Open access


Mon, July 16 – 10 Stories of The Day!

16 Jul,2018


1 – Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials – The Lancet (free)

Commentaries: Weight-adjusted aspirin for cardiovascular prevention – The Lancet (free) AND One dose of aspirin doesn’t fit all – University of Oxford (free)

Practice Changing Article. “Low doses of aspirin (75–100 mg) were only effective in preventing vascular events in patients weighing less than 70 kg, and had no benefit in the 80% of men and nearly 50% of all women weighing 70 kg or more. By contrast, higher doses of aspirin were only effective in patients weighing 70 kg or more.”


2 – Vulnerability to snakebite envenoming: a global mapping of hotspots – The Lancet (free)

Commentaries: Addressing the global challenge of snake envenoming – The Lancet (free) AND New study maps the areas where people are most vulnerable to death following snakebite – London School of Tropical Medicine (free) AND New study finds 93 million people vulnerable to death from snakebites – Institute for Health Metrics and Evaluation (free)


3 – Association of Inferior Vena Cava Filter Placement for Venous Thromboembolic Disease and a Contraindication to Anticoagulation With 30-Day Mortality – JAMA Network Open (free)

Commentaries: Inferior Vena Cava Filters and Mortality: Is It the Underlying Process, the Patient, or the Device? (free)

“Could IVC filters be causing harm? They began being used before @US_FDA started approving devices. This article raises possibility of increased mortality. Maybe where we need trials to determine safety and effectiveness”. (via @hmkyale see Tweet)


4 – 2018 EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis – Annals of Rheumatic Disease (free)


5 – 2018 Guidelines of the Taiwan Society of Cardiology, Taiwan Society of Emergency Medicine and Taiwan Society of Cardiovascular Interventions for the management of non ST-segment elevation acute coronary syndrome – Journal of the Formosan Medical Association (free)

Related Guidelines: 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation (free) AND 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes (free)


6 – CVIT expert consensus document on primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) in 2018 – Japanese Association of Cardiovascular Intervention and Therapeutics (free)


7 – Machine learning of toxicological big data enables read-across structure activity relationships (RASAR) outperforming animal test reproducibility – Toxicological Sciences (free)

Commentaries: New digital chemical screening tool could help eliminate animal testing – Science (free) AND Database Analysis More Reliable Than Animal Testing For Toxic Chemicals – Johns Hopkins Bloomberg School of Public Health (free) AND Software beats animal tests at predicting toxicity of chemicals – Nature News (free)


8 – Review: Cardiac rehabilitation: A class 1 recommendation – Cleveland Clinic Journal of Medicine (free)

Related Guidelines: Cardiac rehabilitation – Scottish Intercollegiate Guidelines Network (free) AND Myocardial infarction: cardiac rehabilitation and prevention of further cardiovascular disease – National Institute for Health and Care Excellence (free)


9 – Hypertension Among Youths — United States, 2001–2016 – Centers for Disease Control and Prevention (free)

Commentaries: 800,000 More Adolescents Classified as Hypertensive Under New Guidelines – NEJM Physician’s First Watch (free) AND New guidelines label 795K more US children as hypertensive – Cardiovascular Business (free)


10 – Serial measures of circulating biomarkers of dairy fat and total and cause-specific mortality in older adults: the Cardiovascular Health Study – American Journal of Clinical Nutrition (free for a limited period)

Commentaries: Study finds no significant link between whole dairy products and heart disease, stroke – News Medical (free) AND Full-fat dairy may actually benefit heart health – Medical News Today (free)

Related Studies: Meta-Analysis: Cheese consumption and risk of cardiovascular disease (link to abstract and commentaries) AND Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality (free study and commentaries)


Fri, July 13 – 10 Stories of The Day!

13 Jul,2018


1 – INSPIRE: Seven strategies for ending violence against children – World Health Organization (free resources)

Fact Sheet: Violence against children – World Health Organization (free)

The package includes the core document describing what the INSPIRE strategies and interventions are; an implementation handbook that provides details on how to implement the interventions, and a set of indicators to measure the uptake of INSPIRE and its impact on levels of violence against children.


