Low Back Pain – Physician’s First Watch (free) AND Evidence does not support the use of gabapentinoids for chronic low back pain – PLOS, via Science Daily (free) AND Gabapentinoids for Chronic Low Back Pain? Not So Fast – Practical Pain Management (free)

Pregabalin and gabapentin have significant risk of adverse effects without any demonstrated benefit in chronic low back pain.

 

5 – Bored reading science? Let’s change how scientists write – The Conversation (free) (RT @Onisillos see Tweet)

“Science communicators, journalists, entrepreneurs, policymakers and interested members of the general public are all motivated to follow the latest scientific research. And yet, strangely enough, science papers are a communication tool but they are not that effective at communication”.

 

6 – The Fight Against Antibiotic-Resistant Bacteria Might Start With Vaccines – Allice Callahan, via FiveThirtyEight (free) (RT @greg_folkers see Tweet with infographic)

 

7 – Cardiovascular mortality and morbidity in patients with type 2 diabetes following initiation of sodium-glucose co-transporter-2 inhibitors versus other glucose-lowering drugs (CVD-REAL Nordic): a multinational observational analysis – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentaries: SGLT2 Agents Cut CV Events in ‘Real-World’ Analysis – MedPage Today (free registration required) AND Cardiovascular disease and mortality appear lower in patients on SGLT2 inhibitors – ACP Diabetes (free)

Related article: Lower Risk of Heart Failure and Death in Patients Initiated on SGLT-2 Inhibitors Versus Other Glucose-Lowering Drugs: The CVD-REAL Study – Circulation (free PDF)

Another observational study suggests this class of drugs may reduce cardiovascular mortality and morbidity.

 

8 – The Risk of Adverse Pregnancy Outcomes Following Nonobstetric Surgery During Pregnancy: Estimates From a Retrospective Cohort Study of 6.5 Million Pregnancies – Annals of Surgery (free)

Source: Journal Watch ($)

we found that the risk associated with nonobstetric surgery was relatively low, confirming that surgical procedures during pregnancy are generally safe”

 

9 – Study: diet soda can really mess with your metabolism – VOX (free)

Original article: Integration of Sweet Taste and Metabolism Determines Carbohydrate Reward – Current Biology (link to abstract – $ for full-text)

See also a related meta-analysis showing little evidence of benefit from the consumption of artificial sweeteners for weight loss in our July 18th issue (see #2)

“New research helps explain why artificial sweeteners are linked to obesity and metabolic disease”.

 

10 – Talking therapy given by parents shows promise for childhood anxiety disorders – NIHR Signal (free)

Original article: Clinical outcomes and cost-effectiveness of brief guided parent-delivered cognitive behavioural therapy and solution-focused brief therapy for treatment of childhood anxiety disorders: a randomised controlled trial – The Lancet Psychiatry (free) AND Commentary: Low-intensity interventions for anxiety disorders (free)

“70% of children receiving guided parent-delivered CBT had recovered from anxiety six months after treatment” (RT @NIHR_DC see Tweet)

 

Wed, August 16 – 10 Stories of The Day!

16Aug
2017

 

1 – The Effects of Cannabis Among Adults With Chronic Pain and an Overview of General Harms: A Systematic Review – Annals of Internal Medicine (free)

Related article: Benefits and Harms of Plant-Based Cannabis for Posttraumatic Stress Disorder: A Systematic Review – Annals of Internal Medicine (free)

Commentaries: Evidence on cannabis for chronic pain and PTSD – American College of Physician’s, via EurekAlert (free) AND Evidence Lacking on Benefits of Cannabis for Treating Chronic Pain, PTSD – Physician’s First Watch (free) AND Limited evidence available to determine effectiveness and safety of cannabis to treat chronic pain – 2 Minute Medicine (free) AND Little evidence that marijuana helps chronic pain, PTSD, studies find – CNN (free text and video)

 

2 – Blood pressure targets for hypertension in older adults – Cochrane Library (free)

Full review: Blood pressure targets for hypertension in older adults – Cochrane Library (link to abstract – $ for full-text)

Related guideline: Pharmacologic Treatment of Hypertension in Adults Aged 60 Years or Older to Higher Versus Lower Blood Pressure Targets: A Clinical Practice Guideline From ACP and AAFP (free)

“At the present time there is insufficient evidence to know whether a higher BP target (less than150 to 160/95 to 105 mmHg) or a lower BP target (less than 140/90 mmHg) is better for older adults with high BP”

 

3 – Analysis of Plasma Epstein–Barr Virus DNA to Screen for Nasopharyngeal Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: EBV DNA Screening for Nasopharyngeal Carcinoma (free)

Commentaries: Can a ‘liquid biopsy’ detect cancer and save lives? – STAT (free) AND Liquid Biopsy Passes Test for Nasopharyngeal Cancer – MedPage Today (free registration required) AND Early Detection of Nasopharyngeal Cancer With EBV DNA – Medscape (free registration required) AND Plasma Epstein–Barr virus DNA useful for nasopharyngeal carcinoma screening – 2 Minute Medicine (free)

 

4 – Association of Previous Cesarean Delivery With Surgical Complications After a Hysterectomy Later in Life – JAMA Surgery (free)

Commentaries: C-Section Delivery Associated with Increased Risk of Complications from Hysterectomy – The JAMA Network (free) AND C-Section Now, Hysterectomy Complications Later? – MedPage Today (free registration required)

 

5 – Risk of head and traumatic brain injuries associated with antidepressant use among community-dwelling persons with Alzheimer’s disease: a nationwide matched cohort study – Alzheimer’s Research & Therapy (free)

Commentary: Antidepressant use increases risk of head injuries among persons with Alzheimer’s disease – University of Eastern Finland, via EurekAlert (free)

 

6 – Cholera count reaches 500 000 in Yemen – World Health Organization (free)

Commentaries: Yemen’s cholera outbreak passes 500,000 cases – CIDRAP (free) AND More Than 500,000 Infected With Cholera in Yemen – The New York Times (10 articles per month are free)

 

7 – Surgery must be a core part of health care – even in the poorest countries – The Guardian (free)

Related book: Essential Surgery – Disease Control Priorities 3 (DCP3) (free)

Related report: Global Surgery 2030 (free PDF)

Related commentary on the subject: In countries with a shortage of surgeons, other health care workers can fill in the gaps – STAT (free)

 

8 – Dexamethasone before bowel surgery reduces postoperative nausea and vomiting – NIHR Signal (free)

Original article: Dexamethasone versus standard treatment for postoperative nausea and vomiting in gastrointestinal surgery: randomised controlled trial (DREAMS Trial) – The BMJ (free)

 

9 – Relationship of Alcohol Consumption to All-Cause, Cardiovascular, and Cancer-Related Mortality in U.S. Adults – Journal of The American College of Cardiology (link to abstract and infographic – $ for full-text)

Commentaries: Consuming Alcohol in Moderation Can Lower Mortality Risks – American College of Cardiology, Latest in Cardiology (free) AND Alcohol Consumption and All-Cause, CV, and Cancer-Related Mortality – American College of Cardiology, Latest in Cardiology (free) AND Can drinking a little bit help you live longer? – Reuters (free)

 

10 – Addressing Alcohol Use Practice Manual: An Alcohol Screening and Brief Intervention Program – American Academy of Family Physicians (free PDF)

Press release: AAFP, Baylor Partner to Create Alcohol Screening Practice Manual (free)

Commentary: Alcohol screening and brief intervention: A practice manual for clinicians – Clinical Advisor (free)

 

Tue, August 15 – 10 Stories of The Day!

15Aug
2017

 

1 – Eliminating Creatine Kinase–Myocardial Band Testing in Suspected Acute Coronary Syndrome: A Value-Based Quality Improvement – JAMA Internal Medicine (free) (RT @EricTopol see Tweet)

Author interview: Eliminating Creatine Kinase–Myocardial Band Testing in Suspected ACS (free)

Commentaries: Eliminating CK-MB Testing in Suspected ACS – American College of Cardiology, Latest in Cardiology (free) AND Research review recommends eliminating widely ordered blood test for diagnosing heart attacks – Johns Hopkins Medicine, via Science Daily (free)

Review is first publication from national consortium of academic medical centers working to eliminate unnecessary medical tests, treatments and procedures” (from Science Daily)

 

2 – Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort – JAMA Neurology (link to abstract – $ for full-text)

Commentaries: Midlife cardiovascular risk factors may increase chances of dementia – NIH News Releases (free) AND Midlife smoking, diabetes, and hypertension associated with late life dementia – 2 Minute Medicine (free) AND Heart-healthy middle age tied to lower risk of dementia – Medical News Today (free) AND Heart disease risk in middle age tied to dementia later – Reuters (free)

 

3 – Day-to-Day Blood Pressure Variability and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study – Circulation (free)

Commentaries: Fluctuations in home-monitored blood pressure may raise dementia risk – Circulation Journal Report (free) AND Fluctuations in Blood Pressure Linked to Vascular Dementia – MedPage Today (free registration required) AND Fluctuating Home Blood Pressure Linked to Dementia – Medscape (free registration required) AND Blood pressure fluctuations linked to dementia – Reuters (free)

 

4 – Self-management interventions including action plans for patients with Chronic Obstructive Pulmonary Disease (COPD) – Cochrane Library (free)

Full review: Self-management interventions including action plans for exacerbations versus usual care in patients with chronic obstructive pulmonary disease (link to summary – $ for full-text)

Related: Asthma self-management programmes can reduce unscheduled care – NIHR Signal (free)

Self-management interventions that include a COPD exacerbation action plan are associated with improvements in health-related quality of life and lower probability of respiratory-related hospital admissions.

 

5 – Delayed breastfeeding initiation and infant survival: A systematic review and meta-analysis – PLOS One (free)

This systematic review and meta-analysis mostly of observational studies suggests early breastfeeding initiation is associated with increased survival. The authors acknowledge that there are many reasons for delayed breastfeeding initiation that may confound the relationship between breastfeeding initiation and mortality, but remember that randomized trials would not be considered ethical, so we must rely on high quality observational data. Based on their analysis, the authors suggest the implementation of programs that emphasize the importance of early initiation of breastfeeding, in addition to promoting exclusive breastfeeding.

