Open access

Fri, September 22 – 10 Stories of The Day!



1 – Weight and Metabolic Outcomes 12 Years after Gastric Bypass – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Benefits of gastric bypass persist for 12 years – Reuters (free) AND Gastric bypass surgery benefits continue for 12 years – (free) AND Bariatric Surgery’s Benefits Last Over a Decade – Physician’s First Watch (free)


2 – Do interventions that reduce the cost of smoking cessation treatment increase quit rates, quit attempts or use of treatments? – Cochrane Library (free)

Original article: Healthcare financing systems for increasing the use of tobacco dependence treatment – Cochrane Library (link to abstract – $ for full-text)

Full financial interventions directed at smokers when compared to no financial interventions increase the proportion of smokers who attempt to quit, use smoking cessation treatments, and succeed in quitting”.


3 – Lung Cancer Mortality Associated With Smoking and Smoking Cessation Among People Living With HIV in the United States – JAMA Internal Medicine (free)

Editorial: If We Are Smart Enough to Stop HIV From Replicating, Why Can’t We Help People to Stop Smoking? (free)

Commentaries: People with HIV who smoke are more likely to die from lung cancer than from HIV itself – eCancer (free) AND Smoking cuts life expectancy in HIV more than AIDS does – OnMedica (free)


4 – Randomized clinical trial of antibiotic therapy for uncomplicated appendicitis – British Journal of Surgery (link to abstract – $ for full-text)

See also a  related meta-analysis suggesting the safety of nonoperative treatment for uncomplicated cases (free) and a recent guideline that incorporates the possibility of non-operative treatment for uncomplicated disease (free)

“1st RCT to show uncomplicated appendicitis resolve even without antibiotics (let alone surgery)” (RT @villesallinen see Tweet)


5 – All Hypertensive Disorders of Pregnancy Increase the Risk of Future Cardiovascular Disease – Hypertension (link to abstract – free PDF via @unpaywall)

Commentaries: Hypertensive disorders of pregnancy increase future risk of heart disease – Cardiovascular Business (free) AND A type of hypertension during pregnancy more dangerous than thought – AHA News (free)

See related articles and commentaries in our August 22nd issue (see #3)


6 – Association of Trial Registration With Reporting of Primary Outcomes in Protocols and Publications – JAMA (free)

Commentaries: Discrepancy between trial goals, results may mask treatment risks – Reuters (free) AND Clinical Trials Often Unregistered, Unpublished – The JAMA Network (free)


7 – The interstitial lung disease multidisciplinary meeting: A position statement from the Thoracic Society of Australia and New Zealand and the Lung Foundation Australia (free)


8 – Cancer patients need better care, not just more technology – Nature News (free)


9 – Juvenile Stroke: A Practice-Oriented Overview – Deutsches Ärzteblatt international (free)

Commentary: German study dissects etiology behind juvenile stroke – Cardiovascular Business (free)


10 – FDA Drug Safety Communication: FDA recommends separating dosing of potassium-lowering drug sodium polystyrene sulfonate (Kayexalate) from all other oral drugs (free)

Commentary: Don’t Give Kayexalate With Other Oral Drugs, FDA Warns – Medscape (free registration required)

“Patients should take orally administered prescription and over-the-counter (OTC) medicines at least 3 hours before or 3 hours after sodium polystyrene sulfonate”


Thu, September 21 – 10 Stories of The Day!



1 – The world is running out of antibiotics, WHO report confirms – World Health Organization (free)

See WHO Reports: Antibacterial Agents in Clinical Development (free) AND Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics (free)

See also WHO Resources on Antibiotic Resistance

Commentaries: WHO report paints dire picture of antibiotic development – CIDRAP (free) AND Too few antibiotics in pipeline to tackle global drug-resistance crisis, WHO warns – The Guardian (free) AND The world is running out of antibiotics, WHO says – CNN (free text and video)


2 – Rapid Recommendation: Corticosteroids for sore throat: a clinical practice guideline – The BMJ (free text and infographic)

See also other Rapid Recommendations from The BMJ (all free)


3 – Improving health systems in low-income countries – 3 New Cochrane Library Reviews

Article 1: Implementation strategies for health systems in low-income countries: an overview of systematic reviews (free) AND Summary: Implementation strategies for health systems in low-income countries (free)

Article 2: Governance arrangements for health systems in low-income countries: an overview of systematic reviews (free) AND Summary: Effects of governance arrangements for health systems in low-income countries (free)

