Open access


Mon, April 23 – 10 Stories of The Day!

23 Apr,2018


1 – Report: WHO Expert Consultation on Rabies – World Health Organization (free)

News release: WHO publishes new rabies guidelines and recommendations on lifesaving immunization (free)


2 – Simplifying the use of prognostic information in traumatic brain injury – Journal of Neurosurgery

Part 1: The GCS-Pupils score: an extended index of clinical severity (free)

Part 2: Graphical presentation of probabilities (free)

Commentaries: New Glasgow Coma Scale–Pupils Score and Multifactor Probability Outcome Charts for Use in Patients with TBI – Journal of Neurosurgery, via NewsWise (free) AND New scoring system will speed up assessment of brain injuries – OnMedica (free) AND Glasgow Coma Scale Gets an Eye-Opening Update – Medscape (free registration required)


3 – Revised SAGE recommendation on use of dengue vaccine – World Health Organization (free)

Commentaries: A new dengue vaccine should only be used in people who were previously infected, WHO says – Science (free) AND WHO recommends testing before use of Sanofi’s dengue vaccine – Reuters (free)


4 – Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition – Cephalalgia (free PDF) (via @adamcifu)

News release and website: The International Classification of Headache Disorders 3rd edition (free)

Commentary: International Classification of Headache Disorders – The Lancet Neurology (free)


5 – Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder – Bipolar Disorders (free)

Related Guideline: Bipolar disorder: assessment and management – National Institute for Health and Care Excellence (free)


6 – Diagnosis and Management of Primary Aldosteronism: the Endocrine Society guideline 2016 revisited – European Journal of Endocrinology (free)


7 – Review: Hypokalemia: a clinical update – Endocrine Connections (free)


8 – Role of Immunotherapy in the Treatment of Asthma – Agency for Healthcare Research and Quality (free)

Source: EvidenceAlerts


9 – Effect of 5-Day Nitrofurantoin vs Single-Dose Fosfomycin on Clinical Resolution of Uncomplicated Lower Urinary Tract Infection in Women: A Randomized Clinical Trial – JAMA (free)

Editorial: Nitrofurantoin vs Fosfomycin: Rendering a Verdict in a Trial of Acute Uncomplicated Cystitis – JAMA (free)


10 – Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Intranasal Esketamine Found Effective in Rapid Reduction of Depression, Suicidal Thoughts – Psychiatric News Alert (free) AND Fast-acting benefits of ketamine for depression and suicidality – American Psychiatric Association, via ScienceDaily (free) AND Ketamine ‘shows promise’ in treating depression – OnMedica (free) AND Ketamine Spray Effective for Suicidality, but Abuse Concerns Linger – Medscape (free registration required)

Related: ‘Cautious Optimism’ Marks Outlook for Ketamine, Mood Disorders – Psychiatric News (free)


Fri, April 20 – 10 Stories of The Day!

20 Apr,2018


1 – The “Top 12” Recommendations That Are Reducing Overuse – Choosing Wisely (free) (via @kennylinafp)

Learn more on the Choosing Wisely Initiative and see other lists of low-value practices in Choosing Wisely U.S. / Choosing Wisely UKChoosing Wisely Australia AND Choosing Wisely Canada


2 – Choosing Wisely Campaigns: A Work in Progress – JAMA (free for a limited period) (via @ChooseWiselyCA  see Tweet)


3 – Association of Repeated Measurements With Blood Pressure Control in Primary Care – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Repeat BP Measurements in the Office Are Key, Study Highlights – TCTMD (free) AND Should Blood Pressure Measurement Be Repeated During Primary Care Visit? – MedicalResearch.com (free) AND Second BP Measurement Often Brings Better News – MedPage Today (free registration required) AND Repeated BP Measures Linked to Drop in Initially Elevated BP – Physician’s Weekly (free)


4 – Prospective International Randomized Phase II Study of Low-Dose Abiraterone With Food Versus Standard Dose Abiraterone In Castration-Resistant Prostate Cancer – Journal of Clinical Oncology (free)

Commentaries: Taking a Standard Prostate Cancer Drug with Food Boosts Impact, Lowers Cost – University of Chicago Medical Center, via NewsWise (free) AND Low-Dose Prostate Drug Can Match Standard Dose, Cut Costs – Medscape (free registration required)

Related: Tackling the High Cost of Cancer Care (free commentaries issued when this paper was first presented at the 2017 ASCO annual meeting)

“Savings per patient could reach as high as $300,000” (from NewsWise)