 

6 – State of the Art Review: Advances in the diagnosis and management of neck pain – The BMJ (free)

Related guideline: Neck Pain: Revision 2017 – Clinical Practice Guidelines Linked to the International Classification of Functioning, Disability and Health from the Orthopaedic Section of the American Physical Therapy Association (free)

 

7 – Neurologic Complications Associated With the Zika Virus in Brazilian Adults – JAMA Neurology (free)

Editorial: The Expanding Spectrum of Zika Virus Infections of the Nervous System (free)

Commentary: Brazilian study sheds new light on Zika neuro complications in adults – CIDRAP (free)

 

8 – Richard Lehman’s journal review, 14 August 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – New, Occasional, and Frequent Use of Zolpidem or Zopiclone (Alone and in Combination) and the Risk of Injurious Road Traffic Crashes in Older Adult Drivers: A Population-Based Case–Control and Case-Crossover Study – CNS Drugs (free)

Car crashes in older adult drivers: Zolpidem (aOR 2.27) > zolpidem + zopiclone combo (aOR 2.20)” (RT @psychopharmacol see Tweet)

 

10 – Risk of Stroke With Various Types of Menopausal Hormone Therapies: A National Cohort Study – Stroke (link to abstract – $ for full-text)

Source: EvidenceAlerts

This large cohort confirms an increased stroke risk with oral hormone therapies, but suggests no increased risk of stroke with transdermal or vaginal estrogen application.

 

Mon, August 14 – 10 Stories of The Day!

14Aug
2017

 

1 – Use of Alternative Medicine for Cancer and Its Impact on Survival – Journal of the National Cancer Institute (link to abstract – $ for full-text)

Commentary: Use of alternative medicine hastens death of cancer patients – Edzard Ernst (free) AND Cancer Survival Takes a Hit with Alternative Medicine – MedPage Today (free) AND Using Alternative Medicine Only for Cancer Linked to Lower Survival Rate – Yale Cancer Center, via NewsWise (free) AND ‘Alternative Medicine’ for Cancer Ups Death Risk – Medscape (free registration required)

 

2 – Free Online Courses Starting Today

– Design and Interpretation of Clinical Trials – Johns Hopkins University and Coursera

– Understanding Clinical Research: Behind the Statistics – University of Cape Town and Coursera

– Public Health in Humanitarian Crises – Johns Hopkins University and Coursera

– Health Across the Gender Spectrum – Stanford University and Coursera

– Major Depression in the Population: A Public Health Approach – Johns Hopkins University and Coursera

– An Introduction to Global Health – University of Conpenhagen and Coursera

– Health Care IT: Challenges and Opportunities – Icahn School of Medicine at Mount Sinai and Coursera

– Leading Healthcare Quality and Safety – The George Washington University and Coursera

– Easing the burden of obesity, diabetes and cardiovascular disease – The University of Sydney and Coursera

– The People, Power, and Pride of Public Health – Johns Hopkins University and Coursera

 

3 – Prevention of suicide with regulations aimed at restricting access to highly hazardous pesticides: a systematic review of the international evidence (free)

Commentaries: Regulatory control of highly hazardous pesticides to prevent self-poisoning – The Lancet Global Health (free) AND Highly hazardous pesticides: policies should focus on bans, rather than secure storage, Lancet studies suggest – Bristol Health Partners (free)

Related: Effectiveness of household lockable pesticide storage to reduce pesticide self-poisoning in rural Asia: a community-based, cluster-randomised controlled trial – The Lancet (free) AND Learning from a negative trial of lockable pesticide storage – The Lancet (free)

“A worldwide ban on the use of highly hazardous agricultural pesticides is likely to prevent tens of thousands of deaths every year”.

 

4 – Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis – The Lancet Global Health (free)

Invited commentary: Universal eye health: are we getting closer? (free)

Commentary: Global blindness set to ‘triple by 2050′ – BBC (free) (via Global Health NOW Newslellter)

“Blindness is set to rise at an alarming rate reaching 115 million by 2050” (RT @UniMelbMDHS see Tweet)

 

5 – Guideline: Counseling Adolescents About Contraception – American Congress of Obstetricians and Gynecologists (free)

Commentary: Contraception and adolescents: ACOG releases counseling recommendations for clinicians – Clinical Advisor (free)

 

6 – Severe infections and subsequent delayed cardiovascular disease – European Journal of Preventive Cardiology (free)

Commentary: Pneumonia Or Sepsis in Adults Associated With Increased Risk of Cardiovascular Disease – European Society of Cardiology Press Releases (free) AND Elevated Cardiovascular Risk May Linger for Several Years After a Severe Infection – TCTMD (free) AND CVD risk may rise sixfold in the year after pneumonia, sepsis – Medical News Today (free)

 

7 – Thromboembolic Risk, Bleeding Outcomes and Effect of Different Antithrombotic Strategies in Very Elderly Patients With Atrial Fibrillation: A Sub‐Analysis From the PREFER in AF (PREvention oF Thromboembolic Events–European Registry in Atrial Fibrillation) – Journal of The American Heart Association (free)

Observational study suggests anticoagulation for stroke prevention in patients with atrial fibrillation is beneficial even for very elderly subjects.

 

8 – Sildenafil for pulmonary hypertension in neonates – Cochrane Library (link to summary – $ for full-text)

“Sildenafil may help reduce mortality and improve oxygenation in neonates with pulmonary hypertension” (RT @CochraneUK see Tweet)

 

9 – Preventing Severe Asthma Exacerbations in Children. A Randomized Trial of Mite-Impermeable Bedcovers – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)

Commentary: Mite-proof covers may reduce severity of asthma exacerbations in allergic children – News Medical (free)

Source: EvidenceAlerts

 

10 – Treatments for reducing menopausal hot flushes are ranked for effectiveness – NIHR Signal (free)

Original article: Vasomotor symptoms resulting from natural menopause: a systematic review and network meta-analysis of treatment effects from the National Institute for Health and Care Excellence guideline on menopause – British Journal of Obstetrics and Gynaecology (free)

 

Fri, August 11 – 10 Stories of The Day!

11Aug
2017

 

1 – The association of depression at any time to the risk of death following coronary artery disease diagnosis – European Heart Journal – Quality of Care and Clinical Outcomes (link to abstract – $ for full-text)

Commentaries: Having depression and heart disease could double death risk – Medical News Today (free) AND Death risk doubles for heart patients with depression – Cardiovascular Business (free)

Related: AAFP Guideline for the Detection and Management of Post–Myocardial Infarction Depression – Annals of Family Medicine (free)

 

2 – Incidence of and risk factors for nephrolithiasis in patients with gout and the general population, a cohort study – Arthritis Research & Therapy (free)

Commentaries: Gout Patients Run Higher Risk of Kidney Stones – MedPage Today (free registration required) AND Gout associated with elevated risk for kidney stones – MedWire News (free)

“60% increased risk of first-time nephrolithiasis versus general population, with little protection from allopurinol” (from MedPage Today)

 

3 – Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study – The Lancet HIV (free registration required)

Commentaries: PrEP on demand or every day? – The Lancet HIV (free registration required) AND HIV pre-exposure prophylaxis can be taken as needed – Reuters (free)

“four doses of PrEP around the time of sexual activity cut the risk of HIV by 97 percent” (from Reuters Health)

 

4 – Interventions for emergency contraception – Cochrane Library (link to abstract – $ for full-text)

Summary: Methods of emergency contraception (free)

 

5 – Effects of CPAP and Mandibular Advancement Devices on Health-Related Quality of Life in OSA – Chest (free)

See also a recent study showing CPAP does not reduce cardiovascular events in our July 13th issue (see #2)

“CPAP is effective in improving health-related quality of life in OSA, and Mandibular Advancement Devices may be just as effective, but further RCTs comparing the two treatments are required”.

 

6 – Strategies to prevent death by suicide: meta-analysis of randomised controlled trials – British Journal of Psychiatry (link to abstract – $ for full-text)

Commentary: Brief Intervention and Contact (BIC) to prevent suicide – Dave Cesarini, via Medium (free)

Related article: Effectiveness of brief intervention and contact for suicide attempters: a randomized controlled trial in five countries – Bulletin of the World Health Organization (free)

Source: Psychiatry Research Review

“The WHO BIC is a promising suicide prevention strategy. No other intervention showed a statistically significant effect in reducing suicide”.

 

7 – Suicide Prevention in an Emergency Department Population: The ED-SAFE Study – JAMA Psychiatry (link to abstract – Free Full Text PDF via @unpaywall)

Commentaries: Intervention Phone Calls May Save The Lives Of Suicidal Patients, Reduce New Attempts, Trial Finds – Medical Daily (free) AND National study shows interventions like telephone calls can reduce suicides – EurekAlert (free) AND Intervention Curbs New Suicide Attempts in At-Risk ED Patients – Medscape (free registration required)

Source: Psychiatry Research Review

Patients who received a multifaceted intervention that included follow-up telephone calls resulted in a 30 percent reduction in future suicide attempts” (from Medical Daily)

 

8 – The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis – The Lancet Public Health (free) (RT @equitylist see Tweet)

Invited commentary: Inequality and intergenerational transmission of complex adversity (free)

Editorial: Our greatest untapped resource (free)

 

9 – Diet and Risk of Cholecystectomy: A Prospective Study Based on the French E3N Cohort – American Journal of Gastroenterology (link to abstract – $ for full-text)

Commentary: Fewer gallbladder surgeries with Mediterranean diets – Reuters (free)

 

10 – Neuroprotective Diets Are Associated with Better Cognitive Function: The Health and Retirement Study – Journal of The American Geriatrics Society (free)

Commentaries: Cognitive decline could be reduced with a Mediterranean-style diet – Medical News Today (free) AND Mediterranean-style diets linked to better brain function in older adults – Journal of the American Geriatrics Society Research Summary (free)

 

Thu, August 10 – 10 Stories of The Day!