Article 3: Delivery arrangements for health systems in low-income countries: an overview of systematic reviews (free) AND Summary: Effects of delivery arrangements for health systems in low-income countries (free)


4 – Comprehensive geriatric assessment for older adults admitted to hospital – Cochrane Library (free)

Original article: Comprehensive geriatric assessment for older adults admitted to hospital – Cochrane Library (link to abstract – $ for full-text)

Related: Comprehensive assessment may reduce risk of delirium after hip fracture – NIHR Signal (free)

“Older patients are more likely to be alive and in their own homes at follow-up if they received comprehensive geriatric assessment on admission to hospital”.


5 – Low alcohol consumption and pregnancy and childhood outcomes: time to change guidelines indicating apparently ‘safe’ levels of alcohol during pregnancy? A systematic review and meta-analyses – BMJ Open (free)

Commentaries: No change to alcohol guidelines for pregnancy – NHS Choices (free) Health risks of light drinking in pregnancy confirms that abstention is the safest approach – The Conversation (free)


6 – Association of spontaneous abortion with receipt of inactivated influenza vaccine containing H1N1pdm09 in 2010–11 and 2011–12 – Vaccine (link to abstract – $ for full-text)

Commentaries: Study signals association between flu vaccine, miscarriage – CIDRAP (free) AND New study finds link between flu vaccine and miscarriage. But is it real? – Science (free) AND Study shows miscarriage risk may have increased after flu shots, puzzling researchers – STAT (free) AND A new finding of a possible flu shot-miscarriage link shows science prioritizes vaccine safety – STAT (free)

“This study does not and cannot establish a causal relationship between repeated influenza vaccination and SAB, but further research is warranted”.


7 – Metabolically Healthy Obese and Incident Cardiovascular Disease Events Among 3.5 Million Men and Women – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: New evidence shows that healthy obesity is a myth – The Conversation (free) AND Study shows so-called ‘healthy obesity’ is harmful to cardiovascular health – Medical News Today (free) AND Obesity, even without other risk factors, leads to higher rate of cardiovascular disease – STAT (free) AND Another Study Challenges Notion of ‘Healthy Obese’ – TCTMD (free)

See related article and commentaries in our August 21st issue (see #1)


8 – Expert consensus document: A ‘diamond’ approach to personalized treatment of angina – Nature Reviews Cardiology (free)


9 – What Does the Future Hold for Scientific Journals? Visual Abstracts and Other Tools for Communicating Research – Clinics in Colon and Rectal Surgery (free)


10 – Effect of Axillary Dissection vs No Axillary Dissection on 10-Year Overall Survival Among Women With Invasive Breast Cancer and Sentinel Node Metastasis: The ACOSOG Z0011 (Alliance) Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Author interview: Breast Cancer Surgery: Less Is More (free audio)

Commentary: In Treating Breast Cancer, Less Can Be As Good As More – American Council on Science and Health (free)


Wed, September 20 – 10 Stories of The Day!



1 – Corticosteroids in patients hospitalized with community-acquired pneumonia: systematic review and individual patient data meta-analysis – Clinical Infectious Diseases (link to abstract – $ for full-text)

Related Meta-analysis: Efficacy and Safety of Adjunctive Corticosteroids Therapy for Severe Community-Acquired Pneumonia in Adults: An Updated Systematic Review and Meta-Analysis – PLOS One (free) AND Efficacy and Safety of Corticosteroids for Community-Acquired Pneumonia – Chest (free) AND Adjunctive Systemic Corticosteroids for Hospitalized Community-Acquired Pneumonia: Systematic Review and Meta-Analysis 2015 Update – Scientific Reports (free)


2 – Summaries with 10 key points to remember of the latest European Society of Cardiology Guidelines – Latest in Cardiology, American College of Cardiology

– 2017 ESC Guidelines for the Management of STEMI (free)

– 2017 ESC/EACTS Guidelines for Management of Valvular Heart Disease (free)

– 2017 ESC Guidelines for PAD Diagnosis and Treatment (free)

– 2017 ESC Focused Update on DAPT in CAD (free)

See also our selection of the most relevant articles and commentaries from the Meeting, #ESCCongress Part I, #ESCCongress Part II and #ESCCongress Part III


3 – Noncommunicable Diseases Progress Monitor 2017 – World Health Organization (free)

News release: WHO launches new NCDs Progress Monitor (free)