2 – Comparison of the Safety Planning Intervention With Follow-up vs Usual Care of Suicidal Patients Treated in the Emergency Department – JAMA Psychiatry (free for a limited period)

Author Interview: Association of Safety Planning Intervention With Subsequent Suicidal Behavior Among ER-Treated Suicidal Patients (free)

Commentaries: ED Intervention with Follow-Up Appears to Reduce Suicidal Behaviors – NEJM Physician’s First Watch (free) AND A Simple Emergency Room Intervention Can Help Cut Suicide Risk – NPR (free)

Related Studies: Suicide Prevention in an Emergency Department Population (free study and commentaries) AND Strategies to prevent death by suicide (link to abstract and commentaries)


3 – Concomitant Oral Anticoagulant and Nonsteroidal Anti-Inflammatory Drug Therapy in Patients With Atrial Fibrillation – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Bleeding Risk Increased With NSAID Use in Anticoagulated A-fib Patients: RE-LY Analysis – TCTMD (free) AND NSAID, anticoagulant combo ups risk for bleeding events in AFib patients – Cardiovascular Business (free) Concomitant NSAIDs and Anticoagulants in Atrial Fibrillation – American College of Cardiology (free)


4 – Infographic: Testing for non-alcoholic fatty liver disease -The BMJ (free PDF)


5 – The right diet can boost potency of cancer drugs – Nature News (free)

Original article: Suppression of insulin feedback enhances the efficacy of PI3K inhibitors – Nature (link to abstract – $ for full-text)

Related: Top oncologist to study effect of diet on cancer drugs – The Guardian (free)

“Diets appear to matter in mouse cancer Rx – can these preclinical findings be translated to humans?” (via @Aiims1742 see Tweet)


6 – Report: Research into physiotherapy for musculoskeletal conditions – NIHR Dissemination Centre (free PDF)

This new NIHR report brings together key research relevant to those delivering musculoskeletal physiotherapy services.


7 – Last Month in Oncology with Dr. Bishal Gyawali: June 2018 – eCancer News (free)

This review has an interesting opinion on changing definitions of clinically meaningful endpoints in cancer research.


8 – Research Methods & Reporting: Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians – The BMJ (free)


9 – Anticoagulation for perioperative thromboprophylaxis in people with cancer – Cochrane Library (free)

Summary: Blood thinners for the prevention of blood clots in people with cancer undergoing surgery – Cochrane Library (free)


10 – Effect of Alteplase vs Aspirin on Functional Outcome for Patients With Acute Ischemic Stroke and Minor Nondisabling Neurologic Deficits: The PRISMS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Stopping the Alteplase Indication Creep – Emergency Medicine Literature of Note (free) AND Alteplase unlikely to reduce disability after mild stroke without disabling deficits – 2 Minute Medicine (free) AND Lytic No Better Than Aspirin for Mild Ischemic Stroke – MedPage Today (free registration required)


Thu, July 12 – 10 Stories of The Day!

12 Jul,2018


1 – Guideline: Rheumatoid arthritis in adults: management – National Institute for Health and Care Excellence (free)


2 – Guideline: Brain tumours (primary) and brain metastases in adults – National Institute for Health and Care Excellence (free)


3 – Impact of 2017 ACC/AHA guidelines on prevalence of hypertension and eligibility for antihypertensive treatment in United States and China: nationally representative cross sectional study – The BMJ (free)

Commentary: Expert reaction to study looking at American blood pressure guidelines and how many people in the USA and China would be classed as having high blood pressure – Science Media Centre (free)


4 – Efficacy of short-course antibiotic treatments for community-acquired pneumonia in adults: A systematic review and meta-analysis – Antimicrobial Agents and Chemotherapy (link to abstract – $ for full-text)

Commentary: Is Short-Course Antibiotic Treatment for CAP Effective? – MPR (free)


5 – News Release: Trial wipes out more than 80 per cent of disease-spreading mozzie – Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australian Government (free)

Commentary: Australian experiment wipes out over 80% of disease-carrying mosquitoes – CNN (free)


6 – Perspective: Fractional-Dose Yellow Fever Vaccination — Advancing the Evidence Base – New England Journal of Medicine (free)

Related Research: Immunogenicity of Fractional-Dose Vaccine during a Yellow Fever Outbreak — Preliminary Report – The New England Journal of Medicine (free)


7 – Cumulative Incidence of Hypertension by 55 Years of Age in Blacks and Whites: The CARDIA Study – Journal of the American Heart Association (free)

Commentaries: Most black adults have high blood pressure before age 55 – AHA / ASA Newsroom (free) AND New CARDIA Data: 75% of African-Americans Have Hypertension by Age 55 – TCTMD (free)


