Open access


Tue, October 16 – 10 Stories of The Day!

16 Oct,2018


1 – Attention deficit hyperactivity disorder late birthdate effect common in both high and low prescribing international jurisdictions: systematic review – The Journal of Child Psychology and Psychiatry (free)

Commentary: Global study finds youngest in class more likely to be diagnosed with ADHD – University of Adelaide (free)

“Youngest kids in class much more likely get ADHD diagnosis than oldest. Bad News: Simple immaturity now turned into mental illness & treated with meds” (via @AllenFrancesMD see Tweet)


2 – Many Analysts, One Data Set: Making Transparent How Variations in Analytic Choices Affect Results – Advances in Methods and Practices in Psychological Science (free) (via @f_g_zampieri)

“This is one of most important studies published this century. 29 teams used same data set to address same research question; estimated effect sizes ranged from 0.89 to 2.93 in odds-ratio units. Dramatic implications for observational research.” (via @hmkyale see Tweet)


3 – WHO Statement: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Related: DR Congo: managing Ebola virus in war – The Lancet (free) AND Ebola experts from CDC were pulled from outbreak zone amid security concern – STAT (free) AND Ebola showed up in a war zone. It’s not going well – VOX (free) AND Experts Said A War Zone Ebola Outbreak Would Be A Nightmare. It’s Been Even Worse – HuffPost (free) AND DRC Ebola cases top 200 as security problems fuel the spike – CIDRAP (free)


4 – A pandemic killing tens of millions of people is a real possibility — and we are not prepared for it – VOX (free)

Related: Innovation for Pandemics (free perspectives and video on the subject)


5 – Ann Robinson’s research reviews, 15 October 2018 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.


6 – Demystifying serotonin syndrome (or serotonin toxicity) – Canadian Family Physician (free)


7 – Approach to the detection and management of chronic kidney disease: What primary care providers need to know – Canadian Family Physician (free)


8 – Oliguria in critically ill patients: a narrative review – Journal of Nephrology (free)

Source: Critical Care Reviews Newsletter


9 – β-Blocker Use in Pregnancy and the Risk for Congenital Malformations: An International Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Beta-Blocker Use in First Trimester Seems Safe – Physician’s First Watch (free) AND Beta-blocker Use in Pregnancy Doesn’t Up Birth Defect Risk, Study Suggests – TCTMD (free)


10 – Identity inference of genomic data using long-range familial searches – Science (free for a limited period)

Commentaries: Most White Americans’ DNA Can Be Identified Through Genealogy Databases – The New York Times (10 articles per month are free) AND How an Unlikely Family History Website Transformed Cold Case Investigations – The New York Times (10 articles per month are free) AND ‘We are increasingly exposed’: New studies show how easy it is to identify people using genetic databases – STAT (free) AND Supercharged crime-scene DNA analysis sparks privacy concerns – Nature (free)


Mon, October 15 – 10 Stories of The Day!

15 Oct,2018


1 – WHO recommendations: non-clinical interventions to reduce unnecessary caesarean sections – World Health Organization (free PDF)

News Release: New WHO guidance on non-clinical interventions specifically designed to reduce unnecessary caesarean sections (free)

Related Cochrane Review: Non‐clinical interventions for reducing unnecessary caesarean section (free review and summary)


2 – Series: Optimising caesarean section use – The Lancet (free articles and commentaries, registration required)

Commentaries: Caesarean section use has almost doubled globally since 2000 – The Lancet (free) AND C-section births rise rapidly to more than 20 percent worldwide – Reuters (free) AND Rate Of C-Sections Is Rising At An ‘Alarming’ Rate, Report Says – NPR (free) AND C-section deliveries nearly doubled worldwide since 2000, study finds – CNN (free) AND C-section births surge to ‘alarming’ rates worldwide – study – BBC (free)


3 – A blueprint for the primary prevention of cancer: Targeting established, modifiable risk factors – CA: A Cancer Journal for Clinicians (free)

Commentary: Comprehensive report says tobacco control must be highest priority in cancer control – American Cancer Society (free)