Related WHO resources: Noncommunicable diseases: the slow-motion disaster – World Health Organization (free) AND Preventing noncommunicable diseases (NCDs) by reducing environmental risk factors – World Health Organization (free) AND Other dimensions of the NCD crisis: from mental health, ageing, dementia and malnutrition to deaths on the roads, violence and disability (free) AND Tools for implementing WHO PEN (Package of essential noncommunicable disease interventions) (free) AND WHO’s work on NCDs (free)


4 – Ethics and the Legalization of Physician-Assisted Suicide: An American College of Physicians Position Paper (free)

Commentaries: ACP reaffirms opposition to physician-assisted suicide – ACP Internist (free) AND ACP Reaffirms Position Against Physician-Assisted Suicide – Physician’s First Watch (free)


5 – Association of Cigarette Price Differentials With Infant Mortality in 23 European Union Countries – JAMA Pediatrics (free)

Commentaries: Budget cigs linked to higher infant mortality: Stopping their sale could reduce deaths – Irish Health (free) AND The Fatal Toll of Cheap Cigarettes – The New York Times (10 articles per month are free)


6 – Impact of Electronic Cigarettes on the Cardiovascular System – Journal of The American Heart Association (free)


7 – Guideline: Contemporary Management of Cardiogenic Shock: A Scientific Statement From the American Heart Association – Circulation (free PDF)

Top Ten Things to Know: Contemporary Management of Cardiogenic Shock (free PDF)


8 – Cancer’s Invasion Equation – The New Yorker (free)

We can detect tumors earlier than ever before. Can we predict whether they’re going to be dangerous?


9 – Medical News & Perspectives: Going With the Flow: The Promise and Challenge of Liquid Biopsies – JAMA (free)

Related: Emerging concepts in liquid biopsies – BMC Medicine (free) AND Can a ‘liquid biopsy’ detect cancer and save lives? – STAT (free)


10 – Use of public defibrillators linked to out-of-hospital cardiac arrest survival – NIHR Signal (free)

Original article: The Effects of Public Access Defibrillation on Survival After Out-of-Hospital Cardiac Arrest: A Systematic Review of Observational Studies – Circulation (link to abstract – $ for full-text)

“Each minute of delay to defibrillation is estimated to reduce the probability of long-term survival by 10%” (RT @NIHR_DC see Tweet)


Tue, September 19 – 10 Stories of The Day!



1 – Report: Diet, Nutrition, Physical Activity and Colorectal Cancer – American Institute for Cancer Research (AICR) and the World Cancer Research Fund (WCRF) (Free PDF)

News release: New Report finds whole grains lower colorectal cancer risk, processed meat increases risk (free)

Infographic: Preventing Colorectal Cancer (free)

Almost half cases of colorectal cancer cases can be prevented by staying lean, eating healthy, and moving more.


2 – Guideline: Adolescent and Young Adult Tattooing, Piercing, and Scarification – Pediatrics (free)

Commentaries: Clinical Guidance on Body Modification Among Youth – Journal Watch (free) AND When Adolescents Want Tattoos or Piercings – The New York Times (10 articles per month are free)


3 – The cumulative burden of surviving childhood cancer: an initial report from the St Jude Lifetime Cohort Study (SJLIFE) – The Lancet (link to abstract – $ for full-text)

Commentaries: Survivors of Childhood Cancer Face Continuing Chronic Health Conditions – Physician’s First Watch (free) AND Severe Health Problems Plague Survivors of Childhood CA – Medscape (free registration required) AND Comprehensive Study of Chronic Disease Reveals Vulnerability of Childhood Cancer Survivors – NewsWise (free)


4 – Viewpoint: Nutrition Counseling in Clinical Practice: How Clinicians Can Do Better – JAMA (free)


5 – How alcohol industry organisations mislead the public about alcohol and cancer – Drug and Alcohol Review (free)

Commentaries: Alcohol increases cancer risk, but don’t trust the booze industry to give you the facts straight – The Conversation (free) AND Drinks industry distorts alcohol cancer risk: scientists – Reuters (free) AND Drinks industry downplaying alcohol-cancer link – The Guardian (free) AND Drinks industry accused of downplaying ‘alcohol-cancer risk’ – NHS Choices (free)


6 – Safety of Medical Abortion Provided Through Telemedicine Compared With in Person – Obstetrics & Gynecology (free PDF)