10Aug
2017

 

1 – Developmental follow-up of children and young people born preterm – NICE Guideline (free)

 

2 – Sleep Disorder Diagnosis During Pregnancy and Risk of Preterm Birth – Obstetrics & Gynecology (link to abstract – $ for full-text)

Commentaries: Sleep Disorders in Pregnancy Linked to Preterm Birth – Medscape (free registration required) AND Insomnia linked to premature birth in study of 3 million mothers – Nature News (free)

“Women with sleep disorders were about twice as likely to deliver babies more than six weeks early” (from Nature News)

 

3 – Effect of marijuana use on cardiovascular and cerebrovascular mortality: A study using the National Health and Nutrition Examination Survey linked mortality file – European Journal of Preventive Cardiology (free)

Commentaries: Marijuana associated with three-fold risk of death from hypertension – European Society of Cardiology, via Science Daily (free) AND Marijuana use holds three-fold blood pressure death risk: study – Reuters (free) AND Marijuana Use Tied to Death from Hypertension, Study Suggests – Physician’s First Watch (free) AND Marijuana ‘may be worse than cigarettes for cardiovascular health’ – Medical News Today (free)

 

4 – The verdict: is blogging or tweeting about research papers worth it? – The London School of Economics and Political Science (free) (RT @CLAHRC_West and @CebmOxford)

Researchers can no longer ignore social media.

 

5 – What do hypnotics cost hospitals and healthcare? – F1000 Research (free)

Source: Hospital Medicine Virtual Journal Club

“A best estimate is that U.S. costs of hypnotic harms to healthcare systems are on the order of $55 billion, but conceivably might be as low as $10 billion or as high as $100 billion”.

 

6 – Treating subclinical thyroid dysfunction in pregnancy probably has no benefit – NIHR Signal (free) (RT see Tweet)

Related: Subclinical Hypothyroidism – NEJM Resident 360 (free) AND Levothyroxine Shows No Benefit in Older Adults with Subclinical Hypothyroidism – Physician’s First Watch (free)

“Treating subclinical thyroid dysfunction in pregnancy probably has no benefit” (RT @NIHR_DC see Tweet)

 

7 – Gadolinium deposition in the brain: summary of evidence and recommendations – The Lancet Neurology (free registration required)

Commentaries: Gadolinium deposition: practical guidelines in the face of uncertainty – The Lancet Neurology (free registration required) AND MRI Contrast Agents Accumulate in the Brain – Case Western Reserve University, via NewsWise (free)

 

8 – A systematic review to identify and assess the effectiveness of alternatives for people over the age of 65 who are at risk of potentially avoidable hospital admission – BMJ Open (free) (RT @NIHR_DC)

Alternatives to hospital admission for people aged over 65 years can be safe and reduce costs across a range of acute and chronic conditions.

 

9 – All-Cause and Specific-Cause Mortality Risk After Roux-en-Y Gastric Bypass in Patients With and Without Diabetes (link to abstract – $ for full-text)

Commentary: Gastric Bypass Sharply Lowers Death Risk for People With Diabetes, Study Finds – AJMC (free)

Case-control study suggests the procedure may reduce the risk of death in patients with diabetes.

 

10 – Tai Chi for Risk of Falls. A Meta-analysis – Journal of The American Geriatrics Society (link to abstract – $ for full-text)

Commentaries: Meta-Analysis: Tai Chi Keeps Seniors from Falling – MedPage Today (free registration required) AND Tai chi may help reduce rate of falls in older and at-risk adults – News Medical (free)

‘Can reduce fall rates by almost half during the first year’ (from MedPage Today)

 

Wed, August 9 – 10 Stories of The Day!

9Aug
2017

 

1 – New NICE Guideline: Fever in under 5s: assessment and initial management (free)

 

2 – Interventions during pregnancy and childbirth for preventing cerebral palsy: an overview of Cochrane reviews (free)

 

3 – Acute mesenteric ischemia: guidelines of the World Society of Emergency Surgery – World Journal of Emergency Surgery (free)

 

4 – Prognostic Factors for Treatment Failure in Acute Otitis Media – Pediatrics (link to abstract – $ for full-text)

Commentaries: Features predicting treatment failure in acute otitis media – 2 Minute Medicine (free) AND Study IDs Children With AOM Who Benefit From Antibiotics – Medscape (free registration required)

“Children with severe bulging of the tympanic membrane seem to benefit most from antimicrobial treatment of AOM”

 

5 – Half of papers searched for online are free to read – Nature News (free)

“Large study of open research analysed reader data from Unpaywall tool, which finds freely available versions of articles”.

 

6 – Expansion of Treatment for Hepatitis C Virus Infection by Task Shifting to Community-Based Nonspecialist Providers: A Nonrandomized Clinical Trial – Annals of Internal Medicine (free)

Commentaries: Nonspecialists Could Safely Provide Hepatitis C Care – Physician’s First Watch (free) AND HCV treatment by NPs, PCPs appears safe, effective as that provided by subspecialists – ACP Internist (free)

“Expansion of Treatment for HCV Infection by Task Shifting to Community-Based Nonspecialists” (RT @kennylinafp see Tweet)

 

7 – ANMCO Scientific Statement: clinical management of hypercholesterolaemia in patients with acute coronary syndromes – European Heart Journal (free)

 

8 – Opinion: How Low Is Too Low With Salt in Heart Failure? Randomized Studies Needed to Resolve Concern – Circulation (free)

See more on sodium intake and cardiovascular disease in our July 11th issue (see #1)

 

9 – Association of Estimated Sodium Intake With Adverse Cardiac Structure and Function – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Typical adults eat enough salt to damage heart – Reuters (free) AND High Dietary Sodium Linked to Subclinical Cardiac Dysfunction – Medscape (free registration required)

 

10 – How long should I take antibiotics? Exploring the Goldilocks problem – Robin Centor in KevinMD.com Blog (free)

Related: The antibiotic course has had its day – The BMJ (free) AND Keep taking the tablets: three reasons to stay the full antibiotics course – The Conversation (free) (RT @Onisillos) AND Why you really should take your full course of antibiotics – The Conversation (free)

 

Tue, August 8 – 10 Stories of The Day!

8Aug
2017

 

1 – Optimal timing of an invasive strategy in patients with non-ST-elevation acute coronary syndrome: a meta-analysis of randomised trials – The Lancet (link to abstract – $ for full-text)

Commentary: Optimal Timing of an Invasive Strategy in NSTE-ACS Patients – American College of Cardiology, Latest in Cardiology (free)

An early invasive strategy does not reduce mortality compared with a delayed invasive strategy in most patients with NSTE-ACS, but seems to reduce mortality in high-risk patients.

 

2 – Outbreak-Related Disease Burden Associated with Consumption of Unpasteurized Cow’s Milk and Cheese, United States, 2009–2014 – Emerging Infectious Diseases (free)

Commentaries: Raw milk: a superfood or super risky? – The Guardian (free) AND Raw milk and cheese cause 840 times more illnesses than pasteurized products – STAT News (free)

 

3 – State of The Art Review: Advances in the diagnosis of pneumonia in children – The BMJ (free)

 

4 – Longer sleep is associated with lower BMI and favorable metabolic profiles in UK adults: Findings from the National Diet and Nutrition Survey – PLOS One (free)

Commentary: Short sleep linked to body mass, waist size – Reuters Health (free)

 

5 – simple guide to CRISPR, one of the biggest science stories of the decade – VOX (free) (RT @Students4BE see Tweet)

 

6 – Association of Resistance Exercise, Independent of and Combined With Aerobic Exercise, With the Incidence of Metabolic Syndrome – Mayo Clinic Proceedings (free)

Commentaries: Metabolic syndrome: An hour of resistance training per week may cut risk – Medical News Today (free) AND Resistance Training Tied to Lower Risk for Metabolic Syndrome – Physician’s First Watch (free)

 

7 – Factors Associated With Achieving a Body Mass Index of Less Than 30 After Bariatric Surgery – JAMA Surgery (link to abstract – $ for full-text)

Commentaries: Opting for Weight-Loss Surgery at Lower BMIs May Be Best for Patients’ Health, Study Suggests – University of Michigan, via NewsWise (free) AND Delayed Weight Loss Surgery Tied to Worse Outcomes – MedPage Today (free registration required) AND Weight-loss surgery may work better when patients aren’t too obese – Reuters (free) AND With bariatric surgery, a patient’s starting weight makes a difference, study finds – STAT (free)

 

8 – Richard Lehman’s journal review, 7 August 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Review: Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes – BMC Medicine (free)

 

10 – Review: Subclinical thyrotoxicosis: prevalence, causes and choice of therapy – European Journal of Endocrinology (free)

 

Mon, August 7 – 10 Stories of The Day!

7Aug
2017

 

1 – Guideline: Nutrition support for adults: oral nutrition support, enteral tube feeding and parenteral nutrition – National Institute for Health and Care Excellence (NICE – UK) (free)

 

2 – Free online courses starting today:

– Community Change in Public Health – Johns Hopkins University and Coursera

– Health for All Through Primary Health Care – Johns Hopkins University and Coursera

– Global Health at the Human-Animal-Ecosystem Interface – University of Geneva and Coursera

– Childbirth: A Global Perspective – Emory University and Coursera

– An Introduction to Population Health – University of Manchester and Coursera

– Global Adolescent Health – University of Melbourne and Coursera 

– Positive Psychiatry and Mental Health – University of Sidney and Coursera

 

3 – ANMCO Position Paper: long-term follow-up of patients with pulmonary thromboembolism – European Heart Journal (free)

 

4 – Too Many Meds? America’s Love Affair With Prescription Medication – Consumer Reports (free)

See more on “Deprescribing” in our May 8th issue (see #4), May 9th issue (see #7) and May 15th issue (see #2), and also a related article on Current and future perspectives on the management of polypharmacy (free)

“Yes. Way Too Many Meds. Think De-prescribe”. (RT @EricTopol see Tweet)

 

5 – Design Thinking for Doctors and Nurses – New York Times (10 articles per month are free)

 

6 – Have Smartphones Destroyed a Generation? – The Atlantic (free)

Long read… very interesting.

 

7 – A comprehensive guide to the new science of treating lower back pain – VOX (free)

“Mainstream medicine has failed people with chronic back pain”

 

8 – Modifiable Risk Factors for Incident Heart Failure in Atrial Fibrillation – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentary: Risk for Incident Heart Failure in Atrial Fibrillation – American College of Cardiology, Latest in Cardiology (free)

“Lose weight, treat hypertension & diabetes, stop smoking: That’s how we might prevent heart failure” (RT @JACCJournals see Tweet)

 

9 – 2017 consensus of the Asia Pacific Heart Rhythm Society on stroke prevention in atrial fibrillation – Journal of Arrhythmia (free)

 

10 – The global crackdown on parents who refuse vaccines for their kids has begun – VOX (free)

See more on mandatory vaccination in our May 29th (see #6) and July 12th (see #5) issues

“Countries like Italy and Australia are tired of measles outbreaks — so they’re moving to fine anti-vaccine parents”.