5 – Cancer treatment in the last 6 months of life: when inaction can outperform action – eCancer Medical Science (free)


6 – Debate on systematic reviews and meta-analyses: (via @trished)

Viewpoint 1: Are systematic reviews and meta-analyses still useful research? We are not sure – Intensive Care Medicine (free)

Viewpoint 2: Are systematic reviews and meta-analyses still useful research? Yes (free)


7 – Recommended Standard Care for People with Suicide Risk: Making Health Care Suicide Safe – National Action Alliance for Suicide Prevention (free PDF)

News Release: New Recommended Standard Care for People with Suicide Risk Aims to Fundamentally Improve Suicide Care Delivered Nationwide (free PDF)

Commentary: First-Ever Suicide Prevention Recommendations Released – Medscape (free registration required)


8 – Report: Multimorbidity: a priority for global health research – The Academy of Medical Sciences (free) (via @equitylist)

News Release: Global burden of multiple serious illnesses must be urgently addressed (free)

Commentaries: Burden of patients with multiple diseases could sink health systems around the world, warn medical experts – Independent (free) AND People with multiple health conditions get raw deal, says report – OnMedica (free)

See also: related articles on the Caring for High-Need, High-Cost Patients (free reports, articles and commentaries)


9 – Association of Cannabis With Cognitive Functioning in Adolescents and Young Adults: A Systematic Review and Meta-analysis – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Marijuana’s effects on young brains diminish 72 hours after use, research says – CNN (free) AND ‘Poorer Cognitive Functioning’ of Marijuana Users Detailed in New Study – Inverse (free)


10 – British HIV Association Standards of care for people living with HIV 2018 (free)

Commentary: New care standards for HIV aim to boost quality despite funding pressures – OnMedica (free)


Thu, April 19 – 10 Stories of The Day!

19 Apr,2018


1 – Relationship between Clinic and Ambulatory Blood-Pressure Measurements and Mortality – New England Journal of Medicine (free)

Editorial: The Value in an Ambulatory Blood-Pressure Registry (free)

Commentaries: Value of Ambulatory BP Monitoring Bolstered by Large Study – TCTMD (free) AND 24-hour ambulatory BP measurements strongly predict mortality – The Hospitalist (free) AND Expert reaction to study looking at blood pressure measurement method and predicting risk of heart disease – Science Media Centre (free)


2 – Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia – New England Journal of Medicine (free)

Editorial: Gene Therapy as a Curative Option for β-Thalassemia (free)

Quick Take Video Summary: LentiGlobin Gene Therapy for β-Thalassemia (free)

Commentaries: Gene therapy could free some people from a lifetime of blood transfusions – MIT Technology Review (free) AND Gene Therapy For Inherited Blood Disorder Reduced Transfusions – NPR (free) AND Expert reaction to study on gene therapy for beta-thalassaemia – Science Media Centre (free)


3 – A randomized trial of normothermic preservation in liver transplantation – Nature (free PDF for a limited period)

Commentaries: Room temperature liver storage technique improves transplant success – University of Oxford (free) AND Keeping livers ‘alive’ boosts transplant success, trial finds – BBC (free) AND A ‘breakthrough in organ preservation’: Study shows keeping livers warm helps preserve them for transplant – STAT (free)


4 – Viewpoint: Another Nail in the Coffin for Fish Oil Supplements – JAMA (free for a limited period)


5 – Time to challenge the spurious hierarchy of systematic over narrative reviews? – European Journal of Clinical Investigation (free) (via @kennylinafp and @Abraham_RMI)


6 – Artificial pancreas treatment for outpatients with type 1 diabetes: systematic review and meta-analysis – The BMJ (free)

Editorial: Closed loop systems in type 1 diabetes (free for a limited period)


7 – First-line drugs for hypertension – Cochrane Library (free)

Summary: Thiazides best first choice for hypertension – Cochrane Library (free)

 “First-line low-dose thiazides reduced all morbidity and mortality outcomes in adult patients with moderate to severe primary hypertension. First-line ACE inhibitors and calcium channel blockers may be similarly effective, but the evidence was of lower quality”.


8 – Transradial versus transfemoral approach for diagnostic coronary angiography and percutaneous coronary intervention in people with coronary artery disease – Cochrane Library (link to abstract – $ for full-text)

Summary: Radial artery versus femoral artery approach for performing coronary catheter procedures in people with coronary artery disease – Cochrane Library (free)

“Transradial approach for diagnostic coronary angiography or PCI (or both) in CAD may reduce short-term net adverse clinical events, cardiac death, all-cause mortality, bleeding, and access site complications”.