Commentaries: Abortion via telemedicine as safe as seeing doctor in person – Reuters (free) AND Abortion Via Telemedicine Is Totally Safe, Study Says – HuffPost (free) AND Medical Abortion Via Telemedicine Found Safe – MedPage Today (free registration required)


7 – The Weekend Effect in Hospitalized Patients: A Meta-Analysis – Journal of Hospital Medicine (link to abstract – free full-text PDF via @unpaywall)

Commentary: Review finds evidence for weekend effect on mortality in hospitalized patients – ACP Hospitalist (free)

Related article: Weekends affect mortality risk and chance of discharge in critically ill patients: a retrospective study in the Austrian registry for intensive care – Critical Care (free) AND Commentary: “Weekend effects” in intensive care units – On Medicine (free)


8 – Richard Lehman’s journal review, 18 September 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.


9 – Trends in standardized mortality among individuals with schizophrenia, 1993–2012: a population-based, repeated cross-sectional study – Canadian Medical Association Journal (free)

Commentaries: Schizophrenia linked to threefold increase in death risk – Medical News Today (free) AND People with schizophrenia have threefold risk of dying – CMAJ, via EurekAlert (free)


10 – Strategies to reduce antibiotic prescribing for acute respiratory infections in primary care – Cochrane Library (free)

Original article: Clinician-targeted interventions to influence antibiotic prescribing behaviour for acute respiratory infections in primary care: an overview of systematic reviews – Cochrane Library (link to abstract – $ for full-text)


Mon, September 18 – 10 Stories of The Day!



1 – Life, death, and disability in 2016: latest estimates from The Global Burden of Disease Study – The Lancet

Editorial: Life, death, and disability in 2016 (free)

– Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016 (free)

– Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016 (free)

– Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016 (free)

– Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016 (free)

– Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2016 (free)

– Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries (free)

Commentaries: New global study finds countries saving more lives, despite a ‘triad of troubles’ in obesity, violence, and mental illness – Institute of Health Metrics and Evaluation (free) AND Smoking And Poor Diet Still Leading Killers Worldwide – Pursuit (free)

See also: GBD Compare Interactive Tool – Explore which causes & risk factors are causing the most death & disability in your country over time (free tool)


2 – Guideline: Type 2 diabetes: prevention in people at high risk – National Institute for Health and Care Excellence (NICE) (free)


3 – Guideline: Depression in children and young people: identification and management – National Institute for Health and Care Excellence (NICE) (free)


4 – Percutaneous Coronary Intervention vs Coronary Artery Bypass Grafting in Patients With Left Main Coronary Artery Stenosis: A Systematic Review and Meta-analysis – JAMA Cardiology (free)

Commentary: CABG, PCI show similar long-term outcomes – Cardiovascular Business (free)


5 – Meat, Dietary Heme Iron, and Risk of Type 2 Diabetes Mellitus: The Singapore Chinese Health Study – American Journal of Epidemiology (link to abstract – $ for full-text)

Commentary: Eating meat linked to higher risk of diabetes – DukeNUS Medical School, via EurekAlert (free)

Related articles: Meat Consumption as a Risk Factor for Type 2 Diabetes – Nutrients (free) AND Meat consumption and the risk of type 2 diabetes: a systematic review and meta-analysis of cohort studies – Diabetologia (free) AND Red meat consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis – American Journal of Clinical Nutrition (free)

“The Singapore Chinese Health Study reveals increased risk of diabetes with higher intake of red meat and poultry, partially attributed to the dietary iron content in these meats” (from EurekAlert)


6 – How Big Business Got Brazil Hooked on Junk Food – The New York times (10 articles per month are free) (RT @glassmanamanda see Tweet)

“As growth slows in wealthy countries, Western food companies are aggressively expanding in developing nations, contributing to obesity and health problems”.


7 – Evaluation of a Rapid Molecular Drug-Susceptibility Test for Tuberculosis – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Detecting Tuberculosis Resistance (free)

Commentary: New rapid molecular test for MDR-TB shows promise – CIDRAP (free)


8 – European guidelines on perioperative venous thromboembolism prophylaxis: Surgery in the elderly – European Journal of Anaesthesiology (free PDF)


9 – Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentary: Sulfonylureas, Pioglitazone Similarly Safe for Add-On Therapy in Type 2 Diabetes – Physician’s First Watch (free)


10 – Review: Drug-induced liver injury: recent advances in diagnosis and risk assessment – Gut (free)


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