8 – News Release: FDA updates warnings for fluoroquinolone antibiotics on risks of mental health and low blood sugar adverse reactions – U.S. Food and Drug Administration (free)

Commentaries: FDA Strengthens Warnings for Fluoroquinolone Antibiotics – MPR (free) AND FDA Announces Labeling Changes for Fluoroquinolones Due to Mental Health AEs, Blood Sugar Disturbances – MD Magazine (free)


9 – Effect of cannabis use in people with chronic non-cancer pain prescribed opioids: findings from a 4-year prospective cohort study – The Lancet Public Health (free)

Commentaries: A painful lesson: are we repeating previous mistakes in pain management? – The Lancet Public Health (free) AND Use of illicit cannabis does not reduce chronic pain, according to new Australian study – RACGP (free)

Related: Efficacy and adverse effects of medical marijuana for chronic noncancer pain: Systematic review of randomized controlled trials – Canadian Family Physician (free) AND Benefits and Harms of Cannabis in Chronic Pain or Post-traumatic Stress Disorder: A Systematic Review – VA Evidence-based Synthesis Program (free) AND Cannabis products for adults with chronic neuropathic pain – Cochrane Library (free)


10 – Marijuana Use, Respiratory Symptoms, and Pulmonary Function: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Smoking Marijuana May Be Tied to Cough, Sputum Production – HealthDay (free) AND Regular marijuana use is associated with development of respiratory issues – 2 Minute Medicine (free)


Wed, July 11 – 10 Stories of The Day!

11 Jul,2018


1 – Risk Assessment for Cardiovascular Disease With Nontraditional Risk Factors: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorial: USPSTF Recommendations for Assessment of Cardiovascular Risk With Nontraditional Risk Factors: Finding the Right Tests for the Right Patients (free)

“The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of adding the ankle-brachial index (ABI), high-sensitivity C-reactive protein (hsCRP) level, or coronary artery calcium (CAC) score to traditional risk assessment for cardiovascular disease (CVD) in asymptomatic adults to prevent CVD events”.


2 – Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis – Circulation: Cardiovascular Quality and Outcomes (free for a limited period)

Editorial: Multivitamins Do Not Reduce Cardiovascular Disease and Mortality and Should Not Be Taken for This Purpose: How Do We Know That? (free)

Commentaries: Study: Multivitamins Do Not Prevent Strokes, Heart Attacks or Cardiovascular Disease Deaths – University of Alabama at Birmingham, via NewsWise (free) AND Multivitamin-mineral supplements do not reduce heart disease, deaths – Reuters (free)

Related: Supplements Not Effective for CVD Prevention and Treatment (link to abstract and commentaries) AND Multivitamins are probably a waste of money (free commentaries)


3 – Comparative Benefits and Harms of Basal Insulin Analogues for Type 2 Diabetes: A Systematic Review and Network Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Newer, older insulin formulations may offer similar glucose-lowering effects – ACP Internist (free) AND HbA1c Reduction Similar in Old, New Basal Insulin Analogues – MedPage Today (free registration required)


4 – Association of Early Introduction of Solids With Infant Sleep: A Secondary Analysis of a Randomized Clinical Trial – JAMA Pediatrics (free)

Author Interview: Effects of Early Solid Food Introduction on Infant Sleep (free audio)

Commentaries: Babies fed solids earlier ‘sleep better’ – NHS Choices (free) AND Feeding your baby solids early may help them sleep, study suggests – The Guardian (free) AND Giving your baby solid food early won’t help them sleep better – The Conversation (free)


5 – Effect of a Home-Based Wearable Continuous ECG Monitoring Patch on Detection of Undiagnosed Atrial Fibrillation: The mSToPS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Video: Effect of a Home-Based Wearable ECG Patch Monitor on Detection of Undiagnosed Atrial Fibrillation in Individuals at Increased Risk of Atrial Fibrillation (free)

Commentary: If You Look For Atrial Fibrillation You Will Find Atrial Fibrillation – Cardiobrief (free)

Related: Wearable technology to screen for atrial fibrillation: does it raise more questions than it answers? (free commentaries)


6 – Review: Update on infection control practices in cancer hospitals – CA: A Cancer Journal of Clinicians (free)


7 – Review:  Optimal pain management for patients with cancer in the modern era – CA: A Cancer Journal of Clinicians (free)