4 – Analysis: Treatment burden should be included in clinical practice guidelines – The BMJ (free for a limited period)


5 – Opinion: Professional Societies Should Abstain From Authorship of Guidelines and Disease Definition Statements – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Professional Societies, Clinical Specialists, and Guidelines – Circulation: Cardiovascular Quality and Outcomes (free) AND Turn Cardiology Guidelines Over to Outsiders – MedPage Today (free registration required)

John Ioannidis, MD. “questioned whether cardiovascular guidelines “homogenize biased, collective, and organized ignorance” through use of predominantly “insider” experts as authors.” (from MedPage Today)


6 – Diagnosis and management of non-dialysis chronic kidney disease in ambulatory care: a systematic review of clinical practice guidelines – BMC Nephrology (free)


7 – KAAACI Evidence-Based Clinical Practice Guidelines for Chronic Cough in Adults and Children in Korea – Allergy, Asthma & Immunology Research (free)

Related: Managing Patients with Chronic Cough (free CHEST guidelines on the subject)


8 – Supplement: Digital Health and Health Systems of the Future – Global Health: Science and Practice (free articles)

Source: International Health Policies Newsletter


9 – Association of Mechanical Bowel Preparation and Oral Antibiotics Before Elective Colorectal Surgery With Surgical Site Infection: A Network Meta-analysis – JAMA Network Open (free)

Invited Commentary: When Will the Surgical Community Acknowledge the Evidence Regarding Prophylaxis With Oral Antibiotics for Scheduled Colorectal Operations? (free)

Bowel Preparation and Oral Antibiotics Before Elective Colorectal Surgery. Once again the combination of oral antibiotic and oral mechanical cathartic bowel preparation yields the lowest rates of surgical site infections” (via @SWexner see Tweet)


10 – Unapproved Pharmaceutical Ingredients Included in Dietary Supplements Associated With US Food and Drug Administration Warnings – JAMA Network Open (free)

Editorial: The FDA and Adulterated Supplements—Dereliction of Duty – JAMA Network Open (free)

Commentaries: Nearly 800 dietary supplements contained unapproved drug ingredients, study finds – CNN (free) AND No Wonder It Works So Well – NPR (free) AND Hundreds of Dietary Supplements Are Tainted with Prescription Drugs – Scientific American (free) AND Hundreds of health, weight loss products contain unapproved ingredients: Study – UPI (free) AND Some dietary supplements contain potentially harmful drugs – Reuters (free)


Fri, October 12 – 10 Stories of The Day!

12 Oct,2018


1 – Review: What treatments are effective for common cold in adults and children? – The BMJ (free review and infographic)

Commentaries: What works for treating children’s colds? – BBC (free) AND Doctors should steer young children away from decongestants – OnMedica (free)


2 – How To Prevent Brain-Sapping Delirium In The ICU – NPR (free text and podcast)

Related: ABCDEF Bundle – Society of Critical Care Medicine (free resource) AND The ABCDEF Bundle: Science and Philosophy of How ICU Liberation Serves Patients and Families – Critical Care Medicine (free)


3 – Correspondence: Real-Time Patient–Provider Video Telemedicine Integrated with Clinical Care – New England Journal of Medicine (free)


4 – Perspective: The approach to predictive medicine that is taking genomics research by storm – Nature (free)

“Polygenic risk scores represent a giant leap for gene-based diagnostic tests. Here’s why they’re still so controversial.”


5 – Review: Venous thromboembolism prophylaxis may cause more harm than benefit: an evidence-based analysis of Canadian and international guidelines – Thrombosis Journal (free) (via @amtejani)


6 – Review: A New Vaccine for Shingles – Therapeutics Initiative (free)

“Need to vaccinate 31 people to prevent one instance of HZ; Need to vaccinate 358 people to prevent one instance on post herpetic neuralgia” (via @amtejani)


7 – Environmental Noise Guidelines for the European Region (2018) – World Health Organization (free PDF)

Commentary: Noise: The other pollution hurting our health – CNN (free)


8 – Clinical management of cutaneous adverse events in patients on targeted anticancer therapies and immunotherapies: a national consensus statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology – Clinical and Translational Oncology (free)