 

Fri, August 4 – 10 Stories of The Day!

4Aug
2017

 

1 – Special issue: Public Health Research & Practice – July 2017 Edition

Editorial: Cancer screening: concerns, controversy and evidence (free)

– PSA testing for men at average risk of prostate cancer (free)

– What is overdiagnosis and why should we take it seriously in cancer screening? (free)

– History, development and future of cancer screening in Australia (free)

– Assessing the efficacy of cancer screening (free)

– Improving communication about cancer screening: moving towards informed decision making (free)

“A special issue to check out if you’re interested in cancer screening (including communication)” (RT @hildabast see Tweet)

 

2 – Discover and defeat your diagnostic errors – ACP Internist (free) (RT @acpinternist  see Tweet)

“Experts explain the causes and solutions for common mistakes in diagnosis”.

 

3 – Evidence for Health Decision Making: Beyond Randomized, Controlled Trials – New England Journal of Medicine (free)

Commentary: Why the ‘gold standard’ of medical research is no longer enough – STAT (free)

See also other articles in The Changing Face of Clinical Trials Series (all free)

 

4 – Oral fluoroquinolones and risk of secondary pseudotumor cerebri syndrome – Neurology (link to abstract – $ for full-text)

Commentary: Fluoroquinolones May Up Risk of PTCS, a Rare But Serious Condition – MPR (free) (RT @AmeshAA see Tweet)

 

5 – A soft robotic exosuit improves walking in patients after stroke – Science Translational Medicine (free)

Commentaries: Robotic Exosuit Improves Walking After Stroke – Medscape (free registration required) AND Watch a robotic exoskeleton help a stroke patient walk – Science (free text and video)

 

6 – Prescribing regular drugs to prevent febrile convulsions risks more harm than benefit – NIHR Signal (free)

Original article: Prophylactic drug management for febrile seizures in children – Cochrane Library (link to summary – $ for full-text)

Benefits of anti-epileptic medication for children who’ve had a convulsion while feverish, do not outweigh harms” (RT @NIHR_DC see Tweet)

 

7 – Utilization of Statins Beyond the Initial Period After Stroke and 1‐Year Risk of Recurrent Stroke – Journal of The American College of Cardiology (free)

Commentary: Quitting statins after stroke may raise risk of another stroke – AHA / ASA Newsroom (free) AND Many Stroke Patients Stop Statins or Never Start, With Dire Consequences – TCTMD (free) AND Stopping statins after stroke may increase second-stroke risk – Reuters (free)

 

8 – Iatrogenesis in Pediatrics – AMA Journal of Ethics (free) (RT @JournalofEthics)

New issue with series of articles exploring strategies clinicians need to know to respond to adverse outcomes.

 

9 – Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine HIV pre-exposure prophylaxis: clinical guidelines (free)

 

10 – Effect of Oral Methylprednisolone on Clinical Outcomes in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Steroid treatment for type of kidney disease associated with increased risk for serious infections – The JAMA Network (free)

Renal outcomes seemed to be less frequent in the group using methylprednisolone (5,9% vs 15,9%), but the trial was stopped early due to a significantly increased risk of serious adverse events with oral methylprednisolone vs placebo (14.7% vs 3.2%, primarily excess infections).

 

Thu, August 3 – 10 Stories of The Day!

3Aug
2017

 

1 – Correction of a pathogenic gene mutation in human embryos – Nature (free)

Nature News & Views: Biotechnology: At the heart of gene edits in human embryos (free)

Commentaries: Embryo Gene-Editing Experiment Reignites Ethical Debate – Scientific American (free) AND Scientists successfully used CRISPR to fix a mutation that causes disease. This is huge – VOX (free) AND U.S. scientists edit genome of human embryo, but cast doubt on possibility of ‘designer babies’ – STAT (free) AND Human embryos edited to stop disease – BBC (free) AND In Breakthrough, Scientists Edit a Dangerous Mutation From Genes in Human Embryos – The New York Times (10 articles per month are free)

 

2 – Choosing Wisely: An International Campaign to Combat Overuse, with new Top 10 recommendations (free) (RT @ChooseWiselyCA and @CADTH_ACMTS see Tweet with infographic)

See more on the Choosing Wisely initiative in our April 5 issue (see #6)

Choosing Wisely has prioritized 10 recommendations for limiting overuse internationally.

 

3 – Guidelines for Drinking-Water Quality: Fourth Edition Incorporating the First Addendum – World Health Organization (free)

 

4 – Neck Pain: Revision 2017 – Clinical Practice Guidelines Linked to the International Classification of Functioning, Disability and Health from the Orthopaedic Section of the American Physical Therapy Association (free)

 

5 – Subgroup analyses of the effectiveness of oral glucosamine for knee and hip osteoarthritis: a systematic review and individual patient data meta-analysis from the OA trail bank – Annals of Rheumatic Diseases (link to abstract – $ for full-text) (RT @PhysioMeScience see Tweet)

“Currently, there is no good evidence to support the use of glucosamine for hip or knee OA”

 

6 – Benefits and Harms of Treatment of Asymptomatic Bacteriuria: A Systematic Review and Meta-analysis by the European Association of Urology Urological Infection Guidelines Panel (free)

“For most people, treatment was not beneficial and may be harmful. Antibiotic treatment did appear to benefit women in pregnancy and those about to undergo urological surgery”.

 

7 – Antiemetics: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

Related guideline: NCCN Guidelines Insights: Antiemesis, Version 2.2017 (free)

Commentaries: Antipsychotic Added to ASCO Antiemetic Guide – MedPage Today (free registration required) AND New Antiemetic Guidelines Issued by ASCO – Medscape (free registration required)

 

8 – Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association (free)

 

9 – ESC Joint Working Groups on Cardiovascular Surgery and the Cellular Biology of the Heart Position Paper: Peri-operative myocardial injury and infarction in patients undergoing coronary artery bypass graft surgery (free)

Summary with 10 key points to remember: Perioperative Myocardial Injury and Infarction After CABG – American College of Cardiology, Latest in Cardiology (free)

 

10 – Canadian Urological Association-Pediatric Urologists of Canada (CUA-PUC) guideline for the diagnosis, management, and followup of cryptorchidism (free)

 

Wed, August 2 – 10 Stories of The Day!

2Aug
2017

 

1 – Breastfeeding Week Reports: Tracking Progress for Breastfeeding Policies and Programmes: Global breastfeeding scorecard 2017 – World Health Organization, UNICEF (free PDF) AND Nurturing the Health and Wealth of Nations: The Investment Case for Breastfeeding – World Health Organization, UNICEF (free PDF)

News release: Babies and mothers worldwide failed by lack of investment in breastfeeding – World Health Organization (free)

See also: UNICEF page on breastfeeding (free)

New analysis shows an investment of US$4.70 per newborn could generate US$300 billion in economic gains by 2025.

 

2 – New Series from the Lancet journals: Fungal Infections – Lancet Infectious Diseases (RT @Onisillos see Tweet)

Comment: Recovery from serious fungal infections should be realisable for everyone (free registration required)

– Fungal infections in HIV/AIDS (free registration required)

– Candida and invasive mould diseases in non-neutropenic critically ill patients and patients with haematological cancer (free registration required)

– Emerging issues, challenges, and changing epidemiology of fungal disease outbreaks (free registration required)

– Pulmonary and sinus fungal diseases in non-immunocompromised patients (free registration required)

– Improvement of fungal disease identification and management: combined health systems and public health approaches (free registration required)

– The global problem of antifungal resistance: prevalence, mechanisms, and management (free registration required)

– Immunotherapeutic approaches to treatment of fungal diseases (free registration required)

– Neglected endemic mycoses (free registration required)

“This Series of eight reports brings readers up to date on fungal infections and addresses how fungal infection management can be integrated into health systems in low-income and middle-income countries”

 

3 – New Online Calculator: The Smart Risk Score – European Society of Cardiology (RT @JGrapsa see Tweet)

“The SMART Risk Score is a tool to estimate 10-year risk for recurrent vascular events in patients with manifest cardiovascular disease”

 

4 – Guideline: Intrapartum Management of Intraamniotic Infection – American College of Obstetricians and Gynecologists (ACOG) (free)

Commentary: Guidelines on Intraamniotic Infection Released by ACOG – Medscape (free registration required)

 

5 – Predicting Risk of Serious Bacterial Infections in Febrile Children in the Emergency Department – Pediatrics (link to abstract – $ for full-text)

Commentaries: UK researchers fine-tune diagnostic tool for serious bacterial infections – CIDRAP (free) AND Clinical and biomarker-based diagnostic model identifies serious bacterial infections – 2 Minute Medicine (free)

 

6 – Report: The Metabolic Syndrome in Children and Adolescents: Shifting the Focus to Cardiometabolic Risk Factor Clustering – American Academy of Pediatrics (free)

 

7 – Only Six Nations Have Evaluated Readiness for Global Pandemic – New York Times (10 articles per month are free)

Original Report: From panic and neglect to investing in health security : financing pandemic preparedness at a national level – The World Bank (free PDF)

 

8 – Periodontal Disease and Incident Cancer Risk among Postmenopausal Women: Results from the Women’s Health Initiative Observational Cohort – Cancer Epidemiology, Biomarkers & Prevention (link to abstract – $ for full-text)

Commentary: Gum infections linked to several cancers in women – Reuters (free)

 

9 – A surprising amount of medical research isn’t made public. That’s dangerous – VOX (free)

“When the results of clinical trials aren’t made public, the consequences can be dangerous — and potentially deadly” (RT @Students4BE see Tweet)

 

10 – Internet Searches for Suicide Following the Release of “13 Reasons Why” – JAMA Internal Medicine (free)

Editorial: A Call for Social Responsibility and Suicide Risk Screening, Prevention, and Early Intervention Following the Release of the Netflix Series “13 Reasons Why” (free)

Commentaries: ‘13 Reasons Why’ might have triggered suicide searches online – STAT News (free) AND Is ’13 Reasons Why’ Helping Kids Kill Themselves? – MedPage Today (free registration required) AND Google Searches on Suicide Surge After ’13 Reasons Why’ Release: Study – Newsweek (free) Suicide-Related Internet Searches Elevated After Debut of “13 Reasons Why” – Physician’s First Watch (free)

 

Tue, August 1 – 10 Stories of The Day!