8 – Periconception glycaemic control in women with type 1 diabetes and risk of major birth defects: population based cohort study in Sweden – The BMJ (free)

Commentary: Higher risk of heart defects in babies of mothers with type 1 diabetes – Karolinska Institutet, via EurekAlert (free)


9 – Public health implications of overscreening for carotid artery stenosis, prediabetes, and thyroid cancer – Public Health Reviews (free)


10 – Consensus Report: Returning Individual Research Results to Participants: Guidance for a New Research Paradigm (2018) – National Academies of Sciences, Engineering, and Medicine (free PDF)

Commentaries: National Academies panel urges researchers to routinely share test results with study participants – STAT (free) AND If you give your DNA and tissues to science, should you get a peek at what they might contain? – Science (free) AND New report says individual research results should be shared with participants more often – National Academies of Sciences, Engineering, and Medicine (free)

Related Viewpoint: Return of Research Results to Study Participants: Uncharted and Untested – JAMA (free for a limited period)


Tue, July 10 – 10 Stories of The Day!

10 Jul,2018


1 – Summary of the international clinical guidelines for the management of hospital-acquired and ventilator-acquired pneumonia – ERJ Open Research (free)

Editorial: Treating nosocomial pneumonia: what’s new (free)

Related Guidelines: International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia (free) AND Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society (free)

Source: Critical Care Reviews Newsletter


2 – Guideline: Recommendations on screening for asymptomatic bacteriuria in pregnancy – Canadian Task Force on Preventive Health Care (free)

See also: Summary of recommendations for clinicians and policy-makers / other resources from CTFPHC (all free)


3 – Draft Statement: Antibiotics should be restricted for COPD – National Institute for Health and Care Excellence (free)

Commentaries: Antibiotics should be restricted for COPD, says NICE – OnMedica (free) AND UK officials recommend limits on antibiotics for COPD – CIDRAP (free)

The draft antimicrobial guidance recommends that antibiotics should be offered to people who have a severe flare up of symptoms, also known as a severe acute exacerbation”


4 – Oposition to Breast-Feeding Resolution by U.S. Stuns World Health Officials – The New York Times (10 articles per month are free)


5 – Richard Lehman’s journal review, 9 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals


6 – Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Cabozantinib in Hepatocellular Carcinoma – NEJM Resident 360 (free)

Median overall survival was 10.2 months with cabozantinib and 8.0 months with placebo, but the rate of high-grade adverse events in the cabozantinib group was approximately twice that observed in the placebo group. (more on this study in Richard Leeman’s review above)


7 – Percutaneous coronary intervention for stable angina in ORBITA – Authors’ reply – The Lancet (free) – The Lancet (free)

Original study: Percutaneous coronary intervention in stable angina (ORBITA) (link to abstract and commentaries)

Related commentaries: Viewpoint: Placebo Effect of the Heart (free) AND Sham Surgeries: A Tale of Medical Reversals & the Role of the Media (free)

Related research: Research: Physiology-Stratified Analysis of ORBITA (free research and commentaries)


8 – Richard Smith: Reducing global road traffic crashes and injuries – The BMJ Opinion (free)

Related reports: The High Toll of Traffic Injuries : Unacceptable and Preventable – The World Bank (free PDF) AND Save LIVES: a road safety technical package (free) AND Unfinished Journey: The Global Health Response to Children & Road Traffic – FIA Foundation (free PDF) AND Securing safe roads: the politics of change – World Resources Institute Ross Center for Sustainable Cities (free news release and PDF)


9 – Negative pressure wound therapy for open traumatic wounds – Cochrane Library (free)

Summary: Negative pressure wound therapy for open traumatic wounds – Cochrane Library (free)

Related Research: Randomized Trial: Negative Pressure Wound Therapy No Better Than Regular Dressing in Severe Open Fracture of the Lower Limb (link to abstract and commentaries)


10 – Physician Burnout, Well-being, and Work Unit Safety Grades in Relationship to Reported Medical Errors – Mayo Clinic Proceedings (link to abstract – $ for full-text)

Commentaries: Medical errors may stem more from physician burnout than unsafe health care settings – Stanford Medicine, via ScienceDaily (free) AND Physician burnout, depression can lead to major medical errors: Study – ABC News (free) AND Burnout Tied to Twofold Higher Risk for Medical Errors – Medscape (free registration required)

Related: Perspective: The Burnout Crisis in American Medicine (free commentaries on the subject)


Mon, July 9 – 10 Stories of The Day!