9 – British Thoracic Society Quality Standards for acute non-invasive ventilation in adults – BMJ Open Respiratory Research (free)

Related Guidelines: Clinical practice guidelines for the use of noninvasive positive-pressure ventilation and noninvasive continuous positive airway pressure in the acute care setting – Canadian Medical Association Journal (free) AND BTS/ICS guideline for the ventilatory management of acute hypercapnic respiratory failure in adults – Thorax (free)

Source: Critical Care Reviews Newsletter


10 – Association Between Baseline LDL-C Level and Total and Cardiovascular Mortality After LDL-C Lowering: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)

Commentaries: Patients With Highest LDL Levels Benefit Most From Lipid-Lowering Drugs – MedicalResearch.com (free) AND New Study Finds that Statins Prevent Cardiovascular Deaths – Science Based Medicine (free) AND Meta-Analysis: ‘Floor’ for Lipid-Lowering Mortality Benefits May Be Real – MedPage Today (free registration required)

“In meta-analyses of LDL-C lowering drug trials, we found that total and cardiovascular mortality were reduced only when the mean baseline LDL-C in the trial was >100 mg/dl” (from MedicalResearch.com)


Wed, April 18 – 10 Stories of The Day!

18 Apr,2018


1 – Interventions to Prevent Falls in Community-Dwelling Older Adults: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: Preventing Fractures and Falls: A Limited Role for Calcium and Vitamin D Supplements? (free) AND New Prevention Guidelines for Falls and Fractures—Looking Beyond the Letters (free)

Author Interview: USPSTF Recommendation: Calcium and Vitamin D to Prevent Fractures and Interventions to Prevent Falls in Community-Dwelling Adults (free)

Commentaries: Exercise, not vitamins, urged to prevent falls in seniors – MedicalXpress (free) AND Older adults may not need vitamin D to prevent falls and fractures – Reuters (free)

“Many older adults should avoid taking vitamin D and calcium supplements to prevent falls and fractures, and focus instead on exercises to improve balance and coordination, U.S. doctors recommend” (from Reuters)


2 – Association Between Use of Sodium-Glucose Cotransporter 2 Inhibitors, Glucagon-like Peptide 1 Agonists, and Dipeptidyl Peptidase 4 Inhibitors With All-Cause Mortality in Patients With Type 2 Diabetes – JAMA (free)

Multimedia (2 minute video): Association Between Newer Antidiabetic Drug Classes and Mortality in Patients With Type 2 Diabetes (free)

Commentary: Diabetes drug may not reduce risk of death – Imperial College London (free)


3 – State of Global Air 2018 (free report and interactive website)

Commentaries: Over 7 Billion People Face Unsafe Air: State of Global Air 2018 – Institute for Health Metrics and Evaluation (free) AND More than 95% of world’s population breathe dangerous air, major study finds – The Guardian (free) AND More than 95% of world’s population breathing unhealthy air, says new report – CNN (free)


4 – Opinion: The Case Against Thrombolytic Therapy in Stroke – By John Mandrola, in Medscape (free registration required)

Related: For Many Strokes, There’s an Effective Treatment. Why Aren’t Some Doctors Offering It? – The New York Times (10 articles per month are free)


5 – Incremental Benefits and Harms of the 2017 American College of Cardiology/American Heart Association High Blood Pressure Guideline – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: New blood pressure guidelines may make millions anxious that they’re at risk of heart disease – The Conversation (free) AND New blood pressure guidelines could put lives at risk – The University of Sydney (free)

Related: AAFP Decides to Not Endorse AHA/ACC Hypertension Guideline – American Academy of Family Physicians (free) AND The Hypertension Guideline War Is Not A Fake War – Cardiobrief (free) AND Redefining Hypertension: Assessing the New Blood-Pressure Guidelines – New England Journal of Medicine (free)


6 – Nut consumption and incidence of seven cardiovascular diseases – Heart (free)

Commentary: Nuts May Be Good for the Heart, but Are Hardly a Miracle Food – The New York Times (10 articles per month are free)


7 – Clinical Guideline Synopsis: Management of Ventricular Arrhythmias and Sudden Cardiac Death Risk Related to Ischemic and Nonischemic Cardiomyopathy – JAMA (free for a limited period)

Original Guideline: 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death – Circulation (free PDF)