9 – Effectiveness of the Stand More AT (SMArT) Work intervention: cluster randomised controlled trial – The BMJ (free)

Editorial: Reducing sedentary behaviour in the workplace (free)

Commentaries: Standing-desk workers ‘less tired, more engaged’ – BBC (free) AND Sit-stand desks may improve job performance, psychological health – UPI (free)


10 – Association of Unrecognized Myocardial Infarction With Long-term Outcomes in Community-Dwelling Older Adults: The ICELAND MI Study – JAMA (free for a limited period)

Commentaries: Silent Infarcts Have Similar Mortality Over 10 Years as Clinically Recognized MI – TCTMD (free) AND Association of Unrecognized MI With Long-Term Outcomes – American College of Cardiology (free)

Related Study: Silent Myocardial Infarction and Long-Term Risk of Heart Failure (link to abstract and commentaries)


Thu, October 11 – 10 Stories of The Day!

11 Oct,2018


1 – The Lancet Commission on global mental health and sustainable development (free registration required)

Commentaries: Mental health crisis could cost the world $16 trillion by 2030 – Reuters (free) AND Mental health disorders will cause ‘monumental suffering’ and cost £12 TRILLION a year worldwide by 2030 – The Daily Mail (free) AND World in mental health crisis of ‘monumental suffering’, say experts – The Guardian (free)


2 – Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2018 update – Canadian Medical Association Journal (free)


3 – Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis – New England Journal of Medicine (link to abstract – $ for full-text)

Video Summary: Renal-Replacement Therapy for AKI (free)

Commentary: Is Kidney Dialysis Always Needed When Septic Shock Strikes? – HealthDay (free)

“Trial comparing early vs. delayed strategies of renal-replacement therapy in patients with early-stage septic shock who had severe acute kidney injury finds no significant between-group difference in overall mortality at 90 days.” (via @NEJM see Tweet)


4 – Effect of Immediate vs Delayed Pushing on Rates of Spontaneous Vaginal Delivery Among Nulliparous Women Receiving Neuraxial Analgesia: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Video Summary: Immediate vs Delayed Pushing During Second Stage of Labor (free)

Commentaries: When Giving Birth For The First Time, Push Away – NPR (free) AND In childbirth, when to begin pushing does not affect C-section rates – Washington University in St. Louis (free) AND Vaginal delivery not affected by delayed pushing, study says – UPI (free)


5 – Review: Management of severe acute exacerbations of COPD: an updated narrative review – Multidisciplinary Respiratory Medicine (free)


6 – Review: An update on the use of inhaled therapy in COPD – Clinical Medicine (free)


7 – Review: What is the significance of monoclonal gammopathy of undetermined significance? – Clinical Medicine (free)


8 – Ghost authorship haunts industry-funded clinical trials – Nature (free)

Original Article: Collaboration Between Academics and Industry in Clinical Trials (free study and commentaries)


9 – Evaluation of the diet wide contribution to serum urate levels: meta-analysis of population based cohorts – The BMJ (free)

Editorial: The role of diet in serum urate concentration (free)

Commentary: Diet Might Play Less of a Role in Gout Than Previously Thought – Physician’s First Watch (free)


10 – Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin – BMJ Case Reports (free)

Commentaries: Planned intermittent fasting may help reverse type 2 diabetes, suggest doctors – BMJ (free) AND Therapeutic Fasting Could Be an Alternative to Insulin for Some Diabetes Patients – Physician’s First Watch (free)


Wed, October 10 – 10 Stories of The Day!