1Aug
2017

 

1 – Treatment of Latent Tuberculosis Infection: An Updated Network Meta-analysis – Annals of Internal Medicine (free)

Related: Guidelines on the management of latent tuberculosis infection – World Health Organization (free)

 

2 – Efficacy of corticosteroid treatment for severe community-acquired pneumonia: A meta-analysis – American Journal of Emergency Medicine (link to abstract – $ for full-text)

Source: More Evidence That Steroids Are Beneficial in Community-Acquired Pneumonia – Journal Watch ($)

In this meta-analysis of randomized controlled trials in patients with severe community-acquired pneumonia, corticosteroid treatment was associated with reduced in-hospital mortality and length of hospital stay.

 

3 – Targeted Temperature Management for 48 vs 24 Hours and Neurologic Outcome After Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Targeted Temperature Management for 24 vs. 48 Hours After OHCA – American College of Cardiology, Latest in Cardiology (free) AND Longer Induced Cooling Not Better After Cardiac Arrest – MedPage Today (free registration required)

“Small trial shows no advantage to an additional day of cooling” (from MedPage Today)

 

4 – Diagnostic Stewardship – Leveraging the Laboratory to Improve Antimicrobial Use – JAMA (free)

“This Viewpoint discusses the potential benefits and harms of diagnostic stewardship – modifying the ordering, performance, and reporting of diagnostic tests to improve antimicrobial use”

 

5 – Report: Antibiotic Use in the United States, 2017: Progress and Opportunities – Centers for Disease Control and Prevention (free)

Commentary: CDC antibiotics report calls for all-out stewardship efforts – CIDRAP (free)

CDC report: antibiotic stewardship protects patients, saves $, slows antibiotic resistance” (RT @IDSAInfo see Tweet)

 

6 – A ‘perfect storm’ superbug: How an invasive fungus got health officials’ attention – STAT (free)

Related: CDC keeping a watchful eye on Candida auris – CIDRAP (free) AND CDC reports uptick in Candida auris cases – CIDRAP (free)

 

7 – A Dangerous, “Silent Reservoir” For Gonorrhea: The Throat – The New York Times (10 articles per month are free)

See related WHO report on the rising of “Untreatable Gonorrhea” in our July 10th issue (see #1)

“Drug-resistant gonorrhea is increasing. Now scientists say the epidemic is being driven by oral sex”. (RT @NYTHealth see Tweet)

 

8 – Richard Lehman’s journal review, 31 July 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Really Rapid Review: Paris IAS 2017 – HIV and ID Observations in Journal Watch Blogs (free) (RT @CarlosdelRio7 see Tweet)

Highlights from the latest International AIDS Society meeting.

 

10 – New National Guideline Clearinghouse (NGC) Summaries in Low back, Cervical and Thoracic Spine Disorders with focus on occupational health.

Low Back Disorders – American College of Occupational and Environmental Medicine (free summary from NGC – $ see original guideline in ACOEM website)

Cervical and thoracic spine disorders – American College of Occupational and Environmental Medicine (free summary from NGC – $ see original guideline in ACOEM website)

 

Mon, July 31 – 10 Stories of The Day!

31Jul
2017

 

1 – World Hepatitis Day (28 July 2017) – World Health Organization Campaign (free)

News release: Eliminate hepatitis: WHO (free)

WHO Updated Factsheets (free): Hepatitis A, Hepatitis B, Hepatitis C, Hepatitis D and Hepatitis E

 

2 – Tenofovir reduces mother-to-child hepatitis B transmission – NIHR Signal (free)

Original article: Systematic review with meta-analysis: the efficacy and safety of tenofovir to prevent mother-to-child transmission of hepatitis B virus – Alimentary Pharmacology and Therapeutics (link to abstract – $ for full-text)

 

3 – The clinical practice guideline for the management of ARDS in Japan – Journal of Intensive Care (free)

Source: Critical Care Reviews Newsletter (free)

 

4 – “It is like texting at the dinner table”: a qualitative analysis of the impact of electronic health records on patient–physician interaction in hospitals – Journal of Innovation in Health Informatics (free)

Commentary: Doctors frustrated that electronic records steal time from patients – Reuters (free)

Related guideline: Putting Patients First by Reducing Administrative Tasks in Health Care: A Position Paper of the American College of Physicians (free)

 

5 – Why you really should take your full course of antibiotics – The Conversation (free)

Commentary against a recent article in the BMJ arguing the antibiotic course has had its day

 

6 – FDA announces comprehensive regulatory plan to shift trajectory of tobacco-related disease, death – U.S. Food and Drug Administration (free)

Commentaries: The FDA just took a radical step to cut nicotine in cigarettes so they’re not addictive – VOX (free) AND FDA Proposes Reducing Nicotine In Cigarettes – NPR (free) AND FDA Targets Cigarettes in Broadening of Fight Against Addiction – Bloomberg (free text and video) AND FDA announces plans to slash nicotine levels in cigarettes – STAT News (free) AND FDA plans to reduce nicotine in cigarettes to non-addictive levels – The Guardian (free)

“Woooow. FDA wants to cut the nicotine in cigarettes to nonaddictive levels. This is a public health power move” (RT @onceuponA see Tweet)

 

7 – Interventions for the prevention of recurrent erysipelas and cellulitis – Cochrane Library (link to summary – $ for full-text)

Commentary: Ongoing Antibiotic Prophylaxis Helps Prevent Cellulitis Recurrence – Medscape (free registration required)

 

8 – Alcohol drinking patterns and risk of diabetes: a cohort study of 70,551 men and women from the general Danish population – Diabetologia (link to abstract – $ for full-text)

Commentaries: Drinking Alcohol 3 to 4 Days a Week Tied to Lowest Risk for Diabetes – Physician’s First Watch (free) AND Moderate drinkers less likely to develop diabetes – OnMedica (free) AND Regular alcohol consumption could cut diabetes risk, study finds  – The Guardian (free) AND Diabetes Risk May Be Lowest Drinking 3 to 4 Days Per Week – Medscape (free registration required)

Observational data suggests moderate alcohol consumption may have a possible protective effect against diabetes.

 

9 – Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis – The Lancet (link to abstract – $ for full-text)

Diclofenac 150 mg/day is the most effective NSAID available at present, but are the cardiac and renal risks worth it? Paracetamol does not seem to work for this condition.

 

10 – Peer review is a black box. Let’s open it up – STAT News (free)

Related commentaries: Exposing peer review – Research Information (free) AND More than just being open: giving control to authors and credit to peer reviewers – F1000Research blog (free) AND The peer-review system for academic papers is badly in need of repair – The Conversation (free) AND Manipulating the peer review process: why it happens and how it might be prevented – LSE Impact of Social Sciences blog (free) AND ‘You never said my peer review was confidential’ — scientist challenges publisher – Nature News (free)

 

Fri, July 28 – 10 Stories of The Day!

28Jul
2017

 

1 – Application of a Lifestyle-Based Tool to Estimate Premature Cardiovascular Disease Events in Young Adults: The Coronary Artery Risk Development in Young Adults (CARDIA) Study – JAMA Internal Medicine (free) (RT @JAMAInternalMed see Tweet)

Commentaries: Healthy Heart Score performed moderately well in assessing cardiovascular disease risk in young adults – 2 Minute Medicine (free) AND Online tool predicts heart risk in young adults – Reuters Health (free)

See Health Heart Score Calculator

“An online calculator may help young people predict their risk of developing heart disease in middle age – in time to make lifestyle changes to minimize their odds of myocardial infarction or stroke” (from Reuters)

 

2 – Long working hours as a risk factor for atrial fibrillation: a multi-cohort study – European Heart Journal (free)

Commentaries: Long working week ‘may increase risk of irregular heartbeat’ – NHS Choices (free) AND Long Workdays May Be Bad for Your Heart – The New York Times (10 articles per month are free) AND Long working hours linked to heightened irregular heart rhythm risk – OnMedica (free)

 

3 – Transcatheter aortic valve implantation for aortic stenosis –NICE Guideline (free)

 

4 – Chronic kidney disease in adults – NICE Quality Standard (free)

Commentary: Give chronic kidney disease patients a statin, doctors urged – OnMedica (free)

 

5 – Low back pain and sciatica in over 16s – NICE Quality Standard (free)

Related guideline: Low back pain and sciatica in over 16s: assessment and management – NICE (free)

 

6 – Big names in statistics want to shake up much-maligned P value – Nature News (free)

“One of scientists’ favorite statistics — the P value — should face tougher standards, say leading researchers”

 

7 – Association of Changing Hospital Readmission Rates With Mortality Rates After Hospital Discharge – JAMA (link to abstract – $ for full-text)

Commentaries: Pushing Hospitals To Reduce Readmissions Hasn’t Increased Deaths – NPR (free) AND Reduction in Hospital Readmission Rate Not Associated With Increased Risk of Death Following Discharge – The JAMA Network (free) AND Lower Readmissions Not Linked to Post-Discharge Mortality Risk – MedPage Today (free registration required) AND Study: Reducing readmissions does not harm patients – Becker’s Hospital Review (free)

 

8 – Temporal trends in sperm count: a systematic review and meta-regression analysis – Human Reproduction Update (free)

Commentaries: Sperm counts among western men have halved in last 40 years: study – The Guardian (free) AND Sperm Concentrations Have Fallen 50% in Western World – Medscape (free registration required)

 

9 – Sugar intake from sweet food and beverages, common mental disorder and depression: prospective findings from the Whitehall II study – Scientific Reports (free)

Commentaries: Too much sugar could increase depression risk in men, study suggests – The Guardian (free) AND High sugar diets linked to heightened depression risk in men – The Independent (free)

Association does not imply causation, but this observational study suggests sugar intake has adverse effects on long-term psychological health.