9 Jul,2018


1 – Guidelines On The Management Of Acute Respiratory Distress Syndrome – Intensive Care Society (free PDF) (via @CritCareReviews)

Related Guidelines: The clinical practice guideline for the management of ARDS in Japan – Journal of Intensive Care (free) AND An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome (free)


2 – WHO Manual: Preventing disease through a healthier and safer workplace – World Health Organization (free PDF)

Source: International Health Policies Newsletter


3 – Clinical Update: Long-acting Reversible Contraception—Highly Efficacious, Safe, and Underutilized – JAMA (free for a limited period)

Clinical Review Audio: Return of the IUD: Long-acting Reversible Contraception Is Safe and Effective (free)


4 – Seriously, Juice Is Not Healthy – The New York Times (10 articles per month are free)

“Would you take a multivitamin if it contained 10 teaspoons of sugar? No. Then why are you drinking juice?” (via @NYTHealth see Tweet)


5 – Effect of Screening With Primary Cervical HPV Testing vs Cytology Testing on High-grade Cervical Intraepithelial Neoplasia at 48 Months: The HPV FOCAL Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: For Women Over 30, There May Be A Better Choice Than The Pap Smear – NPR (free) AND Study Suggests HPV Test More Accurate Than Pap Smear for Cervical Cancer Screening – AJMC (free) AND HPV testing could be more accurate than smear tests for initial screening of cervical cancer – NHS Choices (free)


6 – The health benefits of the great outdoors: A systematic review and meta-analysis of greenspace exposure and health outcomes – Environmental Research (free) (via @Mental_Elf and @AllenFrancesMD)

Commentary: It’s official — spending time outside is good for you – University of East Anglia, via ScienceDaily (free)


7 – A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients: Should We Aim for Less? – BioMed Research International (free)

Related Meta-Analysis:  Liberal vs Conservative Oxygen Therapy in Acutely ill Adults (link to abstract and commentary)

Source: Critical Care Reviews Newsletter


8 – Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Related: Ebola virus outbreak likely over in Congo, WHO says – NBC News (free) AND Good news: the Ebola outbreak in DRC is contained – VOX (free)


9 – Use of ‘smart drugs’ on the rise – Nature (free)

Related: A ‘smart’ approach to performance drugs – ACP Internist (free) AND Growing use of smart drugs by students could be a recipe for disaster – The Conversation (free) AND Brain Hackers Seeking Peak Performance Use Risky Chemical Cocktails: “Smart drugs” are not clinically proven and could be dangerous – Scientific American (free) AND Universities must do more to tackle use of smart drugs, say experts – The Guardian (free) AND Tweaking brains with ‘smart drugs’ to get ahead in Silicon Valley – The Washington Post (free) AND Professors take same ‘smart drugs’ as students to keep up with workloads, claims academic – Independent (free)


10 – Association of Prenatal Exposure to Population-Wide Folic Acid Fortification With Altered Cerebral Cortex Maturation in Youths – JAMA Psychiatry (free)

Commentaries: Folic acid linked to healthy brain development through childhood – Reuters (free) AND Folic Acid Fortification May Have Role in Sustaining Mental Health – AJMC (free) AND Prenatal Exposure to Folic Acid Appears to Promote Healthy Brain Development – Psychiatric News Alert (free) AND Perinatal Folic Acid May Protect Against Serious Mental Illness in Young People – MedicalResearch.com (free)


Fri, July 6 – 10 Stories of The Day!

6 Jul,2018


1 – Report: Delivering quality health services: A global imperative for universal health coverage – World Health Organization (free)

News Release: Low quality healthcare is increasing the burden of illness and health costs globally (free)

Commentary: Universal quality healthcare coverage—a commitment to building a healthier and more productive society – The BMJ Opinion (free)

Related: Handbook for national quality policy and strategy: A practical approach for developing policy and strategy to improve quality of care – World Health Organization (free)


2 – Hypothalamic–Pituitary and Growth Disorders in Survivors of Childhood Cancer: An Endocrine Society Clinical Practice Guideline – The Journal of Clinical Endocrinology & Metabolism (free PDF)

Commentaries: Up to half of childhood cancer survivors will develop hormone disorders – The Endocrine Society, via ScienceDaily (free) AND Guideline Addresses Endocrine Effects After Childhood Cancer – Medscape (free registration required)