10 Oct,2018


1 – Cluster Randomized Clinical Trial of FAITH (Faith-Based Approaches in the Treatment of Hypertension) in Blacks – Circulation: Cardiovascular Quality and Outcomes (free)

Editorial: Of Barbershops and Churches: Can Community-Based Interventions Improve Cardiovascular Risk in High-Risk Patients? (free)

Commentaries: Faith-based approach to changing lifestyle lowers blood pressure – AHA Newsroom (free) AND How church communities can help lower African-Americans’ blood pressure – CNN (free) AND Church-Based Lifestyle Intervention Shows Promise for Lowering BP in Hypertensive African-Americans – TCTMD (free)

Related Study: Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops (free study and commentaries)


2 – Fluoroquinolone and quinolone antibiotics: PRAC recommends new restrictions on use following review of disabling and potentially long-lasting side effects – European Medicines Agency (free)

Commentaries: EMA committee recommends restrictions on fluoroquinolone, quinolone antibiotics – Reuters (free) AND PRAC Recommends Restrictions on Fluoroquinolone, Quinolones – Medscape (free registration required)

Related FDA Safety Alert: Warnings for Fluoroquinolones on Risks of Mental Health and Low Blood Sugar Adverse Reactions (free statement and commentaries)


3 – Evidence synthesis for health policy and systems: a methods guide – World Health Organization (free PDF) (via @trishgreenhalgh)


4 – Non-celiac gluten/wheat sensitivity (NCGS)—a currently undefined disorder without validated diagnostic criteria and of unknown prevalence – Position statement of the task force on food allergy of the German Society of Allergology and Clinical Immunology (DGAKI) (free)


5 – Review: Managing the Patient with Heart Failure in the Emergency Department – European Heart Journal (free) (via @gonzaeperez)


6 – Review: Office approach to small fiber neuropathy – Cleveland Clinic Journal of Medicine (free)


7 – Review: Bicuspid aortic valve: Basics and beyond – Cleveland Clinic Journal of Medicine (free)


8 – Nine ways research could save the NHS money – NHS Dissemination Centre (free)

New infographic series with selected NIHR Signals covering a range of treatments and initiatives that are cost effective.


9 – 800,000 people kill themselves every year. What can we do? – The Guardian (free) (via @onisillos)

Related Guidelines: Preventing suicide: A community engagement toolkit – World Health Organization (free PDF) AND Preventing suicide in community and custodial settings – National Institute for Health and Care Excellence (free)

“In too many places mental health support services are non-existent and those with treatable conditions are criminalized. Bold action is long overdue”


10 – Electronic cigarette explosion and burn injuries, US Emergency Departments 2015–2017 – Tobacco Control (link to abstract – $ for full-text)

Commentaries: E-cigarette explosion and burn injuries have been underestimated by federal agencies – George Mason University (free) AND Study: E-Cigarette Injuries Drastically Underestimated – MedPage Today (free registration required)


Tue, October 9 – 10 Stories of The Day!

9 Oct,2018


1 – Level 3 guideline on the treatment of patients with severe/multiple injuries – German Trauma Society (free)

News Release: The updated German “Polytrauma – Guideline”: an extensive literature evaluation and treatment recommendation for the care of the critically injured patient (free)

Source: Critical Care Reviews Newsletter


2 – ESPEN guideline on clinical nutrition in the intensive care unit – Clinical Nutrition (free)

Source: Critical Care Reviews Newsletter


3 – Non‐clinical interventions for reducing unnecessary caesarean section – Cochrane Library (free for a limited period)

Summary: Non-clinical interventions for reducing unnecessary caesarean section (free)


4 – Pelvic floor muscle training versus no treatment, or inactive control treatments, for urinary incontinence in women – Cochrane Library (free)

Based on the data available, we can be confident that pelvic floor muscle training can cure or improve symptoms of stress urinary incontinence and all other types of urinary incontinence”


5 – Perspective: The Name of the Dog – New England Journal of Medicine (free)

“During morning rounds, I had presented a patient who was admitted for chest pain after walking his dog. My attending had asked, ‘What was the name of his dog?’ ” (via @fischmd see Tweet)


6 – Zackary Berger’s journal reviews, 8 October 2018 – The BMJ Opinion (free)

Zackary Berger reviews the latest research from the top medical journals.


7 – Last Month in Oncology with Dr. Bishal Gyawali: September 2018 – eCancer News (free)


8 – Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention (via @EricTopol)


9 – Laparoscopic cholecystectomy versus percutaneous catheter drainage for acute cholecystitis in high risk patients (CHOCOLATE): multicentre randomised clinical trial – The BMJ (free)

“Laparoscopic cholecystectomy compared with percutaneous catheter drainage reduced the rate of major complications in high risk patients with acute cholecystitis.”