 

10 – Retrospective analysis of newly recorded certifications of visual impairment due to diabetic retinopathy in Wales during 2007–2015 – BMJ Open (free)

Commentaries: Diabetic sight loss cut by screening, research shows – BBC (free) AND Eye screening linked to fall in sight loss in people with diabetes – NHS Choices (free)

 

Thu, July 27 – 10 Stories of The Day!

27Jul
2017

 

1 – Opinion: The antibiotic course has had its day – The BMJ (free)

Commentaries: Some Doctors Now Say to Stop Antibiotics When You Feel Better – TIME (free) AND Rule that patients must finish antibiotics course is wrong, study says – The Guardian (free)

“Experts suggest patients should stop taking the drugs when they feel better rather than completing their prescription” (from The Guardian)

 

2 – A Prospective Study on the Effect of Sport Specialization on Lower Extremity Injury Rates in High School Athletes – American Journal of Sports Medicine (link to abstract – $ for full-text)

Commentary: Student Athletes Who Specialize Early Are Injured More Often, Study Finds – NPR (free)

Related Reports: Sports Specialization and Intensive Training in Young Athletes – American Academy of Pediatrics (free) AND Overuse injuries and burnout in youth sports: a position statement from the American Medical Society for Sports Medicine (free)

 

3 – E-cigarette use and associated changes in population smoking cessation: evidence from US current population surveys – The BMJ (free)

Editorial: Rise in e-cigarette use linked to increase in smoking cessation rates (free)

Commentaries: Rise in e-cigarettes linked to rise in smokers quitting, say researchers – The BMJ, via EurekAlert (free) AND Study links rising U.S. e-cigarette use to rise in smokers quitting – Reuters (free) AND Rise in E-Cigarettes Linked to Rise in Smokers Quitting – Scoop Health (free)

Related: The shadow of Big Tobacco looms over e-cigarettes and harm reduction – STAT (free) (“Should we settle for lesser harms?”)

 

4 – Use of Prescription Smoking Cessation Medications After Myocardial Infarction Among Older Patients in Community Practice – JAMA (link to abstract – $ for full-text)

Commentaries: Stop-Smoking Meds Underused in Post-MI Setting – MedPage Today (free registration required) AND Heart attack patients don’t adhere to smoking cessation prescriptions – Cardiovascular Business (free) AND Heart attack patients missing out on smoking cessation drugs – Reuters Health (free)

 

5 – 2017 ACS Quality and Safety Conference: “Strong for Surgery” Shows Promise in Reducing Smoking Rates for Patients Facing Surgery – American College of Surgeons, via NewsWise (free)

“Study suggests big drop in smoking rates when surgeons help patients quit before their operations”.

 

6 – Tobacco Use in Top-Grossing Movies — United States, 2010–2016 – MMWR / CDC (free)

Commentaries: A new CDC report could reignite the debate over Hollywood’s influence on teen tobacco use – VOX (free) AND Health Experts Are Worried About a Huge Rise in Smoking in Movies – TIME (free) AND Tobacco gets more screen shots in blockbuster movies, study shows – New York Times (10 articles per month are free)

Source: Medscape

 

7 – Public Health and Economic Consequences of Vaccine Hesitancy for Measles in the United States – JAMA Pediatrics (free)

Commentaries: Study: Small drop in vaccine uptake can trigger measles outbreak – CIDRAP (free) AND Small decline in MMR vaccination rates could have dramatic effect, experts warn – The Guardian (free)

“A 5% drop in measles, mumps and rubella vaccinations could cause a threefold increase of measles cases, costing the public sector millions, US study shows” (from The Guardian)

 

8 – Contemporary Reviews in Critical Care Medicine: Update in Management of Severe Hypoxemic Respiratory Failure – Chest (free PDF)

 

9 – Report: Finding a Path to Safety in Food Allergy: Assessment of the Global Burden, Causes, Prevention, Management, and Public Policy – National Academies of Sciences, Engineering, and Medicine (free)

Summary: Critical Issues in Food Allergy: A National Academies Consensus Report – Pediatrics (free)

Commentary: Food Allergy: Consensus Report Stresses Diagnostic Accuracy – Medscape (free registration required)

 

10 – The Diagnosis and Treatment of Hemoptysis – Deutsches Ärzteblatt international (free)

Source: Critical Care Reviews Newsletter

 

Wed, July 26 – 10 Stories of The Day!

26Jul
2017

 

1 – Consolidated Guideline on Sexual and Reproductive Health and Rights of Women Living with HIV – World Health Organization (free)

See also: Executive Summary (free)

 

2 – Update: Interim Guidance for Health Care Providers Caring for Pregnant Women with Possible Zika Virus Exposure – MMWR / CDC (free)

Commentaries: CDC Updates Guidelines on Caring for Pregnant Women with Possible Zika Exposure – Physician’s First Watch (free) AND Updated CDC Guidance on Zika in Pregnancy – Medscape (free registration required)

 

3 – Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football – JAMA (free)

Author interview: Evaluation of Chronic Traumatic Encephalopathy in Football Players (free video)

Commentaries: High Prevalence of Evidence of CTE in Brains of Deceased Football Players – JAMA Network (free) AND Brain disease CTE seen in most football players in large report – STAT News (free) AND 110 N.F.L. Brains – The New York Times (10 articles per month are free) AND Signs of brain disease in 99 percent of ex-NFL players studied: paper – Reuters (free) AND Study: CTE Found In Nearly All Donated NFL Player Brains – NPR (free)

“A neuropathologist has examined the brains of 111 N.F.L. players — and 110 were found to have C.T.E., the degenerative disease linked to repeated blows to the head” (from NYT).

 

4 – Long-acting intramuscular cabotegravir and rilpivirine in adults with HIV-1 infection (LATTE-2): 96-week results of a randomised, open-label, phase 2b, non-inferiority trial – The Lancet (free)

Commentary: Long-Acting Injectable HIV Regimens Show Promise – Physician’s First Watch (free) AND Injections ‘next revolution’ in HIV: study – BBC (free)

 

5 – Brazilian guidelines on prevention of cardiovascular disease in patients with diabetes: a position statement from the Brazilian Diabetes Society (SBD), the Brazilian Cardiology Society (SBC) and the Brazilian Endocrinology and Metabolism Society (SBEM) – Diabetology & Metabolic Syndrome (free)

 

6 – Guidelines for the understanding and management of pain in chronic pancreatitis – Pancreatology (free)

 

7 – Cardiocerebral and cardiopulmonary resuscitation – 2017 update – Acute Medicine & Surgery (free)

Source: Critical Care Reviews Newsletter

 

8 – 2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry (free)

 

9 – Report: WHO MERS-CoV Global Summary and Assessment of Risk – World Health Organization (free PDF)

Commentary: WHO: Hospital outbreaks underscore MERS challenges – CIDRAP (free)

See also: WHO’s Work on Middle East respiratory syndrome coronavirus (MERS-CoV)

 

10 – Comparative effectiveness of high-dose versus standard-dose influenza vaccination on numbers of US nursing home residents admitted to hospital: a cluster-randomised trial – The Lancet Respiratory Medicine (free)

Commentaries: Study: High-dose flu vaccine cuts hospitalizations in nursing home residents – CIDRAP (free) AND High-dose influenza vaccine for nursing home residents reduces hospitalisations – OnMedica (free) AND High Dose Influenza Vaccine Leads to Lower Rate of Hospitalization From Respiratory Illnesses in Nursing Home Residents – University Hospitals Cleveland Medical Center, via NewsWise (free)

 

Tue, July 25 – 10 Stories of The Day!

25Jul
2017

 

1 – Association of History of Dizziness and Long-term Adverse Outcomes With Early vs Later Orthostatic Hypotension Assessment Times in Middle-aged Adults – JAMA Internal Medicine (free)

Invited commentary: Early Orthostatic Hypotension and Orthostatic Intolerance—More Than an Observation or Annoyance (free)

Practice Changing – Orthostatic hypotension within 1 min of standing (rather than at 3 minutes) has greater relation to falls, fracture, syncope, motor vehicle crash, and mortality.

 

2 – Latest European Society of Cardiology Clinical Practice Guidelines Summary Cards are now available (Atrial Fibrillation, Heart Failure, CVD Prevention, Cardio-Oncology – free PDF summaries).

See Complete list:

– Atrial Fibrillation

– Heart Failure

– European CVD Prevention in Clinical Practice

– Cardio-oncology

– Infective Endocarditis    

– Hypertrophic Cardiomyopathy

– Cardiac Pacing & CRT

– Arterial Hypertension

– Diabetes & Pre-Diabetes, CVD

– Valvular Heart Disease  

 

3 – Public health interventions may offer society a return on investment of £14 for each £1 spent – NIHR Signal (free)

Original article: Return on investment of public health interventions: a systematic review – Journal of Epidemiology & Community Health (free)

 

4 – Viewpoint: Inconsistent Guideline Recommendations for Cardiovascular Prevention and the Debate About Zeroing in on and Zeroing LDL-C Levels With PCSK9 Inhibitors – JAMA (free)

Balanced point of view regarding the use of PCSK9 Inhibitors.

 

5 – Update on pediatric sepsis: a review – Journal of Intensive Care (free)

Source: Critical Care Reviews Newsletter

 

6 – Richard Lehman’s journal review, 24 July 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.

 

7 – Why are doctors plagued by depression and suicide? A crisis comes into focus – STAT News (free)

Related: Protecting interns and other physicians from depression and suicide – STAT News (free)

 

8 – Is cyclobenzaprine useful for pain? – Therapeutics Initiative (free)

“…cyclobenzaprine is a long-acting sedative, not a muscle relaxant, and questioning whether any potential benefits are worth the side effects”. (from TI Newsletter). “If prescribed, a dose of 5 mg at bedtime should be tried first.  Evidence suggests titration based on response and tolerability to a maximum dose of 15 mg/day, for no longer than one week”.

 

9 – Canadian Cardiovascular Society and Canadian Pediatric Cardiology Association Position Statement on the Approach to Syncope in the Pediatric Patient (free)

See also: Guidelines Summary: National Guideline Clearinghouse (free)

 

10 – Damage control resuscitation in patients with severe traumatic hemorrhage: A practice management guideline from the Eastern Association for the Surgery of Trauma (free)

See also: Guideline Summary: National Guideline Clearinghouse (free)

 

Mon, July 24 – 10 Stories of The Day!