3 – Cost-effectiveness and Benefit-to-Harm Ratio of Risk-Stratified Screening for Breast Cancer: A Life-Table Model – JAMA Oncology (free)

Editorial: Implementation Challenges for Risk-Stratified Screening in the Era of Precision Medicine (free)

Author Interview: Cost-effectiveness and Benefit-to-Harm Ratio of Risk-Stratified Breast Cancer Screening (free)

Commentaries: New approach to breast cancer screening — tailoring guidelines for each patient — may save lives and money, study says – STAT (free) AND No screening is better for women with low breast cancer risk, finds study – Guardian (free) AND Breast Cancer Screening Only for Women at Higher Risk – Medscape (free registration required)


4 – Review: Heart failure with preserved ejection fraction: from mechanisms to therapies – European Heart Journal (free)


5 – Review: Anemia and Iron Deficiency in Heart Failure: Current Concepts and Emerging Therapies – Circulation (free)


6 – Hidden conflicts? – Science Magazine (free)

““Pay-later conflicts of interest” have gone largely unnoticed & entirely unpoliced”. (via @cpiller see Tweet)


7 – Clinical practice guidelines for the management of non-specific low back pain in primary care: an updated overview – European Spine Journal (free)


8 – Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care – The BMJ (free)

Commentary: Analysis Finds Less Bleeding — But Potentially Greater Mortality Risk — with Some Newer Anticoagulants – NEJM Physician’s First Watch (free)


9 – Species-specific activity of antibacterial drug combinations – Nature (link to abstract – $ for full-text)

Commentaries: Study: For antibiotics, good things may come in pairs – CIDRAP (free) AND Combining antibiotics alters effectiveness, study says – UPI (free) AND As drug resistance grows, combining antibiotics could turn up new treatments – STAT (free)


10 – Continuous low-dose antibiotic prophylaxis for adults with repeated urinary tract infections (AnTIC): a randomised, open-label trial – The Lancet Infectious Diseases (free)

Invited Commentary: Preventing urinary tract infections in patients with neurogenic bladder (free)


Thu, July 5 – 10 Stories of The Day!

5 Jul,2018


1 – Guideline for Antibiotic Use in Adults with Community-acquired Pneumonia – The Korean Society of Infectious Disease (free)

Related Guideline: Pneumonia: Diagnosis and Management of Community- and Hospital-Acquired Pneumonia in Adults – National Institute for Health and Care Excellence (free)


2 – An evidence-based approach to evaluation and management of the febrile child in Indian emergency department – International Journal of Critical Illness & Injury Science (free)


3 – Pathophysiology, diagnosis and management of MINOCA: an update – European Heart Journal: Acute Cardiovascular Care (free)


4 – Presentation, Clinical Profile, and Prognosis of Young Patients With Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): Results From the VIRGO Study – Journal of the American Heart Association (free)

Editorial: Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): It’s Time to Face Reality! (free)


5 – Treatment of Angina: Where Are We? – Cardiology (free)

Source: Critical Care Reviews Newsletter


6 – Adverse effect of long work hours on incident diabetes in 7065 Ontario workers followed for 12 years – BMJ Open Diabetes Research & Care (free)

Commentaries: Clocking up 45+ working hours/week linked to heightened risk of diabetes in women – BMJ, via ScienceDaily (free) AND Greater Risk of Diabetes in Women With Longer Work Week – MedicalResearch.com (free)

Related Study: Effect of Work Stressors on the Risk of Type 2 Diabetes (link to abstract and commentary)


7 – Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates – Nature Medicine (link to abstract – $ for full-text)

Commentaries: Pregnancy loss occurs in 26 percent of Zika-infected monkeys – NIH News Releases (free) AND Monkey studies suggest Zika role in miscarriage may be higher than thought – CIDRAP (free)


8 – Alarming polio outbreak spreads in Congo, threatening global eradication efforts – Science (free)


9 – Carbohydrate Replacement of Rice or Potato with Lentils Reduces the Postprandial Glycemic Response in Healthy Adults in an Acute, Randomized, Crossover Trial – The Journal of Nutrition (link to abstract – $ for full-text)

Commentaries: Lentils significantly reduce blood glucose levels – University of Guelph, via ScienceDaily (free) AND Replace Carbs With Lentils to Blunt Glucose Spike After Meals – Medscape (free registration required)