10 – Statins and Multiple Noncardiovascular Outcomes: Umbrella Review of Meta-analyses of Observational Studies and Randomized Controlled Trials – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Statin Benefits: Yes for CVD but No for Everything Else, Says New Review – TCTMD (free) AND Statins’ benefits beyond heart health aren’t clear-cut, analysis says – CNN (free)


Mon, October 8 – 10 Stories of The Day!

8 Oct,2018


1 – Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) – Diabetes Care (free PDF)

Commentaries: New Consensus Report from the American Diabetes Association® (ADA) and the European Association for the Study of Diabetes (EASD) Calls for Paradigm Shift to Patient-Centered Care for Type 2 Diabetes – American Diabetes Association (free) AND New EASD-ADA consensus guidelines on managing hyperglycaemia in type 2 diabetes launched at EASD meeting – Diabetologia (free)

Related Guidelines: WHO Guideline: Medicines for the Treatment of Diabetes in Low-Resource Settings (free guideline and commentaries) AND Pharmacologic Glycemic Management of Type 2 Diabetes in Adults – Canadian Journal of Diabetes (free) AND ADA 2018 Standards of Medical Care in Diabetes (free guideline and commentaries) AND ACP Guideline: Hemoglobin A1c Targets for Glycemic Control in Type 2 Diabetes (free guideline and commentaries)


2 – Supplement: ESMO Updated Clinical Practice Guidelines – European Society of Medical Oncology (free)


3 – Perspective: What the tests don’t show – The Washington Post (a few articles per month are free)

“Many doctors are surprisingly bad at reading test results and/or fail to grasp how false positives work. This is putting patients at risk” (via @pash22 see Tweet)


4 – Perspective: Why Employers Should Stop Giving Away Snacks – Pacific Standart (free)

Source: Global Health NOW Newsletter


5 – Outpatient antibiotics widely prescribed without an infection diagnosis – CIDRAP (free)

Related Commentary: Study Finds Almost Half of Antibiotic Prescriptions Written Without a Diagnosis – Pharmacy Times (free)


6 – Review: The Diagnosis and Treatment of Anxiety Disorders – Deutsches Ärzteblatt international (free)


7 – Review: Cardiovascular disease and COPD: dangerous liaisons? – European Respiratory Review (free)


8 – COPD Guidelines: A Review of the 2018 GOLD Report – Mayo Clinic Proceedings (free)

Related: Highlights from the New GOLD COPD Guidelines (free guideline and commentaries)


9 – Closed-loop insulin delivery in suboptimally controlled type 1 diabetes: a multicentre, 12-week randomised trial – The Lancet (free)

Commentaries: Enlarging the loop: closed-loop insulin delivery for type 1 diabetes – The Lancet (free) AND Hybrid Closed Loop System Aid for Tighter Glucose Control – MedPage Today (free registration required)


10 – Effectiveness of Online vs In-Person Care for Adults With Psoriasis: A Randomized Clinical Trial – JAMA Network Open (free)

Commentary: Treating psoriasis in the future could be as easy as going online – USC News (free)


Fri, October 5 – 10 Stories of The Day!

5 Oct,2018


1 – Acceleration of BMI in Early Childhood and Risk of Sustained Obesity – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Childhood BMI Acceleration and Sustained Obesity (free)

Commentary: BMI in Early Childhood and Sustained Obesity – American College of Cardiology (free)


2 – Effects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, and trial sequential analysis – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentaries: The Lancet Diabetes & Endocrinology: Vitamin D supplementation in adults does not prevent fractures, falls or improve bone mineral density – The Lancet (free) AND Vitamin D supplements don’t help bone health, major study concludes – The Guardian (free) AND Millions of Americans take vitamin D. Most should just stop – VOX (free)

Related: Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It (free commentaries and NICE Guideline) AND Vitamin D Not Linked to Fracture Risk (free study and commentaries)


3 – Clinical Update: Immune Checkpoint Inhibitor Toxicity in 2018 – JAMA (free for a limited period)

Related Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)

Related Review: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)


4 – Perspective: Given Their Potential for Harm, It’s Time to Focus on the Safety of Supplements – JAMA (free) (via @NUNESDOC)

“About 23 000 visits to emergency departments each year can be attributed to adverse events from dietary supplements.”