8 – Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: a mixed methods review – Cochrane Library (free)


9 – Smoking even one cigarette a day raises risk for coronary heart disease – The Washington Post (a few articles per month are free) (via @DrFrieden see Tweet)

See original article: Meta-Analysis: Just One Cigarette a Day Seriously Elevates Cardiovascular Risk (free article and commentaries)


10 – Cardiovascular and Cerebrovascular Emergency Department Visits Associated With Wildfire Smoke Exposure in California in 2015 – Journal of the American Heart Association (free for a limited period)

Commentaries: Air quality linked to cardiac ‘events,’ heart disease patients unaware – Reuters (free) AND Wildfire smoke associated with more ER visits for heart, stroke ailments among seniors – American Heart Association, via ScienceDaily (free)


Tue, April 17 – 10 Stories of The Day!

17 Apr,2018


1 – Addressing Social Determinants to Improve Patient Care and Promote Health Equity: An American College of Physicians Position Paper – Annals of Internal Medicine (free)


2 – Guidelines for the investigation of chronic diarrhoea in adults: British Society of Gastroenterology, 3rd edition – Gut (free)

Source: Hospital Medicine Virtual Journal Club


3 – Atrial Fibrillation Burden: Moving Beyond Atrial Fibrillation as a Binary Entity: A Scientific Statement From the American Heart Association – Circulation (free PDF)

Commentary: Atrial Fibrillation beyond “All or None”: The Missing Piece in Understanding Atrial Fibrillation? (free)

Top Ten Things to Know: Atrial Fibrillation Burden—Moving Beyond AF as a Binary Entity (free PDF)


4 – Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer – New England Journal of Medicine (free)

Commentaries: AACR 2018: Combination therapy doubles survival in metastatic lung cancer – eCancer News (free) AND Lung Cancer Patients Live Longer With Immune Therapy – New York Times (10 articles per month are free)


5 – Associations between chronotype, morbidity and mortality in the UK Biobank cohort – Chronobiology International (free)

Commentaries: ‘Night owls’ slightly more likely to die sooner than ‘early birds’ – NHS Choices (free) AND Why being a night owl may lead to earlier death – VOX (free) AND Night Owls Could Face Higher Risk Of Premature Death, Study Suggests – Forbes (free)


6 – Acid‐suppressive drugs and risk of kidney disease: A systematic review and meta‐analysis – Journal of Gastroenterology and Hepatology (link to abstract – $ for full-text)

Source: Hospital Medicine Virtual Journal Club

Proton pump inhibitors were associated with higher risks of acute interstitial nephritis (HR, 2.78; 95% CI, 1.25‐6.17), acute kidney injury (HR, 1.85; 95% CI, 1.33‐2.59), chronic kidney disease (HR, 1.47; 95% CI, 1.03‐2.09), and end‐stage renal disease (HR, 1.61; 95% CI, 1.26‐2.04) than non‐PPI therapy. Similar risks were not identified for H2RA therapy.


7 – Global burden of mental disorders among children aged 5–14 years – Child and Adolescent Psychiatry and Mental Health (free)

Commentary: Mental disorders among leading causes of illness in children worldwide – BioMed Central, via ScienceDaily (free)


8 – Richard Lehman’s journal review, 16 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.


9 – New Series from The Lancet Journals: Preconception health (free registration required)

Commentaries: Obese couples could be risking health of future children, studies say – The Guardian (free) AND Parents’ Preconception Well-Being Affects Child’s Future Health – Medscape (free registration required)


10 – The Risk of Fatigue and Sleepiness in the Ridesharing Industry: An American Academy of Sleep Medicine Position Statement – Journal of Clinical Sleep Medicine (free)

Commentary: AASM: Ridesharing Industry Needs to Do More to Promote Safety – MPR (free)


Mon, April 16 – 10 Stories of The Day!