24Jul
2017

 

1 – Guidelines for the managing advanced HIV disease and rapid initiation of antiretroviral therapy – World Health Organization (free) (RT @greg_folkers see Tweet with infographic)

 

2 – WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection – World Health Organization (free) (RT @equitylist see Tweet)

Summary: WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection (free PDF)

See also: WHO’s Work on Pre-exposure prophylaxis (free resources)

 

3 – Review: Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) (free)

 

4 – Effects of control interventions on Clostridium difficile infection in England: an observational study – The Lancet Infectious Diseases (free)

Invited Commentary: Fluoroquinolone restriction to control fluoroquinolone-resistant Clostridium difficile (free)

“Very important finding! Restricting fluoroquinolones more important than infection control measures to prevent CDI” (RT @sanjaysaint see Tweet)

 

5 – Why cancer is not a war, fight, or battle – CNN (free)

Related: He’s a Fighter – The Atlantic (free)

“Cancer is a process, it’s not a war. No winners or losers. Stop military metaphors”. (RT @lucadf see Tweet)

 

6 – “A misuse of scarce funds”: NHS to end prescription of homeopathic remedies – The Guardian (free)

Related: NHS to ban homeopathy and herbal medicine, as ‘misuse of resources’ – The Telegraph (free) AND NHS plans to scrap homeopathy treatments – BBC (free)

 

7 – Effects of Non–Vitamin K Antagonist Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease: A Systematic Review and Meta‐Analysis – Journal of The American Heart Association (free)

“Among patients with AF and native VHD, NOACs reduce stroke and systemic embolism compared with warfarin”.

 

8 – High prevalence of erectile dysfunction in diabetes: a systematic review and meta-analysis of 145 studies – Diabetic Medicine (link to abstract – $ for full-text)

Commentary: Screening for Erectile Dysfunction Should Be Routine in Diabetes – Medscape (free registration required)

“Erectile dysfunction 3.5 times more common in diabetes” (RT @kamleshkhunti see Tweet)

 

9 – Diabetic retinopathy: current understanding, mechanisms, and treatment strategies – JCI Insight (free)

“It affects 100 M people WW, but under-diagnosed/treated: excellent review of diabetes retinopathy” (RT @EricTopol see Tweet)

 

10 – The Myth of Drug Expiration Dates – ProPublica (free)

“Hospitals and pharmacies are required to toss expired drugs, no matter how expensive or vital. Meanwhile the FDA has long known that many remain safe and potent for years longer”.

 

Fri, July 21 – 10 Stories of The Day!

21Jul
2017

 

1 – Report: HIV drug resistance report 2017 – World Health Organization (free)

News release: WHO urges action against HIV drug resistance threat (free)

Commentaries: HIV drug resistance could undermine progress in AIDS battle: WHO – Reuters (free) AND Drug-Resistant HIV Is On the Rise – TIME (free)

 

2 – Report: Ending AIDS: Progress Towards the 90-90-90 Target – Joint United Nations Programme on HIV/AIDS (UNAIDS) (free PDF)

Fact Sheet: Latest Statistics on The Status of The Aids Epidemic – UNAIDS (free) (RT @greg_folkers see Tweet)

Related editorial: The global HIV/AIDS epidemic—progress and challenges – The Lancet (free)

Commentary: For first time in history, half of all people with HIV are getting treatment – Science (free) (source: GlobalHealthNOW newsletter)

 

3 – Parkinson’s disease in adults – National Institute for Health and Care Excellence (NICE) Guideline (free)

 

4 – Antiplatelet Regimen for Patients With Breakthrough Strokes While on Aspirin: A Systematic Review and Meta-Analysis – Stroke (link to abstract – $ for full-text)

Commentary: Adjusting Antiplatelet Regimen Could Decrease Risk For Stroke Patients on Aspirin Monotherapy – American College of Cardiology, Latest in Cardiology (free)

Meta-analysis of cohort studies: in patients who experienced an ischemic stroke or transient ischemic attack while on aspirin monotherapy, the addition of or a switch to another antiplatelet agent, versus aspirin monotherapy, was associated with a 32 percent reduction in the risk of major adverse cardiovascular events (HR 0.68; 0.54–0.85) and 30 percent reduction in recurrent strokes (HR, 0.70; 0.54–0.92). Additional randomized trials would better clarify the best antiplatet regimen for these patients.

 

5 – Antidepressants during pregnancy and autism in offspring: population based cohort study – The BMJ (free)

Editorial: Prenatal antidepressant use and risk of autism (free)

Commentaries: Antidepressants and pregnancy: study didn’t find they actually cause autism – The Conversation (free) AND Antidepressant use in pregnancy linked to autism in children – OnMedica (free) AND Study finds slight autism risk link to antidepressants in pregnancy – Reuters (free)

 

6 – Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials – The BMJ (free)

Editorial: Diet and exercise in pregnancy (free)

Commentaries: Risk of caesarean reduced by healthy diet and physical activity during pregnancy, study finds – NewsMedical (free) AND C-Section Risk Reduction Linked to Healthy Lifestyle – MedPage Today (free)

 

7 – The Effects of Public Access Defibrillation on Survival After Out-of-Hospital Cardiac Arrest: A Systematic Review of Observational Studies – Circulation (link to abstract – $ for full-text)

Commentary: Bystander CPR Best Hope for Out-of-Hospital Cardiac Arrest? – Medscape (free registration required)

See related article on Bystander Efforts and 1-Year Outcomes in Out-of-Hospital Cardiac Arrest in our May 4th issue (see #2)

 

8 – Report: Dementia prevention, intervention, and care – The Lancet (free registration required)

Commentaries: Experts: 1 in 3 cases of dementia preventable, nonmedical therapies ideal for dementia – University of Southern California, via EurekAlert (free) AND One Third of Dementia May Be Preventable With Lifestyle Change – Medscape (free registration required) AND Over a Third of Dementia Cases Tied to Modifiable Risk Factors – Physician’s First Watch (free) AND Living healthily, learning more could cut dementia cases by a third – Reuters (free) AND Lifestyle changes could prevent a third of dementia cases, report suggests – The Guardian (free)

 

9 – The Uncertain Future of Genetic Testing – The Atlantic (free)

“Bringing genetics into medicine leads to more accuracy, better diagnosis, and personalized treatment—but for some, gene testing has only resulted in unanswered questions”.

 

10 – An emergency department protocol to restore circulation doesn’t improve outcomes in septic shock – NIHR Signal (free)

Original article: Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis – New England Journal of Medicine (link to abstract – $ for full-text)

 

Thu, July 20 – 10 Stories of The Day!

20Jul
2017

 

1 – WHO report on the global tobacco epidemic 2017 – World Health Organization (free)

Full report: WHO Report on The Global Tobacco Epidemic: 2017 Monitoring tobacco use and prevention policies (free PDF)

Press release: WHO report finds dramatic increase in life-saving tobacco control policies in last decade (free)

Infographics: Protecting people from tobacco (free)

Commentaries: Taxation: Most effective but still the least-used tobacco control measure, by Patricio V. Marquez via The World Bank Blogs (free) AND Tobacco industry blocking anti-smoking moves: WHO – Reuters (free) AND Tobacco firms ‘hamper anti-smoking push’ – BBC News (free) AND Tobacco companies interfere with health regulations, WHO reports – The Guardian (free)

See also our coverage of World No Tobacco Day in our May 31 issue (see #1).

 

2 – Enhanced Prophylaxis plus Antiretroviral Therapy for Advanced HIV Infection in Africa – New England Journal of Medicine (free)

Editorial: The Enduring Challenge of Advanced HIV Infection (free)

Among HIV-infected patients with advanced immunosuppression (CD4+ count < 100 cells/mm3), enhanced antimicrobial prophylaxis combined with ART resulted in reduced rates of death.

 

3 – Efficacy and Safety of Spironolactone in Acute Heart Failure: The ATHENA-HF Randomized Clinical Trial – JAMA Cardiology (link to abstract – $ for full-text)

Commentaries: High-dose spironolactone didn’t affect acute heart failure outcomes – ACP Hospitalist (free) AND High-Dose Spironolactone in Acute Heart Failure – American College of Cardiology, Latest in Cardiology (free)

 

4 – Use of antibiotics during pregnancy and the risk of major congenital malformations: A population based cohort study – British Journal of Pharmacology (link to abstract – $ for full-text)

Commentary: New study finds link between certain antibiotics during pregnancy and risk for birth defects – News Medical (free)

Related article: Use of antibiotics during pregnancy and risk of spontaneous abortion – Canadian Medical Association Journal (free)

In this large canadian cohort clindamycin, doxycycline, quinolones, macrolides, and phenoxymethylpenicillin were associated with congenital malformations. Amoxicillin, cephalosporins, and nitrofurantoin were not associated with birth defects.

 

5 – Position statement: American Society of Clinical Oncology Position Statement On Addressing the Affordability of Cancer Drugs (free PDF)

Commentaries: ASCO Offers Path to Addressing Affordability of Cancer Drugs in New Position Statement – ASCO Post (free) AND ASCO Tackles Affordability of Cancer Drugs – Physician’s First Watch (free) AND ASCO Advocates Value in Drug Pricing – MedPage Today (free registration required) AND ASCO Addresses High Cost of Cancer Drugs – Medscape (free registration required)

 

6 – Treating axial spondyloarthritis and peripheral spondyloarthritis, especially psoriatic arthritis, to target: 2017 update of recommendations by an international task force – Annals of Rheumatic Diseases (free)

Commentary: International Guidelines Say Use Treat-to-Target for SpA, PsA – Medscape (free registration required)

 

7 – Clinical Review: Community-associated methicillin-resistant Staphylococcus aureus infection: Literature review and clinical update – Canadian Family Physician (free)

 

8 – The Aging Physician and the Medical Profession: A Review – JAMA Sugery (free) (RT @EricTopol see Tweet)

 

9 – New Choosing Wisely Canada List: Hepatology: Five Things Physicians and Patients Should Question (free) (RT @ChooseWiselyCA see Tweet)

See more on the Choosing Wisely initiative in our April 5 issue (see #6).