5 – Perspective: When Conventional Wisdom Is Put on Trial – UNDark (free) (via @EricTopol)

“The author of “Randomistas” shows how randomized trials have overturned many popular findings, from hormone therapy to the benefits of multivitamins.”


6 – Report: The future of healthcare – The Economist (free PDF)


7 – Effect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Weight loss drug shows positive effect on diabetes – Brigham and Women’s Hospital (free) AND Weight Loss Drug Helped Prevent Diabetes in Overweight People – MedPage Today (free registration required)

Related Article: Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients (link to abstract and commentaries)


8 – Collaboration between academics and industry in clinical trials: cross sectional study of publications and survey of lead academic authors – The BMJ (free)

Commentaries: Shining a light on industry collaboration – The BMJ Opinion (free) AND Industry funders involved in most aspects of funded trials – OnMedica (free)


9 – Perspective: New Tools in the Ebola Arsenal – New England Journal of Medicine (free)

Related: DRC Ebola cases rise as security concerns continue – CIDRAP (free) AND Officials fear Ebola epidemic may be spinning beyond their control, threatening regional spread – STAT (free) AND Ebola Likely to Spread From Congo to Uganda, W.H.O. Says – The New York Times (10 articles per month are free)


10 – Prescribed Exercise With Compression vs Compression Alone in Treating Patients With Venous Leg Ulcers: A Systematic Review and Meta-analysis – JAMA Dermatology (link to abstract – $ for full-text)

Commentaries: Adding Exercise to Compression Improves Outcomes in Venous Leg Ulcers – Physcian’s First Watch (free) AND Compressions May Remedy Venous Leg Ulcers – MedPage Today (free)


Thu, October 4 – 10 Stories of The Day!

4 Oct,2018


1 – NICE Guideline: Renal replacement therapy and conservative management – National Institute for Health and Care Excellence (free)


2 – The projected timeframe until cervical cancer elimination in Australia: a modelling study – The Lancet Public Health (free)

Commentaries: Modelling cervical cancer elimination – The Lancet Public Health (free) AND Australia on track to wipe out cervical cancer within 20 years – The Guardian (free) AND In Australia, Cervical Cancer Could Soon Be Eliminated – The New York Times (10 articles per month are free)


3 – Global, regional, and national burden of Parkinson’s disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet Neurology (free)

Invited Commentary: The burden of Parkinson’s disease: a worldwide perspective (free)

“In 2016, 6·1 million people worldwide had Parkinson’s disease, 2·9 million (48%) women & 3·2 million (52%) men; the increase in burden since 1990 was not exclusively explained by an increasing number of older people” (via @TheLancet see Tweet)


4 – Guidelines for Perioperative Care in Esophagectomy: Enhanced Recovery After Surgery (ERAS®) Society Recommendations – World Journal of Surgery (free for a limited period)


5 – Recommendations for the use of Electrophysiological Study: Update 2018 – Helenic Journal of Cardiology (free)


6 – Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society Clinical Practice Guideline – Journal of Clinical Endocrinology and Metabolism (free PDF)

News Release: Managing congenital adrenal hyperplasia requires shared decisions among patients, families, and heal – The Endocrine Society (free)


7 – Evaluating Progression-Free Survival as a Surrogate Outcome for Health-Related Quality of Life in Oncology: A Systematic Review and Quantitative Analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Health-related quality of life overlooked in cancer drug studies – McMaster University (free) AND Investigators Question the Use of PFS as a Surrogate End Point – Cancer Therapy Advisor (free) AND Preventing tumor spread may not improve quality of life – Reuters (free) AND Research: Consider quality of life when evaluating cancer drug studies – UPI (free)