16 Apr,2018


1 – Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies – The Lancet (free)

Editorial: Thresholds for safer alcohol use might need lowering (free)

Commentaries: Drinking a pint of beer may lower your life expectancy by the same amount as smoking a cigarette – new research – The Conversation (free) AND Expert reaction to study looking at drinking alcohol, life expectancy and alcohol limits – Science Media Centre (free) AND More than six weekly glasses of wine could curb life expectancy by up to five years – OnMedica (free) AND Consuming more than five drinks a week could shorten your life – University of Cambridge, via ScienceDaily (free) AND How much alcohol is too much? A new study says it’s found the number – PBS News Hour (free)


2 – Short-term Elevation of Fine Particulate Matter Air Pollution and Acute Lower Respiratory Infection – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)

Commentaries: Brief SExposure to Tiny Air Pollution Particles Triggers Childhood Lung Infections – Intermountain Medical Center, via NewsWise (free) AND Spikes in air pollution can heighten risk of chest infections, research suggests – The Guardian (free) AND Air Pollution May Pose Serious Risks to Young Children – The New York Times (10 articles per month are free) AND Short-Term Pollution Spikes Trigger Lung Infections in Young Kids – MedPage Today (free registration required)


3 – Primary care of adults with intellectual and developmental disabilities: 2018 Canadian consensus guidelines – Canadian Family Physician (free)

Related guideline: Care and support of people growing older with learning disabilities – National Institute for Health and Care Excellence (free)


4 – New affordable hepatitis C combination treatment shows 97 percent cure rate – Drugs for Neglected Diseases Initiative, via EurekAlert (free)

Related: Non-profit’s $300 hepatitis C cure as effective as $84,000 alternative – The Guardian (free) AND Hepatitis C: simplified curative treatments can drive global scale-up – World Health Organization (free)


5 – Association of Survival With Adherence to the American Cancer Society Nutrition and Physical Activity Guidelines for Cancer Survivors After Colon Cancer Diagnosis: The CALGB 89803/Alliance Trial – JAMA Oncology (free for a limited period)

Editorial: Helping Colorectal Cancer Survivors Benefit From Changing Lifestyle Behaviors: Implementation Science and Private Industry Collaboration to the Rescue (free for a limited period)

Commentaries: Colon Cancer Patients Who Follow a Healthy Lifestyle Have Longer Survival – NEJM Physician’s First Watch (free) AND Adherence to ACS Guidelines Linked to Survival in Colon Cancer – Physician’s Briefing (free)


6 – Sedentary behavior associated with reduced medial temporal lobe thickness in middle-aged and older adults – PLOS One (free)

Commentaries: Sitting Is Bad for Your Brain – Not Just Your Metabolism or Heart – University of California – Los Angeles, via NewsWise (free) AND Could Too Much Sitting Possibly Make Your Brain Thinner? – Forbes (free)


7 – n−3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease – New England Journal of Medicine (free for a limited period)

Commentaries: Omega-3s From Fish Oil Supplements No Better Than Placebo for Dry Eye – NIH, National Eye Institute (NEI), via NewsWise (free) AND Fish oil capsules don’t help dry eye symptoms, study finds – STAT (free) AND Fish oil supplements ineffective against dry eye – Reuters (free)


8 – The Clinical Trial Is Open. The Elderly Need Not Apply – The New York Times (10 articles per month are free)

Related: Cardiac Patients in Trials Don’t Reflect Real-World Populations (link to abstract and commentaries on the subject)

“There’s a shocking lack of data on effective treatments for older people. So what do doctors do? Make guesses”. (via @NYTHealth see Tweet)


9 – Gallstones: Watch and wait, or intervene? – Cleveland Clinic Journal of Medicine (free)

“Consider laparoscopic cholecystectomy for symptomatic cholelithiasis, expectant management for asymptomatic cases”.


10 – Effectiveness of a long-lasting piperonyl butoxide-treated insecticidal net and indoor residual spray interventions, separately and together, against malaria transmitted by pyrethroid-resistant mosquitoes: a cluster, randomised controlled, two-by-two factorial design trial – The Lancet (free)

Commentaries: Insecticide-resistant malaria vectors must be tackled – The Lancet (free) AND Advanced insecticidal nets protect against malaria, study shows – CIDRAP News Scan for Apr 12, 2018 (free) AND ‘Resistance breaking’ mosquito net provides children with greater protection against malaria – London School of Hygiene & Tropical Medicine (free)

“The novel net nearly halves malaria infection rate in Tanzanian children compared to standard long-lasting pyrethroid nets” (from London School of Hygiene & Tropical Medicine)


Fri, April 13 – 10 Stories of The Day!