 

10 – Improving people’s health through spatial planning – Public Health England (free) (RT @pash22 see Tweet)

Related reports: Spatial planning for health: evidence review – Public Health England (free) AND Healthy people healthy places evidence tool: Evidence and practical linkage for design, planning and health – University of the West of England (free)

Related WHO Report: Preventing disease through healthy environments: a global assessment of the burden of disease from environmental risks (free) AND News release: An estimated 12.6 million deaths each year are attributable to unhealthy environments (free)

 

Wed, July 19 – 10 Stories of The Day!

19Jul
2017

 

1 – Healthful and Unhealthful Plant-Based Diets and the Risk of Coronary Heart Disease in U.S. Adults – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Some Plant-Based Diets May Increase Heart Disease Risk –American College of Cardiology, Latest in Cardiology (free) AND Not All Vegetarian, Plant-Based Diets Equal for CHD Risk – Medscape (free registration required) AND Not all plant-based diets are created equal – American College of Cardiology, via ScienceDaily (free)

 

2 – Screening Criteria for Ophthalmic Manifestations of Congenital Zika Virus Infection – JAMA Pediatrics (free)

Commentaries: Zika: Check All Potentially Exposed Infants for Eye Damage – Medscape (free registration required) AND Which Infants Exposed to Zika Virus Infection in Pregnancy Should Have Eyes Examined? – The JAMA Network (free)

“All infants with potential Zika virus exposure should have ophthalmic screening regardless of other abnormalities” (RT @PreetiNMalani see Tweet)

 

3 – The Association Between Vasectomy and Prostate Cancer: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Meta-Analysis: Vasectomy Likely Does Not Cause Prostate Cancer – Physician’s First Watch (free) AND Weak Link Between Vasectomy, Prostate Cancer – MedPage Today (free registration required)

 

4 – Draft Recommendation Statement: Ovarian Cancer: Screening – U.S. Preventive Services Task Force (free)

Commentaries: USPSTF Again Recommends Against Screening General Population for Ovarian Cancer – Physician’s First Watch (free) AND USPSTF Stays Course on Ovarian Cancer Screening: No screening for asymptomatic women – MedPage Today (free registration required)

 

5 – Review: Emerging arboviruses: Why today? – One Health (free) (RT @greg_folkers see Tweet)

 

6 – Cochrane What is the best medication for a fungal infection of the toenail? – Cochrane Library (free)

Full review: Oral antifungal medication for toenail onychomycosis – Cochrane Library (link to abstract – $ for full-text)

Terbinafine probably leads to better cure rates than azoles, with the same risk of adverse events. Griseofulvin is no better and has more adverse effects than azoles.

 

7 – Homepage – New European Society of Medical Oncology (ESMO) Updated Clinical Practice Guidelines

New available guidelines are:

– Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Chronic myeloid leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Newly diagnosed and relapsed mantle cell lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with leptomeningeal metastasis from solid tumours (free)

– Management of infusion reactions to systemic anticancer therapy: ESMO Clinical Practice Guidelines (free)

– Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

 

8 – Patient Outcomes in Dose Reduction or Discontinuation of Long-Term Opioid Therapy: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Tapering long-term opioid therapy may improve outcomes in chronic pain, review finds – ACP Internist (free) AND Opioid Reduction Therapy Offers Some Benefits to Patients with Chronic Pain – Physician’s First Watch (free) AND How tapering off opioids can help people with chronic pain – CNN (free)

“Opioid tapering:

– less pain: 8 of 8 studies

– Improved function: 5 of 5 studies

– Improved QOL: 3 of 3 studies” (RT @DavidJuurlink see Tweet)

 

9 – As Workouts Intensify, a Harmful Side Effect Grows More Common – New York Times (10 articles per month are free)

Related practical review: Exercise-Induced Emergencies in the Heat: Rhabdomyolysis & Exertional Heat Stroke – emDocs (free)

 

10 – Randomized clinical trial of comprehensive geriatric assessment and optimization in vascular surgery – British Journal of Surgery (link to abstract – $ for full-text)

Source: ACP Journal Club ($ resource to find articles of interest)

In this RCT, a comprehensive preoperative geriatric assessment and optimization before vascular surgery was associated with shorter length of hospital stay, lower incidence of complications, and patients were less likely to be discharged to a higher level of dependency.

 

Tue, July 18 – 10 Stories of The Day!

18Jul
2017

 

1 – Report: Progress and Challenges with Achieving Universal Immunization Coverage: 2016 Estimates of Immunization Coverage – WHO / UNICEF (free PDF)  (RT @WHO see Tweet )

News Release: 1 in 10 infants worldwide did not receive any vaccinations in 2016 – World Health Organization (free)

 

2 – Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies – Canadian Medical Association Journal (free)

Commentaries: Artificial Sweeteners Not Tied to Lower BMI and May Even Increase It – Physician’s First Watch (free) AND Artificial Sweeteners Don’t Help People Lose Weight, Review Finds – NPR (free) AND The Irony Of Artificial Sweeteners – Forbes (free) AND Low-calorie sweeteners don’t help with weight loss — and may lead to gained pounds – STAT News (free)

 

3 – What proportion of health outcomes are attributable to health care – Sheffield DPH (free) (RT @gmacscotland and @felly500 see Tweet)

 

4 – The hidden truth about our prescription medications – Ideas.Ted.Com (free)

“Around half of the clinical trials that were done on the medicines we use today have never published their results…” (RT @Students4BE see Tweet)

 

5 – Why are these countries the most obese? Walking is just one reason – CNN (free) (RT @kamleshkhunti see Tweet)

Related studies: Health Effects of Overweight and Obesity in 195 Countries over 25 Years – New England Journal of Medicine (free) AND NIH-funded team uses smartphone data in global study of physical activity – NIH News Release (commentary, see original article$)

 

6 – Position Statement: American Association of Clinical Endocrinologists And American College Of Endocrinology Position Statement On Menopause – 2017 Update (free)

Related Position Statement: The 2017 hormone therapy position statement of The North American Menopause Society (free PDF)

Related Draft Recommendation Statement: Menopausal Hormone Therapy: Primary Prevention of Chronic Conditions – U.S. Preventive Services Task Force (free)

 

7 – Richard Lehman’s journal review, 17 July 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – Evidence-based guidelines for fall prevention in Korea – The Korean Association of Internal Medicine and The Korean Geriatrics Society (free)

 

9 – Financing transformative health systems towards achievement of the health Sustainable Development Goals: a model for projected resource needs in 67 low-income and middle-income countries – The Lancet Global Health (free) (RT @LancetGH see Tweet)

Invited commentaries: Financing health systems to achieve the health Sustainable Development Goals (free) AND All roads lead to universal health coverage, by Tedros Adhanom Ghebreyesus, Director-General of WHO (free)

WHO News Release: WHO estimates cost of reaching global health targets by 2030 (free)

Commentaries: Global health price tag could be $371 billion a year by 2030, WHO says – Reuters (free)

 

10 – New research program and website: Access to Healthcare – Economist Intelligence Unit (all resources are free) (RT @anetrid see Tweet)

Report: Global access to healthcare: Building sustainable health systems – Economist Intelligence Unit report (free)

“This research programme, created by The Economist Intelligence Unit, examines the challenges and opportunities countries face as they attempt to improve access to high-quality healthcare that meets the needs of their populations. It consists of the Global Access to Healthcare Index, covering 60 countries with a diversity of income levels; a global report; an animated infographic introducing the key findings from the index; six infographics on the main domains of the index; and five regional summary papers”.

 

Mon, July 17 – 10 Stories of The Day!

17Jul
2017

 

1 – The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines – World Journal of Emergency Surgery (free)

Related guideline: The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection – Surgical Infections (free)

 

2 – Constipation in children and young people: diagnosis and management – National Institute for Health and Care Excellence (NICE) Guideline (free)

 

3 – High-flow nasal cannula oxygen therapy is superior to conventional oxygen therapy but not to noninvasive mechanical ventilation on intubation rate: a systematic review and meta-analysis – Critical Care (free)

Source: Hospital Medicine Virtual Journal Club (free resource to find articles of interest)

 

4 – Systematic review: Antiepileptic drug monotherapy (single drug treatment) for epilepsy – Cochrane Library (free)

Original article: Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data (link to summary – $ for full-text)

 

5 – Studies suggest apneic oxygenation reduces hypoxemia during emergency intubation:

Meta-analysis 1: Apneic oxygenation during intubation in the emergency department and during retrieval: A systematic review and meta-analysis – The American Journal of Emergency Medicine (link to abstract – $ for full-text)

Meta-analysis 2: Apneic oxygenation reduces the incidence of hypoxemia during emergency intubation: A systematic review and meta-analysis – The American Journal of Emergency Medicine (link to abstract – $ for full text)

Source: Apneic Oxygenation Prevents Desaturation During Intubation – Journal Watch ($ resource to find articles of interest)

 

6 – Risk of post-pregnancy hypertension in women with a history of hypertensive disorders of pregnancy: nationwide cohort study – The BMJ (free)

Related article: Lifestyle in progression from hypertensive disorders of pregnancy to chronic hypertension in Nurses’ Health Study II: observational cohort study – The BMJ (free)

Editorial: Hypertensive disorders of pregnancy – The BMJ (free)

Commentaries: Hypertensive Disorders of Pregnancy Tied to Increased Hypertension Risk Decades Later – Physician’s First Watch (free)

 

7 – How to spot a misleading graph, by Lea Gaslowitz – TED Talks (free YouTube video)

“How to spot a misleading graph – Great video by Lea Gaslowitz @TEDTalks” (RT @CochraneUK see Tweet)

 

8 – Opinion: Physicians need to openly discuss medical mistakes and near misses – STAT News (free) (RT @statnews see Tweet)

 

9 – “Pathologists debating their future in the era of #AI” (RT @EricTopol see Tweet)

Editorial 1: AlphaGo, Deep Learning, and the Future of the Human Microscopist – Archives of Pathology & Laboratory Medicine (free)

Editorial 2: Artificial Intelligence and the Pathologist: Future Frenemies? – Archives of Pathology & Laboratory Medicine (free)

See more on the impact of artificial intelligence in healthcare in our June 14th issue (see #2 and #3)

 

10 – A must read perspective on “Machine Learning and Prediction in Medicine — Beyond the Peak of Inflated Expectations” – Cross Invalidation (free) (RT @pash22 see Tweet)

 

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