8 – Committee Opinion: Well-Woman Visit – American College of Obstetrics and Gynecology (free)

News Release: ACOG and WPSI Release Materials to Support Women’s Preventive Care at Every Life Stage (free)

Commentary: ACOG Stresses Role of Ob/Gyns in Preventive Care For Women – Medscape (free registration required)


9 – Two antiplatelet drugs may prevent further strokes but increase major bleeds – NIHR Signal (free)

Original Article: Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA – New England Journal of Medicine (link to abstract – $ for full-text)


10 – A Population-Based Analysis of the Relationship Between Substance Use and Adolescent Cognitive Development – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Teen cannabis use is not without risk to cognitive development – Université de Montréal (free) AND Cannabis ‘more harmful than alcohol’ for teen brains – BBC (free)


Wed, October 3 – 10 Stories of The Day!

3 Oct,2018


1 – Ten Principles for More Conservative, Care-Full Diagnosis – Annals of Internal Medicine (free) (via @EricTopol)


2 – Management of Malignant Pleural Effusions. An Official ATS/STS/STR Clinical Practice Guideline – American Journal of Respiratory and Critical Care Medicine (free)

Related Guideline: ERS/EACTS statement on the management of malignant pleural effusions – European Respiratory Journal (free)


3 – Effect of Early Surgery vs Physical Therapy on Knee Function Among Patients With Nonobstructive Meniscal Tears: The ESCAPE Randomized Clinical Trial – JAMA (free for a limited period)

Commentary: PT an Alternative to Surgery for Some Meniscal Tears – Physician’s First Watch (free)

Related: Adverse Outcomes After Arthroscopic Partial Meniscectomy (free study, commentary and guideline on the subject)

 “Our Dutch multi center RCT demonstrates noninferiority of physical therapy compared with early surgery with arthroscopic partial meniscectomy for improving self-reported knee function in patients with nonobstructive meniscal tears.” (via @RudolfPoolman see Tweet)


4 – Association of Thyroid Hormone Therapy With Quality of Life and Thyroid-Related Symptoms in Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)

Commentaries: Most Patients With Subclinical Hypothyroidism May Not Require Thyroid Medication – MedicalResearch.com (free) AND Hormone Tx May Not Benefit Subclinical Hypothyroidism – MedPage Today (free registration required) AND Treating Subclinical Hypothyroidism Is of Little Benefit – Medscape (free registration required)


5 – A systematic review into the incidence, severity and duration of antidepressant withdrawal effects: Are guidelines evidence-based? – Addictive Behaviours (free PDF)

Commentaries: Antidepressant withdrawal ‘hits millions’ – BBC (free) AND Antidepressant withdrawal symptoms severe, says new report – The Guardian (free)

Related: Antidepressant Withdrawal Syndrome (free review and NYT article)


6 – Association is not causation: treatment effects cannot be estimated from observational data in heart failure – European Heart Journal (free)


7 – Fracture Prevention with Zoledronate in Older Women with Osteopenia – New England Journal of Medicine (free)

Editorial: A Not-So-New Treatment for Old Bones (free)

Commentary: Study Suggests More Older Women May Benefit From Bone Drugs – The Associated Press (free)


8 – Review: Neuro-Ophthalmology at the bedside: A clinical guide – Journal of Neurosciences in Rural Practice (free)


9 – Efficacy of Low-Dose Amitriptyline for Chronic Low Back Pain: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Low-dose antidepressants ease back pain – Australian Hospital + Healthcare Bulletin (free) AND Antidepressant Amitriptyline Might Help Ease Low Back Pain – Physician’s First Watch (free)


10 – Six months versus 12 months dual antiplatelet therapy after drug-eluting stent implantation in ST-elevation myocardial infarction (DAPT-STEMI): randomised, multicentre, non-inferiority trial – The BMJ (free)

Related Research: 6-month versus 12-month or longer dual antiplatelet therapy after percutaneous coronary intervention in patients with acute coronary syndrome (link to abstract and commentaries)

In this study, DAPT for 6 months was non-inferior to DAPT for 12 months after drug-eluting stent implantation in ST-elevation myocardial infarction.


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