13 Apr,2018


1 – Evaluation and Management of Right-Sided Heart Failure: A Scientific Statement From the American Heart Association – Circulation (free PDF)

Commentary: Taking the Good With the Bad – Assigning Value and Blame to the Right Heart in Cardiovascular Disease (free)

Top Ten Things to Know: Evaluation and Management of Right-Sided Heart Failure (free PDF)


2 – Protecting, promoting, and supporting breastfeeding in facilities providing maternity and newborn services: the revised Baby-friendly Hospital Initiative 2018 – World Health Organization, UNICEF (free)

News release: WHO and UNICEF issue new guidance to promote breastfeeding in health facilities globally (free)

Related guideline: Protecting, promoting and supporting breastfeeding in facilities providing maternity and newborn services – World Health Organization (free)

Commentary: Hospitals must support breastfeeding which saves lives – WHO, UNICEF – Reuters (free)


3 – Systemic Antibiotics for the Treatment of Skin and Soft Tissue Abscesses: A Systematic Review and Meta-Analysis – Annals of Emergency Medicine (free)

Commentary: Meta-Analysis Favors Antibiotics After Drainage of Skin Abscesses – NEJM Journal Watch (free)

See related guideline with infographic: Antibiotics after incision and drainage for uncomplicated skin abscesses: a clinical practice guideline – The BMJ (free) AND Meta-Analysis: Antibiotics for uncomplicated skin abscesses: systematic review and network meta-analysis – BMJ Open (free)


4 – Clinical Practice Guidelines for the Antibiotic Treatment of Community-Acquired Urinary Tract Infections – The Korean Society of Infectious Diseases and Korean Society for Chemotherapy (free)


5 – 2018 update of the EULAR recommendations for the management of Behçet’s syndrome – Annals of Rheumatic Disease (free)

Commentary: Behcet’s Syndrome: Treatment Guidelines Updated – MedPage Today (free registration required)


6 – The health, poverty, and financial consequences of a cigarette price increase among 500 million male smokers in 13 middle income countries: compartmental model study – The BMJ (free)

Editorial: The benefits of taxing cigarettes in middle income countries (free)

See also: To Improve Global Health, Tax the Things that are Killing Us (free policies, articles and commentaries) AND The Lancet Taskforce on NCDs and economics (free registration required for all articles and commentaries)


7 – Last Month in Oncology with Dr. Bishal Gyawali: March 2018 – eCancer News (free)


8 – Laboratory-confirmed respiratory infections as triggers for acute myocardial infarction and stroke: a self-controlled case series analysis of national linked datasets from Scotland – European Respiratory Journal (free)

Commentaries: Flu and pneumonia infections increase risk of having a heart attack and stroke – European Respiratory Foundation, via Eurekalert (free) AND Do Pneumococcal and Respiratory Virus Infections Trigger Cardiovascular Morbidity? – NEJM Journal Watch (free for a limited period)

See also: related study published recently showing a similar six-fold increase in myocardial infarctions in the week following a flu diagnosis (link to abstract and commentaries).


9 – Advanced machine learning in action: identification of intracranial hemorrhage on computed tomography scans of the head with clinical workflow integration – NPJ Digital Medicine (free) (via @EricTopol see Tweet)


10 – Risk of Unnatural Mortality in People With Epilepsy – JAMA Neurology (free for a limited period)

Editorial: Deaths in Epilepsy: What We Are Missing (free for a limited period)

Commentaries: Patients with epilepsy have greater risk of unnatural death – OnMedica (free) AND Epilepsy Diagnosis Tied to Suicide, Accident Risk – MedPage Today (free registration required)


Thu, April 12 – 10 Stories of The Day!

12 Apr,2018


1 – Zika Virus Shedding in Semen of Symptomatic Infected Men – New England Journal of Medicine (free)

Editorial: Virus in Semen and the Risk of Sexual Transmission (free)

Commentaries: New findings on Zika virus in semen may alter CDC guidance – CIDRAP (free) AND Study suggests risk of sexual transmission of Zika may dissipate quickly – STAT (free)


2 – American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis – Gastroenterology (free)

Source: New Clinical Practice Guidelines, April 2018 Edition – Medscape (free registration required)

Related guideline: Clinical practice guideline: management of acute pancreatitis – Canadian Journal of Surgery (free)


3 – Guideline: Lyme disease – National Institute for Health and Care Excellence (free)

News release: New advice will help doctors spot and treat Lyme disease early, says NICE (free)


4 – β-Amyloid accumulation in the human brain after one night of sleep deprivation – Proceedings of the National Academies of Sciences (free)

Commentaries: Don’t lose sleep over reports that one bad night can spark dementia – NHS Choices (free) AND One night of sleep deprivation leads to increase in Alzheimer’s protein – New Atlas (free) AND Expert reaction to study investigating sleep deprivation and amyloid build up – Science Media Centre (free)