10 – Hypertensive Disorders of Pregnancy and Maternal Cardiovascular Disease Risk Factor Development: An Observational Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Hypertensive disorders during pregnancy associated with increased rates of later CVD – ACP Internist (free) AND High blood pressure in pregnancy tied to heart disease risk afterward – Reuters (free) AND Women who experience hypertensive disorders during pregnancy are at high risk for developing high blood pressure, diabetes, and high cholesterol later in life – 2 Minute Medicine (free)

Related Studies: All Hypertensive Disorders of Pregnancy Increase the Risk of Future Cardiovascular Disease (free PDF and commentaries) AND Hypertensive Disorders in Pregnancy and the Risk of Subsequent Cardiovascular Disease (link to abstract and free commentaries) AND Gestational Hypertension and Future Risk of Cardiovascular Disease (free research and editorial)


Wed, July 4 – 10 Stories of The Day!

4 Jul,2018


1 – Anticonvulsants in the treatment of low back pain and lumbar radicular pain: a systematic review and meta-analysis – Canadian Medical Association Journal (free)

Commentaries: Class of drugs used as alternative to opioids for back pain are ineffective, have potentially serious side effects: report – The Globe and Mail (free) AND Anticonvulsant drugs ineffective for low back pain and can cause harm, despite increased prescribing – CMAJ, via EurekAlert (free)

Related Meta-Analysis: Benefits and safety of gabapentinoids in chronic low back pain (free research and commentaries)


2 – The Carbohydrate-Insulin Model of Obesity: Beyond “Calories In, Calories Out” – JAMA Internal Medicine (free for a limited period)


3 – Epinephrine Versus Norepinephrine for Cardiogenic Shock After Acute Myocardial Infarction – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Epinephrine vs. Norepinephrine for Cardiogenic Shock – American College of Cardiology (free) AND Norepinephrine Bests Epinephrine in Battle of the Vasopressors in Cardiogenic Shock – TCTMD (free)


4 – Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Related Perspective: Metastasis-free Survival — A New End Point in Prostate Cancer Trials – New England Journal of Medicine (free)

Commentaries: Enzalutamide: Now Also for Earlier Use in Prostate Cancer? – Medscape (free registration required) AND Enzalutamide Improves Outcomes for Aggressive Prostate Cancer – MPR (free) AND Enzalutamide Postpones Metastasis for a Subset of High-Risk Patients With Prostate Cancer – Cancer Therapy Advisor (free)


5 – Editorial: Immunotherapy: hype and hope – The Lancet Oncology (free) (via @OphiraG)

Related: What Precisely Is Precision Oncology—and Will It Work? – The ASCO Post (free) AND Hope and hype around cancer immunotherapy – CNN (free)


6 – Fertility Preservation for Patients with Malignant Disease. Guideline of the DGGG, DGU and DGRM – Recommendations and Statements for Girls and Women – Geburtshilfe Frauenheilkd (free)

Related guidelines: Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update – Journal of Clinical Oncology (free) AND Fertility preservation for patients with gynecologic malignancies: The Korean Society for Fertility Preservation clinical guidelines – Clinical and Experimental Reproductive Medicine (free) AND Fertility preservation for medical reasons in girls and women: British fertility society policy and practice guideline – Human Fertility (free)


7 – Influenza vaccine for chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)

Summary: Influenza vaccine for people with chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)


8 – Maternal and infant outcomes associated with lithium use in pregnancy: an international collaborative meta-analysis of six cohort studies – The Lancet (link to abstract – $ for full-text)

Commentaries: Increased risk of birth defects in babies after first-trimester exposure to lithium – Mount Sinai School of Medicine, via ScienceDaily (free) AND Lithium in Pregnancy Tied to Infant Morbidity, Malformation Risk – Medscape (free)


9 – Metformin exposure in first trimester of pregnancy and risk of all or specific congenital anomalies: exploratory case-control study – The BMJ (free)

In this large international, population-based database, no evidence was found of an overall increased risk of congenital anomalies after first trimester metformin exposure.


10 – Australia wins landmark WTO ruling on plain tobacco packaging – Reuters (free)

Other commentaries: WTO Tobacco Ruling Opens Door to New Plain-Packaging Laws – Bloomberg (free) AND ‘Resounding victory’: Australia wins tobacco plain packaging dispute – The Guardian (free) AND Australian Tobacco Plain Packaging Upheld In Decision At WTO – Intellectual Property Watch (free)

Source: International Health Policies Newsletter


Tue, July 3 – 10 Stories of The Day!