5 – Long-term risk of dementia among people with traumatic brain injury in Denmark: a population-based observational cohort study – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentaries: Study confirms link between traumatic brain injury and dementia – UW Medicine, via EurekAlert (free) AND Traumatic brain injury increases risk of dementia – OnMedica (free) AND Brain injury may increase dementia risk – NHS Choices (free)

Related articles: Traumatic brain injury and the risk of dementia diagnosis: A nationwide cohort study – PLOS One (free) AND Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football – JAMA (free)


6 – NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease – Alzheimer’s & Dementia (free)

Commentaries: Scientists Push Plan To Change How Researchers Define Alzheimer’s – NPR (free) AND Researchers Propose New Alzheimer’s Definition Based on Biomarkers – MedPage Today (free registration required) AND New biological research framework for Alzheimer’s seeks to spur discovery – NIH / National Institute on Aging, via EurekAlert (fee)


7 – Guideline: Evaluation and Management of Testosterone Deficiency – American Urological Association (free)

Commentary: AUA: New Guidelines for Diagnosis, Management of Testosterone Deficiency – MPR (free)

Related Guideline: Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline – The Journal of Clinical Endocrinology & Metabolism (free)


8 – Estimating the health and economic effects of the proposed US Food and Drug Administration voluntary sodium reformulation: Microsimulation cost-effectiveness analysis – PLOS Medicine (free)

Commentaries: FDA’s Proposed Sodium Reduction Plan Could Have a Big Impact, Analysis Suggests – TCTMD (free) AND US FDA sodium reformulation targets projected to save lives and costs – PLOS, via EurekAlert (free) AND Study highlights the health and economic benefits of a US salt reduction strategy – University of Liverpool (free)


9 – Investing in non-communicable disease prevention and management to advance the Sustainable Development Goals – The Lancet (free registration required)

See complete series: The Lancet Taskforce on NCDs and economics (free registration required for articles and commentaries)

“Economic case to #BeatNCDs: benefit-cost ratio of investing in prevention and treatment of #NCDs is 5.6 for economic returns – 10.9 if social returns are included” (via @TheLancet see Tweet)


10 – Effectiveness of preventive cognitive therapy while tapering antidepressants versus maintenance antidepressant treatment versus their combination in prevention of depressive relapse or recurrence (DRD study): a three-group, multicentre, randomised controlled trial – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentary: Preventive cognitive therapy is an effective alternative and addition to antidepressants for preventing depression relapse, study finds – ACP Internist (free) AND Preventive Cognitive Therapy Helps Limit Depression Recurrence – NEJM Physician’s First Watch (free) AND Depression: preventive cognitive therapy improves outcome in recurrent depression – Univadis (free registration required)


Wed, April 11 – 10 Stories of The Day!

11 Apr,2018


1 – The State of US Health, 1990-2016: Burden of Diseases, Injuries, and Risk Factors Among US States – JAMA (free)

Editorial: Toward a United States of Health: Implications of Understanding the US Burden of Disease (free)

Author interview: US Burden of Diseases, Injuries, and Disease Risk Factors, 1990-2016 (free)

Commentaries: Warning Signs: New US Health Study Reveals ‘Dangerous Disparities’ among States – Institute for Health Metrics and Evaluation (free) AND The states where disease and death are highest: A visual guide – CNN (free)

“NEW global burden of disease study on US health is most comprehensive state-by-state health assessment ever undertaken & includes estimates for all 50 states & Washington DC & the nation overall” (via @IHME_UW see Tweet)


2 – Associations of Fitness, Physical Activity, Strength, and Genetic Risk With Cardiovascular Disease: Longitudinal Analyses in the UK Biobank Study – Circulation (free PDF for a limited period)

Commentaries: Outrunning Your Genes: Exercise Offsets CVD Events Among High-Risk Subjects – TCTMD (free) AND When heart disease runs in the family, exercise tied to lower risk – Reuters (free)


3 – Honey for acute cough in children – Cochrane Library (link to abstract – $ for full-text)

Summary: Honey for acute cough in children – Cochrane Library (free)

“Honey probably relieves cough symptoms to a greater extent than no treatment, diphenhydramine, and placebo, but may make little or no difference compared to dextromethorphan.” 


4 – Effect of pasta in the context of low-glycaemic index dietary patterns on body weight and markers of adiposity: a systematic review and meta-analysis of randomised controlled trials in adults – BMJ Open (free)

Commentary: Pasta unlikely to cause weight gain as part of a healthy diet – NHS Choices (free)


5 – Weight loss as a predictor of cancer in primary care: a systematic review and meta-analysis – British Journal of General Practice (free)

Commentaries: Weight loss is an important predictor of cancer – University of Oxford (free)


6 – A Mini Review of the Zoonotic Threat Potential of Influenza Viruses, Coronaviruses, Adenoviruses, and Enteroviruses – Frontiers in Public Health (free)

Source: Global Health NOW Newsletter


7 – EASL Clinical Practice Guidelines: Management of alcohol-related liver disease – Journal of Hepatology (free)


8 – EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma – Journal of Hepatology (free)


9 – EASL Recommendations on Treatment of Hepatitis C 2018 – Journal of Hepatology (free)


10 – Associations Between Brain Structure and Connectivity in Infants and Exposure to Selective Serotonin Reuptake Inhibitors During Pregnancy – JAMA Pediatrics (free for a limited period)

Author interview: Associations Between SSRI Exposure During Pregnancy and MRI-Assessed Brain Structure and Connectivity in Infants (free)

Commentaries: We’re beginning to learn how moms’ antidepressants can affect fetuses – VOX (free) AND MRI study finds prenatal exposure to certain antidepressants may alter brain development – Health Imaging (free) AND SSRI use in pregnancy may affect fetal brain development – OnMedica (free) AND Antidepressants in pregnancy tied to changes in babies’ brains – Reuters (free)


Tue, April 10 – 10 Stories of The Day!

10 Apr,2018


1 – Clinical Practice Guideline:  Iron Deficient Anemia – Toward Optimized Practice (TOP) (free PDF)

See also: Summary and Algorithm (free PDF)

Related: see all TOP Clinical Practice Guidelines, a practical resource for Family Physicians at the point of care.


2 – Dialysis Initiation and Mortality Among Older Veterans With Kidney Failure Treated in Medicare vs the Department of Veterans Affairs – JAMA Internal Medicine (free for a limited period)

Invited commentary: Appropriate Time for Chronic Dialysis Initiation: A Cause for Humility (free for a limited period)

Related articles: Treatment decisions for older adults with advanced chronic kidney disease – BMC Nephrology (free) AND Timing of Dialysis Initiation – What Has Changed Since IDEAL? – Seminars in Nephrology (free)


3 – Childhood predictors of lung function trajectories and future COPD risk: a prospective cohort study from the first to the sixth decade of life – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

Related article: Lung function trajectories from pre-school age to adulthood and their associations with early life factors: a retrospective analysis of three population-based birth cohort studies – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

Commentaries: Three-quarters of COPD cases are linked to childhood risk factors that are exacerbated in adulthood – The Lancet, via ScienceDaily (free) AND Early intervention may minimise later lung problems – The Melbourne Newsroom (free) AND COPD Risk Factors Evident Early in Life – NEJM Physician’s First Watch (free)


4 – Seminar: Malaria – The Lancet (free registration required)


5 – Perspective: Many People Taking Antidepressants Discover They Cannot Quit – The New York Times (10 articles per month are free)


6 – The burden of online friends: the effects of giving up Facebook on stress and well-being – The Journal of Social Psychology (free)

Commentaries: Quitting Facebook can reduce stress – University of Queensland (free) AND Giving up Facebook leads to a drop in the stress-related hormone cortisol, study finds – PsyPost (free) AND Does Quitting Facebook Really Make You Less Happy? Probably Not – Forbes (free) AND Want to de-stress? Delete Facebook, study suggests – Medical News Today (free)


7 – Alpha-blockers as medical expulsive therapy for ureteral stones – Cochrane Library (link to abstract – $ for full-text)

Summary: Alpha-blockers for ureteral stones in adult patients with symptoms of stone disease – Cochrane Library (free)


8 – Consolidated principles for screening based on a systematic review and consensus process – Canadian Medical Association Journal (free)


9 – AHA Policy Statement: Projected Costs of Informal Caregiving for Cardiovascular Disease: 2015 to 2035 – Circulation (free)

Commentary: Skyrocketing Costs of CVD Will Be Amplified by Informal Caregiving: AHA – TCTMD (free)


10 – Pharmaceutical Industry Payments and Oncologists’ Selection of Targeted Cancer Therapies in Medicare Beneficiaries – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Payments to Doctors Linked to Prescription Practices for Two Cancer Types – University of North Carolina (free) AND Pharma Dollars Appear to Sway Oncologist Rx Habits – MedPage Today (free registration required)


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