3 Jul,2018


1 – A Multicenter Study of Patient-Reported Infectious and Noninfectious Complications Associated With Indwelling Urethral Catheters – JAMA Internal Medicine (free)

Commentary: Foleys Aren’t Fun: Patient Study Shows Catheter Risks – University of Michigan, via NewsWise (free)

“More than half of patients surveyed while they had a urinary catheter, and again weeks later, reported a complication – and infections were only part of the problem” (from NewsWise)


2 – Out-of-hours discharge from intensive care, in-hospital mortality and intensive care readmission rates: a systematic review and meta-analysis – Intensive Care Medicine (free)

Source: Critical Care Reviews Newsletter

“Out-of-hours discharge from an ICU is strongly associated with both in-hospital death and ICU readmission. Whether these increases in mortality and readmission result from patient differences, differences in care, or a combination remains unclear”.


3 – Review: Chronic hyperkalemia in non-dialysis CKD: controversial issues in nephrology practice – Journal of Nephrology (free)


4 – Opinion: Endless Gaming May Be a Bad Habit. That Doesn’t Make It a Mental Illness – The New York Times (10 articles per month are free)

Related: Gaming addiction as a mental disorder: it’s premature to pathologise players – The Conversation (free)

“The World Health Organization has made “internet gaming” a diagnosable disorder. But many experts aren’t even sure it exists”.


5 – Richard Lehman’s journal review, 2 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.


6 – Outbreak of Ebola virus disease in the Democratic Republic of the Congo, April–May, 2018: an epidemiological study – The Lancet (free)

Invited Commentary: Ebola virus disease: 11 323 deaths later, how far have we come? (free)

Related: Ebola Outbreak in Congo ‘Largely Contained’, says WHO (free statement and commentary)


7 – Management of multimorbidity using a patient-centred care model: a pragmatic cluster-randomised trial of the 3D approach – The Lancet (free)

Commentaries: Patient-centred care for multimorbidity: an end in itself? – The Lancet (free) AND Results of the largest ever multimorbidity trial in primary care challenge current thinking -NIHR News (free)

Related: Designing a High-Performing Health Care System for Patients with Complex Needs: Ten Recommendations for Policymakers (series of free articles on the topic) AND Multimorbidity: A Priority for Global Health Research (free report and commentaries)

“In the largest ever trial of an intervention to treat people with multiple long-term conditions (multimorbidity) in primary care, NIHR-researchers found that the patient-centred approach taken improved patients’ experience of their care but did not improve their health-related quality of life. This is a challenge to current thinking on which UK and international guidelines are based”. (from NIHR News)


8 – Association of Coffee Drinking With Mortality by Genetic Variation in Caffeine Metabolism: Findings From the UK Biobank – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Expert reaction to research association between coffee and lower risk of death – Science Media Centre (free) AND Fresh grounds for coffee: Study shows it may boost longevity – Associated Press (free) AND Coffee Drinkers Are More Likely To Live Longer. Decaf May Do The Trick, Too – NPR (free)

Related Studies: Meta-Analysis: Coffee consumption and health (free research and commentaries) AND Coffee Drinking and Mortality Studies (link to abstract and commentaries)

Another observational study showing possible benefits from drinking coffee.


9 – Endocrine Late Effects in Survivors of Cancer in Adolescence and Young Adulthood: A Danish Population-Based Cohort Study – JAMA Network Open (free)

Invited Commentary: Unmet Survivorship Care Needs of Adolescent and Young Adult Cancer Survivors (free)

Related Reviews: Endocrine late-effects of childhood cancer and its treatments – European Journal of Endocrinology (free) AND Metabolic syndrome induced by anticancer treatment in childhood cancer survivors – Annals of Pediatric Endocrinology & Metabolism (free) AND Screening and management of adverse endocrine outcomes in adult survivors of childhood and adolescent cancer – The Lancet Diabetes & Endocrinology (free)


10 – Cardiovascular Toxicity in Cancer Survivors: Current Guidelines and Future Directions – American College of Cardiology (free)

Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Cardio-Onco-Hematology in Clinical Practice. Position Paper and Recommendations – Revista Espanola de Cardiologia (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)


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